Sci Transl Med September 2015 PMID 26378246

Effects of caffeine on the human circadian clock in vivo and in vitro.

Tina M Burke, Rachel R Markwald, Andrew W McHill, Evan D Chinoy, Jesse A Snider, Sara C Bessman, Christopher M Jung, John S O'Neill, Kenneth P Wright

Mentions

213
Peak: 6 in Jun 2023
across 6 sources since Aug 2021

Extended reach

1,198,791
potential audience

Total likes

19,237

Video views

1,072,913

Mentions per month

Aug 2021 – Nov 2024

Where it's discussed

  • News134 articles
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  • Facebook23 posts
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  • YouTube8 videos
  • Reddit2 posts

AI synopsis

What people are saying

Several social discussions highlight the scientific importance of the article, discussing caffeine's delay of melatonin rhythms and its cellular effects, with language emphasizing its relevance and potential impact, such as describing the research as 'scientific' or 'breaking new ground.' This choice of words indicates a strong appreciation of the study's significance and a high level of engagement with its findings.

AgreementModerate agreement

Most discussions and social discussions support the findings of the publication, emphasizing caffeine's role in delaying circadian rhythms and its biological mechanisms.

InterestHigh interest

The posts demonstrate high interest, with many referencing the research's implications, such as caffeine's effect on sleep and wakefulness, and exploring scientific mechanisms.

EngagementModerate engagement

The discussions include technical details, such as mechanisms involving adenosine receptors and cyclic AMP, indicating active and thoughtful engagement.

ImpactModerate impact

Users recognize the publication's significance, with some describing caffeine's effects as influential or potentially game-changing for understanding sleep regulation.

Abstract in brief

  • Caffeine consumption in the evening can delay the human circadian melatonin rhythm by about 40 minutes, which is nearly half the delay caused by exposure to bright light at night.
  • In laboratory experiments with cells, caffeine was found to lengthen the internal biological clock cycles through mechanisms involving adenosine receptors and cyclic AMP, a signaling molecule.
  • Overall, caffeine influences human circadian timing by affecting core cellular clock components, explaining how this widely consumed drug impacts sleep and alertness regulation.]

Top posts

Most liked on X and Bluesky
Society for Research on Biological Rhythms
@SRBR_Outreach · X

Caffeine has a circadian effect in organisms from humans to funghi. In contrast to humans, where it works on the clock via cAMP (https://t.co/6Ok5rXgCJD), @lflarrondo shows that caffeine affects the #fungalclock independently of PDE-cAMP-PKA signaling: https://t.co/eBInJsfZSw

Jun 5, 2023 · 15 likes · 3 shares · 5,452 followers View post →
Ayush Noori
@ayushnoori · X

@prmshra 100%. In humans, looks like caffeine acts on serpentine adenosine receptors, binding competitively with adenosine and, as an inverse agonist, causing excitatory signaling to promote wakefulness. Not sure what this means for optimal use, though. https://t.co/gkYF0RWCS9

Jan 26, 2024 · 8 likes · 2 shares · 1,875 followers View post →
平野 瑛士
@Eijipt0320 · X

寝る前のカフェインとブルーライトで体内時計は狂いまくります。 とのこと・ 今コーヒー飲みながらパソコンでツイートしてます。 私からは以上です。 https://t.co/uqJewI2sjS

Jun 15, 2023 · 8 likes · 523 followers View post →
Zeptej se vědce
@Zeptej_se_vedce · X

Nov 19, 2024 · 4 likes · 16,644 followers View post →
脳筋シャカコꐕ
@sakatopv · X

カフェインはアデノシン受容体シグナルを介して時計さん®︎の周期を延長する 朝飲むのはどうなんすか https://t.co/XZgOQb5gt1

Apr 5, 2022 · 4 likes · 250 followers View post →
【公式】ナイトプロテイン|オトコの悩み解決
@NightProtein_jp · X

参考: https://t.co/e3hqB9ZHOz

Sep 10, 2024 · 2 likes · 7,922 followers View post →

All mentions

Philip Moran
@notphilipmoran · X

Publications for your reference: 1. Tina M. Burke et al. ,Effects of caffeine on the human circadian clock in vivo and in vitro.Sci. Transl. Med.7,305ra146-305ra146(2015).DOI:10.1126/scitranslmed.aac5125

Nov 22, 2024 · 412 followers View post →
Zeptej se vědce
@Zeptej_se_vedce · X

Nov 19, 2024 · 4 likes · 16,644 followers View post →
Anna
@AniaSzulkowska · X

https://t.co/URP7w6lb2H

Sep 27, 2024 · 237 followers View post →
【公式】ナイトプロテイン|オトコの悩み解決
@NightProtein_jp · X

参考: https://t.co/e3hqB9ZHOz

Sep 10, 2024 · 2 likes · 7,922 followers View post →
Phill Vandersky
@Vandersky777 · X

Ciemna strona kawy. Badania naukowe. https://t.co/2OSrMy7MOI przez @YouTube

Mar 16, 2024 · 92 followers View post →
Satoshi Nakamoto
@JDBtracker · X

RT @ayushnoori: @prmshra 100%. In humans, looks like caffeine acts on serpentine adenosine receptors, binding competitively with adenosine…

Jan 27, 2024 · 2 shares · 1,660 followers View post →
Ayush Noori
@ayushnoori · X

RT @ayushnoori: @prmshra 100%. In humans, looks like caffeine acts on serpentine adenosine receptors, binding competitively with adenosine…

Jan 26, 2024 · 2 shares · 1,875 followers View post →
Ayush Noori
@ayushnoori · X

