A systematic review of extravasation and local tissue injury from administration of vasopressors through peripheral intravenous catheters and central venous catheters.

Osama M Loubani, Robert S Green

June 2015 J Crit Care

Synopsis of Social media discussions

The discussions analyze the safety of peripheral vasopressor infusions, with posts citing specific data like infusion durations of around 55 hours, and some participants debating complications and best practices, emphasizing a nuanced understanding of the article's findings through technical language and clinical context.

A
Agreement
 Moderate agreement

Most users acknowledge the findings, highlighting the balance between peripheral and central line use, with some emphasizing the safety of short-term peripheral administration.

I
Interest
 High level of interest

Discussions reflect high curiosity due to clinical relevance, with mentions of infusion durations and complication rates.

E
Engagement
 Moderate level of engagement

Posts include specific data points like infusion times and incidents, showing moderate active engagement rather than passive reading.

I
Impact
 Moderate level of impact

The posts discuss practical implications such as earlier use of peripheral lines and safety considerations, indicating a moderate influence on clinical practice.

Social Mentions

YouTube

2 Videos

Bluesky

3 Posts

Facebook

1 Posts

Twitter

1 Posts

Blogs

6 Articles

News

9 Articles

Reddit

10 Posts

Metrics

Video Views

5,055

Total Likes

178

Extended Reach

23,330

Social Features

32

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Safety of Norepinephrine Infusions in Surgery

Safety of Norepinephrine Infusions in Surgery

This video discusses the safety of using norepinephrine infusions through peripheral IV lines during surgery. With a review of 14,385 patients, the study suggests a very low risk of complications, significantly aiding in hypotension management.

Ta de Clinicagem

January 29, 2023

4,898 views

Safety of Peripheral Vasopressor Use in Critically Ill Patients

Safety of Peripheral Vasopressor Use in Critically Ill Patients

Contributor Aaron Lessen MD discusses the safety of peripheral vasopressor administration, highlighting low tissue injury risks and safety measures such as larger bore and proximal IV sites, which suggest peripheral use can be safe in critical care.

Emergency Medical Minute

September 15, 2020

158 views

  • Anthony Lau, PharmD BCPS
    @alaurx.bsky.social (Bluesky)

    "There were 204 local tissue injury events from peripheral administration of vasopressors, with an average duration of infusion of 55.9 hours (±68.1), median time of 24 hours, and range of 0.08 to 528 hours." #medsky #EMsky #nursesky #pharmsky pubmed.ncbi.nlm.nih.gov/25669592/
    view full post

    November 18, 2024

  • Anthony Lau, PharmD BCPS
    @alaurx.bsky.social (Bluesky)

    Before, we've stuck to central lines for pressors to avoid extravasation but waiting for CL isn't an option when profoundly hypotensive. Short-term peripheral admin of pressors is safe. Complications arise after ~55h of infusion #medsky #EMsky #nursesky #pharmsky pubmed.ncbi.nlm.nih.gov/25669592/
    view full post

    November 18, 2024

    23

    11

  • Vitor Borin P. de Souza
    @vitorborin_ (Twitter)

    @anabenzaprina @miauhelo @camomiwa Olha, casos de extravasamento são bem raros e mesmo assim, necrose local é mais rara ainda. Pra acontecer nos 4 membros? Ou alguém fez algo muito errado ou não foi os vasopressores. https://t.co/FPj012qffa +
    view full post

    June 26, 2023

    1

  • Gav
    @dentongavin.bsky.social (Bluesky)

    A systematic review of extravasation and local tissue injury from administration of vasopressors through pvc or cvc http://www.wessexics.com/The_Bottom_Line/Review/index.php?id=6892495633638977747
    view full post

    June 27, 2015

  • Sốc nhiễm trùng | PDF

    J Crit Care. 2015 Jun;30(3):653.e9-17. doi: 10.1016/j.jcrc.2015.01.014 [PubMed] • 26014852 Cardenas-Garcia J, Schaub KF, Belchikov YG, Narasimhan M, Koenig ...
    view full post

    December 12, 2025

    News

  • DiseaseandHealthResearch NewInsightsVol.1 Ebook 1 | PDF ...

