February 2016 PMID 26752337

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease.

Benjamin Lazarus, Yuan Chen, Francis P Wilson, Yingying Sang, Alex R Chang, Josef Coresh, Morgan E Grams

Full text PDF Download social card

Mentions

279

Peak: 2 in Sep 2019

across 6 sources since Sep 2019

Extended reach

101,002

potential audience

Total likes

298

Video views

10,080

Mentions per month

Sep 2019 – Aug 2025

Where it's discussed

News173 articles
Facebook75 posts
Blogs15 articles
X / Twitter12 posts
YouTube2 videos
Reddit2 posts

AI synopsis

What people are saying

The overall discourse demonstrates strong agreement and high engagement, with posts citing specific research articles like Lazarus et al., and emphasizing the potential for medication management improvement. The tone varies from clinical references to personal or professional insights, underscoring the topic’s relevance in medical and patient communities.

AgreementModerate agreement

Most discussions acknowledge the association between PPI use and increased risk of CKD, reflecting general support or recognition of the findings.

InterestHigh interest

Numerous posts emphasize the importance of the research, discussing implications for patient care and medication management, showing high interest.

EngagementHigh engagement

Posts include references to specific studies, personal experiences, and calls to action, indicating deep engagement with the topic.

ImpactModerate impact

The discussions suggest the article has significant influence, potentially changing prescribing habits or raising awareness about long-term kidney health.

Abstract in brief

Proton pump inhibitors (PPIs) are widely used medications that have been linked to acute kidney issues, but their connection to long-term kidney damage (chronic kidney disease, CKD) is less clear.
A study involving over 10,000 participants from the ARIC cohort and a larger group from Geisinger found that PPI use was associated with an increased risk of developing CKD, even after adjusting for other factors like age, race, and health conditions.
The research showed that PPI users had about a 50% higher risk of CKD compared to non-users, suggesting that PPI use may contribute to long-term kidney health problems.

Read the full abstract

All mentions

Risks of Over-the-Counter Medications: Hidden Dangers and Long-Term Effects

Many people use OTC medications like Paracetamol, Ibuprofen, and ASS casually, unaware of serious side effects such as liver failure, heart issues, and kidney damage. This video highlights the importance of…

Präventiv-Apothekerin Fanny Patzschke · Aug 29, 2025 9,662 views

Risks of Excessive Use of Proton Pump Inhibitors for Acid Reflux

AWAS Bahaya Minum Obat Asam Lambung PPI Terlalu Sering. Overusing PPI medications like omeprazole and lansoprazole can cause serious health issues. Learn about the risks, side effects, and healthy alternatives for…

Dokter Sarwo · May 29, 2025 419 views

飴村ファーマ

@vt_pharma · X

Jun 24, 2022 · 12 likes · 9,424 followers View post →

Syed Shahrul Naz

@drshahrul80 · X

RT @kidney_boy: @almoskow @drjohnm same vein, observation of new CKD with PPI and no signal in placebo controlled trials RCT: https://t.co…

May 10, 2022 · 1 share · 6,933 followers View post →

Joel M. Topf, MD FACP

@kidney_boy · X

May 8, 2022 · 14 likes · 1 share · 63,676 followers View post →

Dr. Teoto (Reumatólogo)

@JoannesCarolus · X

Riesgo de enfermedad renal: Lazarus B, Chen Y, Wilson FP, Sang Y, Chang AR, Coresh J, Grams ME. Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease. JAMA Intern Med. 2016 Feb;176(2):238-46. doi: 10.1001/jamainternmed.2015.7193. PMID: 26752337; PMCID: PMC4772730. https://t.co/6LcTntDQ6h

Mar 9, 2022 · 629 followers View post →

Mohamed Eid

@Mohamedmagdieid · X

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease | Acute Kidney Injury | JAMA Internal Medicine | JAMA Network https://t.co/12d0yPyrQ9

Nov 5, 2021 · 1,912 followers View post →

Maurice Preter MD

@DrMauricePreter · X

Worth reposting/rereading! Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease Proton Pump Inhibitor https://t.co/euKqItiCng

Dec 3, 2020 · 987 followers View post →

Peter Dingle (PhD)

@drdingle · X

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease https://t.co/CIAHoH3Jcg

Sep 11, 2020 · 2,288 followers View post →

Kimberley Horner, ND, MS

@KimberleyHorne1 · X

@5gHAARPcrystals @__ice9 https://t.co/yxXczf8dh2

Apr 2, 2020 · 197 followers View post →

Jan Patenaude RD CLT

@DineRight · X

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease https://t.co/a1IJatcd8i #LoveLEAP LEAP often allows our clients to get off these meds when we figure out what is triggering their heartburn.

Jan 1, 2020 · 846 followers View post →

عبدالرحمن الغانم

@ar5man0 · X

RT @dralibalharith: Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease | Acute Kidney Injury | JAMA Internal Medicine | JAMA…

Oct 6, 2019 · 2 shares · 682 followers View post →

العمدة علي حمد رخيم

@alirkhem · X

RT @dralibalharith: Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease | Acute Kidney Injury | JAMA Internal Medicine | JAMA…

Sep 28, 2019 · 2 shares · 2,850 followers View post →

dralibalharithد. علي بالحارث

@dralibalharith · X

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease | Acute Kidney Injury | JAMA Internal Medicine | JAMA Network https://t.co/zlfa9sOUFh

Sep 28, 2019 · 1 like · 2 shares · 483 followers View post →