PubHawk
Cell January 2015 PMID 25542313

Endogenous hydrogen sulfide production is essential for dietary restriction benefits.

Christopher Hine, Eylul Harputlugil, Yue Zhang, Christoph Ruckenstuhl, Byung Cheon Lee, Lear Brace, Alban Longchamp, Jose H Treviño-Villarreal, Pedro Mejia, C Keith Ozaki, Rui Wang, Vadim N Gladyshev, Frank Madeo, William B Mair, James R Mitchell

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Mentions

70
Peak: 2 in Mar 2025
across 6 sources since Jan 2021

Extended reach

2,092
potential audience

Total likes

9

Video views

746

Mentions per month

Jan 2021 – Mar 2025

Where it's discussed

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  • Reddit4 posts
  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

Many comments reference previous work, such as the 2015 Cell paper, highlighting ongoing scientific interest in how dietary restriction influences H2S production through pathways like mTORC1. The tone suggests curiosity and acknowledgment of the publication’s contribution to understanding the mechanistic basis of dietary benefits, emphasizing its relevance for potential clinical applications.

AgreementModerate agreement

Most posts seem to align with the idea that endogenous H2S plays a key role in dietary restriction benefits, showing partial agreement or curiosity about the findings.

InterestModerate interest

Discussions show some curiosity, particularly when referencing mechanisms like TSP and historical research, but overall interest appears moderate.

EngagementModerate engagement

Participants engage enough to connect the study to prior research, suggesting a moderate depth of discussion about the mechanistic implications.

ImpactModerate impact

The conversation indicates that the publication could influence future research directions and therapeutic approaches, though it's not seen as a revolutionary breakthrough for all.

Abstract in brief

  • Dietary restriction (DR) without malnutrition enhances longevity and stress resistance, with a key mechanism involving increased hydrogen sulfide (H2S) production via the transsulfuration pathway (TSP).
  • Restricting sulfur amino acids (SAA) boosts the enzyme cystathionine lyase (CGL), leading to higher H2S levels, which protect organs like the liver from injury; disrupting this process diminishes DR's benefits.
  • This TSP-dependent H2S production is evolutionarily conserved across species such as yeast, worms, flies, and rodents, indicating its fundamental role in mediating the health benefits of dietary restriction, with potential clinical applications.
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Top posts

Most liked on X and Bluesky
Rui Wang
@RuiWangMarkham · X

@steveroedde @AlexFreedman40 They are related. In our 2015 Cell paper https://t.co/Z6S2B7qCMO, it said "DR Stimulates Endogenous H2S Production via Repression of mTORC1 and Activation of the TSP".

Jan 26, 2021 · 2 likes · 453 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits https://t.co/WCOx8zcqTj To gain mechanistic & therapeutic insights into COVID-19: https://t.co/6ySOYVgCcD https://t.co/3q3H8bcOAL https://t.co/ZGNRi4CquW Twitter: @DrLBoominathan https://t.co/HYZMkFf3oi

Dec 28, 2021 · 894 followers View post →

All mentions

Dr L Boominathan PhD
@DrLBoominathan · X

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits https://t.co/WCOx8zcqTj To gain mechanistic & therapeutic insights into COVID-19: https://t.co/6ySOYVgCcD https://t.co/3q3H8bcOAL https://t.co/ZGNRi4CquW Twitter: @DrLBoominathan https://t.co/HYZMkFf3oi

Dec 28, 2021 · 894 followers View post →
Rui Wang
@RuiWangMarkham · X

@steveroedde @AlexFreedman40 They are related. In our 2015 Cell paper https://t.co/Z6S2B7qCMO, it said "DR Stimulates Endogenous H2S Production via Repression of mTORC1 and Activation of the TSP".

Jan 26, 2021 · 2 likes · 453 followers View post →