Melissa officinalis L. - A review of its traditional uses, phytochemistry and pharmacology.

Abstract in brief

• Melissa officinalis L has been traditionally used in European and Middle Eastern medicine for various health issues and as a culinary herb, contributing flavor to dishes.
• Research shows that the plant contains compounds like volatile oils, flavonoids, phenolic acids, and triterpenoids, which are linked to its pharmacological effects, including anxiety reduction, antiviral activity, and effects on mood and cognition.
• Modern studies validate many traditional uses by demonstrating mechanisms such as AChE inhibition and receptor stimulation, highlighting its potential for neurological benefits, though further research is needed to explore its full pharmacological potential and safety.