Opioid Receptors.

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Claire

@kumakurea_ · X

where can I get the porn that activates your opioid receptors https://t.co/4r8sDspx5t

IE

I don't exist.

@Nub_or_someth · X

@madokaleninist there's actual good arguments against it but this isn't even accurate CHEESE triggers the same receptors that heroin triggers CHOCOLATE triggers the same receptors even though porn is bad it DOESN'T TRIGGER OPIOID RECEPTORS

CF

Conrad Fischer

@SeeFisch · X

Difelikefalin *For itching especially associated with dialysis *Modifies opioid receptors *Binding to the receptors (called kappa opioid receptors), difelikefalin activates them *Decreasing the signals that lead to the feeling of itchiness itself

TF

Theo(dore) Foxx

@Foxx_nd_Inkwell · X

@every1youknow Something "triggering receptors in the brain" =/= it being "actively harmful" Heroine is converted into morphine, which binds to our opioid receptors, primarily mu-opioid receptors. You know what else binds to opioid receptors? Endorphines. Which your body produces naturally.

As someone who knows a lot of folks who do recreational intoxicants I HAVE BEEN HEARING A LOT OF BAD STUFF ABOUT THIS 'Feel Free' THING. It's sold at gas stations next to junk like delta 8, only I think it might be even easier to get? Reacts with opioid receptors, causes BAD WITHDRAWAL BE CAREFUL

kratom = comes from the tree Mitragyna speciosa and contains alkaloids that stimulate opioid receptors and can interfere with potassium currents in the heart and cause sudden death addiction is possible and people may need help to to get off it It is illegal in some US states

M

Matthew

@Loki519 · X

@VentHighwayMan @MarioNawfal Your brain also has receptors for: heroin (opioids), nicotine, strychnine (glycine), capsaicin (pain), etc. Plants evolved these toxins to repel or kill threats. THC fitting CB receptors no more proves weed was "made for us" than heroin fitting opioid receptors proves poppies

DF

Dillon Fancher

@VentHighwayMan · X

@Killthejuice88 @SovrnInsurgent @MarioNawfal THC requires heavy chronic use in fat neurotypical people to totally depress the CB1 receptors- fentanyl is 100x more potent than morphine and requires 1 f^ng dose to mess up the opioid receptors. It takes about 7-14 days to get back to 80-90% normal CB1 activation, fent-months.

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1776

@Killthejuice88 · X

@SovrnInsurgent @MarioNawfal The brain also has opioid receptors. So fentanyl is good now?

J

james

@ninjasinparis42 · X

@LCDouglas1 @Sneak0o god gave you opioid receptors so smoke fetanyal too

Synthetic opioids called “nitazenes” known as “ISO” — is 5 to 9 times stronger than fentanyl & 25 to 50 times stronger than heroin “They are unrelated to opioids derived from morphine or fentanyl, but function similarly by acting on opioid receptors" causing analgesia, euphoria, sedation, & death

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JAY

@swagginglikjay · X

fuck these pills are so fuckign good they’re pills that activate opioid receptors in ur body without actually being opioids

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Marko

@Markotelomerase · X

RT @SeeFisch: Difelikefalin *For itching especially associated with dialysis *Modifies opioid receptors *Binding to the receptors (called k…

MA

Mohammad Aleidi

@aleidimed · X

RT @SeeFisch: Difelikefalin *For itching especially associated with dialysis *Modifies opioid receptors *Binding to the receptors (called k…

Précis of Elizabeth Yuko’s report follows ⤵

SH

soda_troubles,https://med-mastodon.com/@haysam

@set_fortess · X

RT @SeeFisch: Difelikefalin *For itching especially associated with dialysis *Modifies opioid receptors *Binding to the receptors (called k…

ME

Mohammad Elidy

@elidyynwa · X

RT @SeeFisch: Difelikefalin *For itching especially associated with dialysis *Modifies opioid receptors *Binding to the receptors (called k…

CF

Conrad Fischer

@SeeFisch · X

Difelikefalin *For itching especially associated with dialysis *Modifies opioid receptors *Binding to the receptors (called kappa opioid receptors), difelikefalin activates them *Decreasing the signals that lead to the feeling of itchiness itself

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PharmacyPhunQuiz

@PhunQuiz · X

Answer: D. Diphenoxylate is an antidiarrheal. Its mechanism of action is agonism of mu opioid receptors in the enteric nervous system. Diphenoxylate is paired with atropine (Lomotil) to avoid abuse. By the way, difelikefalin is a kappa opioid agonist. https://t.co/Yso9ATPIYg

Ok, I thought it made sense since it does work on the opioid receptors and opioids can cause itching (right?)

ᴬ

ᴬᴷ°᭄

@SicckArmani · X

@mts__kid Yah..ngano inakuanga na protein inaitwa "gliadin" which leads to binding of opioid receptors in the brain after digestion. This doesn't create addiction but cravings for more ngano & increased appetite na ndo maana unashindwa kuacha.

MW

Marie Walicki

@mcwalicki · X

Check out some of my thesis work from the Birdsong Lab at UMich

CW

Clara H. Whyte

@ClaraHWhyte · X

RT @biorxiv_neursci: Delta Opioid Receptors on Parvalbumin Neurons are Necessary for the Convulsant and Anxiolytic Effects of the Delta Ago…

H

Harry

@harryhaarsh · X

Endorphins are natural brain chemicals that bind to opioid receptors, blocking pain and boosting pleasure. Released during stress, pain, or exercise, they act as the body’s own painkillers and mood boosters.

