PubHawk
January 2016 PMID 26712023

Distance from sub-Saharan Africa predicts mutational load in diverse human genomes.

Brenna M Henn, Laura R Botigué, Stephan Peischl, Isabelle Dupanloup, Mikhail Lipatov, Brian K Maples, Alicia R Martin, Shaila Musharoff, Howard Cann, Michael P Snyder, Laurent Excoffier, Jeffrey M Kidd, Carlos D Bustamante

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Mentions

51
Peak: 5 in Feb 2024
across 7 sources since Feb 2016

Extended reach

146,670
potential audience

Total likes

2,949

Video views

131,358

Mentions per month

Feb 2016 – Oct 2025

Where it's discussed

  • X / Twitter17 posts
  • News16 articles
  • Blogs11 articles
  • Facebook3 posts
  • Reddit2 posts
  • Bluesky1 posts
  • YouTube1 videos

AI synopsis

What people are saying

The social discussions reveal a mixture of interest in the scientific insights, with some users emphasizing the genetic diversity and evolutionary aspects, while others distort or politically interpret the findings, such as claims about racial superiority or racist ideologies. The tone varies from scientific curiosity to dismissiveness or bigotry, which influences the overall moderate scores for agreement and impact.

AgreementLow agreement

Most discussions seem to support or acknowledge the scientific findings, though some, like the racist comments, reject or distort the conclusions.

InterestModerate interest

The majority of posts express curiosity or recognition of the scientific implications, indicating moderate interest.

EngagementModerate engagement

Several users delve into topics of genetics, human diversity, and societal implications, showing active engagement.

ImpactNeutral impact

The discussions reflect awareness but not profound influence on societal views or policy debates at this stage.

Abstract in brief

  • The study investigates how the migration of modern humans out of sub-Saharan Africa around 50,000 years ago, characterized by successive founder events, has affected the accumulation of deleterious mutations in different populations worldwide.
  • Sequencing of genomes from diverse groups shows only modest differences in harmful mutations, but simulations suggest that the global distribution of these mutations aligns with the idea that many are recessive and less affected by natural selection during the expansion.
  • The findings indicate strong natural selection within Africa to remove harmful mutations, but once humans left Africa, many deleterious mutations, especially recessive ones, accumulated due to reduced selection effectiveness, leading to a higher mutational load in non-African populations.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Bioinfhotep
@pp0196 · X

@shi_huang5 Okay you mean that the San have less mutational load. I am shocked

Feb 22, 2024 · 10 likes · 4 shares · 1,195 followers View post →
Bioinfhotep
@pp0196 · X

@shi_huang5 Yes: https://t.co/NfffrLmOvB And yes again : https://t.co/xbPPmviMNo

Jan 15, 2023 · 3 likes · 1,195 followers View post →
metroidder
@Metroidder · X

a ironia dos racistas eugenistas é que a carga genética das populações humanas é tanto maior quanto mais distante elas estão da áfrica, e nesse sentido a população africana seria a mais adaptada (portanto o povo geneticamente superior ?) https://t.co/KsHr1onPOq

Jan 9, 2025 · 3 likes · 346 followers View post →
Baron
@TheCeddosGhostX · X

@cfreshco4700 @Conserv28263300 @Theesovereignn @LaurenWitzkeDE Not to mention the litany of genetic diseases. The more farther removed from us you are genetically, the more mutational load. https://t.co/omFVYOh3HU

Aug 12, 2023 · 2 likes · 1,041 followers View post →
Petorian Renaissance
@WhiteFatvocate · X

https://t.co/zmOja1MoMS

Sep 19, 2025 · 1 like · 3,387 followers View post →
Vic
@Vic18246223 · X

@Only1Subliminal @melinated80273 @mrsnya4 @ZuluX11 They are the top of every society and built civilization. This is why u invented racism U need to create an entire ideology of envy and hate to deal with them. They are your genetic superior. https://t.co/3EVIf1lNKq

May 5, 2024 · 1 like · 265 followers View post →

All mentions

Hab Tera
@terez14366 · X

@Zoltan_47 https://t.co/holTzs9Ozb https://t.co/8nqOVcQSJ3 https://t.co/kS5PpmrLy7 https://t.co/OVFjbg7fu9 https://t.co/HLX0YdbPGc https://t.co/GwYRnAURSz https://t.co/1uS4tla8hX https://t.co/Fxuxc9CY0D https://t.co/nA506qFI63

