PubHawk
Biol Psychiatry April 2016 PMID 26698193

An Introduction to the Endogenous Cannabinoid System.

Hui-Chen Lu, Ken Mackie

Full text PDF Download social card

Mentions

126
Peak: 3 in Jan 2023
across 5 sources since Mar 2019

Extended reach

103,715
potential audience

Total likes

2,124

Video views

51,849

Mentions per month

Mar 2019 – Aug 2025

Where it's discussed

  • News89 articles
  • X / Twitter16 posts
  • Blogs15 articles
  • Facebook4 posts
  • YouTube2 videos

AI synopsis

What people are saying

Many comments reflect genuine curiosity and recognition of the ECS’s importance, such as mentions of the role of cannabinoids and references to cannabis culture. The tone varies from informational to casual, with some posts connecting the science to social discussions about cannabis, thereby demonstrating interest and moderate engagement without deep technical analysis.

AgreementModerate agreement

Most discussions acknowledge the importance of the ECS and support its relevance, but few explicitly express strong agreement with the publication.

InterestHigh interest

Posts show high interest, with many questions and mentions of cannabis-related phenomena, indicating engagement with the topic’s implications.

EngagementModerate engagement

Some comments go beyond surface-level mentions, referencing specific parts of the article and related concepts, but overall depth remains moderate.

ImpactModerate impact

The discussions highlight the social and scientific relevance of the ECS, especially in relation to cannabis use, suggesting moderate potential influence.

Abstract in brief

  • The endocannabinoid system (ECS) is a widespread neuromodulatory system involved in brain development, synaptic plasticity, and responses to both internal and external stressors, consisting of receptors, endogenous cannabinoids, and enzymes.
  • CB1 receptors are the most common in the ECS, but other receptors like CB2, transient receptor potential channels, and PPARs also interact with cannabinoids, including external ones like THC from cannabis.
  • Research on the ECS, especially regarding its role in synaptic plasticity and schizophrenia, has expanded due to the social use of cannabis and the biological importance of endocannabinoids like 2-arachidonoyl glycerol and anandamide.
Read the full abstract

Top posts

Most liked on X and Bluesky
Cannabis Clearwater
@CCH2OHOME · X

An introduction to the endogenous cannabinoid system https://t.co/19JkkAdyYp #medicinalmarijuana #cannabiscommunity #cannabis #marijuana #medicalmarijuana #thc #cbd #weed #recreationalmarijuana #cannabisculture #marijuanamovement #medicalcannabis #relax #cannabisclearwater

Jan 18, 2023 · 2 likes · 2 shares · 359 followers View post →
KnightroGlistening
@KnightroGlisten · X

An Introduction to the Endogenous Cannabinoid System https://t.co/SeHD8aBnlJ

Jun 6, 2019 · 16,171 followers View post →
❤️Harold Coxeter is my math hero, prove me wrong.
@deepgreendesign · X

@na_cig42 I use the term cannabis. An introduction to the endogenous cannabinoid system: https://t.co/lXMMSwqb1s

Nov 17, 2022 · 10,969 followers View post →
MRX
@researchmrx · X

RT @CCH2OHOME: An introduction to the endogenous cannabinoid system https://t.co/19JkkAdyYp #medicinalmarijuana #cannabiscommunity #cannabi…

Jan 18, 2023 · 2 shares · 7,730 followers View post →
Eat Ezekiel Cannabis Leaf
@MimiTexasAngel · X

#IBelieve Endogenous Cannabinoid System is our Immune System which operates solely on what food we consume from Seed ~ Genesis 1:29 eat herb as meat God says ~ An Introduction to the Endogenous Cannabinoid System https://t.co/7nAH5lhWt2

Jan 6, 2021 · 6,087 followers View post →
Cannabis Chris
@cannabisXchris · X

How much do you know about the Endogenous Cannabinoid System (ECS), and is your ECS working properly? https://t.co/WLggEa4KFV https://t.co/4JNcpRJSke

Feb 13, 2025 · 5,755 followers View post →

All mentions

BearlyThere
@BkblairBobbie · X

An introduction to the endogenous cannabinoid system (April 1, 2017) https://t.co/E6qhpVdSs3 https://t.co/Vho3ngTz7e

