December 2014 PMID 25502052

Caffeine as an analgesic adjuvant for acute pain in adults.

Christopher J Derry, Sheena Derry, R Andrew Moore

Mentions

19
Peak: 3 in Mar 2020
across 2 sources since Apr 2019

Extended reach

184,620
potential audience

Total likes

265

Video views

4,221

Mentions per month

Apr 2019 – Nov 2025

Where it's discussed

  • X / Twitter17 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight key points such as the evidence suggesting small benefits of adding caffeine to painkillers, exemplified by mentions of dosage levels like 100mg, and reference to authoritative reviews such as Cochrane. The tone balances scientific referencing with cautious interpretation, reflecting a nuanced understanding and moderate engagement overall.

AgreementNeither agree nor disagree

The discussions show a mix of support and skepticism regarding the effectiveness of caffeine as an analgesic adjuvant, with some posts referencing positive effects while others highlight limited or inconclusive evidence.

InterestModerate interest

The participants show moderate interest, particularly when discussing specific data like the 100mg caffeine dosage or referencing medical reviews, but overall curiosity seems balanced with caution.

EngagementModerate engagement

Posts reflect some direct engagement through sharing evidence, citing studies, and discussing potential applications, yet the tone suggests an analytical rather than emotional or deep engagement.

ImpactNeutral impact

The collective discussions have a neutral impact; they present valuable information but do not convey a sense of transformative or immediate significance for health practices.

Abstract in brief

  • This review examines whether adding caffeine to common painkillers like paracetamol, ibuprofen, or aspirin actually improves pain relief in adults with acute pain, highlighting that existing evidence is limited and often unreliable.
  • The researchers analyzed randomized, double-blind studies comparing single doses of analgesics with and without caffeine, assessing pain relief effectiveness, patient satisfaction, and serious side effects, but found no new studies since the last review in 2012.
  • Overall, the findings suggest that there's insufficient high-quality evidence to confirm that caffeine significantly enhances analgesic effects or reduces adverse events when combined with analgesics for acute pain.]

Top posts

Most liked on X and Bluesky
小嶋 慎二@community pharmacist
@kojima_aponet · X

鎮痛成分にカフェイン配合に意味があるのは知らなかった アブストラクトは和訳があります 【Cochrane Database Syst Rev】 Caffeine as an Analgesic Adjuvant for Acute Pain in Adults https://t.co/78v2dqtXWh

Mar 20, 2020 · 31 likes · 3 shares · 8,178 followers View post →
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X

Fun fact: the pain relieving effects of painkillers (ibuprofen or paracetamol) may be enhanced if they are taken with > 100 mg of #caffeine (about 1 cup of coffee's worth of caffeine) https://t.co/ICZyBbcpLF

Oct 21, 2021 · 10 likes · 6 shares · 8,785 followers View post →
Coley Parker
@facaldaqui · X

@JudeeeC "Addition of caffeine (≥ 100 mg) to a standard dose of commonly used analgesics provides a small but important increase in the proportion of participants who experience a good level of pain relief." Derry et al, "Caffeine as an analgesic adjuvant for acute pain in adults", 2014

Aug 20, 2021 · 1 like · 1,054 followers View post →
TrialsChangLives
@GoodluckJBers14 · X

#CochraneDaily Around your health in 100 Cochrane Reviews. 9: ADDING CAFFEINE FOR PAIN RELIEF. @CochraneLibrary Review found that adding 100mg #caffeine (equivalent to a cup of #coffee) to a standard dose of common painkillers provided better #pain relief https://t.co/XZHyOqppuZ

Apr 18, 2023 · 1 like · 45 followers View post →
Cochrane
@cochranecollab · X

@LTrainDotCom This one? https://t.co/Gh2N6NGrze We are happy to hear it could help inform your health decisions. Please see here if you would like to share your story of using Cochrane evidence more widely: https://t.co/UR6DTjmFk0

Feb 27, 2020 · 120,713 followers View post →
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X

RT @angryhacademic: Fun fact: the pain relieving effects of painkillers (ibuprofen or paracetamol) may be enhanced if they are taken with >…

Oct 21, 2025 · 6 shares · 8,785 followers View post →

All mentions

masa 薬剤師
@MasahideOr66774 · X

珈琲(カフェイン)☕が有効なのはこれ以外に 1.鎮痛剤の効果増強 疼痛(歯痛、産後痛、頭痛など)時の鎮痛剤(カロナールやイブプロフェン)にカフェイン100mg以上併用 →鎮痛剤単独よりも更に約5~10%が鎮痛レベル(4~6時間で最大鎮痛量の50%以上)を達成(Cochrane Library2014) https://t.co/BDceSZ7ehQ