RX

Rob 2x2

@2x2Rob · X

@rsdcrpsfire They are an opioid... which means they work off the mu opioid receptors.... a opiate is a drug made out of the poppy plant such as morphine, herion, pain killers.. ect..

RX

Rob 2x2

@2x2Rob · X

So yes kratom is MOST definitely a opioid... not and opiate... it works of the opioid receptors in your brain.. do your research before you post please.. I do.... https://t.co/U4mGKjjHiG

J

JAY

@swagginglikjay · X

so these pills work as an opioid but it’s a natural pill and it like works with your opioid receptors…? idk that’s what google said i think.. and they make me feel really good but they work so well for pain too that why i took it but the “high” is als nice i wanna try real pills

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SciencesNetwork

@SciencesNetwork · X

Delta Opioid Receptors on Parvalbumin Neurons are Necessary for the Convulsant and Anxiolytic Effects of the Delta Agonist SNC80 https://t.co/VkEmji1KUF

BN

bioRxiv Neuroscience

@biorxiv_neursci · X

Delta Opioid Receptors on Parvalbumin Neurons are Necessary for the Convulsant and Anxiolytic Effects of the Delta Agonist SNC80 https://t.co/5pHwBIw6a0 #biorxiv_neursci

Delta Opioid Receptors on Parvalbumin Neurons are Necessary for the Convulsant and Anxiolytic Effects of the Delta Agonist SNC80 https://www.biorxiv.org/content/10.1101/2025.11.14.688475v1

Delta Opioid Receptors on Parvalbumin Neurons are Necessary for the Convulsant and Anxiolytic Effects of the Delta Agonist SNC80 https://www.biorxiv.org/content/10.1101/2025.11.14.688475v1

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Lt. Dan

@LtDan45056 · X

@skyqueen62 @SaraCarterDC @ONDCP @JackPosobiec If you administer narcan to someone not under the influence of opioids, it will do nothing and not harm them. If they are, narcan blocks opioid receptors in the brain and revives them. Be aware they usually come up swinging. Bottom line, whether you know or not, no harm giving

KS

Kaiser Sozei

@UsualSozei · X

@fdeyoung669 @tomweedlaw Pot reduces inflammation which causes pain. A narcotic targets opioid receptors. Cannabis targets endocanabinoid receptors and stimulates appetite.

XA

@XVGWhale Backup Account

@DomainsVvs · X

@IjazTheTrini Though not sure if they gave your opioids, have to be careful if combining opioids with benzos, as the two can slow breathing and heart rate if too much(through kratom is much more mild/doesn’t bind to the opioid receptors that suppress breathing in high doses as much)

UF

Unconvicted Felon

@AntiScamite · X

@_MrThc If mankind has cannabinoid, nicotinoid, or opioid receptors in their body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@BlackLabelAdvsr If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@medicalgrower42 If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@Babygravy9 If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@davegreenidge57 If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@AmericanVsGov If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@CollapseTalkPod If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@BabyD1111229 If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@PLegalization If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@vufan03 If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@_MrThc If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@_MrThc If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@DanPatrick If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@shame0360 If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@Freedom2Fart @POTUS @WhiteHouse @RobertKennedyJr @RepThomasMassie @GOP @PressSec @DrMakaryFDA @SpeakerJohnson @LeaderJohnThune @RapidResponse47 If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@KittensShitPost If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

UF

Unconvicted Felon

@AntiScamite · X

@_MrThc If man has cannabinoid, nicotinoid, or opioid receptors in his body, how can consumption of those substances which contain them be anything other than a God given, Constitutionally protected RIGHT?

B

box

@lnanalgesia · X

@sobertito @mkhammer @kittypurrzog naltrexone is an opioid, it just antagonizes opioid receptors. similar to naloxone, its also an opioid. just not an agonist. https://t.co/ujLFrISJoQ

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Grok

@grok · X

@FrancisJeffrey7 @fantasmagorra @Millbstrd Progress in pain management has been incremental but meaningful: from opioid receptors in '73 to suzetrigine's 2025 FDA approval as a non-opioid acute pain reliever, plus neuromodulation, VR therapies, and AI-driven personalization. Chronic, idiopathic pain remains a challenge,

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Grok

@grok · X

@FrancisJeffrey7 @fantasmagorra @Millbstrd True, Candace Pert's 1973 discovery of opioid receptors was groundbreaking, unlocking morphine's mechanisms. Yet progress hasn't stalled: since then, we've seen non-opioid advances like FDA-approved suzetrigine (2025) for acute pain, neuromodulation devices, gene therapies

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VOLUNTEER

@ProudRebelYell · X

RT @TheDankInformer: CBD American Shaman is on the board of U.S. Hemp Roundtable They manufacture a large percentage of 7-OH which is oft…

TI

The Dank Informer

@TheDankInformer · X

CBD American Shaman is on the board of U.S. Hemp Roundtable They manufacture a large percentage of 7-OH which is often falsely advertised as natural kratom extract, when in-fact it is made in a lab. 7-OH is highly addictive and works on opioid receptors. https://t.co/fPfNn5ACu1

ES

ellen snelling

@LNseven5 · X

Cannabis & ⬆️Pain Perception "Experimental evidence suggests that chronic stimulation of cannabinoid receptor type 1 (CB1) may induce receptor downregulation and cross-desensitization with μ-opioid receptors, diminishing endogenous opioid tone and increasing pain perception.

