PubHawk
July 2015 PMID 25650773

Hepatotoxicity associated with agomelatine and other antidepressants: Disproportionality analysis using pooled pharmacovigilance data from the Uppsala Monitoring Centre.

Maximilian Gahr, René Zeiss, Dirk Lang, Bernhard J Connemann, Carlos Schönfeldt-Lecuona

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Mentions

6
Peak: 4 in Jul 2020
across 2 sources since Feb 2019

Extended reach

22,690
potential audience

Total likes

147

Video views

5,039

Mentions per month

Feb 2019 – Jul 2020

Where it's discussed

  • X / Twitter4 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions mainly reference the use of organoids as a platform for personalized treatment approaches, with phrases like 'can be used as a platform' and tags such as #personalizedmedicine. The tone is informational and optimistic, but it lacks detailed critique or exploration of implications, resulting in a neutral overall impact assessment.

AgreementNeither agree nor disagree

The discussions do not explicitly agree or disagree with the publication, focusing more on applications than supporting evidence.

InterestModerate interest

The posts show some curiosity about the potential applications of organoids, indicating moderate interest.

EngagementNeutral engagement

The comments are relatively brief and mainly share information without deep analysis or critique.

ImpactNeutral impact

The discussions highlight ongoing research but do not suggest immediate or widespread changes in practice based on the publication.

Abstract in brief

  • This study analyzed data from the WHO Uppsala Monitoring Centre to investigate the risk of liver damage (hepatotoxicity) associated with the antidepressant agomelatine (AGM) and other medications, finding that AGM is statistically linked to an increased risk of severe liver reactions.
  • The analysis showed that AGM had a significantly higher reporting odds ratio (ROR) for hepatotoxicity, second only to amineptine among the drugs studied, indicating a stronger association with liver toxicity compared to others like nefazodone and tianeptine.
  • However, the researchers noted that the data and methods used do not allow for precise measurement of how severe the hepatotoxicity is for each drug, nor do they provide clear differences between the substances’ risks, highlighting the need for further safety assessments.
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Top posts

Most liked on X and Bluesky
Wake Forest Surgical Oncology
@WakeSurgonc · X

Organoids can be used as a platform for a personalized approach to identify the optimal HIPEC protocol. Our latest publication https://t.co/5wnBUuonUm @AnnSurgOncol @KVotanopoulos @OMoaven @StevenDForsythe #personalizedmedicine #HIPEC #organoids https://t.co/w4zJAmdCfL

Jul 7, 2020 · 8 likes · 4 shares · 432 followers View post →
Annals of Surgical Oncology
@AnnSurgOncol · X

RT @WakeSurgonc: Organoids can be used as a platform for a personalized approach to identify the optimal HIPEC protocol. Our latest publica…

Jul 7, 2020 · 4 shares · 16,553 followers View post →
Omeed Moaven, MD
@OMoaven · X

RT @WakeSurgonc: Organoids can be used as a platform for a personalized approach to identify the optimal HIPEC protocol. Our latest publica…

Jul 7, 2020 · 4 shares · 499 followers View post →
Steven Forsythe
@StevenDForsythe · X

RT @WakeSurgonc: Organoids can be used as a platform for a personalized approach to identify the optimal HIPEC protocol. Our latest publica…

Jul 7, 2020 · 4 shares · 136 followers View post →

All mentions

Annals of Surgical Oncology
@AnnSurgOncol · X

RT @WakeSurgonc: Organoids can be used as a platform for a personalized approach to identify the optimal HIPEC protocol. Our latest publica…

Jul 7, 2020 · 4 shares · 16,553 followers View post →
Steven Forsythe
@StevenDForsythe · X

RT @WakeSurgonc: Organoids can be used as a platform for a personalized approach to identify the optimal HIPEC protocol. Our latest publica…

Jul 7, 2020 · 4 shares · 136 followers View post →
Omeed Moaven, MD
@OMoaven · X

RT @WakeSurgonc: Organoids can be used as a platform for a personalized approach to identify the optimal HIPEC protocol. Our latest publica…

Jul 7, 2020 · 4 shares · 499 followers View post →
Wake Forest Surgical Oncology
@WakeSurgonc · X

Organoids can be used as a platform for a personalized approach to identify the optimal HIPEC protocol. Our latest publication https://t.co/5wnBUuonUm @AnnSurgOncol @KVotanopoulos @OMoaven @StevenDForsythe #personalizedmedicine #HIPEC #organoids https://t.co/w4zJAmdCfL

Jul 7, 2020 · 8 likes · 4 shares · 432 followers View post →