@prmshra 100%. In humans, looks like caffeine acts on serpentine adenosine receptors, binding competitively with adenosine and, as an inverse agonist, causing excitatory signaling to promote wakefulness. Not sure what this means for optimal use, though. https://t.co/gkYF0RWCS9

Jan 26, 2024 · 8 likes · 2 shares · 1,875 followers View post →
anna kwietniewska
@AKwietniewska · X

Ciemna strona kawy. Badania naukowe. https://t.co/5dEkKZSnee przez @YouTube

Jul 10, 2023 · 1,801 followers View post →
平野 瑛士
@Eijipt0320 · X

寝る前のカフェインとブルーライトで体内時計は狂いまくります。 とのこと・ 今コーヒー飲みながらパソコンでツイートしてます。 私からは以上です。 https://t.co/uqJewI2sjS

Jun 15, 2023 · 8 likes · 523 followers View post →
Nisha N Kannan
@NishaNKannan1 · X

RT @SRBR_Outreach: Caffeine has a circadian effect in organisms from humans to funghi. In contrast to humans, where it works on the clock v…

Jun 6, 2023 · 3 shares · 453 followers View post →
Hikari Yoshitane
@HYtane · X

RT @SRBR_Outreach: Caffeine has a circadian effect in organisms from humans to funghi. In contrast to humans, where it works on the clock v…

Jun 5, 2023 · 3 shares · 2,430 followers View post →
jackie pelham
@PelhamJackie · X

RT @SRBR_Outreach: Caffeine has a circadian effect in organisms from humans to funghi. In contrast to humans, where it works on the clock v…

Jun 5, 2023 · 3 shares · 483 followers View post →
Society for Research on Biological Rhythms
@SRBR_Outreach · X

Caffeine has a circadian effect in organisms from humans to funghi. In contrast to humans, where it works on the clock via cAMP (https://t.co/6Ok5rXgCJD), @lflarrondo shows that caffeine affects the #fungalclock independently of PDE-cAMP-PKA signaling: https://t.co/eBInJsfZSw

Jun 5, 2023 · 15 likes · 3 shares · 5,452 followers View post →
ZbiG
@ZbiGlu · X

Ciemna strona kawy. Badania naukowe. https://t.co/2hIDhYDpdD przez @YouTube

May 10, 2023 · 11 followers View post →
Rossana Suárez
@ros045 · X

@Forrest__Gum Burke, T. M., Markwald, R. R., McHill, A. W., Chinoy, E. D., Snider, J. A., Bessman, S. C., Jung, C. M., O'Neill, J. S., & Wright, Effects of caffeine on the human circadian clock in vivo and in vitro. Science translational medicine, 7(305), 305ra146. https://t.co/InQI16po5X

Apr 18, 2023 · 59,602 followers View post →
Wonder Woman
@wdwdisneyland7 · X

Dietitian Tries Bella Hadid’s Model Diet to Stay Lean (HUGE ALMOND MOM F... https://t.co/4GQ5NxgqcJ via @YouTube

Mar 20, 2023 · 2,456 followers View post →
歌島大輔@日本一の整形外科医YouTube(22万人)
@pedro0507 · X

Tina M Burke et al. Sci Transl Med. 2015 Effects of caffeine on the human circadian clock in vivo and in vitro

Jan 12, 2023 · 1 like · 10,291 followers View post →
Wonder Woman
@wdwdisneyland7 · X

Dietitian Tries Bella Hadid’s Model Diet to Stay Lean (HUGE ALMOND MOM F... https://t.co/4GQ5NxgqcJ via @YouTube

Nov 26, 2022 · 2,456 followers View post →
hugo souza da silva jr.
@isampes · X

@srsimsr @Marluxia_asm pior q nem é mito https://t.co/Z8wqefUYm3 https://t.co/bXNBAOTGYI

Oct 25, 2022 · 1 like · 1,824 followers View post →
BeejⒶy - Carnivangelist
@KetoBeejay · X

Effects of & use of caffeine in sync with the human circadian clock https://t.co/wH8yuvihJH

Jul 11, 2022 · 2 likes · 1,749 followers View post →
Dr. Amy M. Bender
@Sleep4Sport · X

@sleeplover16 @michaelgrandner @SleepAndSports @sleepdiplomat @sleepscientist @drcolleencarney Here's a paper showing caffeine delays circadian rhythms (CR) if consumed @ night. Would extrapolate (needs further work) that for AM use it would advance CR =good. Seems caffeine makes you more sensitive to light. Maybe not bad to drink ☕️ in early AM. https://t.co/AMvRIFf9nm

Jun 4, 2022 · 2 likes · 4,912 followers View post →
EnergeticLama
@EnergeticLama · X

@haidut haidut, love your work; what do you think of caffeine buildup delaying one's circadian rhythms --> drop in sleep quality? https://t.co/VgTuPeOKmN, peat argues that caffeine before bed can improve sleep by lowering estrogen and boosting metabolism

May 16, 2022 · 373 followers View post →
脳筋シャカコꐕ
@sakatopv · X

カフェインはアデノシン受容体シグナルを介して時計さん®︎の周期を延長する 朝飲むのはどうなんすか https://t.co/XZgOQb5gt1

Apr 5, 2022 · 4 likes · 250 followers View post →
Михаил Рохин 99+
@MikhailRokhin · X

Продавцы КОФЕ об этом молчат! Как кофеин влияет на наш ферритин, кальций, железо, кортизол https://t.co/V83wysOYbm через @YouTube

Aug 31, 2021 · 62 followers View post →