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J Neurosci August 2015 PMID 26245965

The Effect of Body Posture on Brain Glymphatic Transport.

Hedok Lee, Lulu Xie, Mei Yu, Hongyi Kang, Tian Feng, Rashid Deane, Jean Logan, Maiken Nedergaard, Helene Benveniste

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Mentions

233
Peak: 6 in Aug 2025
across 6 sources since Apr 2019

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224,901
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226

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Apr 2019 – Sep 2025

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AI synopsis

What people are saying

The overall discussions reflect a strong recognition of the article's significance, with many posters supporting the idea that sleep position can substantially affect brain waste clearance. Examples include remarks about the lateral position being 'best' and references to physiological explanations, showing that the tone and choice of technical terms contribute to a sense of importance and depth regarding the study's findings.

AgreementModerate agreement

Most discussions support the finding that body posture influences brain waste clearance, with many emphasizing the lateral position's benefits. Phrases like 'most efficient' and 'best position' indicate strong agreement among posters.

InterestHigh interest

Posts express high curiosity, with multiple questions and references to specific mechanisms, showing genuine interest in understanding the research implications. Words like 'impact,' 'effect,' and 'wonder' highlight this curiosity.

EngagementHigh engagement

Several discussions delve into detailed mechanisms, such as the role of heart positioning and sympathetic tone, demonstrating deep engagement. References to scientific processes and descriptions of sleep positions indicate thoughtful reflection.

ImpactModerate impact

While many acknowledge the potential influence on conditions like Alzheimer's, comments suggest the findings could inform future health practices rather than immediate widespread change, leading to a moderate impact perception.

Abstract in brief

  • The study examined how body posture influences the efficiency of the brain's glymphatic system, which clears waste like amyloid A, and found that lateral sleep positions promote faster waste removal compared to supine or prone positions.
  • Utilizing MRI, fluorescence microscopy, and radioactive tracers, researchers observed that waste clearance was most effective when rodents were in the lateral position, followed by supine, and slowest in the prone position.
  • The findings suggest that the lateral sleep posture has likely evolved to optimize waste clearance during sleep, and this factor should be considered in future diagnostic imaging to better assess CSF and ISF exchange in humans.]
Read the full abstract

Top posts

Most liked on X and Bluesky
LE COLLECTIF
@tatiann69922625 · X

Et si votre position de sommeil impactait votre cerveau ?

Aug 19, 2025 · 6 likes · 3 shares · 63,437 followers View post →
Zaid K. Dahhaj
@zaidkdahhaj · X

2. GLYMPHATIC DRAINAGE A lateral sleeping position is the BEST position to most efficiently remove waste from the brain through the glymphatic system During deep sleep in general, the glymphatic pathway is most efficient Side sleep maxxing https://t.co/c4GKejCCPY https://t.co/aHYWQzGhEg

Jul 5, 2023 · 6 likes · 1 share · 48,621 followers View post →
DerfelTheMighty
@DerfelTheMighty · X

@4therecords @Karl_Lauterbach Auf der Seite schlafen z.b. https://t.co/FPufjXe6U9

Dec 5, 2020 · 4 likes · 1,175 followers View post →
Yoshihito Saito
@yoshihito_saito · X

体の向きによって脳脊髄液の流れが異なるからかなあ。 https://t.co/7UhYhmBKq0 アミロイドベータの除去も仰向けとかの方がいいらしい。 https://t.co/cQnR9hOqjL

Jun 8, 2021 · 4 likes · 1 share · 299 followers View post →
ソーラ@me/cfs
@OMwvw · X

睡眠中の姿勢とグリンパティック系の関係を調べた研究 横向き寝で寝た時が1番効率が良かったとのこと ラットが対象なのでヒトには適用できませんが、例えば睡眠時に頭を高くすることによって睡眠時無期呼吸や逆流性食道炎、血液の循環などに効果があったとする報告もあります https://t.co/z0qq8mqF4i

Oct 15, 2022 · 3 likes · 1 share · 1,288 followers View post →
tune
@keisuke4713 · X

Jun 28, 2022 · 2 likes · 3 shares · 3,732 followers View post →

All mentions

Aubrai
@Aubrai_ · X

@NftScholarr Sleep position alone enhances clearance 40% - lateral beats supine (DOI: 10.1523/JNEUROSCI.1625-15.2015). But selective targeting needs conformational antibodies or PET-guided ultrasound during specific sleep phases. Key challenge: aggregates form where clearance is weakest -

Aug 30, 2025 · 1 like · 10,843 followers View post →
Jubal Harshaww
@Jubalharshaww · X

RT @tatiann69922625: Et si votre position de sommeil impactait votre cerveau ?

Aug 19, 2025 · 3 shares · 326 followers View post →
Emma Nuelle
@Emma81913841 · X

RT @tatiann69922625: Et si votre position de sommeil impactait votre cerveau ?

Aug 19, 2025 · 3 shares · 46 followers View post →
Beauverger Annie
@BeauvergerAnnie · X

RT @tatiann69922625: Et si votre position de sommeil impactait votre cerveau ?

