PubHawk
Front Neurosci March 2015 PMID 25774123

Lactate is always the end product of glycolysis.

Matthew J Rogatzki, Brian S Ferguson, Matthew L Goodwin, L Bruce Gladden

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Mentions

60
Peak: 31 in Aug 2023
across 4 sources since Jan 2019

Extended reach

137,419
potential audience

Total likes

756

Video views

26,166

Mentions per month

Jan 2019 – Aug 2025

Where it's discussed

  • X / Twitter48 posts
  • News9 articles
  • YouTube2 videos
  • Blogs1 articles

AI synopsis

What people are saying

The group's discussions highlight strong support for the main idea, with tweets referencing key authors, studies, and models, such as the mention of the ‘lactate shuttle’, which showcases their deep engagement with the research. The tone varies from affirming support to pointing out necessary updates to existing knowledge, indicating a respectful yet critical interest in the concept's implications.

AgreementStrong agreement

Most discussions fully support the idea that lactate is always the end product of glycolysis, emphasizing its role as a fundamental component of cellular metabolism.

InterestModerate interest

While there is consistent interest in the metabolic implications, only some discussions delve into detailed mechanisms or challenge previous views.

EngagementModerate engagement

Several posts reference scientific concepts, papers, or models, indicating moderate engagement with the details of the publication.

ImpactModerate impact

The discussions reflect recognition of the concept's significance in understanding metabolism, but not all suggest a transformative impact on practice or theory.

Abstract in brief

  • The text explains that lactate (La) is always the end product of glycolysis, challenging the older view that lactate is just a waste product during low oxygen conditions and pyruvate is the main end product when oxygen is available.
  • It emphasizes that lactate levels inside cells depend on factors such as the rate of glycolysis, activity of oxidative enzymes, oxygen levels, and lactate transport across cell membranes, rather than lactate being simply a waste product.
  • The authors propose a "Lactate Shuttle" model, similar to the phosphocreatine shuttle, suggesting that lactate, pyruvate, and NAD/NADH are kept near equilibrium within the cell, linking glycolysis directly to energy production in mitochondria.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Jeremy Loenneke
@jploenneke · X

Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 163 likes · 34 shares · 8,588 followers View post →
Jeremy Loenneke
@jploenneke · X

Trying to wrap your head around "lactate is always the end product of glycolysis" try these two papers (figure from second link) https://t.co/GpJX2eAqrB https://t.co/bYHHqv5xmd https://t.co/GqAV1Il14W

Jan 22, 2019 · 26 likes · 6 shares · 8,588 followers View post →
Iñigo San Millán
@doctorinigo · X

@raphaels7 Absolutely, lactate is always the end product of glycolysis as Schurr and the great @GeorgeABrooks3 have been preaching for years.

Feb 18, 2021 · 9 likes · 42,403 followers View post →
Tom Hughes
@DrTEHughes · X

@jem_arnold @GregLehman Instead, if we look at it as a fuel/flux. And also consider that lactate is the end product of glycolysis (not pyruvate, see ref). Then lactate exists as a flux, with its concentration dependent on lots of factors. 2/ https://t.co/9GLmDfm2ya

Feb 23, 2025 · 4 likes · 2,773 followers View post →
Bernardo N. Ide, Ph.D.
@bernardo_0311 · X

Como pode ser "anti-glicolítico"? https://t.co/LXmpIFvtwm

Jan 21, 2021 · 3 likes · 779 followers View post →
brusicor02
@brusicor02 · X

@campiche_sarah @Blablareau Que votre formulation initiale propage une vision de la glycolyse qui n'est plus à jour. Et pour quelqu'un qui se revendique "fakemed", ne pas voir où est le problème est... problématique. https://t.co/SUTqHxacvD

Aug 5, 2024 · 1 like · 6,140 followers View post →

All mentions

Tom Hughes
@DrTEHughes · X

@jem_arnold @GregLehman Instead, if we look at it as a fuel/flux. And also consider that lactate is the end product of glycolysis (not pyruvate, see ref). Then lactate exists as a flux, with its concentration dependent on lots of factors. 2/ https://t.co/9GLmDfm2ya

Feb 23, 2025 · 4 likes · 2,773 followers View post →
Rene Sugar
@renesugar · X

Lactate is always the end product of glycolysis https://t.co/FrfzhUc9CN

Sep 12, 2024 · 3,967 followers View post →
Hezerminat
@Hezerminator · X

@photobiogenesis Regarding pyruvate, you might need to update your info: https://t.co/j51S02MUgg

Sep 9, 2024 · 1,083 followers View post →
brusicor02
@brusicor02 · X

@campiche_sarah @Blablareau Que votre formulation initiale propage une vision de la glycolyse qui n'est plus à jour. Et pour quelqu'un qui se revendique "fakemed", ne pas voir où est le problème est... problématique. https://t.co/SUTqHxacvD

Aug 5, 2024 · 1 like · 6,140 followers View post →
Hugo | Enseignant en APA
@Hugo_EAPA · X

