Circulation July 2015 PMID 26149435

Homocysteine and MTHFR Mutations.

Stephan Moll, Elizabeth A Varga

Mentions

122
Peak: 9 in Jul 2022
across 7 sources since Feb 2016

Extended reach

83,686
potential audience

Total likes

1,083

Video views

30,345

Mentions per month

Feb 2016 – Dec 2025

Where it's discussed

  • Facebook50 posts
  • X / Twitter27 posts
  • Reddit19 posts
  • TikTok10 posts
  • News9 articles
  • Instagram5 posts
  • YouTube2 videos

AI synopsis

What people are saying

The group's discussions show a strong interest in the implications of MTHFR mutations, with many posts referencing personal health experiences, genetic prevalence data, and supplement advice, indicating active engagement. The tone ranges from informational to personal, emphasizing both curiosity and the significance of understanding how these genetic factors impact health, which reflects moderate but meaningful impact.

AgreementModerate agreement

Most discussions acknowledge the relevance of the publication and agree with its emphasis on MTHFR mutations affecting homocysteine levels, evidenced by statements like 'most don’t know' or affirmations of understanding.

InterestHigh interest

The discussions reflect high interest, with posts sharing personal experiences, research references, and noting the importance of the topic, such as the mention of how many people are affected or how it impacts pregnancies.

EngagementModerate engagement

Posts demonstrate a moderate level of engagement through sharing additional information, personal stories, or critiques, like comments on interpreting genetic mutations and reactions to supplements.

ImpactModerate impact

The conversations suggest the publication has some influence, prompting users to consider genetic testing, dietary adjustments, or recognizing risks, thereby potentially affecting health decisions and awareness.

Abstract in brief

  • The text explains how elevated levels of homocysteine, an amino acid in the blood, are linked to various health issues, especially heart disease, and how genetic mutations in the MTHFR gene can increase these levels.
  • It discusses the function of the MTHFR enzyme in processing folate and homocysteine, highlighting that mutations can impair this process and lead to higher homocysteine concentrations.
  • The document suggests that managing homocysteine levels through diet, supplements, or medical intervention might help reduce associated health risks, especially in individuals with MTHFR mutations.

Top posts

Most liked on X and Bluesky
Alissa Zingman MD MPH - ZebraMD
@DocZing · X

Have to wonder if any relationship w #LongCovid and #EhlersDanlos Septad (esp those w decline after inflammatory insult/illness) https://t.co/rsTc9uuUC3 https://t.co/ImIfpu3HbP

Dec 21, 2021 · 11 likes · 4 shares · 4,209 followers View post →
Duckie Louise
@DuckieLouise · X

@hedge23 @wildcat_of @_parasocial @Intractable1 I learned that blue eyes are a mutation in high school biology class. Mutation doesn’t have to mean it’s a mutation every time. It means it started as a mutation and then became an inheritable trait. Like MTHFR. https://t.co/FbW5XepRWq. https://t.co/7HLA1BASlN

Sep 25, 2024 · 5 likes · 6,280 followers View post →
J Roberts
@JonRob08 · X

@MeganBrownMD @acweyand @PedsHemeDoc @AronFlaggMD @Aka_evilgenius @Carpeshannon01 @hannahfassel @katiemcguinn @JulieJaffray @GuyYoungMD @Clot1 Yes! I get tired of cleaning up referring docs MTHFR testing/misinformation. I hand this paper out to patients routinely. https://t.co/B7GjW0h0iO

Oct 21, 2020 · 5 likes · 786 followers View post →
Jen
@PolitiKellyRite · X

@ChrisRugby7s @stopvaccinating @KristiLeighTV My hematologist told me this. I had the same question as I’m compound heterozygous with a subnormal homocysteine level of 2. https://t.co/KqxyylHWob. https://t.co/VY8SgzsIbL

Sep 23, 2025 · 2 likes · 9,343 followers View post →
Elizabeth Varga
@lizvarga · X

@bolisa3 @AdairaLandryMD I have published on this very topic! See here: https://t.co/a9yEFjKzHd

Jan 2, 2023 · 2 likes · 1,662 followers View post →
Ᏼꭱꮎꮓꭼꮶ
@jonathanbrozek · X

30-40% of population have genetic mutation MTHFR (most don’t know) which effects methylation. Taking B vitamins (folate not folic acid) helps but other symptoms need ox be addressed as well. Homocysteine and MTHFR Mutations - PubMed https://t.co/WFkO5hJ3L9

