Discussions reflect a high level of engagement with several posts referencing relevant clinical trials like ALPS and PARAMEDIC2 to contextualize the results, with tone conveying both curiosity and critical appraisal, suggesting a recognition of the study's potential impact on emergency treatment protocols.
AgreementModerate agreement
Most discussions acknowledge that the study found minimal or no significant benefit from antiarrhythmic drugs, showing a general consensus on the limited effectiveness.
InterestHigh interest
Posts demonstrate high interest by referencing multiple studies, including ALPS and PARAMEDIC2, and highlighting nuances like early administration and witnessed arrests.
EngagementModerate engagement
Participants engage by sharing summaries, linking to trial results, and raising clinical implications, indicating thoughtful involvement beyond surface-level discussion.
ImpactModerate impact
The collective tone suggests the findings could influence clinical practices, especially in emergency medicine, due to the evidence showing limited benefits of these medications.
Abstract in brief
This study compared the effectiveness of amiodarone, lidocaine, and a placebo in adults experiencing out-of-hospital cardiac arrest with shock-refractory ventricular fibrillation or pulseless ventricular tachycardia, finding that amiodarone and lidocaine slightly increased survival to hospital discharge compared to placebo, though the differences were modest.
The results showed no significant difference in neurologic outcomes at discharge between the three groups, and the benefit of the drugs was more pronounced in cases where the arrest was witnessed by bystanders.
The study highlights that while these antiarrhythmic drugs may slightly improve survival rates, their overall impact on neurological outcomes is similar, and the effectiveness may depend on specific circumstances like whether the arrest was witnessed.]
Amiodarona, Lidocaína o Placebo en #ParoCardíaco Extrahospitalario
Interesante Ensayo Clínico y Artículo de NEJM: https://t.co/YJunu6GZRu
Te gusta?? Comparte!!! https://t.co/gsucayxilq
May 25, 2019 · 25 likes · 13 shares · 69,510 followersView post →
SM
Steve Mathieu
@stevemathieu75 · X
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Neither amiodarone nor lidocaine increased survival or good neurological outcome compared with placebo in out-of-hospital cardiac arrest
https://t.co/wTfWX060P3
Mar 25, 2019 · 23 likes · 9 shares · 6,327 followersView post →
R
RCEMLearning
@RCEMLearning · X
You've been assigned a paper called 'Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest' to appraise for your weekly journal club meeting. Details and the Critical Appraisal question here
May 23, 2019 · 17 likes · 11 shares · 21,558 followersView post →
R
RealScientists
@realscientists · X
The Amiodarone, Lidocaine, Placebo Study (ALPS) compared two heart rhythm medications to a placebo. The thought was that once you shock the heart back into a normal rhythm the drugs would keep it from re-fibrillating.
A: No difference. https://t.co/z2YxlcDkF8 https://t.co/1ERAuhFleK
Jan 24, 2021 · 11 likes · 2 shares · 78,660 followersView post →
JS
Juan Senior
@jsenior64 · X
Ahora revisen este más reciente. La importancia de un paro presenciado.
https://t.co/jBgy2BiCO3
De même, on a jamais montré que les anti-arythmiques faisaient mieux que le placebo pour réanimer un arrêt cardiaque...
pubmed.ncbi.nlm.nih.gov/27043165/
This video discusses the clinical use of amiodarone and its role in out-of-hospital cardiac arrest management, highlighting its modest benefit in improving survival and the influence of witness status on outcomes.
This episode examines whether antiarrhythmics like amiodarone or lidocaine improve survival in prehospital cardiac arrests. Studies show they offer modest survival benefits, especially in witnessed cases, with similar…
De même, on a jamais montré que les anti-arythmiques faisaient mieux que le placebo pour réanimer un arrêt cardiaque...
pubmed.ncbi.nlm.nih.gov/27043165/
And the ROC ALPS study comparing amiodarone, lidocaine or placebo … if given early in witnessed arrest there is some benefit #SOA22 https://t.co/BATZjcsvwU
Jul 1, 2022 · 1 like · 1 share · 4,334 followersView post →
EM
Elena Plaza Moreno
@urgenciasemerge · X
El estudio comparaba en 3 grupos aleatorizados amiodarona, lidocaína y placebo en pacientes con FV/TV refractaria tras al menos un intento de desfibrilación. https://t.co/Z6ZMwpWY7D
Resultados:
Jan 24, 2022 · 2 likes · 1 share · 31,919 followersView post →
KM
Ken Milne MD
@TheSGEM · X
This new study is a subgroup analysis of the ALPS trial published in @NEJM https://t.co/YrSqt9LPtN
RT @realscientists: The Amiodarone, Lidocaine, Placebo Study (ALPS) compared two heart rhythm medications to a placebo. The thought was tha…
Jan 24, 2021 · 2 shares · 3,420 followersView post →
DO
Defender of
@e2dot7182818284 · X
RT @realscientists: The Amiodarone, Lidocaine, Placebo Study (ALPS) compared two heart rhythm medications to a placebo. The thought was tha…
Jan 24, 2021 · 2 shares · 4,334 followersView post →
R
RealScientists
@realscientists · X
The Amiodarone, Lidocaine, Placebo Study (ALPS) compared two heart rhythm medications to a placebo. The thought was that once you shock the heart back into a normal rhythm the drugs would keep it from re-fibrillating.
