November 2015 PMID 26272235

Melatonin: an ancient molecule that makes oxygen metabolically tolerable.

Lucien C Manchester, Ana Coto-Montes, Jose Antonio Boga, Lars Peter H Andersen, Zhou Zhou, Annia Galano, Jerry Vriend, Dun-Xian Tan, Russel J Reiter

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Mentions

Peak: 2 in Feb 2020

across 4 sources since Oct 2019

Extended reach

60,931

potential audience

Total likes

447

Video views

17,331

Mentions per month

Oct 2019 – Sep 2024

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AI synopsis

What people are saying

The collective discussions highlight the foundational role of melatonin in oxygen metabolism and cellular protection, with phrases like 'ancient molecule' and 'protective functions' reflecting fascination with its evolutionary history. Words like 'significant' and references to scientific pathways demonstrate a thoughtful and engaged exchange, indicating that the publication is appreciated for its potential to influence future scientific understanding.

AgreementModerate agreement

Most discussions acknowledge the significance of melatonin as described in the publication, with some affirming its evolutionary importance and protective roles.

InterestHigh interest

The discussions show strong interest, often referencing specific functions like antioxidation and immune modulation, indicating engagement with the complex content.

EngagementModerate engagement

Participants engage beyond mere acknowledgment, mentioning mechanisms such as reactive species scavenging and mitochondrial functions, suggesting moderate to deep interest.

ImpactModerate impact

The potential implications for understanding oxygen tolerance and cellular protection hint at meaningful impacts on ongoing research and health sciences.

Abstract in brief

Melatonin is a highly versatile molecule that functions as an antioxidant, regulator of circadian rhythms, anti-inflammatory agent, immune modulator, and potential anti-cancer compound, originally evolved in cyanobacteria to combat toxic radicals generated during photosynthesis.
The primary role of melatonin in early organisms was as an antioxidant, with secondary functions such as regulating biological rhythms and immune responses developing later in evolution; mitochondria and chloroplasts, derived from bacteria that produce melatonin, are likely key sites of its synthesis in eukaryotic cells.
Melatonin effectively prevents oxidative damage by scavenging various reactive species, modulating antioxidant enzymes through pathways like Keap1-Nrf2-ARE, and its high levels within mitochondria suggest these organelles are central to its production and protective functions.

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All mentions

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The Diabetes-Sleep Connection: Melatonin's Role in Management

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Bowie Matteson · Jan 27, 2024 69 views

Jack

@jack_schroder_ · X

Melatonin: an ancient molecule that makes oxygen metabolically tolerable https://t.co/0bBGQwWssB

Sep 9, 2024 · 1 like · 15,620 followers View post →

Dr Kevin Lee

@dr_kevinlee · X

#Melatonin: an ancient molecule that makes oxygen metabolically tolerable https://t.co/AeOoeocHN8 https://t.co/mh3xWcrpvr

Aug 17, 2021 · 3 likes · 5,437 followers View post →

M. Ángeles Bonmatí

@bonmati_m · X

Sep 30, 2020 · 1,926 followers View post →

M. Ángeles Bonmatí

@bonmati_m · X

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Someone, Somewhere

@CapobiaNB · X

RT @dr_kevinlee: Melatonin: an ancient molecule that makes oxygen metabolically tolerable https://t.co/9eFLACFxvQ

Feb 29, 2020 · 1 share · 10,087 followers View post →

Dr Kevin Lee

@dr_kevinlee · X

Melatonin: an ancient molecule that makes oxygen metabolically tolerable https://t.co/9eFLACFxvQ

Feb 29, 2020 · 4 likes · 1 share · 5,437 followers View post →

DrRPalmquist

@DrPalmquist · X

Melatonin: an ancient molecule that makes oxygen metabolically tolerable. - PubMed - NCBI https://t.co/x4S4iwdvFc

Oct 19, 2019 · 3,163 followers View post →