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CustomerService101

@Custome54863411 · X

@mirror_madness9 @juicyjj57543174 In PA and WV you can get them in any head/vape shop. They are expensive. They hit in the opioid receptors just like Oxys do. Florida and Louisiana have outlawed it so far

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Juul⭐️⭐️⭐️

@Juul000 · X

@TBartholomeau @BuenoForMiami @lampstandcritic you can literally buy opiates in gas stations and smoke shops right now. 7-hydroxymitragynine. it’s a kratom derivative that activates your opioid receptors. but sure, destroy thousands of jobs and remove access to medicine for so many people in the hemp industry lmfao https://t.co/3LlJx5nbrH

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Piyush

@drpiyushENT · X

Placebo analgesia activates μ-opioid receptors in prefrontal regions that project to the PAG, triggering descending pain inhibition [8][9]. Religious practices appear to engage these same opioidergic pathways, explaining why spirituality enhances placebo effects [1].

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Piyush

@drpiyushENT · X

The PAG is enriched in μ-opioid receptors and oxytocin receptors—the latter implicated in pair bonding and unconditional love, functions aligned with spiritual experiences [1].

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Kee

@_reallykee_ · X

@ZawaVT Kratom binds to your opioid receptors making it technically an opioid. But yes. It acts as a stimulant, especially when you have a tolerance to it. These fuckheads see “opiate” and assume I’m taking heroin or something. It’s just ignorant tbh

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@CharlesleeTX1911

@Charles07788205 · X

@CMerandi IT's used to help people break opioid addiction by satisfying the opioid receptors without all of the same effects. It's proving to be 80% more effective in breaking addition than treatment s without it. If you OD on water or Oxygen they will both kill you too.

Rfk jr sober implies the heroin riddled remainder of a brain the worm didn't eat...or maybe it just went for those sweet, sweet mu-opioid receptors

SP

selfsuck parker ✰ 18+

@parkerwoodsx · X

@every1youknow • Heroin: binds to opioid receptors • Porn: increases dopamine Porn can’t kill you. Heroin can. The risks of heroin are far more dangerous and porn doesn’t even come close.

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Grok

@grok · X

@_theg00dstuff_ @every1youknow No, that's inaccurate. Heroin primarily binds to opioid receptors (like mu-opioid), inhibiting pain and triggering indirect dopamine surges, while pornography stimulates natural reward pathways via visual cues, leading to dopamine release without directly hitting those opioid

oh shit, skin hunger. making it so only cuddling with BINGHE sates it

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Whritenour

@Whritenour1 · X

@VinoNStrosGal Well, he's right taking drugs that don't work and have terrible safety profile like Ibuprofen isn't safe and effective. His body has opioid receptors for a reason. Not ibuprofen receptors.

AP

Anjuli Pierce

@anjulipie · X

@bitcloud Cheese triggers opioid receptors in your brain.

IE

I don't exist.

@Nub_or_someth · X

@madokaleninist clarification!!! cheese and chocolate are still good for you. heroin isn't because it triggers WAY TOO MANY opioid receptors and almost kills you. also, porn is still bad for you even though it doesn't trigger opioid receptors

IE

I don't exist.

@Nub_or_someth · X

@bighausparty @madokaleninist Claim B1 (straw man of Claim B. It's fine, it's an honest mistake. I did NOT say this but it may have been interpreted as such) Chocolate and cheese trigger opioid receptors the same way heroin does, therefore, the two are bad for you. Because masturbation does not trigger opio-

IE

I don't exist.

@Nub_or_someth · X

@bighausparty @madokaleninist trigger opioid receptors. However, cheese and chocolate are well known to not be harmful to you unlike heroin. This implies the second claim that opioid receptors are not inherently harmful, and by extension, neuroreceptors in general are not inherently harmful.

IE

I don't exist.

@Nub_or_someth · X

@bighausparty @madokaleninist I probably wasn't clear enough, my bad Claim A (original post): Porn and Heroin trigger the same type of neurotransmitter Claim B (my post): Claim A is false: Porn does not trigger opioid receptors, while Heroin does. Cheese and chocolate are provided as examples of foods that-

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Turkeyonce

@AppleTheCreator · X

RT @normalmya: When people talk about opioid receptors like this in any context it is the easiest way to immediately discount what they're…

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Grok

@grok · X

@iwasblacked_ @every1youknow Pornography doesn't directly bind to the same opioid receptors as heroin, which acts as an exogenous agonist on mu-opioid receptors to indirectly surge dopamine. However, excessive porn use hyperstimulates the mesolimbic dopamine pathway—releasing dopamine and endogenous opioids

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pea

@princesiddie · X

RT @kumakurea_: where can I get the porn that activates your opioid receptors

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EurekaMag

@EurekaMag · X

Role of kappa opioid receptors in type 1 astrocyte growth https://t.co/IVRdOAn7X0

TY

Tonight, dinner is you

@Dinnerisyou · X

RT @normalmya: When people talk about opioid receptors like this in any context it is the easiest way to immediately discount what they're…

JW

Jeremy Warner

@JermWar · X

@leuk_o @REDLINETRADUS @truth_antenna @Shawn_Farash well...we dont technically have opioid receptors specifically...we have receptors that react to opioids. They react to all kinds of neat shit though :D

SC

Sam (Shiny and Chrome)

@SC0NSTI0 · X

RT @Foxx_nd_Inkwell: @every1youknow Something "triggering receptors in the brain" =/= it being "actively harmful" Heroine is converted int…

LP

L. Oscar Plains

@leuk_o · X

@REDLINETRADUS @truth_antenna @JermWar @Shawn_Farash Our brains and bodies also have opioid receptors and a whole system related to that, but that doesn't mean we should be dosing fentanyl.

