February 2016 PMID 26814963

Schizophrenia risk from complex variation of complement component 4.

Aswin Sekar, Allison R Bialas, Heather de Rivera, Avery Davis, Timothy R Hammond, Nolan Kamitaki, Katherine Tooley, Jessy Presumey, Matthew Baum, Vanessa Van Doren, Giulio Genovese, Samuel A Rose, Robert E Handsaker, Mark J Daly

Full text PDF Download social card

Mentions

266

Peak: 2 in Jul 2022

across 6 sources since Dec 2021

Extended reach

14,000

potential audience

Total likes

110

Video views

3,447

Mentions per month

Dec 2021 – Nov 2023

Where it's discussed

News165 articles
Blogs51 articles
Facebook40 posts
X / Twitter4 posts
Reddit4 posts
YouTube2 videos

AI synopsis

What people are saying

The group generally agrees that the research on C4 variations provides valuable insights into schizophrenia, demonstrated by phrases such as "complement component 4's role in synaptic pruning" and references to its influence on brain development. The tone stays analytical and respectful, reflecting a balanced curiosity about the implications rather than overwhelming enthusiasm or skepticism.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings related to C4 variations and schizophrenia risk.

InterestModerate interest

Participants show moderate curiosity, especially in linking genetic mechanisms to mental health conditions.

EngagementNeutral engagement

While some posts mention mechanisms and implications, overall engagement appears cautious and observational.

ImpactModerate impact

The conversations suggest that the research is viewed as potentially influential but not definitively changing current understanding.

Abstract in brief

Schizophrenia is a hereditary brain disorder with unclear causes, strongly linked to genetic variations in the major histocompatibility complex (MHC) locus.
New findings highlight that diverse alleles of the complement component 4 (C4) genes contribute to this genetic association, affecting the levels of C4A and C4B expressed in the brain.
C4 protein plays a crucial role in synapse elimination during brain development, suggesting that high levels of complement activity could lead to the reduced synapse counts observed in individuals with schizophrenia.

Read the full abstract

All mentions

Genetic Variations in Complement C4 and Schizophrenia Risk

Schizophrenia is a hereditary brain disorder linked to genetic variations in the MHC locus. New research shows that diverse alleles of the complement component 4 C4 genes influence C4A and C4B levels, affecting synapse…

Podlogy Podcast · Nov 5, 2023 3,245 views

Schizophrenia and Synaptic Pruning During Adolescence

This episode discusses schizophrenia, its causes, and recent research linking it to dysfunction in synaptic pruning during adolescence, a process where excess neural connections are eliminated, impacting brain…

Zaboo Mafut - Pódcast · Jun 12, 2023 203 views

ふみ

@snitori · X

Jul 18, 2022 · 1 share · 3,638 followers View post →

ミヤイリGUY

@Robson_1915 · X

Jul 18, 2022 · 8 likes · 1 share · 4,943 followers View post →

Yuri Milaneschi

@YMilaneschi · X

@giorgiogilestro schizophrenia GWAS https://t.co/VStvirdFOy ---> complement component 4 (C4) pruning mechanisms https://t.co/8muPxiLnSU

May 16, 2022 · 1 like · 1,097 followers View post →

Stetson

@stetson_thacker · X

@jayjoseph22 @RhiannonDauster @vonKriegstein @ThomasMcEvoy19 The dominant paradigm/consensus view in the field: https://t.co/eWMDRLb4DJ https://t.co/0F3D8DObdM https://t.co/jiPZSlikv6

Dec 7, 2021 · 1 like · 872 followers View post →