PubHawk
October 2015 PMID 26438875

A runner's high depends on cannabinoid receptors in mice.

Johannes Fuss, Jörg Steinle, Laura Bindila, Matthias K Auer, Hartmut Kirchherr, Beat Lutz, Peter Gass

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Mentions

228
Peak: 3 in Apr 2022
across 7 sources since Oct 2015

Extended reach

23,350
potential audience

Total likes

250

Video views

3,734

Mentions per month

Oct 2015 – Dec 2024

Where it's discussed

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  • Bluesky1 posts

AI synopsis

What people are saying

Discussions reflect general agreement on the significance of the findings, with mentions of how endocannabinoids relate to mood and pain, as in comments about 'runner’s high' and the role of cannabinoid receptors. The tone is curious and analytical, with some humorous remarks questioning the societal implications, which indicates active and thoughtful engagement.

AgreementModerate agreement

Most discussions highlight the importance of the research, with several explicitly agreeing that cannabinoid receptors are central to the runner's high.

InterestModerate interest

Participants show curiosity and interest, especially with comments questioning the broader implications of the findings.

EngagementModerate engagement

Comments reference specific aspects of the study, like the role of CB1 receptors and how it connects to mood and pain relief, indicating active engagement.

ImpactModerate impact

The discussions suggest this could influence popular views on euphoria, fitness, and even drug perception, so the perceived impact is moderate to high.

Abstract in brief

  • The study shows that the "runner's high" in mice involves activation of cannabinoid receptors, specifically CB1 receptors in the brain for reducing anxiety and CB1 and CB2 receptors in the body for lowering pain.
  • Running increases levels of both endorphins (opioids) and anandamide (an endocannabinoid), but the beneficial effects like anxiety relief and pain reduction are mainly mediated by the endocannabinoid system, not endorphins.
  • Sedation from running does not depend on cannabinoid or opioid receptors, and feelings of euphoria can't be effectively studied in mice, indicating that the "high" involves specific neurochemical pathways.]
Read the full abstract

Top posts

Most liked on X and Bluesky
TheRealGanjaQueen
@realganjaqueen · X

A runner’s high depends on cannabinoid receptors in mice | PNAS https://t.co/w2qsxysoyE

Dec 19, 2024 · 3 likes · 1 share · 2,551 followers View post →
Joe B
@JBianco215 · X

A runner’s high depends on cannabinoid receptors in mice Mice without CB1 receptors on GABAergic neurons cannot experience the runner's high https://t.co/JLoNSmK2BO

Nov 3, 2022 · 2 likes · 4,583 followers View post →
turizemptuj
@turizemptuj · X

@jonatanpallesen "We thus show for the first time to our knowledge that cannabinoid receptors are crucial for main aspects of a runner’s high." https://t.co/RMEDCsPSOY High? Medicine's strict views on good and bad euphoria cannot connect feeling good with feeling better, hence all the CBD bias.

Aug 21, 2023 · 1 like · 822 followers View post →
Stan Alex
@greatnewcity53 · X

@0xMarsDAO @Stepnofficial In a recent study concerning the "euphoria of the runner" https://t.co/Qkv7qtjm6B scientists found out that during running, Endocannabinoids are produced in the human body. Question: Is it possible in this case to read you as drug dealers? :)

Apr 13, 2022 · 1 like View post →
Stan Alex
@greatnewcity53 · X

@0xMarsDAO @Stepnofficial In a recent study concerning the "euphoria of the runner" https://t.co/Qkv7qtjm6B scientists found out that during running, Endocannabinoids are produced in the human body. Question: Is it possible in this case to read you as drug dealers? :)

Apr 13, 2022 · 1 like View post →
Stan Alex
@greatnewcity53 · X

@suXpa @Stepnofficial In a recent study concerning the "euphoria of the runner" https://t.co/Qkv7qtjm6B scientists found out that during running, Endocannabinoids are produced in the human body. Question: Is it possible in this case to read you as drug dealers? :)