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Enmanuel

@SWITCHPOSlTIONS · X

RT @Foxx_nd_Inkwell: @every1youknow Something "triggering receptors in the brain" =/= it being "actively harmful" Heroine is converted int…

D

DEC

@DECfromOH · X

Also to be clear porn does not in any way bind to the opioid receptors in your brain. This person is just very dumb and doesn't know how to mind their own business

Lω

link (`･ω･´)

@goodnightlink · X

RT @kumakurea_: where can I get the porn that activates your opioid receptors

?

☉

@MARXOFUTURISMUS · X

What porn are y'all watching that's activating your mu opioid receptors? Asking for a friend

?

1.6.6

@ActDummy3433 · X

RT @mizzkararose: @polypocketknife I presume that they mean it generates dopamine as porn absolutely doesn’t bind to opioid receptors. Of…

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ThatOneGuy006

@That_One_Guy006 · X

@every1youknow No they don't. The opioid receptors are their own system separate from the one responsible for sexual arousal. You don't care about facts though, you just care about twisting them to fit your biased worldview.

LL

Lithiated Lesbian

@iridium_rose · X

How do I get porn to trigger the mu opioid receptors in my brain? Asking as an ex-opioid addict that's looking to get re addicted for cheap https://t.co/f2iPNsEHxm

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♠ Kolibri ♦

@neutralkolibri · X

RT @Foxx_nd_Inkwell: @every1youknow Something "triggering receptors in the brain" =/= it being "actively harmful" Heroine is converted int…

GC

Gonzalouch Ikari | "Menos Karens, mas Chuchus"

@GonzalouchIkari · X

RT @Foxx_nd_Inkwell: Something "triggering receptors in the brain" =/= it being "actively harmful" Heroine is converted into morphine, whi…

LC

LA Knight & Co (

@LA_Knight89 · X

RT @Foxx_nd_Inkwell: Something "triggering receptors in the brain" =/= it being "actively harmful" Heroine is converted into morphine, whi…

JB

Joam Buttock

@JxnW · X

@Subezdo @boy__onion @every1youknow The reason any compound is psychoactive is because your body has receptors for it. In this case, opioid receptors are usually stimulated by endorphins (endogenous opioids) during arousal.

A

alice

@chibicheekss · X

RT @kumakurea_: where can I get the porn that activates your opioid receptors

?

ًً

@ragertapes · X

@whiskey__wayne @g_reggington @goodoleytdays thats the point, its basically a legal opioid smoke shop Percocet (oxycodone) n opioids r downers idk how 7oh is marketed to calm and relax you but high amount ppl r using it to nod out like illegal or prescription opioids bc 7oh also attacks opioid receptors in u like opioids

UJ

Usama Javaid

@JavaidUsama · X

@madokaleninist opioid receptors to be exact, dopamine is just the hormone that get's produced (and there's a difference between typical rising levels, and sudden skyrocketing + nose diving of it) We need to open the schools ffs

NE

Natalie is thinking about Yamper and nothing else

@budgetzendaya · X

@kumakurea_ anything can trigger the opioid receptors in your brain if enough megachurch pastors agree that it does

HA

Heenz - Sweater Arc

@Heenzli · X

RT @kumakurea_: where can I get the porn that activates your opioid receptors

B

basscatmikey

@basscatmikey · X

RT @Foxx_nd_Inkwell: Something "triggering receptors in the brain" =/= it being "actively harmful" Heroine is converted into morphine, whi…

TF

Theo(dore) Foxx

@Foxx_nd_Inkwell · X

@every1youknow Something "triggering receptors in the brain" =/= it being "actively harmful" Heroine is converted into morphine, which binds to our opioid receptors, primarily mu-opioid receptors. You know what else binds to opioid receptors? Endorphines. Which your body produces naturally.

TF

Theo(dore) Foxx

@Foxx_nd_Inkwell · X

Something "triggering receptors in the brain" =/= it being "actively harmful" Heroine is converted into morphine, which binds to our opioid receptors, primarily mu-opioid receptors. You know what else binds to opioid receptors? Endorphines. Which your body produces naturally. https://t.co/QgtalRoR39

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L

@tresantes · X

RT @evek181818: porn does not bind to the same 5 opioid receptors of the brain - mu, kappa, delta, NOR, & ZOR - because porn is not an opio…

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Claire

@kumakurea_ · X

where can I get the porn that activates your opioid receptors https://t.co/4r8sDspx5t

IE

I don't exist.

@Nub_or_someth · X

@madokaleninist there's actual good arguments against it but this isn't even accurate CHEESE triggers the same receptors that heroin triggers CHOCOLATE triggers the same receptors even though porn is bad it DOESN'T TRIGGER OPIOID RECEPTORS

B

Burner

@Burner1634443 · X

@every1youknow Porn does not trigger your opioid receptors, and if you mean the dopamine release, that happens with almost everything that feels good for people.

RO

Robin Quinn (commissions open)

@bobbytries · X

RT @normalmya: When people talk about opioid receptors like this in any context it is the easiest way to immediately discount what they're…

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Lore

@whatisalore · X

RT @normalmya: When people talk about opioid receptors like this in any context it is the easiest way to immediately discount what they're…

HY

Hayley with a "Y"

@ladyhaylo · X

RT @normalmya: When people talk about opioid receptors like this in any context it is the easiest way to immediately discount what they're…

TL

the brotherhood of evil lesbians

@obiwormkenobi · X

RT @normalmya: When people talk about opioid receptors like this in any context it is the easiest way to immediately discount what they're…

AA

agender autumn

@divalectics · X

RT @normalmya: When people talk about opioid receptors like this in any context it is the easiest way to immediately discount what they're…

JA

Jane Altoids

@staticbluebat · X

RT @normalmya: When people talk about opioid receptors like this in any context it is the easiest way to immediately discount what they're…

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Dagmar

@supremeabjad · X

RT @normalmya: When people talk about opioid receptors like this in any context it is the easiest way to immediately discount what they're…

LC

LA Knight & Co (

@LA_Knight89 · X

RT @IItayaa: you know what also does that? Fun in general. We are OUTLAWING dopamin, serotonin, noradrenalin and absolutely blocking those…

“Kratom users may be able to pursue a claim after studies have come out showing serious adverse effects of kratom use” Wow you mean the drug that works on opioid receptors (along with a whole bunch of others) has serious potential adverse effects when used chronically? Sue!!! Sue!!!!

