Nature May 2015 PMID 25993940

Reproducibility crisis: Blame it on the antibodies.

Monya Baker

Mentions

140
Peak: 4 in Jul 2021
across 7 sources since May 2015

Extended reach

41,136
potential audience

Total likes

9

Video views

24

Mentions per month

May 2015 – Jan 2025

Where it's discussed

  • Facebook50 posts
  • News39 articles
  • Blogs27 articles
  • X / Twitter12 posts
  • Bluesky4 posts
  • YouTube4 videos
  • Reddit4 posts

AI synopsis

What people are saying

The overall tone indicates recognition of antibodies as a key issue in reproducibility, with discussions referencing efforts to improve assay specificity and standardization. Phrases like 'big initiatives' and 'problem resolved' demonstrate focus on actionable solutions, while some posts express ongoing skepticism, adding nuance to the perceived impact.

AgreementModerate agreement

Most discussions support the idea that unreliable antibodies contribute to the reproducibility crisis, with many emphasizing the need for better validation.

InterestModerate interest

The group shows moderate interest, with some posts expressing ongoing concern and curiosity about solutions, though not overwhelmingly passionate.

EngagementModerate engagement

Several posts reference specific technologies and initiatives, such as 'open source' reagents and alternative tools like Affimers, indicating active engagement with potential solutions.

ImpactModerate impact

Discussions highlight the significance of addressing the problem to improve scientific reliability, but some posts reflect skepticism or note progress, indicating moderate perceived impact.

Abstract in brief

  • The "reproducibility crisis" in science refers to the difficulty researchers face in replicating the results of previous studies, which undermines trust in scientific findings.
  • The article suggests that one major factor contributing to this problem is the unreliable nature of antibodies used in experiments, as different batches or sources can produce inconsistent results.
  • It emphasizes the need for better validation and standardization of antibodies to improve reproducibility and overall scientific integrity.]

Top posts

Most liked on X and Bluesky
B2S Life Sciences
@B2SLifeSciences · X

I’m not saying that we solved this...but our clients are. #criticalreagents #buggiestobiotech #bioanalysis #largemolecule #biologics Reproducibility crisis: Blame it on the antibodies : Nature News & Comment https://t.co/u6omwAzaQH

Oct 10, 2019 · 3 likes · 2 shares · 139 followers View post →
Neil Kelleher
@NLKProteomics · X

@JohnRYatesIII @r_l_moritz @UCDProteomics PEA and related tech good to make Ab-based assays more specific and reduce NSB, etc.; big initiatives to ‘open source’ Affinity reagents yet possible; see IPI at Harvard Med, and this Perspective from 2015 in Nature: https://t.co/aCyVtJ5RQ8

Mar 31, 2021 · 2 likes · 3,310 followers View post →
Slavov Laboratory
@slavovlab.bsky.social · Bluesky

Reproducibility crisis: Blame it on the antibodies . www.nature.com/articles/521...

Jan 12, 2025 · 2 likes View post →
Andrew Hobbs
@drewster_1965 · X

@ZivGanOr ... and I thought it was just antibodies (https://t.co/n4AxE4IWUX)

Oct 15, 2020 · 1 like · 373 followers View post →
Andrew Hobbs
@drewster_1965 · X

@Neuronologist1 This article always makes me wonder whether we'll ever find the answer. . . https://t.co/n4AxE4IWUX

Oct 4, 2020 · 1 like · 373 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

RT @KentsisResearch: @slavov_n @metricausa So common. https://t.co/nvXYlwAipT

Aug 6, 2020 · 2 shares · 19,998 followers View post →

All mentions

Slavov Laboratory
@slavovlab.bsky.social · Bluesky

Reproducibility crisis: Blame it on the antibodies . www.nature.com/articles/521...

Jan 12, 2025 · 2 likes View post →
Nyawira.
@NyawiraNjoroge · X

RT @ElinVidevall: Reproducibility crisis: Blame it on the Antibodies. Littering the field with false findings. https://t.co/xAq5912bxz http…

Jan 5, 2022 · 2 shares · 9,479 followers View post →
Neil Kelleher
@NLKProteomics · X

@JohnRYatesIII @r_l_moritz @UCDProteomics PEA and related tech good to make Ab-based assays more specific and reduce NSB, etc.; big initiatives to ‘open source’ Affinity reagents yet possible; see IPI at Harvard Med, and this Perspective from 2015 in Nature: https://t.co/aCyVtJ5RQ8

Mar 31, 2021 · 2 likes · 3,310 followers View post →
Andrew Hobbs
@drewster_1965 · X

@ZivGanOr ... and I thought it was just antibodies (https://t.co/n4AxE4IWUX)

Oct 15, 2020 · 1 like · 373 followers View post →
Andrew Hobbs
@drewster_1965 · X

@Neuronologist1 This article always makes me wonder whether we'll ever find the answer. . . https://t.co/n4AxE4IWUX

Oct 4, 2020 · 1 like · 373 followers View post →
Fadel Muhammad Garishah
@fadelmgarishah · X

Shocked when I read this 2 years ago https://t.co/Bde0IBID1p

Sep 19, 2020 · 71 followers View post →
Vivien Marx
@metricausa · X

RT @KentsisResearch: @slavov_n @metricausa So common. https://t.co/nvXYlwAipT

Aug 6, 2020 · 2 shares · 2,809 followers View post →
Prof. Nikolai Slavov
@slavov_n · X

RT @KentsisResearch: @slavov_n @metricausa So common. https://t.co/nvXYlwAipT

Aug 6, 2020 · 2 shares · 19,998 followers View post →
Kentsis Research Group
@KentsisResearch · X

@slavov_n @metricausa So common. https://t.co/nvXYlwAipT

Aug 6, 2020 · 2 shares · 3,914 followers View post →
Andrew Hobbs
@drewster_1965 · X

@MylesMcNulty @avacta https://t.co/n4AxE4IWUX .... a problem resolved by Affimers

May 6, 2020 · 373 followers View post →
Bill Nowatzke
@wnowatzke · X

RT @B2SLifeSciences: I’m not saying that we solved this...but our clients are. #criticalreagents #buggiestobiotech #bioanalysis #largemole…

Oct 10, 2019 · 2 shares · 219 followers View post →
Aleks Davis
@radavis32 · X

RT @B2SLifeSciences: I’m not saying that we solved this...but our clients are. #criticalreagents #buggiestobiotech #bioanalysis #largemole…

Oct 10, 2019 · 2 shares · 27 followers View post →
B2S Life Sciences
@B2SLifeSciences · X

I’m not saying that we solved this...but our clients are. #criticalreagents #buggiestobiotech #bioanalysis #largemolecule #biologics Reproducibility crisis: Blame it on the antibodies : Nature News & Comment https://t.co/u6omwAzaQH

Oct 10, 2019 · 3 likes · 2 shares · 139 followers View post →
Stuart Buck
@stuartbuck.bsky.social · Bluesky

Reproducibility crisis: Blame it on the antibodies http://www.nature.com/news/reproducibility-crisis-blame-it-on-the-antibodies-1.17586

May 20, 2015 View post →
LRIG.org
@lrig.org · Bluesky

Reproducibility crisis: Blame it on the antibodies http://t.co/9RxQOL4huE

May 19, 2015 View post →
Ed Yong
@edyong209.bsky.social · Bluesky

The latest dispatch from the Department of Irreproducible Science http://www.nature.com/news/reproducibility-crisis-blame-it-on-the-antibodies-1.17586

May 19, 2015 View post →