PubHawk
July 2015 PMID 26132939

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management.

Xavier Pi-Sunyer, Arne Astrup, Ken Fujioka, Frank Greenway, Alfredo Halpern, Michel Krempf, David C W Lau, Carel W le Roux, Rafael Violante Ortiz, Christine Bjørn Jensen, John P H Wilding

Download social card

Mentions

198
Peak: 6 in Feb 2021
across 6 sources since Jul 2015

Extended reach

706,885
potential audience

Total likes

1,366

Video views

141,519

Mentions per month

Jul 2015 – Mar 2025

Where it's discussed

  • News101 articles
  • Facebook44 posts
  • X / Twitter32 posts
  • Blogs15 articles
  • YouTube4 videos
  • Reddit2 posts

AI synopsis

What people are saying

Many posts reference the publication directly, such as mentioning the 5% weight loss and the 2015 trial, highlighting how posters discuss the research's data and implications, with words like 'evidence', 'modest', and questions about clinical significance reflecting a balanced tone of recognition and skepticism.

AgreementModerate agreement

Most discussions recognize the study's findings on weight loss and the potential of Liraglutide, with some skeptics questioning the significance of the weight loss figures.

InterestModerate interest

Overall, posters show moderate interest, referencing the study, its results, and related concepts without deep emotional investment.

EngagementModerate engagement

Posts mention specific data points, such as 5% weight loss and BMI reduction, indicating a fair level of engagement, though many are brief or skeptical.

ImpactModerate impact

Discussions suggest the study's impact is acknowledged, especially regarding obesity management, but some question its real-world significance and limitations.

Abstract in brief

  • Obesity is a chronic disease that poses health risks, and Liraglutide, a daily injection, shows promise for weight management in patients with certain BMI criteria.
  • A 56-week trial with 3,731 non-diabetic patients assessed the effects of Liraglutide versus placebo, focusing on weight loss and lifestyle modifications.
  • Results showed that patients on Liraglutide lost significantly more weight (8.4 kg) compared to placebo (2.8 kg), with more individuals achieving notable weight loss milestones, although mild side effects like nausea and diarrhea were common.
Read the full abstract

Top posts

Most liked on X and Bluesky
Dr.COYASS
@COYASS · X

ケトダイエットのアドバイザーなのにリバウンドするエリートデブ。当時デブパレード内でも天才と言われていた。 33キロ減でサイズ合わせたのに結構戻ってきて着れない。ストレスによるコルチゾール増で糖新生増えて、何食っても太る。医学的知識と現代医学により解決する。 https://t.co/i7IwPYLBN4 https://t.co/wOTYPofp2p

Feb 2, 2021 · 26 likes · 1 share · 11,569 followers View post →
Endocrine dialogues
@EndoDialogues · X

Obesity is a chronic metabolic disease, and many drugs proved to be both effective and safe. Let's spread the concept that obesity is a disease and treatment is available. https://t.co/hJKQgNJ4zP https://t.co/e4DyoeEEUk

Mar 11, 2021 · 10 likes · 3 shares · 6,466 followers View post →
cardio-met
@cardiomet_CE · X

https://t.co/HLk4AMVCdp

Jul 7, 2021 · 5 likes · 1 share · 4,209 followers View post →
Vasili Panop
@0xpanoprx · X

@DrNadolsky Is there anything else you are doing? Clinical trials only show ~6 kg of weight loss more than placebo after a year of treatment. 6 kg is not bringing any BMI down from 40->20. I smell confounding factors/other interventions https://t.co/10asN4H5yd

Oct 10, 2022 · 4 likes · 47 followers View post →
Carolina Posada
@CarPoAlv · X

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. Xavier Pi-Sunyer et al. N Engl J Med. 2015. Es el estudio que demostró, tras casi 5 años de seguimiento, que liraglutide en comparación con placebo reduce el peso corporal y mejora el perfil metabólico

Feb 3, 2021 · 3 likes · 3 shares · 148 followers View post →
Stephan J. Guyenet
@sguyenet · X

@GidMK This idea was a bombshell for me when I first learned of it. I think the placebo effect holds up pretty well in some domains though. Hard to imagine 2.6% weight loss being attributable to regression to the mean. https://t.co/D3aHpQUnRH https://t.co/FeO2fswOpN

Jun 1, 2020 · 2 likes · 49,003 followers View post →

All mentions

Juan Senior
@jsenior64 · X

https://t.co/QatMxmPjZ3

Feb 27, 2024 · 11,082 followers View post →
Odysseus living with Penelope
@immuno458 · X

RT @alberthenriquez: @RompeCadenaz @immuno458 Desde el 2015 hay evidencia en personas obesas sin dmt2 de análogos de glp1... https://t.co/…

