An Introduction to the Endogenous Cannabinoid System.

Hui-Chen Lu, Ken Mackie

April 2016 Biol Psychiatry

Synopsis of Social media discussions

Many comments reflect genuine curiosity and recognition of the ECS’s importance, such as mentions of the role of cannabinoids and references to cannabis culture. The tone varies from informational to casual, with some posts connecting the science to social discussions about cannabis, thereby demonstrating interest and moderate engagement without deep technical analysis.

A
Agreement
 Moderate agreement

Most discussions acknowledge the importance of the ECS and support its relevance, but few explicitly express strong agreement with the publication.

I
Interest
 High level of interest

Posts show high interest, with many questions and mentions of cannabis-related phenomena, indicating engagement with the topic’s implications.

E
Engagement
 Moderate level of engagement

Some comments go beyond surface-level mentions, referencing specific parts of the article and related concepts, but overall depth remains moderate.

I
Impact
 Moderate level of impact

The discussions highlight the social and scientific relevance of the ECS, especially in relation to cannabis use, suggesting moderate potential influence.

Social Mentions

YouTube

2 Videos

Facebook

4 Posts

Twitter

16 Posts

Blogs

15 Articles

News

89 Articles

Metrics

Video Views

51,849

Total Likes

2,124

Extended Reach

103,715

Social Features

126

Timeline: Posts about article

Top Social Media Posts

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  • BearlyThere
    @BkblairBobbie (Twitter)

    An introduction to the endogenous cannabinoid system (April 1, 2017) https://t.co/E6qhpVdSs3 https://t.co/Vho3ngTz7e
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    August 11, 2025

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    @cannabisXchris (Twitter)

    How much do you know about the Endogenous Cannabinoid System (ECS), and is your ECS working properly? https://t.co/WLggEa4KFV https://t.co/4JNcpRJSke
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    February 13, 2025

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    @TribalTownRadio (Twitter)

    An introduction to the endogenous cannabinoid system https://t.co/bAhrUZtVRP
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  • Joe Itallia
    @simplemandude (Twitter)

    An introduction to the endogenous cannabinoid system. #CannabisCommunity #cannabis https://t.co/VARVlxoNhu
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    January 21, 2024

  • MRX
    @researchmrx (Twitter)

    RT @CCH2OHOME: An introduction to the endogenous cannabinoid system https://t.co/19JkkAdyYp #medicinalmarijuana #cannabiscommunity #cannabi…
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  • matt hayashi
    @matthayashi40 (Twitter)

    RT @CCH2OHOME: An introduction to the endogenous cannabinoid system https://t.co/19JkkAdyYp #medicinalmarijuana #cannabiscommunity #cannabi…
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    January 18, 2023

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  • Cannabis Clearwater
    @CCH2OHOME (Twitter)

    An introduction to the endogenous cannabinoid system https://t.co/19JkkAdyYp #medicinalmarijuana #cannabiscommunity #cannabis #marijuana #medicalmarijuana #thc #cbd #weed #recreationalmarijuana #cannabisculture #marijuanamovement #medicalcannabis #relax #cannabisclearwater
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  • ❤️Harold Coxeter is my math hero, prove me wrong.
    @deepgreendesign (Twitter)

    @na_cig42 I use the term cannabis. An introduction to the endogenous cannabinoid system: https://t.co/lXMMSwqb1s
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    November 17, 2022

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    @dreamgbutterfly (Twitter)

    An introduction to the endogenous cannabinoid system @NCBI @dreamgbutterfly
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    @SchubleDoug (Twitter)

    An introduction to the endogenous cannabinoid system https://t.co/9YgWtczYAC
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    July 27, 2021

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    @SchubleDoug (Twitter)

    An introduction to the endogenous cannabinoid system https://t.co/a0IzHQhvcP
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    July 27, 2021

  • Eat Ezekiel Cannabis Leaf
    @MimiTexasAngel (Twitter)

    #IBelieve Endogenous Cannabinoid System is our Immune System which operates solely on what food we consume from Seed ~ Genesis 1:29 eat herb as meat God says ~ An Introduction to the Endogenous Cannabinoid System https://t.co/7nAH5lhWt2
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    January 6, 2021

  • Arnold Warkentin
    @ECS_Education (Twitter)

    An introduction to the endogenous cannabinoid system - Lu & Mackie (2016)⠀ ⠀ While this paper explores the ECS, synaptic plasticity, and schizophrenia. While there's plenty of depth to this paper, for those who were… https://t.co/QMFFJkAs0I
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    @JonneePAc (Twitter)

    An introduction to the endogenous cannabinoid system https://t.co/SHEggyZTzA
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  • KnightroGlistening
    @KnightroGlisten (Twitter)

    An Introduction to the Endogenous Cannabinoid System https://t.co/SeHD8aBnlJ
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Abstract Synopsis

  • The endocannabinoid system (ECS) is a widespread neuromodulatory system involved in brain development, synaptic plasticity, and responses to both internal and external stressors, consisting of receptors, endogenous cannabinoids, and enzymes.
  • CB1 receptors are the most common in the ECS, but other receptors like CB2, transient receptor potential channels, and PPARs also interact with cannabinoids, including external ones like THC from cannabis.
  • Research on the ECS, especially regarding its role in synaptic plasticity and schizophrenia, has expanded due to the social use of cannabis and the biological importance of endocannabinoids like 2-arachidonoyl glycerol and anandamide.