μ-opioid receptors (MOR) mainly signal by activating G proteins. This happens when the G protein swaps its bound GDP molecule for GTP — triggering subunit dissociation and downstream signaling. A classic textbook cartoon, from Alberts et al. - Molecular Biology of the Cell: (1/n)

High-resolution cryo-electron microscopy has captured the step-by-step molecular changes of opioid receptors, offering insights that could inform the development of safer painkillers and improved antidotes.

kratom actually acts on slightly different opioid receptors papaver-based opioids (e.g., morphine, heroin oxy) work primarily on mu-opioid receptors (as full agonists), whereas kratoms main action is on kappa-opioid receptors (it has only partial agonism on mu opioid receptors, fairly limited)

Kappa opioid receptors delay sucrose self-administration by modulating dopamine ramps before operant responding https://www.biorxiv.org/content/10.1101/2025.10.23.684229v1

Kappa opioid receptors delay sucrose self-administration by modulating dopamine ramps before operant responding https://www.biorxiv.org/content/10.1101/2025.10.23.684229v1

National Drug Intelligence Center OxyContin Diversion and Abuse January 2001 Background OxyContin is a trade name product for the generic narcotic oxycodone hydrochloride, an opiate agonist. Opiate agonists provide pain relief by acting on opioid receptors in the spinal cord, brain,

What's in store for you #ThisWeekInNPP⁉️ The latest on: infant sensory gating kappa opioid receptors glutamate dysfunction in the PVT cannabinergic effects on time perception psychosis risk & resilience the nosology of addiction value-based learning in adolescence

people turn to addiction because the brain is an overstressed and overwhelmed organ. the brain does not separate emotional & physical pain --after enough chronic stress & trauma, if external mitigation of gaba, cannabinoid or opioid receptors is introduced the brain demands that offloading continue

The reason tramadol feels so great (to some of us) is it's an opioid AND an anti-depressant/anti-anxiety. It binds to opioid receptors, but ALSO inhibits serotonin reuptake.

Pomrenze et al. demonstrate that ketamine-induced increases in locomotor activity depends on μ-opioid receptors in the central amygdala.

This is Mass Psychosis. Almost all of them are even using the same terms. This whole relationship is similar to endorphins to opioid receptors. The connection to trump is like a drug to their psyche.

Malafoglia et al. find that mu-opioid receptors percentage of expression on B-cell surface could represent a time stable chronic pain biomarker in fibromyalgia. Learn more in #PainReports bit.ly/4lzQd0l

EMT: Get the Narcan. Youth Pastor: You know who else blocks opioid receptors in the brain?

For those that want to know: Kratom is a plant that is a stimulant and atypical opioid, its chemically diverse with multiple alkaloids in it. It is a partial opioid agonist, which means it attaches to the opioid receptors and activates them only part of the way; creating a ceiling affect.

He patiently showed me stained brain sections with e.g. Fos, calbindin, mu-opioid receptors. Amazingly, he could even infer corticolimbic inputs from clusters of Fos expression in striatal sections.

quick crash course in kratom if you need it:

To be fair, I didn't know what this meant until recently :3

And know that if you are trying to give up cheese, and find it hard,don't give up. It is highly addictive similar to hard core drugs. Casein protein breaks down into casomorphins, which can stimulate opioid receptors in the brain, creating feelings similar to those from drugs.

But in all seriousness, it just goes throughout your whole body to reduce inflammation which helps with the pain, we just only notice it in the places we already had pain. Opioids work differently though and go to your opioid receptors in your brain to block them from transmitting the pain signal

It’s not the BEST source, but it was the fastest one I found that noted the known ability of cheese protein to bind to opioid receptors

Did you know cheese protein binds to your opioid receptors

I don't have the energy to see what that narrative review cites or fact check it. This little bit on chocolate (under Carbohydrates) did jump out at me though. IDK, you think that implies chocolate consumption leads to violence? More like the opposite in my experience.

Would actually work. Imodium (Loperamide) activates mu-opioid receptors in the bowels slowing gastric motility.

You *don't* want mega giga permanently blocks all opioid receptors drugs sprayed up everyone's noses? But how are they supposed to market the next piperidine derivatives if people have any functional opioid receptors left?

Plus some interesting neuro background: one possible driver of comorbidity of chronic pain & opioid use disorder is that mu-opioid receptors (the targets of opioid analgesics, e.g., morphine, codeine, fentanyl) are concentrated in many of the same brain regions involved in reward & motivation.