Dec 30, 2022 · 2 likes · 2 shares · 1,081 followers View post →

All mentions

Understanding Postpartum Depression and Genetic Factors

I react to Gary Breckas claim of a gene mutation prenatal vitamins being the NUMBER ONE cause of Postpartum Depression. The abstract explains how MTHFR gene mutations increase homocysteine levels, which are linked to…

stanzy · Apr 12, 2024 543 views
Jen
@PolitiKellyRite · X

@ChrisRugby7s @stopvaccinating @KristiLeighTV My hematologist told me this. I had the same question as I’m compound heterozygous with a subnormal homocysteine level of 2. https://t.co/KqxyylHWob. https://t.co/VY8SgzsIbL

Sep 23, 2025 · 2 likes · 9,343 followers View post →
Hi2u
@RETsetLife · X

“The MTHFR gene normally produces an enzyme that helps regulate homocysteine levels in the body.” Homocysteine and MTHFR Mutations | Circulation ➡️https://t.co/ENDkwBQGK9 https://t.co/krfAAO4FzT

Jan 29, 2025 · 418 followers View post →
Mary Cremer
@cremer_mary · X

@Tetrahydropyran @OGdukeneurosurg https://t.co/VNFcd3eJUV

Jan 25, 2025 · 3,636 followers View post →
Duckie Louise
@DuckieLouise · X

@hedge23 @smith_jsbe8786 @wildcat_of @_parasocial @Intractable1 @RyanMarino Correct

Sep 25, 2024 · 1 like · 6,280 followers View post →
Duckie Louise
@DuckieLouise · X

@hedge23 @wildcat_of @_parasocial @Intractable1 I learned that blue eyes are a mutation in high school biology class. Mutation doesn’t have to mean it’s a mutation every time. It means it started as a mutation and then became an inheritable trait. Like MTHFR. https://t.co/FbW5XepRWq. https://t.co/7HLA1BASlN

Sep 25, 2024 · 5 likes · 6,280 followers View post →
BlackhillsEd
@blackhillsed · X

@BrianRoemmele This is more info on the ethnic groups most affected. Homocysteine and MTHFR Mutations | Circulation https://t.co/sOHjg68wO8 https://t.co/OO8nkwyrno

Nov 19, 2023 · 544 followers View post →
BlackhillsEd
@blackhillsed · X

@LakeWAlife @BrianRoemmele Found this. Homocysteine and MTHFR Mutations | Circulation https://t.co/sOHjg68wO8 https://t.co/0dAegi7gbP

Nov 18, 2023 · 1 like · 544 followers View post →
Bodkin&Thim
@BodkinThimble · X

Varga et al. Homocysteine and MTHFR Mutations Relation to Thrombosis and Coronary Artery Disease Circulation 2005 https://t.co/sbNs6sYci1

Oct 11, 2023 · 107 followers View post →
Ᏼꭱꮎꮓꭼꮶ
@jonathanbrozek · X

RT @jonathanbrozek: 30-40% of population have genetic mutation MTHFR (most don’t know) which effects methylation. Taking B vitamins (fol…

Jul 31, 2023 · 2 shares · 1,081 followers View post →
Matthew D
@DopplerEffect93 · X

@SarahNe39122184 @DrKatEpi https://t.co/unHZGvUiti https://t.co/Ot0Rt8hl4e https://t.co/kDTff2mpP0

Jul 11, 2023 · 732 followers View post →
Celeste Hayes
@Celeste64882539 · X

@TruthQu86255147 @CPoppino My issue is MTHFR. My Homocysteine levels have been elevated for over 20 years & have been rising. I react to methyl folate, niacin above bare minimal dosages, & low dose B12 in any form builds up in my body. I take Lumbrokinase, Serrapeptase and ACV. https://t.co/ph25ev3GXy

Feb 27, 2023 · 1 like · 1,030 followers View post →
Michelle R. Zimmerman, PhD #MIEExpert #LongCovid
@mrzphd · X

If you're interested in more, check out American Heart Association https://t.co/31gYJcLC9F

Feb 21, 2023 · 1 like · 5,897 followers View post →
Control Group, MD
@ControlGroupMD · X

@P_McCulloughMD @ClareCraigPath @drcole12 @drcraigwax @stkirsch Curious parallels. https://t.co/xVG438BxAg

Feb 4, 2023 · 330 followers View post →
Control Group, MD
@ControlGroupMD · X

@WetlanderNW @EthicalSkeptic @PatrioticPurple https://t.co/xVG438BxAg

Feb 4, 2023 · 330 followers View post →
Petri Pellinen
@petri_pellinen · X

RT @jonathanbrozek: 30-40% of population have genetic mutation MTHFR (most don’t know) which effects methylation. Taking B vitamins (fol…