Aug 19, 2025 · 3 shares · 185 followers View post →
LE COLLECTIF
@tatiann69922625 · X

Et si votre position de sommeil impactait votre cerveau ?

Aug 19, 2025 · 6 likes · 3 shares · 63,437 followers View post →
前野真一郎 PLT協会a.k.a.バイメカ厨
@maenoshinichiro · X

引用文献：The Effect of Body Posture on Brain Glymphatic Transport. Nedergaard M.Xie L, Kang H, Xu Q, et al. Journal of Neuroscience, 2015 Jul 1;35(31):11034-44.

Jun 26, 2025 · 1 like · 511 followers View post →
尾定利章
@re_fresh_jp · X

https://t.co/0BpnOgrv1i

Feb 28, 2025 · 10 followers View post →
尾定利章
@re_fresh_jp · X

『横向き寝で老廃物除去』 グリンパティックトランスポートは、仰向けとうつ伏せの姿勢と比較して、横向きで寝ている姿勢が最も効率的だった。 Lee H, Xie L, Yu M, et al. The Effect of Body Posture on Brain Glymphatic Transport. J Neurosci. 2015;35(31):11034-11044.

Feb 28, 2025 · 10 followers View post →
evetbenimzaten
@evetbenimzaten · X

@asiaa_adel https://t.co/5l5vGHa4EA Muhtemelen ek çalışmalarla desteklenmesi gerekiyor. çok detaylı incelemedim henüz. Ancak ilk bulgular bu yönde.

Dec 27, 2024 · 1 like · 188 followers View post →
Dr. David Norton DO
@davidnorton99 · X

@DrDaleBredesen Right lateral decubitus https://t.co/6N9uUQ5DAy

Oct 29, 2024 · 1 like · 398 followers View post →
Mathias Deceuninck
@MathiasDec11843 · X

https://t.co/6lq7dLAotv

Aug 22, 2023 · 9 followers View post →
Max Leyf
@LeyfMax · X

“The analysis showed that glymphatic transport was most efficient in the lateral position compared with the supine or prone positions. “ https://t.co/hDC6Pk24hr

Jul 23, 2023 · 1 like · 468 followers View post →
Zaid K. Dahhaj
@zaidkdahhaj · X

RT @zaidkdahhaj: 2. GLYMPHATIC DRAINAGE A lateral sleeping position is the BEST position to most efficiently remove waste from the brain…

Jul 13, 2023 · 1 share · 48,621 followers View post →
Zaid K. Dahhaj
@zaidkdahhaj · X

2. GLYMPHATIC DRAINAGE A lateral sleeping position is the BEST position to most efficiently remove waste from the brain through the glymphatic system During deep sleep in general, the glymphatic pathway is most efficient Side sleep maxxing https://t.co/c4GKejCCPY https://t.co/aHYWQzGhEg

Jul 5, 2023 · 6 likes · 1 share · 48,621 followers View post →
Rene Sugar
@renesugar · X

https://t.co/3cgeCp7JPK "One possible reason for the advantage of RLD position is that the heart is positioned higher when lying on the right side."

Apr 13, 2023 · 1 like · 3,970 followers View post →
Rene Sugar
@renesugar · X

https://t.co/3cgeCp7JPK "The slight elevation of the heart facilitating pumping of blood and at the greater venous return may increase cardiac stroke volume; in turn, the sympathetic tone is reduced, possibly improving glymphatic influx."

Apr 13, 2023 · 3,970 followers View post →
Rene Sugar
@renesugar · X

https://t.co/3cgeCp7JPK "It has also been shown that sympathetic tone is lower concomitantly with an increase in vagal tone in the right rather than in the left lateral position (Kuo et al., 2000)."

Apr 13, 2023 · 3,970 followers View post →
Rene Sugar
@renesugar · X

https://t.co/3cgeCp7JPK "Because norepinephrine is a potent inhibitor of glymphatic influx, an increase in sympathetic tone might have contributed to the reduction in glymphatic influx in the prone position (Xie et al., 2013)."

Apr 13, 2023 · 3,970 followers View post →
Rene Sugar
@renesugar · X

The Effect of Body Posture on Brain Glymphatic Transport https://t.co/3cgeCp7JPK

Apr 13, 2023 · 3,970 followers View post →
多情仏心
@jiangminjp · X

"仰臥位（背中を下にする姿勢）や伏臥位（お腹を下にする姿勢）を長時間継続すると、この脳のリンパ管が閉じることが分かっています（The effect of body posture on brain glymphatic transport. J Neurosci. (2015) 35:11034–44）"

Nov 12, 2022 · 1,756 followers View post →
ラミパス
@lapis_lazule · X

RT @OMwvw: 睡眠中の姿勢とグリンパティック系の関係を調べた研究 横向き寝で寝た時が1番効率が良かったとのこと ラットが対象なのでヒトには適用できませんが、例えば睡眠時に頭を高くすることによって睡眠時無期呼吸や逆流性食道炎、血液の循環などに効果があったとする報告もありま…