Aug 11, 2025 · 572 followers View post →
Cannabis Chris
@cannabisXchris · X

How much do you know about the Endogenous Cannabinoid System (ECS), and is your ECS working properly? https://t.co/WLggEa4KFV https://t.co/4JNcpRJSke

Feb 13, 2025 · 5,755 followers View post →
Tribal Town Radio
@TribalTownRadio · X

An introduction to the endogenous cannabinoid system https://t.co/bAhrUZtVRP

Sep 1, 2024 · 2,706 followers View post →
Joe Itallia
@simplemandude · X

An introduction to the endogenous cannabinoid system. #CannabisCommunity #cannabis https://t.co/VARVlxoNhu

Jan 21, 2024 · 1,112 followers View post →
MRX
@researchmrx · X

RT @CCH2OHOME: An introduction to the endogenous cannabinoid system https://t.co/19JkkAdyYp #medicinalmarijuana #cannabiscommunity #cannabi…

Jan 18, 2023 · 2 shares · 7,730 followers View post →
matt hayashi
@matthayashi40 · X

RT @CCH2OHOME: An introduction to the endogenous cannabinoid system https://t.co/19JkkAdyYp #medicinalmarijuana #cannabiscommunity #cannabi…

Jan 18, 2023 · 2 shares · 35 followers View post →
Cannabis Clearwater
@CCH2OHOME · X

An introduction to the endogenous cannabinoid system https://t.co/19JkkAdyYp #medicinalmarijuana #cannabiscommunity #cannabis #marijuana #medicalmarijuana #thc #cbd #weed #recreationalmarijuana #cannabisculture #marijuanamovement #medicalcannabis #relax #cannabisclearwater

Jan 18, 2023 · 2 likes · 2 shares · 359 followers View post →
❤️Harold Coxeter is my math hero, prove me wrong.
@deepgreendesign · X

@na_cig42 I use the term cannabis. An introduction to the endogenous cannabinoid system: https://t.co/lXMMSwqb1s

Nov 17, 2022 · 10,969 followers View post →
Dreamgbutterfly
@dreamgbutterfly · X

An introduction to the endogenous cannabinoid system @NCBI @dreamgbutterfly

Sep 23, 2021 · 81 followers View post →
Doug Schuble: hemp-flower-cbd.com
@SchubleDoug · X

An introduction to the endogenous cannabinoid system https://t.co/9YgWtczYAC

Jul 27, 2021 · 34 followers View post →
Doug Schuble: hemp-flower-cbd.com
@SchubleDoug · X

An introduction to the endogenous cannabinoid system https://t.co/a0IzHQhvcP

Jul 27, 2021 · 34 followers View post →
Eat Ezekiel Cannabis Leaf
@MimiTexasAngel · X

#IBelieve Endogenous Cannabinoid System is our Immune System which operates solely on what food we consume from Seed ~ Genesis 1:29 eat herb as meat God says ~ An Introduction to the Endogenous Cannabinoid System https://t.co/7nAH5lhWt2

Jan 6, 2021 · 6,087 followers View post →
Arnold Warkentin
@ECS_Education · X

An introduction to the endogenous cannabinoid system - Lu & Mackie (2016)⠀ ⠀ While this paper explores the ECS, synaptic plasticity, and schizophrenia. While there's plenty of depth to this paper, for those who were… https://t.co/QMFFJkAs0I

Oct 3, 2019 · 2 followers View post →
Bear with us again
@JonneePAc · X

An introduction to the endogenous cannabinoid system https://t.co/SHEggyZTzA

Aug 21, 2019 · 127 followers View post →
KnightroGlistening
@KnightroGlisten · X

An Introduction to the Endogenous Cannabinoid System https://t.co/SeHD8aBnlJ

Jun 6, 2019 · 16,171 followers View post →
Dreamgbutterfly
@dreamgbutterfly · X

An introduction to the endogenous cannabinoid system https://t.co/G9vlYJi3HG

Mar 15, 2019 · 81 followers View post →