A: No difference. https://t.co/z2YxlcDkF8 https://t.co/1ERAuhFleK
Jan 24, 2021 · 11 likes · 2 shares · 78,660 followersView post →
A
Almansour
@malmansour81 · X
RT @accpemedprn: We're back with this month's #emedprnjc on 12/27 @ 1 pm EST! Our first article looks at the recent AHA ACLS comparing Amio…
May 25, 2019 · 1 share · 7,254 followersView post →
P
PacoCampillo
@PacoCampilloPal · X
RT @PatologCritica: Amiodarona, Lidocaína o Placebo en #ParoCardíaco Extrahospitalario
Interesante Ensayo Clínico y Artículo de NEJM: https…
May 25, 2019 · 13 shares · 279 followersView post →
F
Fantasmamagno
@Fantasmamagno · X
RT @PatologCritica: Amiodarona, Lidocaína o Placebo en #ParoCardíaco Extrahospitalario
Interesante Ensayo Clínico y Artículo de NEJM: https…
May 25, 2019 · 13 shares · 23 followersView post →
FM
Francisca Martínez
@famartinez2001 · X
RT @PatologCritica: Amiodarona, Lidocaína o Placebo en #ParoCardíaco Extrahospitalario
Interesante Ensayo Clínico y Artículo de NEJM: https…
May 25, 2019 · 13 shares · 10,027 followersView post →
PC
Patología Crítica
@PatologCritica · X
Amiodarona, Lidocaína o Placebo en #ParoCardíaco Extrahospitalario
Interesante Ensayo Clínico y Artículo de NEJM: https://t.co/YJunu6GZRu
Te gusta?? Comparte!!! https://t.co/gsucayxilq
May 25, 2019 · 25 likes · 13 shares · 69,510 followersView post →
EF
EM3FOAMed
@EM3FOAMed · X
RT @RCEMLearning: You've been assigned a paper called 'Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest' to appraise for…
May 24, 2019 · 11 shares · 10,200 followersView post →
EF
Emergency Medicine Kenya Foundation
@emkefoundation · X
RT @RCEMLearning: You've been assigned a paper called 'Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest' to appraise for…
May 24, 2019 · 11 shares · 3,075 followersView post →
يا
يا غياث المستغيثين
@qoolool · X
RT @RCEMLearning: You've been assigned a paper called 'Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest' to appraise for…
May 23, 2019 · 11 shares · 72 followersView post →
H
Husam
@me_EM_sam · X
RT @RCEMLearning: You've been assigned a paper called 'Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest' to appraise for…
May 23, 2019 · 11 shares · 435 followersView post →
Z
zakiahmj
@zakiahmj · X
RT @RCEMLearning: You've been assigned a paper called 'Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest' to appraise for…
May 23, 2019 · 11 shares · 94 followersView post →
CL
Caroline Leech
@LeechCaroline · X
RT @RCEMLearning: You've been assigned a paper called 'Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest' to appraise for…
May 23, 2019 · 11 shares · 13,636 followersView post →
P
PacoCampillo
@PacoCampilloPal · X
RT @RCEMLearning: You've been assigned a paper called 'Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest' to appraise for…
May 23, 2019 · 11 shares · 279 followersView post →
WE
Wishaw General ED
@wishydocs · X
RT @RCEMLearning: You've been assigned a paper called 'Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest' to appraise for…
May 23, 2019 · 11 shares · 1,715 followersView post →
TM
Thomas Shanahan (Dr.) MRCEM
@clifford0584 · X
RT @RCEMLearning: You've been assigned a paper called 'Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest' to appraise for…
May 23, 2019 · 11 shares · 6,044 followersView post →
R
RCEMLearning
@RCEMLearning · X
You've been assigned a paper called 'Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest' to appraise for your weekly journal club meeting. Details and the Critical Appraisal question here
May 23, 2019 · 17 likes · 11 shares · 21,558 followersView post →
JH
Juan Manuel Hernandez
@JuanmaHernande · X
RT @jsenior64: Ahora revisen este más reciente. La importancia de un paro presenciado.
https://t.co/jBgy2BiCO3
RT @stevemathieu75: Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Neither amiodarone nor lidocaine increased surviva…
Mar 26, 2019 · 9 shares · 1,249 followersView post →
M
MJ
@minja2001 · X
RT @stevemathieu75: Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Neither amiodarone nor lidocaine increased surviva…
Mar 26, 2019 · 9 shares · 109 followersView post →
RW
Richard Ward
@RichardWard_UoC · X
RT @stevemathieu75: Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Neither amiodarone nor lidocaine increased surviva…
Mar 26, 2019 · 9 shares · 1,165 followersView post →
CB
Chris Bishop
@Pipes_n_pumps · X
RT @stevemathieu75: Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Neither amiodarone nor lidocaine increased surviva…
Mar 26, 2019 · 9 shares · 4,070 followersView post →
TE
Tom Quinn etc.
@proftomquinn · X
RT @stevemathieu75: Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Neither amiodarone nor lidocaine increased surviva…
Mar 26, 2019 · 9 shares · 5,613 followersView post →
MF
Mark Forrest
@Obidoc · X
RT @stevemathieu75: Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Neither amiodarone nor lidocaine increased surviva…
Mar 25, 2019 · 9 shares · 11,188 followersView post →
SM
Steve Mathieu
@stevemathieu75 · X
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Neither amiodarone nor lidocaine increased survival or good neurological outcome compared with placebo in out-of-hospital cardiac arrest
https://t.co/wTfWX060P3
Mar 25, 2019 · 23 likes · 9 shares · 6,327 followersView post →
CR
Cliff Reid
@cliffreid.bsky.social · Bluesky
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
http://www.nejm.org/doi/10.1056/NEJMoa1514204
Thanks to @CritCareReviews
Which medication is NOT typically used in the management of ...
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org/doi/full/10.1056/NEJMoa1514204#t=abstract Overall, neither amiodarone nor lidocaine resulted in a significantly higher rate of survival or favorable ...
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