PubHawk
J Health Popul Nutr November 2015 PMID 26825414

The opioid effects of gluten exorphins: asymptomatic celiac disease.

Leo Pruimboom, Karin de Punder

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Mentions

55
Peak: 15 in Dec 2020
across 5 sources since Apr 2019

Extended reach

368,134
potential audience

Total likes

695

Video views

16,698

Mentions per month

Apr 2019 – Oct 2025

Where it's discussed

  • X / Twitter28 posts
  • Facebook21 posts
  • YouTube2 videos
  • News2 articles
  • Blogs2 articles

AI synopsis

What people are saying

The discussions demonstrate a moderate engagement with the article, with examples like mentions of gluten acting as opioids, immune reactions in celiac patients, and biochemical processes like DPP-IV inhibition. The tone combines curiosity with skepticism, highlighting the scientific complexity and potential health significance of gluten exorphins.

AgreementModerate agreement

Most discussions acknowledge the potential effects of gluten exorphins and support the idea that gluten can influence health beyond traditional understanding, though some are skeptical or highlight complexity.

InterestModerate interest

Participants show a moderate level of curiosity about the topic, with many exploring the biochemical mechanisms and health implications, indicating genuine interest.

EngagementModerate engagement

Several posts explore scientific mechanisms, such as DPP-IV inhibition and opioid-like effects, reflecting a thoughtful and engaged discussion on the subject.

ImpactModerate impact

The posts suggest that the discussion is raising awareness of gluten's broader effects and potential health impacts, possibly influencing perceptions and future research directions.

Abstract in brief

  • Gluten from cereals like wheat, barley, and rye is a common part of many people's diets and is linked to conditions such as celiac disease, diabetes, depression, and schizophrenia.
  • Many people with celiac disease are asymptomatic, meaning they don't show typical symptoms like diarrhea or abdominal pain, but still may develop gluten-related health problems.
  • Gluten can be broken down into gluten exorphins, which act like opioids and might hide or reduce the noticeable harmful effects of gluten on the gastrointestinal system, potentially masking its toxicity.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Hacker News Bot
@newsycombinator · X

The opioid effects of gluten exorphins: asymptomatic celiac disease https://t.co/HxXFqTbmKC

Dec 18, 2020 · 6 likes · 4 shares · 226,957 followers View post →
Alzhacker
@Alzhacker · X

https://t.co/upjlvVcyRV グルテン由来のグリアジン、乳製品由来のカゼインはDPP4の阻害、サブスタンPの増加によりオピオイド効果をもたらす可能性がある。 このオピオイド活性が無症候性セリアック病患者が症状を表わさない理由を説明するかもしれない。

Apr 30, 2019 · 6 likes · 2 shares · 33,077 followers View post →
tiktak
@taisukun · X

@Sakato0 この仮説が興味深いです。 グルテンに含まれるグリアジンがDPPIVと結合(阻害)し行き場を無くしたSPの濃度が上昇し下痢や腹痛が起こる。 またグリアジンの存在がC1Qを増加させてシナプス分解に関与するのではと推察しています。 https://t.co/dWGP4h7fmX

Sep 16, 2020 · 4 likes · 311 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

@DrPaulMason A good article on the opioid-like effects of gluten exorphins - could such explain the constipation, slow bowel transit in those with gluten sensitivity without coeliac? also impact on glucose homeostasis via effect on DPP IV enzyme https://t.co/4HJx4T7VqY https://t.co/AygHVgQUHM

Aug 28, 2023 · 2 likes · 5,438 followers View post →
ChrisQross DeyRFooked
@QrossChris · X

@chalfkenny @clif_high Yes it may, because most people have no idea they can have it and that it is and has been affecting their behavior and the way their brain works. Modern wheat, introduced into the market in the mid and late 80's is the worst when. "asymptomatic" https://t.co/05SYxEOTWm

Oct 22, 2023 · 2 likes · 1 share · 1,165 followers View post →
CyberChick
@warriors_mom · X

The opioid effects of gluten exorphins: asymptomatic celiac disease: Gluten intake is associated with the development of celiac disease (CD) & related disorders such as diabetes mellitus type I, depression, & schizophrenia. #Health #FODMAP #MentalHealth https://t.co/PNbstEcAXN