Jan 3, 2023 · 2 shares · 1,437 followers View post →
Elizabeth Varga
@lizvarga · X

@bolisa3 @AdairaLandryMD I have published on this very topic! See here: https://t.co/a9yEFjKzHd

Jan 2, 2023 · 2 likes · 1,662 followers View post →
Ᏼꭱꮎꮓꭼꮶ
@jonathanbrozek · X

30-40% of population have genetic mutation MTHFR (most don’t know) which effects methylation. Taking B vitamins (folate not folic acid) helps but other symptoms need ox be addressed as well. Homocysteine and MTHFR Mutations - PubMed https://t.co/WFkO5hJ3L9

Dec 30, 2022 · 2 likes · 2 shares · 1,081 followers View post →
PediatricB12Awareness
@AwarenessB12 · X

@DevinShuman @babiesafter35 No pregnancy should have high homocysteine. It is toxic to babies and moms and pregnancies. Low B12 is one reason. MTHFR is a risk factor for high homocysteine as well. On what basis are you suggesting it is not? https://t.co/MO9GclY9gL

Sep 18, 2022 · 715 followers View post →
CHRONIC
@chronic_action · X

RT @DocZing: Have to wonder if any relationship w #LongCovid and #EhlersDanlos Septad (esp those w decline after inflammatory insult/illnes…

Dec 22, 2021 · 4 shares · 1,170 followers View post →
Julie Comperchio
@JulesC2022 · X

RT @DocZing: Have to wonder if any relationship w #LongCovid and #EhlersDanlos Septad (esp those w decline after inflammatory insult/illnes…

Dec 22, 2021 · 4 shares · 995 followers View post →
stefanielaine
@stefanielaine · X

RT @DocZing: Have to wonder if any relationship w #LongCovid and #EhlersDanlos Septad (esp those w decline after inflammatory insult/illnes…

Dec 21, 2021 · 4 shares · 1,168 followers View post →
Alissa Zingman MD MPH - ZebraMD
@DocZing · X

Have to wonder if any relationship w #LongCovid and #EhlersDanlos Septad (esp those w decline after inflammatory insult/illness) https://t.co/rsTc9uuUC3 https://t.co/ImIfpu3HbP

Dec 21, 2021 · 11 likes · 4 shares · 4,209 followers View post →
3rdworldJHB
@3rdworldJhb · X

This is very good news for Africa https://t.co/DWLyQWo3Cn,(1%25%E2%80%932%25). https://t.co/yxD3LTAibt https://t.co/HZ3SSbjvpD

Oct 4, 2021 · 361 followers View post →
Sandra
@sgianturco4241 · X

Homocysteine and MTHFR Mutations | Circulation ⁦@kathleengorma13⁩ https://t.co/swBxJcTyWG

Oct 3, 2021 · 1 like · 652 followers View post →
Sandra
@sgianturco4241 · X

Homocysteine and MTHFR Mutations | Circulation https://t.co/swBxJcTyWG

Oct 3, 2021 · 652 followers View post →
Madam Butterfly.
@michellecheatle · X

Homocysteine and MTHFR Mutations https://t.co/N8kA3hZ4kv

Aug 1, 2021 · 2 likes · 1 share · 926 followers View post →
J Roberts
@JonRob08 · X

@MeganBrownMD @acweyand @PedsHemeDoc @AronFlaggMD @Aka_evilgenius @Carpeshannon01 @hannahfassel @katiemcguinn @JulieJaffray @GuyYoungMD @Clot1 Yes! I get tired of cleaning up referring docs MTHFR testing/misinformation. I hand this paper out to patients routinely. https://t.co/B7GjW0h0iO

Oct 21, 2020 · 5 likes · 786 followers View post →
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org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

Jul 6, 2024 View →
Blood test for homocysteine level in CADASIL should be considered ...
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org/doi/full/10.1161/circulationaha.114.013311. Homocysteine and MTHFR Mutations. AHAJOURNALS.ORG. Homocysteine and MTHFR Mutations.

Dec 15, 2023 View →
Маја Велковска | Тестирањето за “мутации“, т.е. други варијанти ...
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... 10.1161/01.cir.0000165142.37711.e7 https://www.ahajournals.org/doi/full/10.1161/circulationaha.114.013311. Кои се вашите информации на оваа ...