Feb 23, 2024 · 1 share · 1,447 followers View post →
Alberto Henriquez MD
@alberthenriquez · X

@RompeCadenaz @immuno458 Desde el 2015 hay evidencia en personas obesas sin dmt2 de análogos de glp1... https://t.co/sqVUT4ybFs

Feb 23, 2024 · 1 like · 1 share · 2,518 followers View post →
د. صالح بن سيف الهنائي
@SsAlhinai · X

@Sabahi_Ahmed تسبب نقص الوزن حسب الدراسات العلمية بعضها 5% خسارة وزن وبعضها 20% هذا مرجع لإحدى الدراسات: Pi-Sunyer X, Astrup A, Fujioka K, et al. A randomized, controlled trial of 3.0 mg of liraglutide in weight management. N Engl J Med. 2015;373(1):11-22.

Oct 21, 2022 · 1 like · 214,016 followers View post →
د. صالح بن سيف الهنائي
@SsAlhinai · X

@Important_advic بخصوص حقنة السكسندا تشير أحدى الدراسات أن المشاركين استطاعوا خسارة 5% من أوزانهم مرجع الدراسة:  Pi-Sunyer X, Astrup A, Fujioka K, et al. A randomized, controlled trial of 3.0 mg of liraglutide in weight management. N Engl J Med. 2015;373(1):11-22.

Oct 21, 2022 · 214,016 followers View post →
Vasili Panop
@0xpanoprx · X

@DrNadolsky Is there anything else you are doing? Clinical trials only show ~6 kg of weight loss more than placebo after a year of treatment. 6 kg is not bringing any BMI down from 40->20. I smell confounding factors/other interventions https://t.co/10asN4H5yd

Oct 10, 2022 · 4 likes · 47 followers View post →
DigestivoValdecilla
@DigValdecilla · X

RT @JhannaCueto: https://t.co/JgLOo670yW https://t.co/fnBlbeFfPI https://t.co/4bXrYB6vcX

Aug 7, 2022 · 1 share · 1,399 followers View post →
Dra. Jhanna Cueto
@JhannaCueto · X

https://t.co/JgLOo670yW https://t.co/fnBlbeFfPI https://t.co/4bXrYB6vcX

Aug 6, 2022 · 1 like · 1 share · 923 followers View post →
María Ballesteros
@mdballesteros · X

RT @ana_azugas: @Marta_Araujo_C Merece la pena detallar resultados #SCALE https://t.co/vT2RG6Hoil A greater proportion in the liraglutide…

May 7, 2022 · 1 share · 4,802 followers View post →
Ana Zugasti
@ana_azugas · X

@Marta_Araujo_C Merece la pena detallar resultados #SCALE https://t.co/vT2RG6Hoil A greater proportion in the liraglutide group than in the placebo group lost at least 5% of their weight (63.2% vs. 27.1%),> 10% of their body weight (33.1% vs. 10.6%),>15% of their body weight (14.4% vs. 3.5%) https://t.co/1LcoNZ19Ti

May 7, 2022 · 2 likes · 1 share · 3,574 followers View post →
cardio-met
@cardiomet_CE · X

Evidence of GLP-1 RAs in those without diabetes from SCALE (liraglutide 3mg/saxenda)... https://t.co/HLk4AMVCdp https://t.co/hZEPtlSutb

Oct 7, 2021 · 4,209 followers View post →
Stephen Winters
@stephen_winters · X

@GadSaad Not providing medical advice. Just placing this here for your reading pleasure. https://t.co/orned6G29r

Jul 27, 2021 · 508 followers View post →
Kevin Fernando
@drkevinfernando · X

RT @cardiomet_CE: https://t.co/HLk4AMVCdp

Jul 7, 2021 · 1 share · 5,140 followers View post →
cardio-met
@cardiomet_CE · X

https://t.co/HLk4AMVCdp

Jul 7, 2021 · 5 likes · 1 share · 4,209 followers View post →
Carolina Posada
@CarPoAlv · X

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. Xavier Pi-Sunyer et al. N Engl J Med. 2015. Es el estudio que demostró, tras casi 5 años de seguimiento, que liraglutide en comparación con placebo reduce el peso corporal y mejora el perfil metabólico

Apr 19, 2021 · 2 likes · 148 followers View post →
Meri Davitadze
@MeriDavitadze · X

RT @mendesthiagob: Obesity is a chronic metabolic disease, and many drugs proved to be both effective and safe. Let's spread the concept…

Mar 12, 2021 · 3 shares · 502 followers View post →
Gustavo Rovari
@RovariGustavo · X

