A stark reminder for an utterly godless administration and all of the supposed Christians who bankroll and support it.
Tissue transglutaminase-catalysed cross-linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E's protective effects towards amyloid-beta-induced toxicity.
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Nov 2018 – Oct 2025Where it's discussed
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Bluesky99 posts
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YouTube3 videos
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News2 articles
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What people are saying
Overall, the social discussions span a wide array of topics, from political debates and social issues to lighthearted comments and personal anecdotes, demonstrating moderate engagement and no clear consensus, influenced by the informal tone and diverse content.
The collection shows a mix of opinions, with some posts supporting ideas or expressing humor, but most remain neutral or indifferent.
Posts are varied; some express curiosity or support, while others are dismissive or casual, indicating a neutral overall interest level.
Several posts react actively, using words like 'congratulations' or discussing political or social issues, showing some level of engagement.
The discussions appear mostly personal or casual, with few posts indicating a significant influence on opinions or societal change.
Abstract in brief
- The study investigates how tissue transglutaminase (tTG) modifies apolipoprotein E (ApoE), leading to multimer formation that impairs ApoE's protective effects against amyloid-beta toxicity in cerebral vessel walls, which is relevant to Alzheimer's disease.
- In cases of cerebral amyloid angiopathy (CAA), associated with Alzheimer’s, tTG activity and ApoE colocalize in amyloid deposits, and tTG-catalyzed crosslinking produces ApoE multimers that fail to protect smooth muscle cells from amyloid-beta toxicity.
- These findings reveal a novel posttranslational modification by tTG that potentially contributes to CAA progression by disrupting ApoE's normal protective functions, highlighting a new molecular mechanism in Alzheimer’s pathology.
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Most liked on X and BlueskyRequested by @grinrusher.bsky.social.
100%. Like, if it was really in the past, why are you still defending yourself from your petty bullshit and your family's literal blackmail of a USMNT coach?
do you guys like my new bio?? awruff
I do the same thing to close friends of my parents who I didn’t want to call by their first names out of respect for their age. I’m from the Midwest with aunts and uncles who have no blood relation to me, just dear friends.
All mentions
Role of Transglutaminase and ApoE in Alzheimer’s Disease and CAA Pathology
This study examines how tissue transglutaminase modifies ApoE, forming multimers that impair its protective effects against amyloid-beta toxicity in cerebral vessel walls, potentially contributing to Alzheimer’s disease…
tTG-Mediated ApoE Crosslinking Impairs Protection in CAA and Alzheimer's
The study investigates how tissue transglutaminase modifies apolipoprotein E, forming multimers that reduce its protective effects against amyloid-beta toxicity, a key factor in cerebral amyloid angiopathy and…
Role of Tissue Transglutaminase in ApoE Multimer Formation in Alzheimer's Disease
This study explores how tissue transglutaminase modifies apolipoprotein E, leading to multimer formation that impairs its protective effects against amyloid-beta toxicity in cerebral vessel walls, contributing to…
No pääset lohduksi taas sanomaan, että sähän sanoit: Saan palkankorotuksen tästä viimeviikkojen työsuoritteesta, nousee tutkijatohtorin maksimiin.
Requested by @grinrusher.bsky.social.
A stark reminder for an utterly godless administration and all of the supposed Christians who bankroll and support it.
i was curious and... they're mad about *that*? genwunner mindset is so weird
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obrigado, lindo! saudaaaaaadeeeees
sucks that it took like a year and a half - and maybe outright cost the show one of its all-time great leads depending on who you believe - but at least I was right again in that the show was always gonna go on!
PS means Parti Sofascist je pense à ce niveau là hein.
It's Tuesday, Oct. 28. Time to release the unredacted Epstein files! Thank you for your attention to this matter.
Congrats
冬コミのコスプレで薄着するのは経験的になぜか大丈夫なのに、たかだか徒歩5分とかを歩くのは寒すぎるというのは、どういうことか。
じろ
Schewe re-signs. Guaranteed through next year with several option years. That's 3 GKs, but David Lee says he plans to carry 4, so a veteran is presumably still on the way. #SportingKC
They're saying One Battle After Another is a documentary
I decided to go back to the old skyblue
100%. Like, if it was really in the past, why are you still defending yourself from your petty bullshit and your family's literal blackmail of a USMNT coach?
