January 2016 PMID 26681795

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.

Sylvia Christakos, Puneet Dhawan, Annemieke Verstuyf, Lieve Verlinden, Geert Carmeliet

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Mentions

24
Peak: 5 in Jul 2022
across 4 sources since Jul 2020

Extended reach

173,066
potential audience

Total likes

305

Video views

6,186

Mentions per month

Jul 2020 – Sep 2023

Where it's discussed

  • X / Twitter15 posts
  • News4 articles
  • YouTube3 videos
  • Blogs2 articles

AI synopsis

What people are saying

The discussions highlight foundational concepts such as how vitamin D influences calcium regulation via PTH suppression and receptor interactions, with posts emphasizing the broad effects of vitamin D on health, while using terms like 'comprehensive review' and 'pleiotropic effects' to underscore its significance in medical research and potential therapies.

AgreementModerate agreement

Most discussions acknowledge the importance of vitamin D's molecular mechanisms and effects, reflecting a shared appreciation for the research's validity and relevance.

InterestHigh interest

The posts show strong interest, as evident in the detailed mentions of vitamin D’s roles in gene regulation, receptor interactions, and therapeutic potentials.

EngagementModerate engagement

While some comments reference specific biochemical processes like PTH suppression and receptor upregulation, others simply mention the publication, indicating moderate engagement.

ImpactModerate impact

Participants recognize that understanding vitamin D’s complex actions has significant implications for health and disease management, suggesting a notable influence on scientific and medical thinking.

Abstract in brief

  • Dihydroxvitamin D3 (125OH2D3) is the active form of vitamin D that works by binding to the vitamin D receptor (VDR), forming a complex with retinoic X receptor (RXR), which then regulates gene activity at various sites in the genome.
  • Recent technological advances like cryoelectron microscopy and other methods have helped researchers better understand the structure of the VDR-RXR complex and its interactions with coactivator proteins, paving the way for targeted clinical treatments.
  • Studies in humans and mice reveal that vitamin D not only influences bone health but also has broader effects, including inhibiting cancer growth, supporting heart health, and modulating immune responses, which could lead to new therapies for various diseases.]

Top posts

Most liked on X and Bluesky
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review on vitamin D, it’s receptor and interactions, it’s metabolism, and effects within the entire human organism. https://t.co/uDPnPCKJEI

Jul 10, 2022 · 29 likes · 8 shares · 134,147 followers View post →
Rene Sugar
@renesugar · X

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/H1oUrYpb0X "A primary signal mediating the induction of 1,25(OH)2D3 synthesis in the kidney is elevated PTH resulting from hypocalcemia"

Nov 10, 2022 · 1 like · 3,952 followers View post →
Yo.Vivo.D
@YoVivoD · X

Referencia: 1. Christakos S, Dhawan P, Verstuyf A, et al. (2016) Vitamin D: metabolism, molecular mechanism of action and pleiotropic effects. Physiol Rev. 96:365–408.

Dec 8, 2021 · 1 like · 1 share · 1,111 followers View post →
Meera K Iyer ☀️
@meerakiyer · X

RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…

Jul 10, 2022 · 8 shares · 7,062 followers View post →
Rene Sugar
@renesugar · X

https://t.co/H1oUrYpb0X "1,25(OH)2D3 in turn suppresses PTH production in the parathyroid gland directly at the level of transcription of the PTH gene and indirectly by increasing serum calcium levels"

Nov 10, 2022 · 3,952 followers View post →
Rene Sugar
@renesugar · X

https://t.co/H1oUrYpb0X "and by upregulating the expression and transcription of the calcium sensing receptor"

Nov 10, 2022 · 3,952 followers View post →

All mentions

Rene Sugar
@renesugar · X

https://t.co/H1oUrYpb0X "and by upregulating the expression and transcription of the calcium sensing receptor"

Nov 10, 2022 · 3,952 followers View post →
Rene Sugar
@renesugar · X

https://t.co/H1oUrYpb0X "1,25(OH)2D3 in turn suppresses PTH production in the parathyroid gland directly at the level of transcription of the PTH gene and indirectly by increasing serum calcium levels"

Nov 10, 2022 · 3,952 followers View post →
Rene Sugar
@renesugar · X

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/H1oUrYpb0X "A primary signal mediating the induction of 1,25(OH)2D3 synthesis in the kidney is elevated PTH resulting from hypocalcemia"

Nov 10, 2022 · 1 like · 3,952 followers View post →
Luke
@LukeDuke1268 · X

RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…

Oct 5, 2022 · 8 shares · 3,681 followers View post →
Mir
@Consummatvmest · X

RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…

Oct 5, 2022 · 8 shares · 121 followers View post →
James Tang
@James69888 · X

RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…

Jul 10, 2022 · 8 shares · 1,603 followers View post →
zerO711
@711phoenixdemon · X

RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…

Jul 10, 2022 · 8 shares · 6 followers View post →
Enneconis
@enneconis_ · X

RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…

Jul 10, 2022 · 8 shares · 153 followers View post →
Meera K Iyer ☀️
@meerakiyer · X

RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…

Jul 10, 2022 · 8 shares · 7,062 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review on vitamin D, it’s receptor and interactions, it’s metabolism, and effects within the entire human organism. https://t.co/uDPnPCKJEI

Jul 10, 2022 · 29 likes · 8 shares · 134,147 followers View post →
Rene Sugar
@renesugar · X

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/H1oUrY71MP "A primary signal mediating the induction of 1,25(OH)2D3 synthesis in the kidney is elevated PTH resulting from hypocalcemia"

May 14, 2022 · 3,952 followers View post →
Yo.Vivo.D
@YoVivoD · X

Referencias: 1. Christakos S, Dhawan P, Verstuyf A, et al. (2016) Vitamin D: metabolism, molecular mechanism of action and pleiotropic effects. Physiol Rev. 96:365–408. 2. Gil A, Plaza-Diaz J, Mesa M. Vitamin D: Classic and Novel Actions. Ann Nutr Metab 2018; 72:87–95

Dec 16, 2021 · 1,111 followers View post →
Juan Ocampo
@juanocaval2 · X

RT @YoVivoD: Referencia: 1. Christakos S, Dhawan P, Verstuyf A, et al. (2016) Vitamin D: metabolism, molecular mechanism of action and plei…

Dec 8, 2021 · 1 share · 851 followers View post →
Yo.Vivo.D
@YoVivoD · X

Referencia: 1. Christakos S, Dhawan P, Verstuyf A, et al. (2016) Vitamin D: metabolism, molecular mechanism of action and pleiotropic effects. Physiol Rev. 96:365–408.

Dec 8, 2021 · 1 like · 1 share · 1,111 followers View post →
Yo.Vivo.D
@YoVivoD · X

Referencia: 1. Christakos S, Dhawan P, Verstuyf A, et al. (2016) Vitamin D: metabolism, molecular mechanism of action and pleiotropic effects. Physiol Rev. 96:365–408.

Dec 8, 2021 · 1,111 followers View post →