Nutrition March 2016 PMID 26706022

Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial.

Ghodarz Akkasheh, Zahra Kashani-Poor, Maryam Tajabadi-Ebrahimi, Parvaneh Jafari, Hossein Akbari, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi, Ahmad Esmaillzadeh

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Mentions

66
Peak: 1 in Oct 2021
across 7 sources since Oct 2021

Extended reach

47,108
potential audience

Total likes

1,992

Video views

45,882

Mentions per month

Oct 2021 – Aug 2025

Where it's discussed

  • News27 articles
  • Facebook26 posts
  • Reddit4 posts
  • Blogs4 articles
  • X / Twitter2 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The posts reflect mixed sentiments, with some acknowledging the potential benefits of probiotics for depression, such as one noting that 'some probiotics have been shown to improve symptoms,' while others express skepticism about study retractions, like 'takes time and undermines science in general,' highlighting concerns about research integrity and the influence of repeated retractions on scientific progress.

AgreementNeither agree nor disagree

The posts show mixed opinions, with some recognizing the study's findings while others critique the repeated retractions and potential scientific issues.

InterestModerate interest

There is a modest curiosity about the topic, especially regarding probiotics and mental health, indicated by informative comments and references to prior studies.

EngagementModerate engagement

Discussions include references to the study's potential for clinical application and mentions of scientific processes, suggesting moderate engagement.

ImpactNeutral impact

Overall, the discussions seem to be of limited immediate impact, as some posts cast doubt on the reliability of the research, affecting its perceived importance.

Abstract in brief

  • The study investigates how probiotics affect depression symptoms, metabolic health, and inflammation markers in patients with Major Depressive Disorder (MDD), finding that probiotic intake significantly reduces depression scores, insulin levels, insulin resistance, and inflammation.
  • It was a randomized, double-blind, placebo-controlled trial with 40 MDD patients who took a probiotic containing Lactobacillus and Bifidobacterium strains or a placebo for 8 weeks, with no significant difference in diet or physical activity between groups.
  • The results suggest that probiotic supplementation could be a beneficial adjunct treatment for depression, potentially improving metabolic and inflammatory profiles alongside mood symptoms.

Top posts

Most liked on X and Bluesky
Marc Veldhoen
@marcveld.bsky.social · Bluesky

RETRACTED: Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double- blind, placebo- controlled trial It happens too many times, takes time and undermines science in general. www.sciencedirect.co...

Aug 18, 2025 · 7 likes · 6 shares View post →
mohamed adow
@mohdadow · X

Some probiotics have been shown to improve symptoms of stress, anxiety and depression https://t.co/VJZIZ3w6GA https://t.co/LnDa3t1Pvy

Oct 11, 2021 · 1 like · 820 followers View post →

All mentions

Marc Veldhoen
@marcveld.bsky.social · Bluesky

RETRACTED: Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double- blind, placebo- controlled trial It happens too many times, takes time and undermines science in general. www.sciencedirect.co...

Aug 18, 2025 · 7 likes · 6 shares View post →
Dragon Slayer aKa Savage JE 20:9
@LashTania · X

@DuthieAlyne An FYI For you - Study done in 2015 Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial - ScienceDirect https://t.co/izH4FgQK5o

Jan 27, 2025 · 394 followers View post →
mohamed adow
@mohdadow · X

Some probiotics have been shown to improve symptoms of stress, anxiety and depression https://t.co/VJZIZ3w6GA https://t.co/LnDa3t1Pvy

Oct 11, 2021 · 1 like · 820 followers View post →