Dec 18, 2020 · 1 like · 2 shares · 13,299 followers View post →

All mentions

Daniel
@DanielW_Kiwi · X

@DataJuggler007 @HEB But for Celiacs like me it triggers an immune reaction that destroys the small intestine. Also as I suspect in my case gives you a mild high because you can't fully break it down https://t.co/BwCzm6eGoz

Feb 20, 2025 · 3,636 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

@_eleanorina @tednaiman @realDaveFeldman @DrEenfeldt The reason that grains- gluten might actually improve insulin sensitivity- gluten breakdown products can inhibit DPP-IV - a la incretin therapy https://t.co/VxVhwtuLi4 https://t.co/MJNZmsEE1r

Mar 12, 2024 · 5,438 followers View post →
carolyn halfkenny
@chalfkenny · X

RT @QrossChris: @chalfkenny @clif_high Yes it may, because most people have no idea they can have it and that it is and has been affecting…

Oct 22, 2023 · 1 share · 1,973 followers View post →
ChrisQross DeyRFooked
@QrossChris · X

@chalfkenny @clif_high Yes it may, because most people have no idea they can have it and that it is and has been affecting their behavior and the way their brain works. Modern wheat, introduced into the market in the mid and late 80's is the worst when. "asymptomatic" https://t.co/05SYxEOTWm

Oct 22, 2023 · 2 likes · 1 share · 1,165 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

@DrPaulMason A good article on the opioid-like effects of gluten exorphins - could such explain the constipation, slow bowel transit in those with gluten sensitivity without coeliac? also impact on glucose homeostasis via effect on DPP IV enzyme https://t.co/4HJx4T7VqY https://t.co/AygHVgQUHM

Aug 28, 2023 · 2 likes · 5,438 followers View post →
#MASTERLUKEY
@LukeCummo · X

@Jenfoxxxy Gluten is considered an opiate, so that can explain why you eat something that's ruining your life. https://t.co/tTvnmrEndP

Aug 1, 2023 · 1 like · 625 followers View post →
Dominique D.
@dm_devito · X

RT @newsycombinator: The opioid effects of gluten exorphins: asymptomatic celiac disease https://t.co/HxXFqTbmKC

Oct 15, 2021 · 4 shares · 1,001 followers View post →
Boris Linke
@1982blink · X

The opioid effects of gluten exorphins: asymptomatic celiac disease via https://t.co/oCtbxPlD96 https://t.co/32qonjbCbg

Dec 21, 2020 · 38 followers View post →
ICYMI HN
@icymihn · X

The opioid effects of gluten exorphins: asymptomatic celiac disease (2015) https://t.co/xztOkpXllt comm: https://t.co/gtzKQLC19u

Dec 19, 2020 · 269 followers View post →
Hacker News 50
@betterhn50 · X

The opioid effects of gluten exorphins: asymptomatic celiac disease (2015) https://t.co/0fYQKnCpOa (https://t.co/YKrhpi9wTJ)

Dec 18, 2020 · 1,739 followers View post →
Rene Petry
@RenePetry2 · X

RT @warriors_mom: The opioid effects of gluten exorphins: asymptomatic celiac disease: Gluten intake is associated with the development of…

Dec 18, 2020 · 2 shares · 2,293 followers View post →
Mental Health Bot
@MentalHealthBo5 · X

RT @warriors_mom: The opioid effects of gluten exorphins: asymptomatic celiac disease: Gluten intake is associated with the development of…

Dec 18, 2020 · 2 shares · 12,716 followers View post →
CyberChick
@warriors_mom · X

The opioid effects of gluten exorphins: asymptomatic celiac disease: Gluten intake is associated with the development of celiac disease (CD) & related disorders such as diabetes mellitus type I, depression, & schizophrenia. #Health #FODMAP #MentalHealth https://t.co/PNbstEcAXN

Dec 18, 2020 · 1 like · 2 shares · 13,299 followers View post →
priya joseph
@ayirpelle · X

RT @newsycombinator: The opioid effects of gluten exorphins: asymptomatic celiac disease https://t.co/HxXFqTbmKC