Apr 13, 2022 · 1 like View post →

All mentions

Leah Patrick
@OGLeahPatrick · X

RT @realganjaqueen: A runner’s high depends on cannabinoid receptors in mice | PNAS https://t.co/w2qsxysoyE

Dec 19, 2024 · 1 share · 602 followers View post →
TheRealGanjaQueen
@realganjaqueen · X

A runner’s high depends on cannabinoid receptors in mice | PNAS https://t.co/w2qsxysoyE

Dec 19, 2024 · 3 likes · 1 share · 2,551 followers View post →
turizemptuj
@turizemptuj · X

@jonatanpallesen "We thus show for the first time to our knowledge that cannabinoid receptors are crucial for main aspects of a runner’s high." https://t.co/RMEDCsPSOY High? Medicine's strict views on good and bad euphoria cannot connect feeling good with feeling better, hence all the CBD bias.

Aug 21, 2023 · 1 like · 822 followers View post →
Tom Speed
@TomSpeed420 · X

@LNseven5 @darkxxglade @LukeNiforatos "We thus show for the first time to our knowledge that cannabinoid receptors are crucial for main aspects of a runner’s high." https://t.co/CtQz85BgtY

Apr 2, 2023 · 2,051 followers View post →
Jesper Lundbom
@JesperLundbom · X

@DrFrankLipman Recent research suggests that "runner's high" is caused by endocannabinoids. https://t.co/vqcBNP3Mju

Mar 15, 2023 · 184 followers View post →
uMRI（高次脳機能障害・発達障害・認知症情報bot）
@sug100foroba · X

長距離を走ったネズミは痛みを感じにくくなる（ランナーズハイの一種）が、この反応は内因性オピオイド（エンドルフィン）の拮抗薬では抑制できなかったけど、内因性カンナビノイド（アナンダマイド）の拮抗薬で抑制できた！等々の報告 私は足が痛いの走り始め10分位だな

Dec 12, 2022 · 8,200 followers View post →
Joe B
@JBianco215 · X

A runner’s high depends on cannabinoid receptors in mice Mice without CB1 receptors on GABAergic neurons cannot experience the runner's high https://t.co/JLoNSmK2BO

Nov 3, 2022 · 2 likes · 4,583 followers View post →
Stan Alex
@greatnewcity53 · X

@suXpa @Stepnofficial In a recent study concerning the "euphoria of the runner" https://t.co/Qkv7qtjm6B scientists found out that during running, Endocannabinoids are produced in the human body. Question: Is it possible in this case to read you as drug dealers? :)

Apr 13, 2022 · 1 like View post →
Stan Alex
@greatnewcity53 · X

@0xMarsDAO @Stepnofficial In a recent study concerning the "euphoria of the runner" https://t.co/Qkv7qtjm6B scientists found out that during running, Endocannabinoids are produced in the human body. Question: Is it possible in this case to read you as drug dealers? :)

Apr 13, 2022 · 1 like View post →
Stan Alex
@greatnewcity53 · X

@0xMarsDAO @Stepnofficial In a recent study concerning the "euphoria of the runner" https://t.co/Qkv7qtjm6B scientists found out that during running, Endocannabinoids are produced in the human body. Question: Is it possible in this case to read you as drug dealers? :)

Apr 13, 2022 · 1 like View post →
Prof. Biology
@ResearchBiology · X

Proceedings of the National Academy of Science- A runner’s high depends on cannabinoid receptors in mice. Wheel running increases endocannabinoids and reduces both anxiety and sensation of pain in mice. https://t.co/QMSb4qxCt7

Mar 15, 2022 · 603 followers View post →
scvblwxq
@scvblwxq · X

@SquawkAlley A runner's high depends on cannabinoid receptors in mice. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13105-8. doi: 10.1073/pnas.1514996112. Epub 2015 Oct 5.

Aug 28, 2019 · 18 followers View post →
Mary Williams @PlantTeaching
@plantteaching.bsky.social · Bluesky

Think this'll get much coverage in the press? "A runner’s high depends on cannabinoid receptors in mice" http://www.pnas.org/content/early/2015/09/29/1514996112.abstract

Oct 6, 2015 View post →