    2017;42:366–72. Available:https://doi.org/10.1016/j.jcrc.2017.11.006 14 ... 2015;64:111–9. Available:http://dx.doi.org/10.1016/j.jcv.2015.01.014 17 ...
    view full post

    December 12, 2025

    News

  • Anesthetic MGT For Sepsis - Septic Shock | PDF | Sepsis | Shock ...

    J Crit Care. (2015) cytokine response in cultured human whole blood. Anesthesiology. (1998) 30:653.e9–653.e17. doi: 10.1016/j.jcrc.2015.01.014 89:1218–27.
    view full post

    December 12, 2025

    News

  • Analyzing Outcomes For Peripheral Versus Central.16 | PDF ...

    vasopressor administration. In patients with equal central 2015;30:653.e9‑17. [DOI: 10.1016/j.jcrc.2015.01.014].
    view full post

    December 12, 2025

    News

  • Drug Extravasation Risk Factors | PDF

    doi:10.1016/j.ijsu.2014.08.355 Care. 2015;30(3):653.e9–17. doi:10.1016/j.jcrc.2015.01.014 7. Shaqdan K, Aran S, Thrall J, et al. Incidence of contrast ...
    view full post

    December 12, 2025

    News

  • Infusion Therapy Standards of Practice 2021 | PDF | Nursing | Health ...

    J Crit Care. Vessel Health and Preservation: The Right Approach for Vascular 2015;30(3):653.e9-653.e6.53E17. doi:10.1016/j.jcrc.2015.01.014. Access ...
    view full post

    December 12, 2025

    News

  • IV Extravasation Management Guide | PDF | Intravenous Therapy ...

    doi:10.1016/j.jcrc.2015.01.014 8. Fox AN, Villanueva R, Miller JL. Management of amiodarone extravasation with intradermal hyaluronidase. Am J Health Syst ...
    view full post

    December 12, 2025

    News

  • A Systematic Review of Extravasation and Local Tissue Injury From ...

    infusion in these areas will cause tissue injury. doi.org/10.1016/j.jcrc.2015.01.014. Because the data from this review are derived principally from case
    view full post

    December 12, 2025

    News

  • Septic Shock - EMCrit Project

    J Crit Care. 2015 Jun;30(3):653.e9-17. doi: 10.1016/j.jcrc.2015.01.014 [PubMed]; 26014852 Cardenas-Garcia J, Schaub KF, Belchikov YG ...
    view full post

    November 11, 2025

    Blogs

  • Peripheral IVs are preferable to central lines for most patients with ...

    doi: 10.1016/j.jcrc.2015.01.014. Epub 2015 Jan 22. PMID: 25669592. https://bmcnurs.biomedcentral.com/articles/10.1186/ ...
    view full post

    September 24, 2025

    Blogs

  • 血管加压药物在急诊休克中的应用专家共识2021 | PDF

    DOI:10.1016/j.resuscitation.2010.08.015. study comparing high-dose ... jcrc.2009.05.003. [55] Dettmer M, Holthaus CV, Fuller BM. The ...
    view full post

    September 14, 2025

    News

  • Normalicemos usar Vasopresores por Vía Periférica Son de seguros ...

    ... 10.1016/j.jcrc. 2015.01.014). Habrá que revisar que vasopresor se usa al inicio (acá en Londres se usa mucho metaraminol periferico). La ...
    view full post

    April 25, 2024

    Facebook

  • Atrial Fibrillation (AF) & Flutter complicating critical illness - EMCrit ...

    doi: 10.1016/j.jcrc.2011.10.011 [PubMed]; 22520937 Gu WJ, Wu ZJ, Wang ... doi: 10.1016/j.jemermed.2015.01.014 [PubMed]; 27043047 Gillinov ...
    view full post

    April 10, 2024

    Blogs

  • Pressors : r/nursing

    ... and central venous catheters. J Crit Care. 2015;30(3):653.e9-653.e6.53E17. doi:10.1016/j.jcrc.2015.01.014. MountainTomato9292. • 3y ago.
    view full post