Differential effects of sodium on agonist-induced conformational transitions and signaling at μ and κ opioid receptors https://www.biorxiv.org/content/10.1101/2025.08.28.672897v1

Differential effects of sodium on agonist-induced conformational transitions and signaling at μ and κ opioid receptors https://www.biorxiv.org/content/10.1101/2025.08.28.672897v1

It's International #OverdoseAwarenessDay Opioids include compounds extracted from the poppy seed as well as semisynthetic & synthetic compounds that can interact with #opioid receptors in the brain

Kratom, an herbal supplement tied to hundreds of deaths, contains compounds that partially activate opioid receptors. A pharma sciences scholar says its promise for pain relief and addiction treatment is driving calls to regulate 7-hydroxymitragynine instead of banning it buff.ly/5wr99dF

So, I've had that Feel Free gas station drink before, the one with kratom, and it did fuck all nothing for me and now that I'm watching all these videos about how awful and addictive it is I know why: It works on opioid receptors. Mine genetically do not work because I have an OPRM1 gene mutation.

i feel considerably better than yesterday, probably because i'm not having active withdrawals impacting my opioid receptors, so let's hunker down and get this shit done twice and 5 all (that's one more than once and 4 all)

Kratom, an herbal supplement tied to hundreds of deaths, contains compounds that partially activate opioid receptors. A pharma sciences scholar says its promise for pain relief and addiction treatment is driving calls to regulate 7-hydroxymitragynine instead of banning it

#eNeuro | Excitatory Synaptic Transmission Is Differentially Modulated by Opioid Receptors along the Claustrocingulate Pathway https://doi.org/10.1523/ENEURO.0219-25.2025

kratom is related to coffee ☕️ & binds to our opioid receptors & helps a ton of folks with chronic pain &… doesn’t have the stop

Cheese is a drug. When you eat cheese, your digestive system breaks down casein, a dairy protein, into smaller compounds called casomorphins. These compounds attach to our opioid receptors, stimulating dopamine release, the same way heroin does. www.mountsinai.org/about/newsro...

to convert a more abundant but less potent psychoactive kratom component called mitragynine into 7-OH. In vitro and animal studies demonstrate that 7-OH is a μ-opioid agonist, the report noted, meaning that it binds to and activates these opioid receptors.

i tried low dose naltrexone a couple years ago, hoping it would improve my fibromyalgia by blocking mu-opioid receptors and such, sadly didnt get anything out of it

Reading about the mechanism of action in low-dose naltrexone for small-fiber neuropathy and I found this presentation deck that describes its various effects, including a neuropeptide called Substance P. I hadn’t heard of substance P before, so I looked it up.

The magic school bus bonding to opioid receptors in the brain to teach the kids about addiction.

There are 3 types of opioid receptors: mu, delta and kappa. MOR agonists(morphine) are effective but can cause respiratory depression and sedation, nausea and substance abuse. KOR is an inhibitory GPCR that is activated by dynorphin. KOR agonists reduce pain and itch, as well as emotional states. /3

Kappa Opioid Receptor Distribution and Function in Primary Afferents pubmed.ncbi.nlm.nih.gov/30236284/ It`s known that KORs (kappa opioid receptors) are expressed in primary afferents. In this study it is shown that KORs are expressed in peptidergic sensory neurons and in low-threshold/1

Kratom absolutely saved my life. I take it for pain relief & it’s more effective & safe than the 90mg of opioids I was RXd. I never use extracts or smoke shop crap-only cGMP vendors who test. It binds to opioid receptors but doesn’t suppress breathing. I have hours of research & 9 yrs daily use.

Yeah, kratom withdrawal can be vicious, especially if you've been using extracts. The active chemicals work on the Mu opioid receptors in the brain, and it takes a while for your brain to adjust to the reduction in painkilling euphorics.

“Anyone and their mother can walk into a gas station and buy this stuff.” Kratom, an unregulated herbal supplement that acts on the brain's opioid receptors, is fueling addictions across the Philly region. With @maxmmarin.bsky.social and @ryanbriggs.bsky.social: www.inquirer.com/news/kratom-...

Yes, I'm bored AF. MORE CHEESE FACTS! Cheese can be addictive. Casein in cheese breaks down into casomorphins during digestion, which can hit opioid receptors in your brain, giving a mild feel-good buzz.

#cannabis & #Kratom together can create psychedelic effects. Both effects the kappa opioid receptors which are responsible for cartoon like hallucinations. Salvia D the world's strongest hallucinogen effects these receptors too. #kanna effects KOR & makes weed more psychedelic .

who up antagonizing they opioid receptors

DPDPE – Purity ≥99.83% | CAS No.: 88373-73-3 | GMP Grade DPDPE ([D-Pen², D-Pen⁵]-enkephalin) is a cyclic enkephalin peptide highly selective for δ-opioid receptors. It exhibits potent antinociceptive activity and serves as a research tool in neuropharmacology and analgesia studies. Purity ≥99.83%,…

do not drink feel free. it is highly addictive. “Kratom acts on your opioid receptors, it can cause dependence and it can cause withdrawal symptoms — no different than using opioids.” people.com/feel-free-en...

When casein breaks down, it binds to opioid receptors in the brain, triggering a release of dopamine.

kratom = comes from the tree Mitragyna speciosa and contains alkaloids that stimulate opioid receptors and can interfere with potassium currents in the heart and cause sudden death addiction is possible and people may need help to to get off it It is illegal in some US states

Dynorphin A (CAS 80448‑90‑4) – Purity 95.18% | GMP Factory Dynorphin A is an endogenous opioid peptide with high affinity for κ-opioid receptors (KOR). Supplied in GMP-quality powder form at ≥95.18% purity—ideal for neuropharmacology, pain, mood, and stress mechanism studies. Laboratory research…

PUBLIC WARNING!!! There’s a gas station drink called “Feel Free” sold in a little blue bottle that is EXTREMELY ADDICTIVE. Kratom Leaf (7-hydroxymitragynine) IS EXTREMELY ADDICTIVE acting on ų-opioid receptors (like morphine), sold in vape & pill form too. PLEASE WATCH & REPOST!!! #news #urgent

I was sending my friends wall of texts messages talking about GABA / u-opioid receptors and shit like that... not appropriate lmao

7-hydroxymitragynine is a partial agonist at mu opioid receptors (that cause most opioid effects). This means while it does cause opioid effects, these are limited & it could actually antagonize those effects (like Narcan) in certain situations. Another partial agonist is buprenorphine, or suboxone.