RT @mendesthiagob: Obesity is a chronic metabolic disease, and many drugs proved to be both effective and safe. Let's spread the concept…

Mar 11, 2021 · 3 shares · 277 followers View post →
Mario Suito
@mariosuitofmd · X

RT @mendesthiagob: Obesity is a chronic metabolic disease, and many drugs proved to be both effective and safe. Let's spread the concept…

Mar 11, 2021 · 3 shares · 454 followers View post →
Endocrine dialogues
@EndoDialogues · X

Obesity is a chronic metabolic disease, and many drugs proved to be both effective and safe. Let's spread the concept that obesity is a disease and treatment is available. https://t.co/hJKQgNJ4zP https://t.co/e4DyoeEEUk

Mar 11, 2021 · 10 likes · 3 shares · 6,466 followers View post →
名前
@akkiii0830 · X

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management https://t.co/ksudtRzWZh

Feb 10, 2021 · 245 followers View post →
Ana María Muñoz R
@Anarestrepo211 · X

RT @CarPoAlv: A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. Xavier Pi-Sunyer et al. N Engl J Med. 2015. Es…

Feb 3, 2021 · 3 shares · 40 followers View post →
Maria Jose Alzate U
@Marialzateu · X

RT @CarPoAlv: A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. Xavier Pi-Sunyer et al. N Engl J Med. 2015. Es…

Feb 3, 2021 · 3 shares · 385 followers View post →
Carolina Posada
@CarPoAlv · X

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. Xavier Pi-Sunyer et al. N Engl J Med. 2015. Es el estudio que demostró, tras casi 5 años de seguimiento, que liraglutide en comparación con placebo reduce el peso corporal y mejora el perfil metabólico

Feb 3, 2021 · 3 likes · 3 shares · 148 followers View post →
ゆずき あや
@noir_noir_noir · X

RT @COYASS: ケトダイエットのアドバイザーなのにリバウンドするエリートデブ。当時デブパレード内でも天才と言われていた。 33キロ減でサイズ合わせたのに結構戻ってきて着れない。ストレスによるコルチゾール増で糖新生増えて、何食っても太る。医学的知識と現代医学により解決する…

Feb 2, 2021 · 1 share · 647 followers View post →
Dr.COYASS
@COYASS · X

ケトダイエットのアドバイザーなのにリバウンドするエリートデブ。当時デブパレード内でも天才と言われていた。 33キロ減でサイズ合わせたのに結構戻ってきて着れない。ストレスによるコルチゾール増で糖新生増えて、何食っても太る。医学的知識と現代医学により解決する。 https://t.co/i7IwPYLBN4 https://t.co/wOTYPofp2p

Feb 2, 2021 · 26 likes · 1 share · 11,569 followers View post →
Harmless Frog
@FrogHarmless · X

@OhhiyoGarmen The best pharmacological method I know of is liraglutide. But even that is only modestly slimming. https://t.co/Ck6kYapsd5

Jan 21, 2021 · 502 followers View post →
炭田 健太郎|Kentaro Sumida
@dubstep_ken · X

@KaoriName 2型糖尿病の薬じゃないですかwww 最悪死者出ますよ

Nov 30, 2020 · 1 like · 1,186 followers View post →
Stephan J. Guyenet
@sguyenet · X

@GidMK This idea was a bombshell for me when I first learned of it. I think the placebo effect holds up pretty well in some domains though. Hard to imagine 2.6% weight loss being attributable to regression to the mean. https://t.co/D3aHpQUnRH https://t.co/FeO2fswOpN

Jun 1, 2020 · 2 likes · 49,003 followers View post →
Michael Albert, MD
@MichaelAlbertMD · X

@MichaelMindrum @IanStockport "After treatment cessation, a mean weight regain of 2.9% occurred in the group that switched from liraglutide 3.0 mg to placebo." [Supplemental Section] https://t.co/kar2aRt7bh

Feb 24, 2020 · 1 like · 16,054 followers View post →
名前
@akkiii0830 · X

リラグルチド3mg かなり体重減るね！ ただ消化器症状もすごいみたい ちょっとみてみましょう https://t.co/anqz7JSRvt https://t.co/0xiycRiqaZ

Dec 18, 2019 · 1 like · 245 followers View post →
Aaron Richterman, MD
@AaronRichterman · X

@Cortes_Penfield @BWDionne @glavaidguy @PaulSaxMD e.g. https://t.co/JYIzFIIGPb

Aug 7, 2019 · 4,123 followers View post →
Dr Rani Khatib FESC
@DrRaniKhatib · X

@f4tema https://t.co/PF6zFC00Ru

Jul 5, 2019 · 5,421 followers View post →