N Engl J Med May 2016 PMID 26943128

Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants.

Michael R Perkin, Kirsty Logan, Anna Tseng, Bunmi Raji, Salma Ayis, Janet Peacock, Helen Brough, Tom Marrs, Suzana Radulovic, Joanna Craven, Carsten Flohr, Gideon Lack

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Mentions

288
Peak: 4 in Jul 2022
across 6 sources since Jan 2019

Extended reach

203,320
potential audience

Total likes

190

Video views

16,047

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Jan 2019 – Sep 2025

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AI synopsis

What people are saying

The discussions reflect a thoughtful engagement with the article, citing examples like the importance of early allergenic food introduction and referencing previous studies like LEAP and observational cohort data. Words like 'convincing,' 'real-world,' and references to specific figures and analyses reveal an interest in the study's depth, while careful tone indicates recognition of its potential impact without overstating it.

AgreementModerate agreement

Many discussions acknowledge the findings and implications of the study, showing general support or recognition of its value.

InterestHigh interest

The discussions indicate high curiosity about the research, with references to specific data points and related studies.

EngagementModerate engagement

Participants refer to detailed aspects such as analysis types and observational data, demonstrating moderate engagement.

ImpactModerate impact

There is an understanding that the research might influence future guidelines, but the overall tone suggests cautious optimism rather than outright revolution.

Abstract in brief

  • The study tested whether giving breastfed infants allergenic foods like peanuts, eggs, milk, sesame, fish, and wheat early in life can prevent food allergies, comparing early introduction to the typical practice of exclusive breastfeeding until 6 months.
  • Results showed that while the initial intention-to-treat analysis did not prove early introduction effective, a per-protocol analysis (which considers only those who actually followed the plan) found a significantly lower rate of food allergies, especially peanut and egg allergies, in the early introduction group.
  • The findings suggest that introducing certain allergenic foods early might help reduce the risk of developing some food allergies, but implementing this strategy is challenging and requires careful consideration of safety and adherence.

Top posts

Most liked on X and Bluesky
青島周一@【書籍】「生成AIと学ぶ医学論文の読み方・考え方」発売中!
@syuichiao89 · X

ITT解析の奥深さを学ぶのに最適な論文です。 https://t.co/lfPR7mfHGL

Jul 24, 2022 · 14 likes · 3 shares · 8,606 followers View post →
さいたまの膠原病内科医
@CTD_US00lover · X

自分がアレルギーマーチの権化ですからね。早期からピーナッツを摂取した方がアレルギーが減る可能性を示した論文を読んだ時はそういうことだったのか!と感動を覚えました(primary endpointは達成できていませんが)https://t.co/a8aPp1U26y 。

Feb 22, 2021 · 5 likes · 4,484 followers View post →
Graham Roberts
@ProfGRoberts · X

Interesting, seemingly convincing OBSERVATIONAL data from 3 cohorts. But is there hidden confounding as within a RCT (https://t.co/uqfc4rIieS) of early introduction of solids, duration of breast feeding in the intervention group was not reduced. #EAT https://t.co/ul6VQNJQaS

Feb 1, 2020 · 4 likes · 2 shares · 2,679 followers View post →
Graham Roberts
@ProfGRoberts · X

References: https://t.co/nT3f9m9oCY & https://t.co/hoyy3PaOhP https://t.co/22qN1aBc9y

Jun 19, 2022 · 3 likes · 1 share · 2,679 followers View post →
SCAAP
@SC_AAP · X

Amrol: EAT trial added allergenic foods at 3mos of age https://t.co/9qeY5FeEAl #scaap23

Aug 12, 2023 · 2 likes · 2 shares · 1,644 followers View post →
RealScientists
@realscientists · X

It looks like not too early, but not delayed introduction of foodstuffs (= before approx. 6 months of age) may have some preventative effect, but again, more research is needed to work out the details. https://t.co/v1eTfiNa9b https://t.co/71WN9bf9KI

Oct 7, 2021 · 1 like · 1 share · 78,671 followers View post →

All mentions

Michael K. Foxworth II, MD, FAAP
@mkfoxworth · X

RT @SC_AAP: Amrol: EAT trial added allergenic foods at 3mos of age https://t.co/9qeY5FeEAl #scaap23

Aug 12, 2023 · 2 shares · 1,045 followers View post →
Deborah Greenhouse
@greenhousemd · X

RT @SC_AAP: Amrol: EAT trial added allergenic foods at 3mos of age https://t.co/9qeY5FeEAl #scaap23

Aug 12, 2023 · 2 shares · 10,388 followers View post →
SCAAP
@SC_AAP · X

Amrol: EAT trial added allergenic foods at 3mos of age https://t.co/9qeY5FeEAl #scaap23

Aug 12, 2023 · 2 likes · 2 shares · 1,644 followers View post →
Mohammed Hudda
@MohammedHudda · X

@adamsonjon @ian_wac @DrSeanMon Yep we had LEAP and then EAT Studies as well https://t.co/bRO9y7Eg7S https://t.co/p6XOxig2TL

