Physiol Behav December 2015 PMID 26095119

Metabolic effects of non-nutritive sweeteners.

M Yanina Pepino

Mentions

30
Peak: 4 in May 2023
across 6 sources since Jun 2016

Extended reach

116,219
potential audience

Total likes

98

Video views

2,922

Mentions per month

Jun 2016 – Oct 2025

Where it's discussed

  • News11 articles
  • X / Twitter10 posts
  • Instagram4 posts
  • YouTube2 videos
  • Facebook2 posts
  • LinkedIn1 posts

AI synopsis

What people are saying

The online exchanges reflect a cautious yet engaged attitude toward the publication, with users referencing mechanisms like gut microbiota and glucose regulation, as seen in phrases like 'metabolic dysfunction' and 'long-term effects.' The tone varies from acknowledgment to curiosity, emphasizing the relevance of the research for understanding health risks associated with non-nutritive sweeteners.

AgreementModerate agreement

Most discussions acknowledge the potential for NNSs to affect metabolism negatively, supporting the publication's findings.

InterestModerate interest

The posts show moderate curiosity, referencing mechanisms and studies but lacking deep exploration.

EngagementModerate engagement

Comments include mentions of specific studies, mechanisms, and ongoing debates, indicating thoughtful engagement.

ImpactModerate impact

The discussions reflect awareness of the importance for public health and dietary guidelines, suggesting a perceived significant impact.

Abstract in brief

  • Nonnutritive sweeteners (NNSs) were initially thought to be healthy alternatives to sugar because they taste sweet but contain few or no calories, yet recent studies indicate their consumption, especially in diet sodas, may be linked to increased risks of obesity, metabolic syndrome, and type 2 diabetes.
  • The article explores three possible mechanisms by which NNSs might cause metabolic issues: disrupting learned responses that regulate glucose and energy, altering gut microbiota leading to glucose intolerance, and interacting with sweet taste receptors in the digestive system that influence glucose absorption and insulin release.
  • Recent research, including findings from the authors’ lab, suggests individual differences in taste sensitivity may influence how NNSs affect metabolism, highlighting the need for further studies to clarify how these sweeteners impact metabolic health and devise safer dietary guidelines.

Top posts

Most liked on X and Bluesky
Journal of Clinical Investigation
@jclinicalinvest · X

#Viewpoint: A closer look at the metabolic effects of non-nutritive sweeteners: https://t.co/wVWVhdNLg0 Samuel Philip Nobs & @EranElinav’s discuss key evidence attributing glycemic responses to NNSs & unresolved findings related to long-term health consequences. @WeizmannScience https://t.co/6czYO45MvW

May 17, 2023 · 10 likes · 3 shares · 51,015 followers View post →
Gabor Erdosi
@gerdosi · X

@AlexJLeaf Regarding (1). RCT shows that non-nutritive sweeteners can have opposing effects on weight and metabolism: https://t.co/B0UEQVJjKq Review that discusses the underlying mechanisms: https://t.co/YP3oifGWdW Regarding 3), I’d argue that there’s direct driver of metabolic issues is

Dec 15, 2024 · 5 likes · 1 share · 25,891 followers View post →
htw
@heniek_htw · X

Long-term Metabolic Effects of Non-Nutritive Sweeteners https://t.co/uFllBC7NRk https://t.co/zwCJFjdUvY

Jul 8, 2024 · 3 likes · 11,357 followers View post →
Ken Gusler
@kgusler · X

Long-term Metabolic Effects of Non-Nutritive Sweeteners - https://t.co/VQHN6CHV8K

Jul 7, 2024 · 1 like · 20,032 followers View post →
ElinavLab
@Elinav_Lab · X

RT @jclinicalinvest: #Viewpoint: A closer look at the metabolic effects of non-nutritive sweeteners: https://t.co/wVWVhdNLg0 Samuel Philip…

May 19, 2023 · 3 shares · 3,824 followers View post →
Samuel P. Nobs
@NobsSamuel · X

RT @jclinicalinvest: #Viewpoint: A closer look at the metabolic effects of non-nutritive sweeteners: https://t.co/wVWVhdNLg0 Samuel Philip…

May 18, 2023 · 3 shares · 391 followers View post →

All mentions

Maverick Doc
@MaverickdocMD · X

@AlexJLeaf NNS are associated with metabolic dysfunction https://t.co/7Fi8p622F0 https://t.co/02hdzNTDjA https://t.co/QdxQhfE4NQ https://t.co/hxVNvKHqbT

Dec 16, 2024 · 64 followers View post →
Gabor Erdosi
@gerdosi · X

@AlexJLeaf Regarding (1). RCT shows that non-nutritive sweeteners can have opposing effects on weight and metabolism: https://t.co/B0UEQVJjKq Review that discusses the underlying mechanisms: https://t.co/YP3oifGWdW Regarding 3), I’d argue that there’s direct driver of metabolic issues is

Dec 15, 2024 · 5 likes · 1 share · 25,891 followers View post →
the paper link
@the_paper_link · X

Trend up+144: Rathaus M, ..., Tirosh A (Mol Metab) __Long-term Metabolic Effects of Non-Nutritive Sweeteners__ https://t.co/dh63pCTakK

Jul 11, 2024 · 136 followers View post →
htw
@heniek_htw · X

Long-term Metabolic Effects of Non-Nutritive Sweeteners https://t.co/uFllBC7NRk https://t.co/zwCJFjdUvY

Jul 8, 2024 · 3 likes · 11,357 followers View post →
Ken Gusler
@kgusler · X

Long-term Metabolic Effects of Non-Nutritive Sweeteners - https://t.co/VQHN6CHV8K

Jul 7, 2024 · 1 like · 20,032 followers View post →
Sean Luke De Silva
@seanlukestar · X

RT @jclinicalinvest: #Viewpoint: A closer look at the metabolic effects of non-nutritive sweeteners: https://t.co/wVWVhdNLg0 Samuel Philip…

May 31, 2023 · 3 shares · 285 followers View post →
ElinavLab
@Elinav_Lab · X

RT @jclinicalinvest: #Viewpoint: A closer look at the metabolic effects of non-nutritive sweeteners: https://t.co/wVWVhdNLg0 Samuel Philip…

May 19, 2023 · 3 shares · 3,824 followers View post →
Samuel P. Nobs
@NobsSamuel · X

RT @jclinicalinvest: #Viewpoint: A closer look at the metabolic effects of non-nutritive sweeteners: https://t.co/wVWVhdNLg0 Samuel Philip…

May 18, 2023 · 3 shares · 391 followers View post →
Journal of Clinical Investigation
@jclinicalinvest · X

#Viewpoint: A closer look at the metabolic effects of non-nutritive sweeteners: https://t.co/wVWVhdNLg0 Samuel Philip Nobs & @EranElinav’s discuss key evidence attributing glycemic responses to NNSs & unresolved findings related to long-term health consequences. @WeizmannScience https://t.co/6czYO45MvW

May 17, 2023 · 10 likes · 3 shares · 51,015 followers View post →
Unforgiven
@Shazuxic · X

@Used2BMrRed @moradidiet https://t.co/ckXxzXUVY4

Sep 6, 2022 · 97 followers View post →
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