Oct 15, 2022 · 1 share · 504 followers View post →
ソーラ@me/cfs
@OMwvw · X

睡眠中の姿勢とグリンパティック系の関係を調べた研究 横向き寝で寝た時が1番効率が良かったとのこと ラットが対象なのでヒトには適用できませんが、例えば睡眠時に頭を高くすることによって睡眠時無期呼吸や逆流性食道炎、血液の循環などに効果があったとする報告もあります https://t.co/z0qq8mqF4i

Oct 15, 2022 · 3 likes · 1 share · 1,288 followers View post →
A.Augustinus
@lovetrustchrist · X

RT @keisuke4713:

Jul 1, 2022 · 3 shares · 195 followers View post →
ウェルウィッチア奈央
@U9HKuVbhNQPGJAU · X

RT @keisuke4713:

Jun 28, 2022 · 3 shares · 138 followers View post →
tune
@keisuke4713 · X

Jun 28, 2022 · 2 likes · 3 shares · 3,732 followers View post →
Ankush Chakraborty
@oonkush · X

@superrsema In addition to all that is said here, you could look at how the CSF flows in the glymphatic system. Apparently arterial pulses affect CSF flow in the brain. You can check these papers. https://t.co/7uCUDp21ya

Aug 29, 2021 · 1 like · 785 followers View post →
Denouncer of Everything
@searchingthru · X

"Although our finding awaits testing in humans, we speculate that the lateral position during sleep has advantage with regard to the removal of waste products including Aβ, because clinical studies have shown that sleep drives Aβ clearance from the brain." https://t.co/7O71LeUysu

Aug 25, 2021 · 396 followers View post →
For health-promoting environments
@SilkeLeFay · X

#Alzheimers #dementia #glymphatic #amyloid #agedcare #sleep #neuroscience #mentalhealth #brain #health #nursing #aging #longevity #smartwatch #apps #healthtech #melatonin #neurology #geriatrics #gerontology #HRV #apps #calm https://t.co/BNyZHDY1JO https://t.co/nTlQy91kQl

Jun 10, 2021 · 1 like · 4,584 followers View post →
Takuma Kitanishi
@tkitanishi · X

RT @yoshihito_saito: 体の向きによって脳脊髄液の流れが異なるからかなあ。 https://t.co/7UhYhmBKq0 アミロイドベータの除去も仰向けとかの方がいいらしい。 https://t.co/cQnR9hOqjL

Jun 8, 2021 · 1 share · 2,691 followers View post →
Yoshihito Saito
@yoshihito_saito · X

体の向きによって脳脊髄液の流れが異なるからかなあ。 https://t.co/7UhYhmBKq0 アミロイドベータの除去も仰向けとかの方がいいらしい。 https://t.co/cQnR9hOqjL

Jun 8, 2021 · 4 likes · 1 share · 299 followers View post →
DerfelTheMighty
@DerfelTheMighty · X

@4therecords @Karl_Lauterbach Auf der Seite schlafen z.b. https://t.co/FPufjXe6U9

Dec 5, 2020 · 4 likes · 1,175 followers View post →
OptimumSleep
@SleepOptimum · X

Source: Lee, Hedok et al. “The Effect of Body Posture on Brain Glymphatic Transport.” The Journal of neuroscience: the official journal of the Society for Neuroscience vol. 35,31 (2015): 11034-44. doi:10.1523/JNEUROSCI.1625-15.2015

Nov 29, 2020 · 3 followers View post →
Cariloha Bambú
@CarilohaBambu · X

Referencia: The Effect of Body Posture on Brain Glymphatic Transport. Hedok Lee, Lulu Xie, Mei Yu, Hongyi Kang, Tian Feng, Rashid Deane, Jean Logan, Maiken Nedergaard and Helene Benveniste. Journal of Neuroscience DOI: https://t.co/TMU8tcmVjs

Nov 4, 2020 · 1 like · 22 followers View post →
tokatti
@tokatti_ · X

論文によれば、大半の痴呆症は睡眠障害と結びついている。睡眠障害が健忘症やアルツハイマーの原因になることは徐々に認められつつある https://t.co/buFgXzQGFb 2012年の研究 寝てる間に脳の細胞が縮みその間を脳脊髄液が流れて脳を掃除してくれる https://t.co/wOjAI3IPpj #自分用メモ

Aug 19, 2020 · 178 followers View post →
Good virtues Japan(グッドバーチューズジャパン)【公式】
@JapanVirtues · X

脳の老廃物アミロイドベータ。 アルツハイマーの人は除去できずに残留している これが横向きで寝た方が解毒促進されるんだってさ アーユルベーダーでは左側向いて寝ろって 教えあるほど。昔の人は知ってたんかね。 https://t.co/cNFSoGCcyW

Jun 8, 2020 · 1 like · 82 followers View post →
David Nowell, Ph.D.
@davidnowell · X

The Effect of Body Posture on Brain Glymphatic Transport https://t.co/fKkegY6jgn

Jan 2, 2020 · 1 like · 3,209 followers View post →
Sueño Sano, Vida Sana
@suenovidasana · X

Fuente: Journal of Neurosciencie DOI. (2015) The Effect of Body Posture on Brain Glymphatic Transport. USA.

Apr 3, 2019 · 10 followers View post →