Dec 18, 2020 · 4 shares · 4,989 followers View post →
Hacker News 20
@betterhn20 · X

The opioid effects of gluten exorphins: asymptomatic celiac disease (2015) https://t.co/hMyfrJjQoK (https://t.co/SfFk0PUWMc)

Dec 18, 2020 · 2,266 followers View post →
Dominique D.
@dm_devito · X

RT @newsycombinator: The opioid effects of gluten exorphins: asymptomatic celiac disease https://t.co/HxXFqTbmKC

Dec 18, 2020 · 4 shares · 1,001 followers View post →
JFPuget
@JFPuget · X

RT @newsycombinator: The opioid effects of gluten exorphins: asymptomatic celiac disease https://t.co/HxXFqTbmKC

Dec 18, 2020 · 4 shares · 17,846 followers View post →
Hacker News Bot
@newsycombinator · X

The opioid effects of gluten exorphins: asymptomatic celiac disease https://t.co/HxXFqTbmKC

Dec 18, 2020 · 6 likes · 4 shares · 226,957 followers View post →
HackerNewsTop10
@HackerNewsTop10 · X

The opioid effects of gluten exorphins: asymptomatic celiac disease Link: https://t.co/L3fX6WYqQ2 Comments: https://t.co/LuszZ0Peqq

Dec 18, 2020 · 803 followers View post →
Winson Tang
@winsontang · X

The opioid effects of gluten exorphins: asymptomatic celiac disease https://t.co/QEveQ0CMNZ https://t.co/QaJttIaeQU

Dec 18, 2020 · 9,047 followers View post →
Marik Brestovisky
@Marikbrest · X

The opioid effects of gluten exorphins: asymptomatic celiac disease https://t.co/lKMFnHIbf4 2

Dec 18, 2020 · 469 followers View post →
HN Front Page
@hn_frontpage · X

The opioid effects of gluten exorphins: asymptomatic celiac disease L: https://t.co/YWoR2ZGX0F C: https://t.co/f6QBQ5p2yc

Dec 18, 2020 · 1 like · 2,544 followers View post →
tiktak
@taisukun · X

@Sakato0 この仮説が興味深いです。 グルテンに含まれるグリアジンがDPPIVと結合(阻害)し行き場を無くしたSPの濃度が上昇し下痢や腹痛が起こる。 またグリアジンの存在がC1Qを増加させてシナプス分解に関与するのではと推察しています。 https://t.co/dWGP4h7fmX

Sep 16, 2020 · 4 likes · 311 followers View post →
tiktak
@taisukun · X

グルテンエクソルフィンのオピオイド効果：無症候性セリアック病 https://t.co/dWGP4h7fmX

Aug 26, 2020 · 311 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

The opioid effects of gluten exorphins: asymptomatic celiac disease | Journal of Health, Population and Nutrition | Full Text https://t.co/JCNI5El3Xa

Oct 30, 2019 · 253 followers View post →
T. Morimura
@hushmark · X

RT @Alzhacker: https://t.co/upjlvVcyRV グルテン由来のグリアジン、乳製品由来のカゼインはDPP4の阻害、サブスタンPの増加によりオピオイド効果をもたらす可能性がある。 このオピオイド活性が無症候性セリアック病患者が症状を表わさない理由を説明…

May 1, 2019 · 2 shares · 1,077 followers View post →
うさ亀
@ark_pt · X

RT @Alzhacker: https://t.co/upjlvVcyRV グルテン由来のグリアジン、乳製品由来のカゼインはDPP4の阻害、サブスタンPの増加によりオピオイド効果をもたらす可能性がある。 このオピオイド活性が無症候性セリアック病患者が症状を表わさない理由を説明…

May 1, 2019 · 2 shares · 787 followers View post →
Alzhacker
@Alzhacker · X

https://t.co/upjlvVcyRV グルテン由来のグリアジン、乳製品由来のカゼインはDPP4の阻害、サブスタンPの増加によりオピオイド効果をもたらす可能性がある。 このオピオイド活性が無症候性セリアック病患者が症状を表わさない理由を説明するかもしれない。

Apr 30, 2019 · 6 likes · 2 shares · 33,077 followers View post →