Mar 19, 2023 · 491 followers View post →
Landmark Trials
@LandmarkTrials · X

In this study published in NEJM we can see a real world example of a drastic difference between ITT and PP analysis. Ultimately the ITT analysis is what was used to make the conclusion. https://t.co/VQxwDRLgri https://t.co/89xPFUbR3G

Aug 28, 2022 · 1 like · 849 followers View post →
somekita@特発性血小板減少症@EBIちゃん号
@mazuisake · X

RT @syuichiao89: ITT解析の奥深さを学ぶのに最適な論文です。 https://t.co/lfPR7mfHGL

Jul 25, 2022 · 3 shares · 832 followers View post →
Satoru Mitsuboshi
@3stars67664378 · X

RT @syuichiao89: ITT解析の奥深さを学ぶのに最適な論文です。 https://t.co/lfPR7mfHGL

Jul 25, 2022 · 3 shares · 1,828 followers View post →
HAL@アンパンマンGO
@standalonhal · X

RT @syuichiao89: ITT解析の奥深さを学ぶのに最適な論文です。 https://t.co/lfPR7mfHGL

Jul 24, 2022 · 3 shares · 264 followers View post →
青島周一@【書籍】「生成AIと学ぶ医学論文の読み方・考え方」発売中!
@syuichiao89 · X

ITT解析の奥深さを学ぶのに最適な論文です。 https://t.co/lfPR7mfHGL

Jul 24, 2022 · 14 likes · 3 shares · 8,606 followers View post →
Florin-Dan
@florindanpopesq · X

RT @ProfGRoberts: References: https://t.co/nT3f9m9oCY & https://t.co/hoyy3PaOhP

Jun 20, 2022 · 1 share · 4,073 followers View post →
Graham Roberts
@ProfGRoberts · X

References: https://t.co/nT3f9m9oCY & https://t.co/hoyy3PaOhP https://t.co/22qN1aBc9y

Jun 19, 2022 · 3 likes · 1 share · 2,679 followers View post →
Peter Guhl bones0@chaos.social chabis ch
@chabis_ch · X

RT @realscientists: It looks like not too early, but not delayed introduction of foodstuffs (= before approx. 6 months of age) may have som…

Oct 8, 2021 · 1 share · 457 followers View post →
RealScientists
@realscientists · X

It looks like not too early, but not delayed introduction of foodstuffs (= before approx. 6 months of age) may have some preventative effect, but again, more research is needed to work out the details. https://t.co/v1eTfiNa9b https://t.co/71WN9bf9KI

Oct 7, 2021 · 1 like · 1 share · 78,671 followers View post →
さいたまの膠原病内科医
@CTD_US00lover · X

自分がアレルギーマーチの権化ですからね。早期からピーナッツを摂取した方がアレルギーが減る可能性を示した論文を読んだ時はそういうことだったのか!と感動を覚えました(primary endpointは達成できていませんが)https://t.co/a8aPp1U26y 。

Feb 22, 2021 · 5 likes · 4,484 followers View post →
NPO日本医療ジャーナリズム研究機構
@jmjri · X

RT @janeway_tlr2: 伊藤隼也氏がRTした下記、原文 https://t.co/7rVDgQu7RV を読むと、「結果はアレルゲンの早期導入群と通常導入群との間で、食物アレルギーの発症率には、有意な差は認められませんでした」とある。 無知、無責任だろう! http…

Nov 25, 2020 · 146 shares · 1,368 followers View post →
Carina Venter PhD RD
@VenterCarina · X

@PeanutRD yes - See figure 3 B in the paper – that is where it shows 2 g of boiled egg per week is needed. https://t.co/hE3Qkb42Yl

Sep 22, 2020 · 5,798 followers View post →
Nottingham Eczema
@eczemasupport · X

RT @ProfGRoberts: Interesting, seemingly convincing OBSERVATIONAL data from 3 cohorts. But is there hidden confounding as within a RCT (htt…

Feb 1, 2020 · 2 shares · 6,912 followers View post →
Alasdair Munro
@apsmunro · X

RT @ProfGRoberts: Interesting, seemingly convincing OBSERVATIONAL data from 3 cohorts. But is there hidden confounding as within a RCT (htt…

Feb 1, 2020 · 2 shares · 52,921 followers View post →
Graham Roberts
@ProfGRoberts · X

Interesting, seemingly convincing OBSERVATIONAL data from 3 cohorts. But is there hidden confounding as within a RCT (https://t.co/uqfc4rIieS) of early introduction of solids, duration of breast feeding in the intervention group was not reduced. #EAT https://t.co/ul6VQNJQaS

Feb 1, 2020 · 4 likes · 2 shares · 2,679 followers View post →
Maria Jenmalm
@mjnmlm · X

@JacobGudiol @aliciapetra Det finns en annan interventionsstudie, där man undersökte hur tidig introduktion av 6 olika allergena födoämnen (jordnöt, tillagat ägg, komjölk, sesam, vit fisk och vete) påverkade födoämnesallergi, se https://t.co/x6rM02WsNg Här finns ännu ingen rapport om hur detta...

Jan 29, 2019 · 937 followers View post →