Circ Res June 2016 PMID 27166251

Proton Pump Inhibitors Accelerate Endothelial Senescence.

Gautham Yepuri, Roman Sukhovershin, Timo Z Nazari-Shafti, Michael Petrascheck, Yohannes T Ghebre, John P Cooke

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Mentions

Peak: 2 in Jun 2024

across 6 sources since Apr 2019

Extended reach

47,134

potential audience

Total likes

Video views

8,073

Mentions per month

Apr 2019 – May 2025

Where it's discussed

News34 articles
X / Twitter10 posts
Facebook8 posts
Blogs5 articles
YouTube2 videos
Reddit2 posts

AI synopsis

What people are saying

The collective tone shows strong agreement with the research, especially with posts like '@PaulJacobDO' urging patient education on chronic PPI use, and references to previous research by '@edgarvlermamd' noting endothelial senescence since 2016. The use of warnings like 'yet another reason not to use long-term' and calls for clinical caution reveal a proactive engagement with health implications, emphasizing both awareness and potential behavioral changes.

AgreementModerate agreement

Most discussions acknowledge and support the findings that PPIs can accelerate endothelial aging, demonstrating general consensus on the adverse effects highlighted.

InterestHigh interest

The posts show high interest by referencing the research, urging caution, and emphasizing patient education about long-term PPI use.

EngagementModerate engagement

Participants actively cite sources, discuss the implications for health management, and share links, indicating moderate but meaningful engagement.

ImpactModerate impact

The emphasis on limiting PPI use and connecting it to broader health risks suggests these discussions could influence clinical practices or patient choices, though the evidence is still evolving.

Abstract in brief

Proton Pump Inhibitors (PPIs), commonly used for GERD, are now often used long-term without medical supervision, which may pose health risks.
The research shows that long-term PPI use damages endothelial cells, speeds up their aging process, and shortens telomeres, leading to vascular dysfunction.
These findings suggest that PPI-induced endothelial aging could explain the increased risk of cardiovascular, renal, and neurological problems tied to prolonged PPI use.]

Read the full abstract

All mentions

Silent Reflux and PPI Risks: Understanding Long-term Effects on Health

Silent Reflux disease involves abnormal gastric content reflux that irritates the throat. Long-term use of Proton Pump Inhibitors may accelerate endothelial cell aging, potentially increasing risks of cardiovascular and…

Reflux Formula · Nov 4, 2022 4,481 views

Limitations of Proton Pump Inhibitors in Treating Silent Reflux

Silent Reflux refers to gastric contents irritating the throat. Long-term use of PPIs may accelerate endothelial aging and increase health risks, highlighting the need for cautious management of reflux treatment.

Reflux Formula · Jun 13, 2023 3,593 views

blueday

@blueday · X

Letter by Marlicz et al Regarding Article, “Proton Pump Inhibitors Accelerate Endothelial Senescence” https://t.co/yylQ25lOzh

May 26, 2025 · 150 followers View post →

blueday

@blueday · X

「プロトンポンプ阻害剤は内皮老化を促進する」といふ研究怖い（こなみ）。 Proton Pump Inhibitors Accelerate Endothelial Senescence https://t.co/TRmdGeO7rZ Can Endothelial Injury Provide the Passage to Explain the Vascular Effects of Proton Pump Inhibitors? https://t.co/nZP1rgiF8G

May 26, 2025 · 150 followers View post →

Mohammed bukhari

@Moh_bukh · X

RT @edgarvlermamd: PPIs accelerate endothelial senescence ca. 2016 from @CircAHA #Nephpearls #NephJC

Jun 26, 2024 · 2 shares · 207 followers View post →

Edgar V. Lerma

@edgarvlermamd · X

PPIs accelerate endothelial senescence ca. 2016 from @CircAHA #Nephpearls #NephJC

Jun 25, 2024 · 10 likes · 2 shares · 33,847 followers View post →

W R

@rylan7 · X

Proton Pump Inhibitors Accelerate Endothelial Senescence https://t.co/A2VzBlOE4W - Yet another reason not to use #PPI drugs long-term - #ulcer

Dec 3, 2020 · 1 like · 1,514 followers View post →

Peter Dingle (PhD)

@drdingle · X

Proton Pump Inhibitors Accelerate Endothelial Senescence and chronic illness https://t.co/z9B8zgZeHG

Aug 3, 2020 · 2,288 followers View post →

Nelson Zamora R. MD

@DrZamu13 · X

RT @edgarvlermamd: PPIs accelerate endothelial senescence ca. 2016 from @CircAHA #Nephpearls

Jun 24, 2020 · 7 shares · 744 followers View post →

gub70725

@gub70725 · X

RT @edgarvlermamd: PPIs accelerate endothelial senescence ca. 2016 from @CircAHA #Nephpearls

Apr 4, 2020 · 7 shares · 54 followers View post →

MyDoctorB

@MyDoctorB · X

May 1, 2019 · 1 like · 68 followers View post →

Gautham Yepuri

@starrisktaker · X

@garvey_timothy @DaveKeto @ethanjweiss @FatEmperor @MdSaladino @TuckerGoodrich https://t.co/ZsIjuwFGZI Thanks Timothy for bringing this up...here is the link for the original article. thought might help you

Apr 9, 2019 · 4 followers View post →