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Nat Rev Neurosci July 2015 PMID 26087681

The neuroscience of placebo effects: connecting context, learning and health.

Tor D Wager, Lauren Y Atlas

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Mentions

126
Peak: 4 in Oct 2021
across 7 sources since Jun 2015

Extended reach

213,708
potential audience

Total likes

437

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12,161

Mentions per month

Jun 2015 – Oct 2025

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AI synopsis

What people are saying

The discussions reflect a strong overall agreement with the publication, with posts referencing its framework and neuroscience insights, such as the role of neurochemicals like opioids and dopamine. The tone and context support the perception that this research could revolutionize understanding of treatment effects and healing mechanisms.

AgreementStrong agreement

Most discussions affirm the significance of the article, emphasizing how the neuroscience of placebo effects links context, learning, and health, suggesting broad agreement with the publication's conclusions.

InterestHigh interest

The posts demonstrate strong interest by highlighting key concepts such as the role of neurochemicals and the relevance of contextual factors, indicating high engagement with the subject matter.

EngagementModerate engagement

Though many comments praise the article's importance, some also reference frameworks and express curiosity, reflecting a moderate depth of engagement beyond surface-level agreement.

ImpactHigh impact

The mentions of potential applications in treatments and the emphasis on understanding placebo mechanisms suggest that discussions perceive the research as influential with significant implications for health sciences.

Abstract in brief

  • Placebo effects are beneficial responses driven by the brain's interpretation of treatment context rather than the treatment itself, influenced by learning, expectations, and social factors.
  • Neuroscience research shows that multiple brain systems and neurochemicals like opioids and dopamine are involved in mediating placebo effects, especially in pain relief (analgesia).
  • A conceptual framework links these brain processes to broader therapeutic outcomes, suggesting that understanding placebo mechanisms can improve various treatment approaches beyond just drugs.]
Read the full abstract

Top posts

Most liked on X and Bluesky
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X

The neuroscience of placebo effects: connecting context, learning and health https://t.co/BuM9QxVvEN https://t.co/gs9H8OHR0f

Oct 3, 2021 · 17 likes · 5 shares · 26,359 followers View post →
RealScientists
@realscientists · X

One of the interesting framework article published in @NatRevNeurosci The neuroscience of placebo effects: connecting context, learning and health https://t.co/1Ecyx5PIMG

Dec 26, 2019 · 11 likes · 78,653 followers View post →
Castalia Fernández, MD.
@FuenteApolo · X

The neuroscience of placebo effects: connecting context, learning and health. https://t.co/uvzwAyiG8e "I would rather know the person who has the disease than the disease the person has. Hippocrates" #hcsm The importance of context

Aug 21, 2023 · 5 likes · 2 shares · 2,892 followers View post →
Nicolas Govin.
@tabaco_logic · X

2/L'effet placebo peut représenter une part significative de l'effet observé dans les traitements particulièrement dans des conditions comme la douleur chronique ( <50%) ou la dépression légère (30/50% max). https://t.co/iJvV6jJj00

Jan 5, 2025 · 3 likes · 1 share · 1,734 followers View post →
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X

@BobVermeeren @SoSimplehealth @GiacomoRoss86 @mgibsonphysio @DrJohnOrchard @ProfJillCook Yes

Sep 27, 2019 · 2 likes · 1 share · 26,359 followers View post →
IntegralAnswers
@IntegralAnswers · X

11/ 2.Wager TD, Atlas LY. “The neuroscience of placebo effects: Connecting context, learning, and health.” Annu Rev Neurosci. 2015;38:431-447.

Oct 14, 2025 · 2 likes · 1 share · 8,530 followers View post →

All mentions

Based Neanderthal
@NiceNeanderthal · X

RT @IntegralAnswers: 11/ 2.Wager TD, Atlas LY. “The neuroscience of placebo effects: Connecting context, learning, and health.” Annu Rev Ne…

Oct 14, 2025 · 1 share · 1,968 followers View post →
IntegralAnswers
@IntegralAnswers · X

11/ 2.Wager TD, Atlas LY. “The neuroscience of placebo effects: Connecting context, learning, and health.” Annu Rev Neurosci. 2015;38:431-447.