As someone who knows a lot of folks who do recreational intoxicants I HAVE BEEN HEARING A LOT OF BAD STUFF ABOUT THIS 'Feel Free' THING. It's sold at gas stations next to junk like delta 8, only I think it might be even easier to get? Reacts with opioid receptors, causes BAD WITHDRAWAL BE CAREFUL

tinfoil hat: those feel free drinks that act on your opioid receptors are a psyop meant to “fix” declining incarceration rates. or a big-pharma push to re-direct the opioid crisis heat onto people who buy shit at gas stations. idk. we’re forming the gluten structure on this one in real time, folks

One specific byproduct of kratom has been of particular concern to officials because it binds to opioid receptors in the brain and has addictive qualities.

Our results indicate a sex-dependent mechanism in melatonin-induced antiallodynic effect in mice. While the activation of melatonin MT2 receptors mediates the effect of melatonin in both female and male mice, activation of spinal opioid receptors plays a more relevant role in male mice.

I disagree about kava; if you underlying issues, it can be dangerous. Especially to the liver. But Kratom is the thing that is really addictive. It hits opioid receptors.

It's different at different doses. It's really unique. It binds to opioid receptors differently than normal opiates. Now they have a synthetic version of the active ingredient in kratom called 7-OH and it really is like heroin. Btw, heroin isn't the demon ppl think it is. Fentanyl is though.

#Kratom & #kanna are similar in a way. Kratom ( has cocaine like effects with opioids) has more dopamine & noradrenaline & Kanna has more nor-epephrine & serotonin ( has a speed/weed MDMA like effect without hallucinations or toxicity). Kanna can also use the opioid receptors.

Yeesh, the marketing. There’s got to be a third option between the drug war and letting companies run dangerous “wellness” grifts.

A lot of stuff gets called "gas station heroin,"and I don't...think that it's a completely fair description of kratom (I think it's absolutely fair to say that about tianeptine, which was being marketed in similar drinks a while back), but it absolutely is an OTC drug that hits your opioid receptors

It’s the kratom leaf that’s addictive. I’ve used kava just fine with no dependence on it. Kratom works on opioid receptors.

Fantastically interesting work upending notions of how ketamine exerts its antidepressant effect. Seems administering naltrexone alongside ketamine attenuates its antidepressant effect suggesting opioid receptors play some kind of role in the drug's therapeutic benefits.

We have opioid receptors on the brain, does that mean I can skag up all I want?

Probably why... Kratom (Mitragyna speciosa) is a tropical tree native to Southeast Asia, closely related to the coffee plant. Its leaves contain psychoactive compounds called alkaloids, primarily mitragynine and 7-hydroxymitragynine, which interact with opioid receptors in the brain.

"It's not new, but it's getting worse. Kratom is dangerous. It binds with mu-opioid receptors like morphine, but also serotonin and dopamine. Very addictive."

A new study using whole-body PET to assess naloxone’s (also known as Narcan) binding to opioid receptors suggests that men and women respond differently to opioid use disorder treatments.

New research in those with depression shows the opioid system is involved in ketamine's antidepressant response. The doses of ketamine used to treat depression are unlikely to interact directly with opioid receptors, but are co-expressed with NMDA receptors on GABAergic interneurons. 1/3

On Ozzy's side his genome is known to have distinct alcohol-metabolisers and opioid receptors: www.biotechniques.com/news/shot-in...

Fentanyl triggers positive reinforcement via µ-opioid receptors on GABA neurons → disinhibition of VTA dopamine → reward surge in NAc. But reward is only half the loop. 7/14

so this is weird. but. ever since my surgery, spicy food has been making me uncomfortably lightheaded, dizzy, almost high off the endorphins. it's terrible. i used to be SUCH a spice fiend, and the heat is still tolerable, but i really hate what my opioid receptors are doing to me. what do i do

Kratom is a southeast Asian plant, that when consumed, hits one’s opioid receptors in the brain. It comes in tabs, capsules, powders and extracts, and younger people are beginning to take notice. It is as addictive as heroin, but marketed as wellness and relaxation.

https://t.co/0m68j1rJDV

“Kratom is marketed as a natural and harmless supplement, but it’s very dangerous, highly addictive and it binds the opioid receptors with opioid-like effects,” Mississippi State Medical Association President Dr. Jennifer Bryan told lawmakers.

I can’t take anything that affects opioid receptors due to biliary disease. Morphine causes me to get liver blockage. I am treated like a drug seeker any time I’m in the er

3/4 You can find it online easily. “The therapeutic benefits of cannabis.” There are more cannabinoid receptors around nerve endings than opioid receptors. It’s medical fact. I use very little to control Peripheral Neuropathy. Before medical cannabis I was using at least one cane. (Cont)

the high affinity of 7-hydroxymitragynine for opioid receptors significantly contributes to the addictive potential of kratom. Other risks include interactions with other CNS depressants & potentially life-threatening respiratory depression when combined with opioids www.medscape.com/viewarticle/...

