J Comp Neurol December 2016 PMID 27187682

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting.

Christopher S von Bartheld, Jami Bahney, Suzana Herculano-Houzel

Mentions

81
Peak: 6 in Sep 2019
across 6 sources since May 2016

Extended reach

37,830
potential audience

Total likes

102

Video views

779

Mentions per month

May 2016 – Sep 2025

Where it's discussed

  • News39 articles
  • X / Twitter19 posts
  • Blogs12 articles
  • Facebook6 posts
  • Bluesky3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The group of discussions showcases a shift from accepting outdated estimates of brain cells to recognizing the significance of newer, more accurate methods; users mention the urban myth of the glia-to-neuron ratio and cite specific research like Suzana Herculano-Houzel's work, illustrating active engagement with both the article and related scientific debates.

AgreementModerate agreement

Most discussions support the idea that traditional estimates about brain cell numbers were overestimated and emphasize the importance of new methods, indicating general agreement with the article's findings.

InterestModerate interest

Posts reflect moderate interest, with some highlighting surprising facts and historical misconceptions, but few delve deeply into complex implications.

EngagementHigh engagement

Many posts reference specific studies, challenge common beliefs, and discuss scientific myths, demonstrating active and thoughtful engagement.

ImpactModerate impact

Discussions underscore that altering long-held assumptions about brain cell counts can significantly influence neuroscience research and understanding of brain function.

Abstract in brief

  • The traditional belief that the human brain contains about 100 billion neurons and a trillion glial cells with a high glia-to-neuron ratio has been challenged by the isotropic fractionator method, which shows a much lower glia-to-neuron ratio of less than 1:1.
  • Historical data and histological studies consistently supported a glia-to-neuron ratio of around 1:1, with the total glial cell count estimated between 40 to 130 billion, contradicting the previous larger estimate of over a trillion glial cells.
  • The review highlights how early cell counting methods and assumptions led to an erroneous consensus, and emphasizes the significance of the new, validated isotropic fractionator in accurately determining cell numbers, which has important implications for understanding brain function and diseases.

Top posts

Most liked on X and Bluesky
Mara Mather
@MaraMather · X

Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that are inaccurate. https://t.co/unH6okQySg

Sep 2, 2019 · 18 likes · 5 shares · 2,425 followers View post →
Luca Ambrogioni
@LucaAmb · X

Apparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct raio is about 1:1! https://t.co/RiQkw8wyvT… A good example of how much science is as vulnerable to unchecked rumors as any other human activity.

Apr 30, 2024 · 12 likes · 4 shares · 6,622 followers View post →
Dr Amanda J. Meyer linkedin.com/in/amandameyerphd
@amandameyerphd · X

There are LESS than 100 billion neurons in the human brain and there are slightly LESS glial cells compared to neurons! #neuroanatomy https://t.co/6aXdqA9nDB https://t.co/c1vFkSBKgY

Jan 14, 2022 · 10 likes · 1 share · 4,138 followers View post →
Se Hoon Choi
@presenilin1 · X

@jonykipnis @BaptisteLacost3 Sorry... :) https://t.co/ilGHPShZw8 https://t.co/BQNxOB8Zjq

Jan 14, 2022 · 5 likes · 1,108 followers View post →
Se Hoon Choi
@presenilin1 · X

@AmarSahay_ Here it is: The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting. https://t.co/qcb69mhg6X

Oct 25, 2019 · 4 likes · 1,108 followers View post →
Ariel K. Frame
@arielframe.bsky.social · Bluesky

Didn’t Suzana Herculano-Houzel show using her brain soup method (10.1523/JNEUROSCI.4526-04.2005) that a better estimate is 86 billion? Review: 10.1002/cne.24040 This seems to have been mentioned in that same brainfacts resource in 2018 www.brainfacts.org/in-the-lab/m...

Nov 21, 2024 · 4 likes · 2 shares View post →

All mentions

Raghav Agrawal @impactology@mastodon.social
@impactology.bsky.social · Bluesky

The Search for True Numbers of Neurons and Glial Cells in the Human Brain: A Review of 150 Years of Cell Counting pmc.ncbi.nlm.nih.gov/articles/PMC... Cerebellum representing about 10% of brain volume contains 50–70 billion neurons while cortex making up 80–85% has 10–20 billion neurons

Sep 14, 2025 · 2 likes · 1 share View post →
Raghav Agrawal
@impactology · X

The Search for True Numbers of Neurons and Glial Cells in the Human Brain: A Review of 150 Years of Cell Counting https://t.co/1SQlMiX1cN Cerebellum representing about 10% of brain volume contains 50–70 billion neurons while cortex making up 80–85% has 10–20 billion neurons

Sep 14, 2025 · 1 like · 3,408 followers View post →
Ariel K. Frame
@arielframe.bsky.social · Bluesky

Didn’t Suzana Herculano-Houzel show using her brain soup method (10.1523/JNEUROSCI.4526-04.2005) that a better estimate is 86 billion? Review: 10.1002/cne.24040 This seems to have been mentioned in that same brainfacts resource in 2018 www.brainfacts.org/in-the-lab/m...