Dec 3, 2023 View →
Wykrywanie mutacji MTHFR a znaczenie kliniczne | KopalniaWiedzy ...
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doi: 10.1161/CIRCULATIONAHA.114.013311. PMID: 26149435. • Undas A, Chojnowski K, Klukowska A, Łętowska M, Mital A, Młynarski W, Musiał J ...

Nov 18, 2023 View →
MTHFR disinfo, pseudoscience and the medical maze that is the ...
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... to see how dysfunctional your body may be: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.114.013311 · MyNameIsRobPaulson. OP • 2y ago.

Sep 21, 2023 View →
**To research your genetic variants, you need to have the following ...
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org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

Jul 16, 2023 View →
Coconut Water & Aloe Vera: Ideal Combo for Gut Health | TikTok
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... 10.1161/CIRCULATIONAHA.114.013311 #mthfrgenemutation #mthfrawareness #healingjourney #pcosawareness · original sound - Remy Kay. 209Likes. 8 ...

Jul 5, 2023 View →
Replying to @Astrid Encina Benefits of Oregano Oil for gut health ...
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... 10.1161/CIRCULATIONAHA.114.013311 #mthfrgenemutation #mthfrawareness #healingjourney #pcosawareness · original sound - Remy Kay. 201Likes. 8 ...

Jun 26, 2023 View →
(Link to other autism and MTHFR video @Lauren ) if you never listen ...
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... 10.1161/CIRCULATIONAHA.114.013311 #mthfrgenemutation #mthfrawareness #healingjourney #pcosawareness · original sound - Remy Kay. 207Likes. 8 ...

May 12, 2023 View →
Hello, is it a good idea to take B vitamins to help a person with ...
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org/doi/full/10.1161/circulationaha.114.013311. Homocysteine and MTHFR Mutations. Myra Lanham Beard and 7 others. 8 reactions ·. 13 comments.

Apr 2, 2023 View →
Autism and the MTHFR mutation. #mthfr #mthfrawareness ...
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... 10.1161/CIRCULATIONAHA.114.013311 #mthfrgenemutation #mthfrawareness #healingjourney #pcosawareness · original sound - Remy Kay. 0Likes. 8 ...

Mar 28, 2023 View →
I'm a carrier of two copies of the MTHFR gene variation, which is ...
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org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

Feb 28, 2023 View →
Replying to @wekstrom Recipes to add more beans & fiber ...
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... 10.1161/CIRCULATIONAHA.114.013311 #mthfrgenemutation #mthfrawareness #healingjourney #pcosawareness · original sound - Remy Kay. 207Likes. 8 ...

Feb 16, 2023 View →
#Genetisk trombofili : r/pregnant
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Jag hittade detta https://www.ahajournals.org/doi/10.1161/circulationaha.114.013311#:~:text=The%20most%20common%20MTHFR%20mutation,(1%25 ...

Jul 9, 2022 View →
#Geneettinen trombofilia : r/pregnant
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Löysin tänhttps://www.ahajournals.org/doi/10.1161/circulationaha.114.013311#:~:text=The%20most%20common%20MTHFR%20mutation,(1%25%E2%80%932%25).

Jul 9, 2022 View →
#Genetik trombofili : r/pregnant
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Hızlıca bir Google'ladım ve bence çok endişelenmene gerek yok. Şunu buldum:https://www.ahajournals.org/doi/10.1161/circulationaha.114.013311#:~: ...

Jul 9, 2022 View →
#Генетическая тромбофилия : r/pregnant
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Я нашел вот это: https://www.ahajournals.org/doi/10.1161/circulationaha.114.013311#:~:text=The%20most%20common%20MTHFR%20mutation,(1%25 ...

Jul 9, 2022 View →
#遗传性血栓形成倾向: r/pregnant
Reddit

我刚快速谷歌了一下,我觉得你不用太担心。我找到了这个https://www.ahajournals.org/doi/10.1161/circulationaha.114.013311#:~:text=The%20most ...

Jul 9, 2022 View →
#Γενετική θρομβοφιλία : r/pregnant
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Βρήκα αυτό https://www.ahajournals.org/doi/10.1161/circulationaha.114.013311#:~:text=The%20most%20common%20MTHFR%20mutation,(1%25%E2%80%932%25).

Jul 9, 2022 View →
#Genetisk trombofili : r/pregnant
Reddit

Jeg fant dettehttps://www.ahajournals.org/doi/10.1161/circulationaha.114.013311#:~:text=The%20most%20common%20MTHFR%20mutation,(1%25%E2%80%932% ...

