Acta Pharm Sin B September 2015 PMID 26579470

Mechanisms of resistance to EGFR tyrosine kinase inhibitors.

Lihua Huang, Liwu Fu

Mentions

14
Peak: 4 in Jul 2021
across 2 sources since Aug 2020

Extended reach

59,069
potential audience

Total likes

8

Video views

459

Mentions per month

Aug 2020 – Sep 2024

Where it's discussed

  • X / Twitter10 posts
  • YouTube4 videos

AI synopsis

What people are saying

The discussions raise awareness about the complex resistance mechanisms identified in the study, with comments like 'diverse mechanisms of resistance,' emphasizing the research's significance, while the tone remains analytical and optimistic about future therapeutic developments, reflecting both interest and recognition of potential impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the research findings on resistance mechanisms, especially emphasizing the importance of understanding diverse pathways like secondary mutations and pathway activations.

InterestHigh interest

Posts clearly demonstrate high interest, with repeated mentions of 'diverse mechanisms' and the potential for improved treatments, indicating engagement with the research's advancements.

EngagementModerate engagement

While some posts share summaries and highlight implications, others are retweets, showing moderate but not deeply analytical engagement.

ImpactModerate impact

The discussions suggest that the research is viewed as an early step toward better management of resistance in lung cancer, indicating a recognition of its relevance but not yet widespread clinical impact.

Abstract in brief

  • Resistance to EGFR tyrosine kinase inhibitors (EGFRTKIs) in non-small cell lung cancer (NSCLC) occurs through multiple mechanisms, including secondary mutations like T790M, activation of alternative pathways such as cMet, HGF, and AXL, and genetic changes like KRAS mutations and loss of PTEN.
  • Additional resistance mechanisms involve impairment of apoptosis pathways, histologic transformation, drug efflux via ABC transporters, and genetic polymorphisms like BIM deletion.
  • Understanding these resistance pathways is crucial for developing new therapies and overcoming drug resistance in NSCLC patients treated with EGFR inhibitors.

Top posts

Most liked on X and Bluesky
Targeted Oncology
@TargetedOnc · X

Physicians are at the early stages of realizing the varying mechanisms of resistance to EGFR tyrosine kinase inhibitors and the methods for managing and/or overcoming resistance. https://t.co/mTSh0J7JmI #lungcancer #lcsm

Aug 9, 2020 · 1 like · 20,711 followers View post →
Targeted Oncology
@TargetedOnc · X

Physicians are at the early stages of realizing the varying mechanisms of resistance to EGFR tyrosine kinase inhibitors and the methods for managing and/or overcoming resistance. https://t.co/mTSh0J7JmI #lungcancer #lcsm

Aug 6, 2020 · 1 like · 20,711 followers View post →
Jerry Lee
@TrueDiagnostics · X

Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer https://t.co/JdUx6CdnKM

Sep 16, 2021 · 1 like · 1 share · 362 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @TrueDiagnostics: Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer https:/…

Sep 16, 2021 · 1 share · 3,836 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @TrueDiagnostics: Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer https:/…

Sep 15, 2021 · 1 share · 3,836 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @epicancerpapers: Single-cell analyses reveal diverse mechanisms of resistance to EGFR tyrosine kinase inhibitors in lung cancer https:/…

Jul 12, 2021 · 1 share · 3,836 followers View post →

All mentions

Single Cell Media
@SingleCellMedia · X

RT @TrueDiagnostics: Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer https:/…

Sep 16, 2021 · 1 share · 3,836 followers View post →
Jerry Lee
@TrueDiagnostics · X

Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer https://t.co/JdUx6CdnKM

Sep 16, 2021 · 1 like · 1 share · 362 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @TrueDiagnostics: Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer https:/…

Sep 15, 2021 · 1 share · 3,836 followers View post →
Jerry Lee
@TrueDiagnostics · X

Single-Cell Analyses Reveal Diverse Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer https://t.co/JdUx6CdnKM

Sep 15, 2021 · 1 share · 362 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @epicancerpapers: Single-cell analyses reveal diverse mechanisms of resistance to EGFR tyrosine kinase inhibitors in lung cancer https:/…

Jul 12, 2021 · 1 share · 3,836 followers View post →
Cancer epigenetics papers
@epicancerpapers · X

Single-cell analyses reveal diverse mechanisms of resistance to EGFR tyrosine kinase inhibitors in lung cancer https://t.co/pMidjTzeLd

Jul 12, 2021 · 1 share · 1,040 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @tam_papers: Single-cell analyses reveal diverse mechanisms of resistance to EGFR tyrosine kinase inhibitors in lung cancer https://t.co…

Jul 12, 2021 · 1 share · 3,836 followers View post →
tampapers
@tam_papers · X

Single-cell analyses reveal diverse mechanisms of resistance to EGFR tyrosine kinase inhibitors in lung cancer https://t.co/a9360Olcxs

Jul 12, 2021 · 1 share · 65 followers View post →
Targeted Oncology
@TargetedOnc · X

Physicians are at the early stages of realizing the varying mechanisms of resistance to EGFR tyrosine kinase inhibitors and the methods for managing and/or overcoming resistance. https://t.co/mTSh0J7JmI #lungcancer #lcsm

Aug 9, 2020 · 1 like · 20,711 followers View post →
Targeted Oncology
@TargetedOnc · X

Physicians are at the early stages of realizing the varying mechanisms of resistance to EGFR tyrosine kinase inhibitors and the methods for managing and/or overcoming resistance. https://t.co/mTSh0J7JmI #lungcancer #lcsm

Aug 6, 2020 · 1 like · 20,711 followers View post →