Nov 10, 2025 · 55 followers View post →
pitifulcmnd
@pitifulcmnd · X

RT @angryhacademic: Fun fact: the pain relieving effects of painkillers (ibuprofen or paracetamol) may be enhanced if they are taken with >…

Oct 21, 2025 · 6 shares · 13 followers View post →
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X

RT @angryhacademic: Fun fact: the pain relieving effects of painkillers (ibuprofen or paracetamol) may be enhanced if they are taken with >…

Oct 21, 2025 · 6 shares · 8,785 followers View post →
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X

RT @angryhacademic: Fun fact: the pain relieving effects of painkillers (ibuprofen or paracetamol) may be enhanced if they are taken with >…

Oct 21, 2024 · 6 shares · 8,785 followers View post →
Anthony Sayegh
@anthony__sayegh · X

RT @AFPJournal: Caffeine as an analgesic adjuvant for acute pain in adults: http://t.co/rOKtFkdrQJ

Feb 10, 2024 · 2 shares · 14 followers View post →
Louisa Frith
@LouisaFrith · X

RT @angryhacademic: Fun fact: the pain relieving effects of painkillers (ibuprofen or paracetamol) may be enhanced if they are taken with >…

Oct 21, 2023 · 6 shares · 128 followers View post →
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X

RT @angryhacademic: Fun fact: the pain relieving effects of painkillers (ibuprofen or paracetamol) may be enhanced if they are taken with >…

Oct 21, 2023 · 6 shares · 8,785 followers View post →
TrialsChangLives
@GoodluckJBers14 · X

#CochraneDaily Around your health in 100 Cochrane Reviews. 9: ADDING CAFFEINE FOR PAIN RELIEF. @CochraneLibrary Review found that adding 100mg #caffeine (equivalent to a cup of #coffee) to a standard dose of common painkillers provided better #pain relief https://t.co/XZHyOqppuZ

Apr 18, 2023 · 1 like · 45 followers View post →
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X

RT @angryhacademic: Fun fact: the pain relieving effects of painkillers (ibuprofen or paracetamol) may be enhanced if they are taken with >…

Oct 21, 2022 · 6 shares · 8,785 followers View post →
Bike How
@HowBike · X

Caffeine as an analgesic adjuvant for acute pain in adults https://t.co/Mk99PDHHmT

May 9, 2022 · 59 followers View post →
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X

Fun fact: the pain relieving effects of painkillers (ibuprofen or paracetamol) may be enhanced if they are taken with > 100 mg of #caffeine (about 1 cup of coffee's worth of caffeine) https://t.co/ICZyBbcpLF

Oct 21, 2021 · 10 likes · 6 shares · 8,785 followers View post →
Coley Parker
@facaldaqui · X

@JudeeeC "Addition of caffeine (≥ 100 mg) to a standard dose of commonly used analgesics provides a small but important increase in the proportion of participants who experience a good level of pain relief." Derry et al, "Caffeine as an analgesic adjuvant for acute pain in adults", 2014

Aug 20, 2021 · 1 like · 1,054 followers View post →
ニック
@purinperan1234 · X

RT @kojima_aponet: 鎮痛成分にカフェイン配合に意味があるのは知らなかった アブストラクトは和訳があります 【Cochrane Database Syst Rev】 Caffeine as an Analgesic Adjuvant for Acute Pai…

Mar 20, 2020 · 3 shares · 385 followers View post →
economicscience
@economicscience · X

RT @kojima_aponet: 鎮痛成分にカフェイン配合に意味があるのは知らなかった アブストラクトは和訳があります 【Cochrane Database Syst Rev】 Caffeine as an Analgesic Adjuvant for Acute Pai…

Mar 20, 2020 · 3 shares · 5,687 followers View post →
小嶋 慎二@community pharmacist
@kojima_aponet · X

鎮痛成分にカフェイン配合に意味があるのは知らなかった アブストラクトは和訳があります 【Cochrane Database Syst Rev】 Caffeine as an Analgesic Adjuvant for Acute Pain in Adults https://t.co/78v2dqtXWh

Mar 20, 2020 · 31 likes · 3 shares · 8,178 followers View post →
Cochrane
@cochranecollab · X

@LTrainDotCom This one? https://t.co/Gh2N6NGrze We are happy to hear it could help inform your health decisions. Please see here if you would like to share your story of using Cochrane evidence more widely: https://t.co/UR6DTjmFk0

Feb 27, 2020 · 120,713 followers View post →
Giuseppe Iaffaldano
@PepponeFX · X

@igorsteinmacher You should try to increase the caffeine: https://t.co/smlu0b9VW1 But find first a solution for insomnia

Apr 9, 2019 · 38 followers View post →