    October 13, 2022

    Reddit

  • 血管升壓劑: r/nursing

    doi:10.1016/j.ajem.2020.01.014. 25. Medlej K, Kazzi AA, El Hajj ... jcrc.2015.01.014. MountainTomato9292. • 3 年前. 我們很少會從周邊靜脈打升 ...
    view full post

    October 13, 2022

    Reddit

  • Pressores : r/nursing

    ... e cateteres venosos centrais. J Crit Care. 2015;30(3):653.e9-653.e6.53E17. doi:10.1016/j.jcrc.2015.01.014. MountainTomato9292. • há 3 anos.
    view full post

    October 13, 2022

    Reddit

  • Прессоры : r/nursing

    ... и центральные венозные катетеры. J Crit Care. 2015;30(3):653.e9-653.e6.53E17. doi:10.1016/j.jcrc.2015.01.014. MountainTomato9292.
    view full post

    October 13, 2022

    Reddit

  • 升压药: r/nursing

    doi:10.1016/j.ajem.2020.01.014. 25. Medlej K, Kazzi AA, El Hajj ... jcrc.2015.01.014. MountainTomato9292. • 3年前. 我们很少通过外周血管给升压 ...
    view full post

    October 13, 2022

    Reddit

  • Pressors : r/nursing

    ... central venous catheters. J Crit Care. 2015;30(3):653.e9-653.e6.53E17. doi:10.1016/j.jcrc.2015.01.014. MountainTomato9292. • 3 taon ang ...
    view full post

    October 13, 2022

    Reddit

  • Pressorer : r/nursing

    ... katetre og sentrale venekatetre. J Crit Care. 2015;30(3):653.e9-653.e6.53E17. doi:10.1016/j.jcrc.2015.01.014. MountainTomato9292. • for 3 år ...
    view full post

    October 13, 2022

    Reddit

  • Presory : r/nursing

    ... i cewniki żylne centralne. J Crit Care. 2015;30(3):653.e9-653.e6.53E17. doi:10.1016/j.jcrc.2015.01.014. MountainTomato9292. • 3 lata temu.
    view full post

    October 13, 2022

    Reddit

  • Pressorer : r/nursing

    ... katetrar och centrala venkatetrar. J Crit Care. 2015;30(3):653.e9-653.e6.53E17. doi:10.1016/j.jcrc.2015.01.014. MountainTomato9292. • för 3 år ...
    view full post

    October 13, 2022

    Reddit

  • Teach me about IV lines : r/pharmacy

    J Crit Care. 2015;30(3):653.e9-653.e6.53E17. doi:10.1016/j.jcrc.2015.01.014. Marsh N, Webster J, Larson E, Cooke M, Mihala G, Rickard CM.
    view full post

    June 12, 2021

    Reddit

  • Preeclampsia & HELLP - EMCrit Project

    J Crit Care. 2015 Jun;30(3):653.e9-17. doi: 10.1016/j.jcrc.2015.01.014 [PubMed]; 26014852 Cardenas-Garcia J, Schaub KF, Belchikov YG ...
    view full post

    May 29, 2021

    Blogs

  • Loubani – The Bottom Line

    doi:10.1016/j.jcrc.2015.01.014. Clinical Question. In patients who are administered vasopressor medication intravenously, what are the ...
    view full post

    June 26, 2015

    Blogs

  • Peripheral Vasopressor Infusions and Vasopressor Extravasation

    ... (10.1016/j.jcrc.2015.01.014); Paul Mayo's group published the LIJ Experience; A paper by Kamal Medlej., et al. “Complications from the ...
    view full post

    September 16, 2013

    Blogs

Abstract Synopsis

  • This systematic review examined reports of tissue injury or extravasation caused by vasopressor drugs administered through peripheral or central IVs, analyzing data up to January 2014.
  • A total of 85 articles involving 270 patients were included, with most tissue injury events (204 out of 270) resulting from peripheral IV vasopressor infusions, which typically lasted around 24 hours.
  • The review highlights that most injuries occurred at sites distal to major joints, and emphasizes the need for further research to better understand the safety of peripheral vasopressor administration.