Reproducibility crisis: Blame it on the antibodies.

Monya Baker

May 2015 Nature

Synopsis of Social media discussions

The overall tone indicates recognition of antibodies as a key issue in reproducibility, with discussions referencing efforts to improve assay specificity and standardization. Phrases like 'big initiatives' and 'problem resolved' demonstrate focus on actionable solutions, while some posts express ongoing skepticism, adding nuance to the perceived impact.

A
Agreement
 Moderate agreement

Most discussions support the idea that unreliable antibodies contribute to the reproducibility crisis, with many emphasizing the need for better validation.

I
Interest
 Moderate level of interest

The group shows moderate interest, with some posts expressing ongoing concern and curiosity about solutions, though not overwhelmingly passionate.

E
Engagement
 Moderate level of engagement

Several posts reference specific technologies and initiatives, such as 'open source' reagents and alternative tools like Affimers, indicating active engagement with potential solutions.

I
Impact
 Moderate level of impact

Discussions highlight the significance of addressing the problem to improve scientific reliability, but some posts reflect skepticism or note progress, indicating moderate perceived impact.

Social Mentions

YouTube

4 Videos

Bluesky

4 Posts

Facebook

50 Posts

Twitter

12 Posts

Blogs

27 Articles

News

39 Articles

Reddit

4 Posts

Metrics

Video Views

24

Total Likes

9

Extended Reach

41,136

Social Features

140

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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July 11, 2021

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Addressing the Scientific Reproducibility Crisis with Targeted Solutions

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Addressing the Scientific Replication Crisis with Targeted Solutions

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July 11, 2021

3 views

Addressing the Scientific Reproducibility Crisis with Targeted Solutions

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The replication crisis in science, especially in psychology and social sciences, cannot be fixed with vague or broad solutions. Targeted efforts to improve research methods, transparency, and data sharing are essential for genuine progress.

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  • Slavov Laboratory
    @slavovlab.bsky.social (Bluesky)

    Reproducibility crisis: Blame it on the antibodies . www.nature.com/articles/521...
    view full post

    January 12, 2025

    2

  • Nyawira.
    @NyawiraNjoroge (Twitter)

    RT @ElinVidevall: Reproducibility crisis: Blame it on the Antibodies. Littering the field with false findings. https://t.co/xAq5912bxz http…
    view full post

    January 5, 2022

    2

  • Neil Kelleher
    @NLKProteomics (Twitter)

    @JohnRYatesIII @r_l_moritz @UCDProteomics PEA and related tech good to make Ab-based assays more specific and reduce NSB, etc.; big initiatives to ‘open source’ Affinity reagents yet possible; see IPI at Harvard Med, and this Perspective from 2015 in Nature: https://t.co/aCyVtJ5RQ8
    view full post

    March 31, 2021

    2

  • Andrew Hobbs
    @drewster_1965 (Twitter)

    @ZivGanOr ... and I thought it was just antibodies (https://t.co/n4AxE4IWUX)
    view full post

    October 15, 2020

    1

  • Andrew Hobbs
    @drewster_1965 (Twitter)

    @Neuronologist1 This article always makes me wonder whether we'll ever find the answer. . . https://t.co/n4AxE4IWUX
    view full post

    October 4, 2020

    1

  • Fadel Muhammad Garishah
    @fadelmgarishah (Twitter)

    Shocked when I read this 2 years ago https://t.co/Bde0IBID1p
    view full post

    September 19, 2020

  • Vivien Marx
    @metricausa (Twitter)

    RT @KentsisResearch: @slavov_n @metricausa So common. https://t.co/nvXYlwAipT
    view full post

    August 6, 2020

    2

  • Prof. Nikolai Slavov
    @slavov_n (Twitter)

    RT @KentsisResearch: @slavov_n @metricausa So common. https://t.co/nvXYlwAipT
    view full post

    August 6, 2020

    2

  • Kentsis Research Group
    @KentsisResearch (Twitter)

    @slavov_n @metricausa So common. https://t.co/nvXYlwAipT
    view full post

    August 6, 2020

    2

  • Andrew Hobbs
    @drewster_1965 (Twitter)

    @MylesMcNulty @avacta https://t.co/n4AxE4IWUX .... a problem resolved by Affimers
    view full post

    May 6, 2020

  • Bill Nowatzke
    @wnowatzke (Twitter)

    RT @B2SLifeSciences: I’m not saying that we solved this...but our clients are. #criticalreagents #buggiestobiotech #bioanalysis #largemole…
    view full post

    October 10, 2019

    2

  • Aleks Davis
    @radavis32 (Twitter)

    RT @B2SLifeSciences: I’m not saying that we solved this...but our clients are. #criticalreagents #buggiestobiotech #bioanalysis #largemole…
    view full post

    October 10, 2019

    2

  • B2S Life Sciences
    @B2SLifeSciences (Twitter)

    I’m not saying that we solved this...but our clients are. #criticalreagents #buggiestobiotech #bioanalysis #largemolecule #biologics Reproducibility crisis: Blame it on the antibodies : Nature News & Comment https://t.co/u6omwAzaQH
    view full post

    October 10, 2019

    3

    2

  • Stuart Buck
    @stuartbuck.bsky.social (Bluesky)

    Reproducibility crisis: Blame it on the antibodies http://www.nature.com/news/reproducibility-crisis-blame-it-on-the-antibodies-1.17586
    view full post

    May 20, 2015

  • LRIG.org
    @lrig.org (Bluesky)

    Reproducibility crisis: Blame it on the antibodies http://t.co/9RxQOL4huE
    view full post

    May 19, 2015

  • Ed Yong
    @edyong209.bsky.social (Bluesky)

    The latest dispatch from the Department of Irreproducible Science http://www.nature.com/news/reproducibility-crisis-blame-it-on-the-antibodies-1.17586
    view full post

    May 19, 2015

Abstract Synopsis

  • The "reproducibility crisis" in science refers to the difficulty researchers face in replicating the results of previous studies, which undermines trust in scientific findings.
  • The article suggests that one major factor contributing to this problem is the unreliable nature of antibodies used in experiments, as different batches or sources can produce inconsistent results.
  • It emphasizes the need for better validation and standardization of antibodies to improve reproducibility and overall scientific integrity.]