January 2016 PMID 26365762

The role of genetically engineered pigs in xenotransplantation research.

David K C Cooper, Burcin Ekser, Jagdeece Ramsoondar, Carol Phelps, David Ayares

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What people are saying

Discussions highlight the groundbreaking nature of genetically engineered pigs in addressing organ shortages, with phrases like 'significant step forward' and 'hope for future transplants' demonstrating positive sentiment. While some comments simply acknowledge the advance, others probe the ethical implications or future clinical applications, indicating a balanced but generally optimistic view of the publication's impact.

AgreementModerate agreement

Most posts express support or positive acknowledgment of the research, indicating general agreement with its significance.

InterestModerate interest

The discussions show moderate interest, with commenters noting the potential for medical breakthroughs but not delving deeply into technical details.

EngagementModerate engagement

Posts include some references to scientific advancements and future implications, suggesting a modest level of engagement.

ImpactModerate impact

Participants characterize the research as potentially transformative for organ transplantation, reflecting a perception of moderate to high impact.

Abstract in brief

The shortage of human organs for transplantation could potentially be addressed by using genetically engineered pigs, which are modified to evade the human immune response.
Genetic engineering has significantly improved the survival rates of pig organ transplants in primates, extending from minutes to months or years, by overcoming immune and biological barriers.
Advances in genetic technology are making it feasible to create pigs with multiple genetic modifications, paving the way for clinical trials of pig organ transplants in humans in the near future.

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All mentions

Advancements in Pig-to-Human Kidney Xenotransplantation

The study reports the first clinical-grade pig kidney xenotransplant in a human decedent model, addressing the organ supply crisis. This experiment shows potential for genetically engineered pigs, achieving stable…

Sciencerely · Feb 3, 2022 151,095 views

Advancements in Xenotransplantation for Organ Supply Solutions

On January 7th, 2022, the first successful xenotransplantation was performed at the University of Maryland Medical Center. This video explores genetic modifications that enable such surgeries, their implications for the…

Demystifying Medicine McMaster · Mar 30, 2022 7,560 views

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