Oct 14, 2025 · 49 followers View post →
Petorian Renaissance
@WhiteFatvocate · X

https://t.co/zmOja1MoMS

Sep 19, 2025 · 1 like · 3,387 followers View post →
metroidder
@Metroidder · X

a ironia dos racistas eugenistas é que a carga genética das populações humanas é tanto maior quanto mais distante elas estão da áfrica, e nesse sentido a população africana seria a mais adaptada (portanto o povo geneticamente superior ?) https://t.co/KsHr1onPOq

Jan 9, 2025 · 3 likes · 346 followers View post →
Bob Sponge
@BobSpon51836066 · X

@nianello6 @Orwellsghost28 No one cares about what Hegel can think. From a measurable and scientific standpoint, at least we can say they contribute to heterozygosity and genetic diversity

Sep 2, 2024 · 1 like · 14 followers View post →
PH78-African Bias American
@Phillip05166897 · X

RT @pp0196: @shi_huang5 Okay you mean that the San have less mutational load. I am shocked

Jun 1, 2024 · 4 shares · 1,520 followers View post →
Vic
@Vic18246223 · X

@YIR2K22 @greenmachine316 @professtruth @CLG98264897 https://t.co/3EVIf1lNKq

May 13, 2024 · 265 followers View post →
Vic
@Vic18246223 · X

@Ragdoll4lyfe @America1stCat @jenkinsblaise2 @SigmaTigerNews @WallStreetSilv https://t.co/3EVIf1lNKq

May 10, 2024 · 265 followers View post →
Vic
@Vic18246223 · X

@stral_astro @PPC4Liberty @WallStreetSilv https://t.co/3EVIf1lNKq

May 10, 2024 · 265 followers View post →
Vic
@Vic18246223 · X

@Only1Subliminal @melinated80273 @mrsnya4 @ZuluX11 They are the top of every society and built civilization. This is why u invented racism U need to create an entire ideology of envy and hate to deal with them. They are your genetic superior. https://t.co/3EVIf1lNKq

May 5, 2024 · 1 like · 265 followers View post →
Ana Calber
@amcalber · X

https://t.co/ji8pYDiOZf

Feb 23, 2024 · 2,264 followers View post →
Alex Palazzo
@ribonucleicacid · X

RT @pp0196: @shi_huang5 Okay you mean that the San have less mutational load. I am shocked

Feb 23, 2024 · 4 shares · 1,159 followers View post →
PH78-African Bias American
@Phillip05166897 · X

RT @pp0196: @shi_huang5 Okay you mean that the San have less mutational load. I am shocked

Feb 22, 2024 · 4 shares · 1,520 followers View post →
Bioinfhotep
@pp0196 · X

@shi_huang5 Okay you mean that the San have less mutational load. I am shocked

Feb 22, 2024 · 10 likes · 4 shares · 1,195 followers View post →
Vic
@Vic18246223 · X

@usernamepads @pearlythingz https://t.co/VyaRo1agI1

Feb 4, 2024 · 265 followers View post →
Baron
@TheCeddosGhostX · X

@cfreshco4700 @Conserv28263300 @Theesovereignn @LaurenWitzkeDE Not to mention the litany of genetic diseases. The more farther removed from us you are genetically, the more mutational load. https://t.co/omFVYOh3HU

Aug 12, 2023 · 2 likes · 1,041 followers View post →
Vic
@Vic18246223 · X

@samaras_12 @Niggazida https://t.co/VyaRo1agI1

Jul 22, 2023 · 265 followers View post →
Bioinfhotep
@pp0196 · X

@shi_huang5 Yes: https://t.co/NfffrLmOvB And yes again : https://t.co/xbPPmviMNo

Jan 15, 2023 · 3 likes · 1,195 followers View post →
James Holland Jones
@juemos.bsky.social · Bluesky

Distance from sub-Saharan Africa predicts mutational load in diverse human genomes http://www.pnas.org/cgi/content/long/113/4/E440

Feb 2, 2016 View post →