Schizophrenia risk from complex variation of complement component 4.

Aswin Sekar, Allison R Bialas, Heather de Rivera, Avery Davis, Timothy R Hammond, Nolan Kamitaki, Katherine Tooley, Jessy Presumey, Matthew Baum, Vanessa Van Doren, Giulio Genovese, Samuel A Rose, Robert E Handsaker, , Mark J Daly

February 2016

Synopsis of Social media discussions

The group generally agrees that the research on C4 variations provides valuable insights into schizophrenia, demonstrated by phrases such as "complement component 4's role in synaptic pruning" and references to its influence on brain development. The tone stays analytical and respectful, reflecting a balanced curiosity about the implications rather than overwhelming enthusiasm or skepticism.

A
Agreement
 Moderate agreement

Most discussions acknowledge the significance of the findings related to C4 variations and schizophrenia risk.

I
Interest
 Moderate level of interest

Participants show moderate curiosity, especially in linking genetic mechanisms to mental health conditions.

E
Engagement
 Neutral engagement

While some posts mention mechanisms and implications, overall engagement appears cautious and observational.

I
Impact
 Moderate level of impact

The conversations suggest that the research is viewed as potentially influential but not definitively changing current understanding.

Social Mentions

YouTube

2 Videos

Facebook

40 Posts

Twitter

4 Posts

Blogs

51 Articles

News

165 Articles

Reddit

4 Posts

Metrics

Video Views

3,447

Total Likes

110

Extended Reach

14,000

Social Features

266

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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November 5, 2023

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Schizophrenia and Synaptic Pruning During Adolescence

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This episode discusses schizophrenia, its causes, and recent research linking it to dysfunction in synaptic pruning during adolescence, a process where excess neural connections are eliminated, impacting brain development.

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June 12, 2023

203 views

  • ふみ
    @snitori (Twitter)

    RT @Robson_1915: この10年でびっくりした研究は、統合失調症と補体が結び付いたことかな。アレは衝撃だった。 Schizophrenia risk from complex variation of complement component 4 https://…
    view full post

    July 18, 2022

    1

  • ミヤイリGUY
    @Robson_1915 (Twitter)

    この10年でびっくりした研究は、統合失調症と補体が結び付いたことかな。アレは衝撃だった。 Schizophrenia risk from complex variation of complement component 4 https://t.co/8kSirn4UV7
    view full post

    July 18, 2022

    8

    1

  • Yuri Milaneschi
    @YMilaneschi (Twitter)

    @giorgiogilestro schizophrenia GWAS https://t.co/VStvirdFOy ---> complement component 4 (C4) pruning mechanisms https://t.co/8muPxiLnSU
    view full post

    May 16, 2022

    1

  • Stetson
    @stetson_thacker (Twitter)

    @jayjoseph22 @RhiannonDauster @vonKriegstein @ThomasMcEvoy19 The dominant paradigm/consensus view in the field: https://t.co/eWMDRLb4DJ https://t.co/0F3D8DObdM https://t.co/jiPZSlikv6
    view full post

    December 7, 2021

    1

Abstract Synopsis

  • Schizophrenia is a hereditary brain disorder with unclear causes, strongly linked to genetic variations in the major histocompatibility complex (MHC) locus.
  • New findings highlight that diverse alleles of the complement component 4 (C4) genes contribute to this genetic association, affecting the levels of C4A and C4B expressed in the brain.
  • C4 protein plays a crucial role in synapse elimination during brain development, suggesting that high levels of complement activity could lead to the reduced synapse counts observed in individuals with schizophrenia.