Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review on vitamin D, it’s receptor and interactions, it’s metabolism, and effects within the entire human organism. https://t.co/uDPnPCKJEI
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
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Jul 2020 – Sep 2023Where it's discussed
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X / Twitter15 posts
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News4 articles
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YouTube3 videos
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Blogs2 articles
AI synopsis
What people are saying
The discussions highlight foundational concepts such as how vitamin D influences calcium regulation via PTH suppression and receptor interactions, with posts emphasizing the broad effects of vitamin D on health, while using terms like 'comprehensive review' and 'pleiotropic effects' to underscore its significance in medical research and potential therapies.
Most discussions acknowledge the importance of vitamin D's molecular mechanisms and effects, reflecting a shared appreciation for the research's validity and relevance.
The posts show strong interest, as evident in the detailed mentions of vitamin D’s roles in gene regulation, receptor interactions, and therapeutic potentials.
While some comments reference specific biochemical processes like PTH suppression and receptor upregulation, others simply mention the publication, indicating moderate engagement.
Participants recognize that understanding vitamin D’s complex actions has significant implications for health and disease management, suggesting a notable influence on scientific and medical thinking.
Abstract in brief
- Dihydroxvitamin D3 (125OH2D3) is the active form of vitamin D that works by binding to the vitamin D receptor (VDR), forming a complex with retinoic X receptor (RXR), which then regulates gene activity at various sites in the genome.
- Recent technological advances like cryoelectron microscopy and other methods have helped researchers better understand the structure of the VDR-RXR complex and its interactions with coactivator proteins, paving the way for targeted clinical treatments.
- Studies in humans and mice reveal that vitamin D not only influences bone health but also has broader effects, including inhibiting cancer growth, supporting heart health, and modulating immune responses, which could lead to new therapies for various diseases.]
Top posts
Most liked on X and BlueskyVitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/H1oUrYpb0X "A primary signal mediating the induction of 1,25(OH)2D3 synthesis in the kidney is elevated PTH resulting from hypocalcemia"
Referencia: 1. Christakos S, Dhawan P, Verstuyf A, et al. (2016) Vitamin D: metabolism, molecular mechanism of action and pleiotropic effects. Physiol Rev. 96:365–408.
RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…
https://t.co/H1oUrYpb0X "1,25(OH)2D3 in turn suppresses PTH production in the parathyroid gland directly at the level of transcription of the PTH gene and indirectly by increasing serum calcium levels"
https://t.co/H1oUrYpb0X "and by upregulating the expression and transcription of the calcium sensing receptor"
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https://t.co/H1oUrYpb0X "and by upregulating the expression and transcription of the calcium sensing receptor"
https://t.co/H1oUrYpb0X "1,25(OH)2D3 in turn suppresses PTH production in the parathyroid gland directly at the level of transcription of the PTH gene and indirectly by increasing serum calcium levels"
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/H1oUrYpb0X "A primary signal mediating the induction of 1,25(OH)2D3 synthesis in the kidney is elevated PTH resulting from hypocalcemia"
RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…
RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…
RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…
RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…
RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…
RT @Grimhood: Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review…
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/R8DDOthEfQ A comprehensive review on vitamin D, it’s receptor and interactions, it’s metabolism, and effects within the entire human organism. https://t.co/uDPnPCKJEI
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects https://t.co/H1oUrY71MP "A primary signal mediating the induction of 1,25(OH)2D3 synthesis in the kidney is elevated PTH resulting from hypocalcemia"
Referencias: 1. Christakos S, Dhawan P, Verstuyf A, et al. (2016) Vitamin D: metabolism, molecular mechanism of action and pleiotropic effects. Physiol Rev. 96:365–408. 2. Gil A, Plaza-Diaz J, Mesa M. Vitamin D: Classic and Novel Actions. Ann Nutr Metab 2018; 72:87–95
RT @YoVivoD: Referencia: 1. Christakos S, Dhawan P, Verstuyf A, et al. (2016) Vitamin D: metabolism, molecular mechanism of action and plei…
Referencia: 1. Christakos S, Dhawan P, Verstuyf A, et al. (2016) Vitamin D: metabolism, molecular mechanism of action and pleiotropic effects. Physiol Rev. 96:365–408.
Referencia: 1. Christakos S, Dhawan P, Verstuyf A, et al. (2016) Vitamin D: metabolism, molecular mechanism of action and pleiotropic effects. Physiol Rev. 96:365–408.