Opioid receptors in cardiovascular function

Those opioid receptors, dang they love to be blocked

Tramadol has 2 metabolites. 1 binds opioid receptors in the CNS providing analgesia, and the other prevents serotonin and norepi reputake. And they’re not metabolized in equal amts. So you’re giving someone an unknown amt of opioid and SNRI

"Oxycodone is a potent semisynthetic opioid agonist prescription medication with agonistic properties on mu-, kappa-, and delta-type opioid receptors. This drug is beneficial when used judiciously for pain management, yet it carries the risk of inducing physical dependence and addiction."

classic vegan talking point is that casein triggers opioid receptors

3/ The #NobelPrize, given in 1978 for the discovery of opioid receptors, failed to recognise her contribution, giving it instead to her supervisor Solomon Synder. Despite the set back, Pert undertook pioneering work in exploring the biochemical basis of emotion.

Kappa opioid receptors control a stress-sensitive brain circuit and drive cocaine seeking https://www.biorxiv.org/content/10.1101/2025.06.23.661181v1

Kappa opioid receptors control a stress-sensitive brain circuit and drive cocaine seeking https://www.biorxiv.org/content/10.1101/2025.06.23.661181v1

I disagree that it’s physically addicting. I’ve been using it for chronic pain daily on & off for years from a reputable supplier and I have never had any trouble stopping. Yes, it binds to opioid receptors. It is not an opiate though. In comparison to an opioid, it has mild effects in my opinion.

It is highly physically addictive, has opioid like effects, and binds to opioid receptors one of the primary chemical components that binds to opioid receptors is also highly variable in test kratom products. www.nature.com/articles/s41... worrying, needs regulated.

What's weird is it has its own receptors in the brain, but there is no analogous neurotransmitter in the body! Like the reason we have opioid receptors is theoretically because of endogenous opioids (opiate-like chemicals released by the body when we're injured) which is why narcotics work on us

“Then the jail began to offer vivitrol and naltrexone, two drug treatments that block opioid receptors in the brain to prevent the high associated with opioids. But people were still dying.”

Do you use it at all? Wicked expensive, but the patients LOVE it. Also, I think it is the best thing to help people move away from the daily habit of taking something and beginning to learn that not every emotion/sensation is due to the relative occupancy of their opioid receptors.

Endorphins fight pain, which is a new thing I learned. Blocking opioid receptors encourages the production of endorphins and will hopefully reset my pain receptors

She wrote down her reasoning and I am grateful for that. It blocks opioid receptors (thus the detox) and apparently those receptors interfere with the production of endorphin. So far, so good, please give me more endorphins

Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists-Inverse Agonists with Reduced Withdrawal Effects pubmed.ncbi.nlm.nih.gov/40454334/ #cryoEM

Things happen for a reason. But this! Casein and Opioid Receptors: Cheese contains casein, a protein that, when digested, breaks down into casomorphins. These casomorphins can bind to opioid receptors in the brain, similar to how opioids like morphine and heroin work. I'm hooked

Fun fact: opioid peptides (which attach to opioid receptors, similar to heroin) are found in many foods, like milk, gluten, soybean, & spinach efsa.onlinelibrary.wiley.com/doi/epdf/10.... ncbi.nlm.nih.gov/pmc/articles... sciencedirect.com/science/arti... febs.onlinelibrary.wiley.com/doi/full/10....

#Neuroscience #Research Blocking Opioid Receptors May Restore Healthy Dopamine Balance

Blocking Opioid Receptors May Restore Healthy Dopamine Balance https://www.europesays.com/uk/148421/ Summary: New research identifies a promising strategy for correcting dopamine imbalances in the brain using a drug that…#uk #news #uknews

I don't think mainlining entheogens and developing relationships with local spiritual entities will have a meaningful effect on anyone's opioid receptors but you have fun.

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Essential learning for every San Francisco resident. “Fentanyl is Very Deadly… Here's Why.” https://t.co/MfU0HNoYZD

RT @SciShow: Illicit Fentanyl use has become a leading cause of opioid overdose, and it's important now more than ever to understand what m…

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@constancecoy555 https://t.co/6vefoYkfq1 To add to the thread.

Do you know what Fentanyl is? Learn more about this dangerous opioid with this quick informative video! https://t.co/SsixVTr1qN

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Fentanyl is Very Deadly… Here is Why 2023 06.27 SciShow #Fentanyl has become a primary cause of the #opioid overdose #epidemic in the past decade. But what is it about this drug that's so dangerous? There's more to the story than meets the eye. https://t.co/YTfcgz7KpK https://t.co/HqhKsgaUoB

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RT @SciShow: Illicit Fentanyl use has become a leading cause of opioid overdose, and it's important now more than ever to understand what m…

RT @SciShow: Illicit Fentanyl use has become a leading cause of opioid overdose, and it's important now more than ever to understand what m…

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RT @SciShow: Illicit Fentanyl use has become a leading cause of opioid overdose, and it's important now more than ever to understand what m…

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SciShow did an episode on Fentanyl. https://t.co/CCkbfrefOT

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@KenCalvert Here's an easy to digest science backed explanation of Fentanyl. 11 minutes. At about 8/9 minutes in, they discuss Harm Reduction. You know whats NOT mentioned in combating Fentanyl? A new drug war. That's only good for Ken's defense contractor donors. https://t.co/lrny1cnJYq

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RT @SciShow: Illicit Fentanyl use has become a leading cause of opioid overdose, and it's important now more than ever to understand what m…

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RT @SciShow: Illicit Fentanyl use has become a leading cause of opioid overdose, and it's important now more than ever to understand what m…

RT @SciShow: Illicit Fentanyl use has become a leading cause of opioid overdose, and it's important now more than ever to understand what m…

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