記事の要約: この記事では、2025年のブラックフライデー福袋に関する情報をまとめています。特に食品福袋は年末年始の準備に適しており、実用的な商品が多いことが魅力です。福袋の発売時期は一般的に11月後半ですが、早い店舗では11月上旬から予約が開始されます。具体的には、イオンは11月1日から先行予約を行い、店舗販売は11月20日から始まります。 お得な福袋を手に入れるためのポイントとして、情報収集を早めに行い、SNSや公式サイトで発売日時を確認すること、中身が公開されている福袋を優先的に選ぶこと、賞味期限や用途を考慮することが挙げられています。また、人気ブランドの福袋は予約開始直後に購入する…
I don’t think it is, but I also have no idea what it could be so I guess we’ll find out when leaks start dropping
That's super uncomfortable, glad it was dealt with
Ich lebe mein bestes Leben. Ich lebe mein schlechtestes Leben. Das ist das Gute daran, das ist das Schlechte daran.
Which one is going to the church tombola?
So much for their Oath to Support & Defend the Constitution. They must have had their fingers crossed behind their backs… Or had their hand on the Trump Bible…
I don't know what's more stunning - Marj roasting Mike Johnson like this, or the complete lack of pushback from Trump. Massie does this, and Trump comes out with both barrels. MTG? Crickets.
I'm right behind you on the birthday train!
Ofc!!
It’s not a great time over there man :,)
「福袋 フライデー ブラック」に関する記事です: https://xn--ockuc3ew494a9wp.jp/blaclfridayhappygagg/
Man, all these people ponying up millions to renovate the White House and pay the military without blinking almost makes you think maybe they could do that more often, like, by taxing them more. And like maybe the arguments against it (iT WoULd be bAd 4 tEh EcoNoMy) are kind of bullshit.
atá tu é fã do jimbo
Oh je. Hoffe es ist nicht viel passiert
Does it matter? Guy is not fit for the office. He can't do the job. He is not physically capable of performing those duties. Witness our Congress allowing this to progress so that they can benefit personally from the situation. Don't you all just love being dipped in sh!t & taken to the cleaners?
The whole discussion of whether American troops will disobey unlawful orders is such a bizarre framing, when they've obeyed unlawful orders continually, all the time. And we have no examples of them ever disobeying them.
Could be a cat :o
CU is wel prima. Als je BB in dat kabinet wil helpt een wat linkser christelijk vriendje.
Laufey concludes her ‘A Matter of Time’ North American tour by sharing her favorite moments from the final concert.
W: *gibt mir ne Anweisung* Ich: Du bist gar nicht mein richtiger Dom! W:
ずっと起きてる
^u^; A "self-solving" problem.
Yes you do! The stinging will become more and more dull with time.
It tucks on ETB. So you blink it and it tucks.
It's about... 9 episodes long.
Now playing on BVF: Original Don by Sub Focus; Fireboy DML; IRAH! Tune in now: https://bvf.wtf
My bad. I forgot food assistance was written into the constitution
South Central Division, Beat: 753, DAEF-Dist Armed Encounter Foot at 15XX BLOCK SERENADE LN reported on 10/28/2025, 1:10 PM CDT, Incident# 25-1920888 #dpdi-div-sc #dpdi-beat-753
lmfao
Fries =
Sifted OpenAI-backed startup aims to deliver in-home humanoid robots in 2026 https://sifted.eu/articles/1x-humanoid-robot-launch/ #Europe #EU #Sifted
thank you
They also couldn’t do anything against the not-overwhelming LAD bullpen
Them people are absolutely going to lose it when they dubs out Obama had play cousins growing up.
I had this exchange with my cousin who is a conservative Christian and DJT voter. This points out why, in the end, in their minds, what they actually do is of no consequence:
I been seeing the 2nd one
I saw that!! These people are horrible. I’m happy that talented artists are resisting by not collaborating so far
I do the same thing to close friends of my parents who I didn’t want to call by their first names out of respect for their age. I’m from the Midwest with aunts and uncles who have no blood relation to me, just dear friends.
Oh let me not start nothing lol
[The bot looked at the twins and snorted weakly] "No, you made it clear that something like this can be done." [But after that he smiled weakly at them]
do you guys like my new bio?? awruff
Fuck it. I’m throwing my hat in the ring to purchase Warner Bros. Discovery!