Nov 21, 2024 · 4 likes · 2 shares View post →
Domenico Bellomo
@BellomoDomenico · X

RT @LucaAmb: Apparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct r…

Apr 30, 2024 · 4 shares · 417 followers View post →
Tzvetan Popov
@TzvetanPopov · X

RT @LucaAmb: Apparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct r…

Apr 30, 2024 · 4 shares · 369 followers View post →
Leo_Vzla_Gocho
@Vzla59986Vzla · X

RT @LucaAmb: Apparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct r…

Apr 30, 2024 · 4 shares · 152 followers View post →
Alireza Modirshanechi
@modirshanechi · X

RT @LucaAmb: Apparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct r…

Apr 30, 2024 · 4 shares · 759 followers View post →
Luca Ambrogioni
@LucaAmb · X

Apparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct raio is about 1:1! https://t.co/RiQkw8wyvT… A good example of how much science is as vulnerable to unchecked rumors as any other human activity.

Apr 30, 2024 · 12 likes · 4 shares · 6,622 followers View post →
Daniel Manrique-Castano, PhD
@danielneuroglia · X

@astrocyteNet @LeaLilchen Just a comment. Despite being found in textbooks and articles, astrocytes do not appear to be the largest set of glial cells. https://t.co/boDUrnh7l1

May 25, 2023 · 863 followers View post →
Se Hoon Choi
@presenilin1 · X

@jonykipnis @BaptisteLacost3 Sorry... :) https://t.co/ilGHPShZw8 https://t.co/BQNxOB8Zjq

Jan 14, 2022 · 5 likes · 1,108 followers View post →
Dr Amanda J. Meyer linkedin.com/in/amandameyerphd
@amandameyerphd · X

RT @amandameyerphd: There are LESS than 100 billion neurons in the human brain and there are slightly LESS glial cells compared to neurons!…

Jan 14, 2022 · 1 share · 4,138 followers View post →
Dr Amanda J. Meyer linkedin.com/in/amandameyerphd
@amandameyerphd · X

There are LESS than 100 billion neurons in the human brain and there are slightly LESS glial cells compared to neurons! #neuroanatomy https://t.co/6aXdqA9nDB https://t.co/c1vFkSBKgY

Jan 14, 2022 · 10 likes · 1 share · 4,138 followers View post →
novemberrain1108
@Tatsunori_Ishii · X

最近では、脳内の神経細胞は推定860億個、グリア細胞はそれとほぼ同じ850億個と推定されているらしい。 グリア細胞は、神経細胞の何十倍も多いと当たり前のように習っているけどアップデートが必要ですね...(これも古くなってる可能性あり) https://t.co/pHdsun0Ndj https://t.co/Vb9FOeaXZj

Oct 24, 2021 · 2 likes · 640 followers View post →
Dr Pérez-González
@dr_jcpg · X

@BlancheEllisArt Aquí lo tienes. Es un descubrimiento genial de @suzanahh y su equipo en 2009 https://t.co/hupHqt8MTj Artículo de revisión: https://t.co/NRklvGGnTc

Mar 15, 2021 · 1 like · 1,264 followers View post →
Se Hoon Choi
@presenilin1 · X

@AmarSahay_ Here it is: The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting. https://t.co/qcb69mhg6X

Oct 25, 2019 · 4 likes · 1,108 followers View post →
Gregory Samanez-Larkin
@GregoryRSL · X

RT @MaraMather: Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that ar…

Sep 2, 2019 · 5 shares · 3,425 followers View post →
Anthony Zanesco
@anthonyzanesco · X

RT @MaraMather: Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that ar…

Sep 2, 2019 · 5 shares · 678 followers View post →
Nicholas Van Dam
@ntvandam · X

RT @MaraMather: Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that ar…

Sep 2, 2019 · 5 shares · 2,160 followers View post →
JohannesAlgermissen@johalgermissen@bsky.social
@johalgermissen · X

RT @MaraMather: Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that ar…

Sep 2, 2019 · 5 shares · 853 followers View post →
Mara Mather
@MaraMather · X

Apparently there are large individual differences in the number of neurons we each have - "a variance of more than eight times the variance of human body height" https://t.co/unH6okQySg

Sep 2, 2019 · 3 likes · 2,425 followers View post →
Mara Mather
@MaraMather · X

Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that are inaccurate. https://t.co/unH6okQySg

Sep 2, 2019 · 18 likes · 5 shares · 2,425 followers View post →
Ye Olde Christlet
@christletx.bsky.social · Bluesky

Counting neurons rather than sheeps to fall asleep tonight? http://onlinelibrary.wiley.com/doi/10.1002/cne.24040/abstract

May 17, 2016 View post →