@Ivanhoe53 @GaelLemaitre @GeekNfit https://t.co/UUb2ktcDWw

Jan 4, 2024 · 544 followers View post →
Rx Readmore Livemore
@SopitaSirirata1 · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Sep 2, 2023 · 34 shares · 174 followers View post →
Wagner Prado
@wagnerprado7 · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 25, 2023 · 34 shares · 603 followers View post →
Ariel Nascimento PT
@Ariel_nasc · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 25, 2023 · 34 shares · 176 followers View post →
Zac Crowley (PhD)
@crowley_zac · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 25, 2023 · 34 shares · 204 followers View post →
The Viking Turtle
@TheVikingTurtle · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 24, 2023 · 34 shares · 146 followers View post →
MD
@MichaelDasaro_ · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 24, 2023 · 34 shares · 8 followers View post →
Harry García Muñoz
@harrygarci · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 24, 2023 · 34 shares · 28 followers View post →
Dani Reyes Olavarría
@Daniitota · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 24, 2023 · 34 shares · 463 followers View post →
Niels Ørtenblad
@nortenblad · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 24, 2023 · 34 shares · 567 followers View post →
♰
@drmistico17 · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 24, 2023 · 34 shares · 841 followers View post →
Viviana
@VivianAya93 · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 133 followers View post →
stephen LoRusso
@stephenLoRusso2 · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 208 followers View post →
Renato Dumbra
@renatodumbra · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 120 followers View post →
¡Elige Moverte!
@EligeMoverte · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 17 followers View post →
Aurelian Gorea, M.Sс., CSCS. 
@AurelianGorea · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 129 followers View post →
S. Jun Son, PhD, ATC
@SJunSon1 · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 130 followers View post →
Joachim Nielsen
@JoachimNielsen6 · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 1,301 followers View post →
Bioquímica, Alimentos e Nutrição
@EBioquimica · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 2,083 followers View post →
Rich (healthcarehero)
@hedonist1 · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 962 followers View post →
Dr. Diógenes el bipolar
@DrDiogenesxxx · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 14,161 followers View post →
Luis Servando
@luiss_servando · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 373 followers View post →
Guillermo Morea
@GuillermoMorea · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 836 followers View post →
Eva Hermann
@RunwithEva · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 687 followers View post →
Madhan Ramanathan
@sportsphysiouk · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 1,148 followers View post →
Thiago Lopes, PhD
@trlopes82 · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 786 followers View post →
Science Archivez
@sciencearchivez · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 69 followers View post →
Andres Felipe
@Anferupu · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 51 followers View post →
aquieojapa
@aquieojapa · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 265 followers View post →
AKSHAY
@Danaveni_Akshay · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 115 followers View post →
awang firmansyah
@awangf_f · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 676 followers View post →
daniel varela PhD
@dr_dvarela_P4T · X

RT @jploenneke: Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 34 shares · 920 followers View post →
Jeremy Loenneke
@jploenneke · X

Lactate is always the end product of glycolysis Link: https://t.co/Km4xtpQ0gs https://t.co/cX33SDK41v

Aug 23, 2023 · 163 likes · 34 shares · 8,588 followers View post →
Shyam Murali
@smuramed · X

Lactate in Critical Illness w/@IcuExplained #ResusX21 Lactate lies at the crossroads of glucose metabolism Even under aerobic conditions, glycolysis may favor the production of lactate Lactate is always the end product of glycolysis https://t.co/r4qHRiyL1q

Nov 2, 2021 · 2,051 followers View post →
Iñigo San Millán
@doctorinigo · X

@raphaels7 Absolutely, lactate is always the end product of glycolysis as Schurr and the great @GeorgeABrooks3 have been preaching for years.

Feb 18, 2021 · 9 likes · 42,403 followers View post →
Bernardo N. Ide, Ph.D.
@bernardo_0311 · X

Como pode ser "anti-glicolítico"? https://t.co/LXmpIFvtwm

Jan 21, 2021 · 3 likes · 779 followers View post →
Paulo Pereira, Ph.D
@paulopereiraPhD · X

@FAhumadaCordoba Rogatzki, M. J., Ferguson, B. S., Goodwin, M. L., & Gladden, L. B. (2015). Lactate is always the end product of glycolysis. Frontiers in neuroscience, 9, 22.

Nov 16, 2019 · 1 like · 226 followers View post →
daniel varela PhD
@dr_dvarela_P4T · X

RT @jploenneke: Trying to wrap your head around "lactate is always the end product of glycolysis" try these two papers (figure from second…

Jan 23, 2019 · 6 shares · 920 followers View post →
Alex
@AlexViKu · X

RT @jploenneke: Trying to wrap your head around "lactate is always the end product of glycolysis" try these two papers (figure from second…

Jan 23, 2019 · 6 shares · 96 followers View post →
Luca T
@QuiteLT · X

RT @jploenneke: Trying to wrap your head around "lactate is always the end product of glycolysis" try these two papers (figure from second…

Jan 22, 2019 · 6 shares · 368 followers View post →
Darren Delaney, MSc ASCC
@DarDelFitness · X

RT @jploenneke: Trying to wrap your head around "lactate is always the end product of glycolysis" try these two papers (figure from second…

Jan 22, 2019 · 6 shares · 372 followers View post →
Paulo Azevedo PhD
@paulohsmazevedo · X

RT @jploenneke: Trying to wrap your head around "lactate is always the end product of glycolysis" try these two papers (figure from second…

Jan 22, 2019 · 6 shares · 1,125 followers View post →
Sean M. Collins
@SMCollinsPhD · X

RT @jploenneke: Trying to wrap your head around "lactate is always the end product of glycolysis" try these two papers (figure from second…

Jan 22, 2019 · 6 shares · 490 followers View post →
Jeremy Loenneke
@jploenneke · X

Trying to wrap your head around "lactate is always the end product of glycolysis" try these two papers (figure from second link) https://t.co/GpJX2eAqrB https://t.co/bYHHqv5xmd https://t.co/GqAV1Il14W

Jan 22, 2019 · 26 likes · 6 shares · 8,588 followers View post →
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