A double-blind randomized study comparing the association of Retinol and LR2412 with tretinoin 0.025% in photoaged skin.

Abstract in brief

• The study compared the effectiveness and tolerance of a combination of Retinol 0.2% and LR2412-2% versus tretinoin 0.025% in women with photoaged skin over 3 months, finding both treatments improved skin features like wrinkles, pigmentation, and pores with no significant differences in clinical outcomes.
• Retinol 0.2%/LR2412-2% was generally better tolerated, causing milder side effects compared to tretinoin, and women perceived it as equally or more effective.
• Overall, Retinol 0.2%/LR2412-2% offers a comparable efficacy to tretinoin with improved tolerability and perception, making it a suitable alternative for skin rejuvenation.]