Oct 14, 2025 · 2 likes · 1 share · 8,530 followers View post →
Aude Smith#TAEM
@AudeSmith5 · X

RT @tabaco_logic: 2/L'effet placebo peut représenter une part significative de l'effet observé dans les traitements particulièrement dans d…

Jan 5, 2025 · 1 share · 2,390 followers View post →
Nicolas Govin.
@tabaco_logic · X

2/L'effet placebo peut représenter une part significative de l'effet observé dans les traitements particulièrement dans des conditions comme la douleur chronique ( <50%) ou la dépression légère (30/50% max). https://t.co/iJvV6jJj00

Jan 5, 2025 · 3 likes · 1 share · 1,734 followers View post →
Adela
@adelapoite · X

RT @FuenteApolo: The neuroscience of placebo effects: connecting context, learning and health. https://t.co/uvzwAyiG8e "I would rather know…

Aug 21, 2023 · 2 shares · 1,256 followers View post →
Dr Pardo
@Doctor_Pardo · X

RT @FuenteApolo: The neuroscience of placebo effects: connecting context, learning and health. https://t.co/uvzwAyiG8e "I would rather know…

Aug 21, 2023 · 2 shares · 4,161 followers View post →
Castalia Fernández, MD.
@FuenteApolo · X

The neuroscience of placebo effects: connecting context, learning and health. https://t.co/uvzwAyiG8e "I would rather know the person who has the disease than the disease the person has. Hippocrates" #hcsm The importance of context

Aug 21, 2023 · 5 likes · 2 shares · 2,892 followers View post →
Vivek Misra
@iVivekMisra · X

One of the interesting framework article published in @NatRevNeurosci The neuroscience of placebo effects: connecting context, learning and health. https://t.co/lUPA2W50GW

Nov 9, 2022 · 2 likes · 2,958 followers View post →
Bewty
@hexagon_555 · X

The neuroscience of placebo effects: connecting context, learning and health | Nature Reviews Neuroscience https://t.co/dKcqvBPriB

Jul 17, 2022 · 47 followers View post →
The Relief Institute
@ReliefInstitute · X

The neuroscience of placebo effects: connecting context, learning and health #thereliefinstitute https://t.co/WrcJ4c2bnW

Jul 11, 2022 · 805 followers View post →
Matt Harris PT, ATC
@MattHarrisPTATC · X

RT @Retlouping: The neuroscience of placebo effects: connecting context, learning and health https://t.co/BuM9QxVvEN https://t.co/gs9H8OHR…

Oct 4, 2021 · 5 shares · 165 followers View post →
Giacomo Rossettini
@GiacomoRoss86 · X

RT @Retlouping: The neuroscience of placebo effects: connecting context, learning and health https://t.co/BuM9QxVvEN https://t.co/gs9H8OHR…

Oct 4, 2021 · 5 shares · 2,878 followers View post →
ACPSEMdance
@ACPSEMdance · X

RT @Retlouping: The neuroscience of placebo effects: connecting context, learning and health https://t.co/BuM9QxVvEN https://t.co/gs9H8OHR…

Oct 3, 2021 · 5 shares · 2,970 followers View post →
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X

The neuroscience of placebo effects: connecting context, learning and health https://t.co/BuM9QxVvEN https://t.co/gs9H8OHR0f

Oct 3, 2021 · 17 likes · 5 shares · 26,359 followers View post →
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X

RT @Retlouping: @BobVermeeren @SoSimplehealth @GiacomoRoss86 @mgibsonphysio @DrJohnOrchard @ProfJillCook Yes

Mar 18, 2021 · 1 share · 26,359 followers View post →
David R Tomlinson
@DRTomlinsonEP · X

@raj_mehta @ProfDFrancis @DrJHoward @drjohnm @mikejohansenmd Very well put.

Nov 16, 2020 · 1 like · 8,106 followers View post →
RealScientists
@realscientists · X

One of the interesting framework article published in @NatRevNeurosci The neuroscience of placebo effects: connecting context, learning and health https://t.co/1Ecyx5PIMG

Dec 26, 2019 · 11 likes · 78,653 followers View post →
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X

@BobVermeeren @SoSimplehealth @GiacomoRoss86 @mgibsonphysio @DrJohnOrchard @ProfJillCook Yes

Sep 27, 2019 · 2 likes · 1 share · 26,359 followers View post →
Castalia Fernández, MD.
@FuenteApolo · X

RT @FuenteApolo: The neuroscience of placebo effects: connecting context, learning and health : https://t.co/JiE0pIwHGu https://t.co/wG24m…

Jan 21, 2019 · 1 share · 2,892 followers View post →
Pierre Kerner
@ssaft.com · Bluesky

The neuroscience of placebo effects: connecting context, learning and health http://dx.doi.org/10.1038/nrn3976

Jun 20, 2015 View post →