Jul 9, 2022 View →
#Trombofilia genetik : r/pregnant
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Aku jumpa nihttps://www.ahajournals.org/doi/10.1161/circulationaha.114.013311#:~:text=The%20most%20common%20MTHFR%20mutation,(1%25%E2%80%932%25) ...

Jul 9, 2022 View →
#Genetic thrombophilia : r/pregnant
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I found this https://www.ahajournals.org/doi/10.1161/circulationaha.114.013311#:~:text=The%20most%20common%20MTHFR%20mutation,(1%25%E2%80 ...

Jul 9, 2022 View →
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253158/ Has ...
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org/doi/full/10.1161/circulationaha.114.013311. Homocysteine and MTHFR Mutations. Myra Lanham Beard and 7 others. 8 reactions ·. 13 comments.

Feb 10, 2022 View →
Could someone please give me information on my mutation? : r ...
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... Share. Comments Section. OwoUwuOwo4u. • 4y ago · https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.114.013311. [deleted]. OP ...

Jul 13, 2021 View →
I tested positive for the mthfr gene mutation. Can someone tell me ...
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org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

Jul 7, 2021 View →
[Question] MTHFR and Paleo : r/Paleo
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... 10.1161/CIRCULATIONAHA.114.013311. Source 5: https://www.obgproject.com/2017/07/23/mthfr-polymorphism-testing-evidence-isnt/. Source 6: https ...

Nov 21, 2020 View →
Hello. Can anyone explain in easy to understand terms these results ...
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org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

Jul 3, 2020 View →
ZINC in the soil of the United States.
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gov/diseases/10953/mthfr-gene-variant https://www.ahajournals. org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/ ...

Jun 12, 2020 View →
Is there a difference is severity if you are hetero verses Homozygous?
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gov/diseases/10953/mthfr-gene-variant https://www.ahajournals. org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/ ...

Apr 18, 2020 View →
Homozygous: Definition, Examples, and Differences to Heterozygous
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https://doi.org/10.1161/CIRCULATIONAHA.114.013311; MTHFR gene variant. (2018). https://rarediseases.info.nih.gov/diseases/10953/mthfr-gene ...

Jan 14, 2020 View →
Interesting I joined the group before I assessed my raw DNA. I knew ...
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org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

Jan 8, 2020 View →
What is the difference between a t and a g in a genetic report?
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org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

Dec 6, 2019 View →
MTHFR gene
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doi: 10.1161/CIRCULATIONAHA.114.013311. No abstract available. Citation on PubMed (https://pubmed.ncbi.nlm.nih.gov/26149435). • Sibani S ...

Oct 1, 2019 View →
MTHFR gene: MedlinePlus Genetics
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doi: 10.1161/CIRCULATIONAHA.114.013311. No abstract available. Citation on PubMed; Sibani S, Christensen B, O'Ferrall E, Saadi I, Hiou-Tim F ...

Oct 1, 2019 View →
What does having one copy of the MTHFR 677CT gene mean?
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org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

Sep 30, 2019 View →
Frameshift is an Altered Reading of the Genetic Code during ...
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org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

May 31, 2019 View →
Is it known where the MTHFR gene comes from? | Facebook
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org/doi/full/10.1161/CIRCULATIONAHA. 114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

Feb 17, 2019 View →
Good night ! We made a genétic test (23andMe) and we also did the ...
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org/doi/full/10.1161/CIRCULATIONAHA. 114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

Feb 17, 2018 View →
MTHFR Gene | PDF | Biology | Genetics
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Homocysteine and MTHFR Mutations. Circulation. 2015 Jul 7;132(1):e6-9. doi: 10.1161/CIRCULATIONAHA.114.013311. Review. Citation on PubMed: ...

Oct 3, 2017 View →
I have MTHFR and it is the cause of my B12. B9 & Pernicious ...
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gov/diseases/10953/mthfr-gene-variant https://www.ahajournals. org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/ ...

Dec 7, 2016 View →
How long blood test of Cadasil? | Facebook
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org/doi/full/10.1161/circulationaha.114.013311. Homocysteine and MTHFR Mutations. Myra Lanham Beard and 7 others. 8 reactions ·. 13 comments.

Feb 4, 2016 View →
Just one heterozygous MAO-A [+/- ] enzyme may not cause any ...
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org/doi/full/10.1161/CIRCULATIONAHA.114.013311 https://www.hindawi. com/journals/crie/2020/6945124/ https://medlineplus.gov/genetics/gene ...

Dec 12, 2014 View →