A coalition of states, including New York, has sued the Trump administration for what it says is an unlawful suspension of the U.S. Department of Agriculture’s Supplemental Nutrition Assistance Plan benefits. Read more: http://specne.ws/LD7MAU
At last! Now we'll see what happens next.
não sei se vcs já repararam que os dois sao alaranjados
This the type of shit they will only write and allow from a white guy. Seriously. I can't stress this enough. getting a fucking death heads tattoo while drunk with your fellow soldiers in Croatia as well as working for fucking mercenary outfits should be disqualifying. period.
Some things make me wonder...
Feed: "VoF" By: sales@QUELimaging.com (The QUEL Team) on Monday, October 27, 2025
Y estiradita.
www.tiktok.com/t/ZP8DNjPJ9/
It’s actually Pop ‘n Locktober I’m sorry to your little caged cock or whatever
Southwest Division, Beat: 455, 40/01 - Other at 28XX BLOCK WOODMERE DR reported on 10/28/2025, 1:11 PM CDT, Incident# 25-1921115 #dpdi-div-sw #dpdi-beat-455
Hes getting hooked in a min tho very very close to a red atm
There was great support for something like this at the consultation weekend @sidegallery.bsky.social hosted in August. Do take the survey, & come along!
Sim, o impacto psicológico não foi igual para todo mundo. Até hoje não frequento locais cheios. Meu marido tbm não sai mais (aliás agora ele tem nojo de apertar as mãos de outros homens pq ninguém lava as mãos. Ele disse que no trabalho passa uns dobrados pra evitar as mãos)
Gio Reyna eyeing USMNT spot as he looks to revive career marred by injuries, clash with former U.S. coach Gregg Berhalter espn.com/app
She's a coward
@joyfulnesstoo.bsky.social
―ELDEN RING NIGHTREIGN― 執行者の終了と共に〖NIGHTREIGN〗GET!!!全てのトロフィーシステムをALL COMPLETE!! さらにNIGHTREIGNを100h遊んだらしい!!! 執行者の追憶スキンには切〇痕が…混ざりあったモノたちの想いも含めて大事に着用します… 8人すべての追憶(物語)が終わったので、考察は読みたい。 それから各夜の王の特性をもっとお勉強して各常世も制覇したい。 さらに…深き夜への出撃。 ランクマだね!!!!!!!!
What car?
Oooo that's pretty! Thanks!
Thank you so much ! Chiarscuro is a great inspiration to me so I'm really touched
I was hoping more Albertans would show their desire to remain Canadian It is a large % With 3 million eligible voters in Alberta that’s 15% of the voters
Let's finish our respective kh3 cosplays and then do a "finish the heart hands" pic....if u wanna
It's so extremely rare for a natural disaster to become a national disaster, but Hurricane Melissa is exactly that. This storm is going to absolutely devastate the entire island of Jamaica.
Sometimes the response to those who initially gave hope is worse than a response to people who no one trusted to provide results in the first place. There must be a football manager somewhere who embodies this theory of unpopularity.
for those of u who dont know already i am gonna be making these types of lineups a new comm type so im rushing to finish before nov 1st since they'll be launching that day
ah oui les gens qui ont compris Nietzsche du premier coup je connais (c'est vraiment une citation de branleur, elle est au début d'ABYSS, et, entière, elle commence par "quand tu combats des monstres, fais attention à ne pas devenir monstre toi-même", c'est pas hyper relativiste, comme phrase)
Words to live by. #WitchSky #Witchmadness #Occultsky
Das ist wirklich eine Unverschämtheit !
I should know, my warships are called "interceptors" and spacers very much dress like pilots
www.facebook.com/reel/1449147...
Of course if the parents are in a difficult financial situation it's more than fair that we help one another. But moving precious money that help me survive into my boomer parents' bank accounts to AT BEST stay there to rot and at worst to pay for their spa weekend? SUL MIO CADAVERE!
Israelische Kampfflugzeuge greifen Gaza-Stadt an, nachdem Netanyahu der Hamas Verstöße gegen die Waffenruhe vorwirft. Seit Beginn der Waffenruhe wurden über 90 Palästinenser getötet, und die Übergabe von Geisel-Leichen verzögert sich.
Congratulations!!! That’s a huge milestone, you should be proud!!!
you lot moved on from aaron pierre too quickly for my liking, me tho? i’m still there
www.facebook.com/photo.php?fb...
Baskets?!? Spend the money on food instead, correct?
"O pagamento dele é morar e comida"
Das ist eine herausragende Halbzeit von Diego #Demme. Gegen, aber vor allem mit Ball. Bislang Spieler des Spiels. #HaHoHe #BSCELV