Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that are inaccurate. https://t.co/unH6okQySg
The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting.
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May 2016 – Sep 2025Where it's discussed
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News39 articles
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X / Twitter19 posts
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What people are saying
The group of discussions showcases a shift from accepting outdated estimates of brain cells to recognizing the significance of newer, more accurate methods; users mention the urban myth of the glia-to-neuron ratio and cite specific research like Suzana Herculano-Houzel's work, illustrating active engagement with both the article and related scientific debates.
Most discussions support the idea that traditional estimates about brain cell numbers were overestimated and emphasize the importance of new methods, indicating general agreement with the article's findings.
Posts reflect moderate interest, with some highlighting surprising facts and historical misconceptions, but few delve deeply into complex implications.
Many posts reference specific studies, challenge common beliefs, and discuss scientific myths, demonstrating active and thoughtful engagement.
Discussions underscore that altering long-held assumptions about brain cell counts can significantly influence neuroscience research and understanding of brain function.
Abstract in brief
- The traditional belief that the human brain contains about 100 billion neurons and a trillion glial cells with a high glia-to-neuron ratio has been challenged by the isotropic fractionator method, which shows a much lower glia-to-neuron ratio of less than 1:1.
- Historical data and histological studies consistently supported a glia-to-neuron ratio of around 1:1, with the total glial cell count estimated between 40 to 130 billion, contradicting the previous larger estimate of over a trillion glial cells.
- The review highlights how early cell counting methods and assumptions led to an erroneous consensus, and emphasizes the significance of the new, validated isotropic fractionator in accurately determining cell numbers, which has important implications for understanding brain function and diseases.
Top posts
Most liked on X and BlueskyApparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct raio is about 1:1! https://t.co/RiQkw8wyvT… A good example of how much science is as vulnerable to unchecked rumors as any other human activity.
There are LESS than 100 billion neurons in the human brain and there are slightly LESS glial cells compared to neurons! #neuroanatomy https://t.co/6aXdqA9nDB https://t.co/c1vFkSBKgY
@jonykipnis @BaptisteLacost3 Sorry... :) https://t.co/ilGHPShZw8 https://t.co/BQNxOB8Zjq
@AmarSahay_ Here it is: The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting. https://t.co/qcb69mhg6X
Didn’t Suzana Herculano-Houzel show using her brain soup method (10.1523/JNEUROSCI.4526-04.2005) that a better estimate is 86 billion? Review: 10.1002/cne.24040 This seems to have been mentioned in that same brainfacts resource in 2018 www.brainfacts.org/in-the-lab/m...
All mentions
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Reevaluating Human Brain Cell Counts: Neurons and Glia Analysis
The Search for True Numbers of Neurons and Glial Cells in the Human Brain: A Review of 150 Years of Cell Counting pmc.ncbi.nlm.nih.gov/articles/PMC... Cerebellum representing about 10% of brain volume contains 50–70 billion neurons while cortex making up 80–85% has 10–20 billion neurons
The Search for True Numbers of Neurons and Glial Cells in the Human Brain: A Review of 150 Years of Cell Counting https://t.co/1SQlMiX1cN Cerebellum representing about 10% of brain volume contains 50–70 billion neurons while cortex making up 80–85% has 10–20 billion neurons
Didn’t Suzana Herculano-Houzel show using her brain soup method (10.1523/JNEUROSCI.4526-04.2005) that a better estimate is 86 billion? Review: 10.1002/cne.24040 This seems to have been mentioned in that same brainfacts resource in 2018 www.brainfacts.org/in-the-lab/m...
RT @LucaAmb: Apparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct r…
RT @LucaAmb: Apparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct r…
RT @LucaAmb: Apparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct r…
RT @LucaAmb: Apparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct r…
Apparently the 10:1 ratio of glia to neurons in the human brain is just a very persistent scientific urban myth. The correct raio is about 1:1! https://t.co/RiQkw8wyvT… A good example of how much science is as vulnerable to unchecked rumors as any other human activity.
@astrocyteNet @LeaLilchen Just a comment. Despite being found in textbooks and articles, astrocytes do not appear to be the largest set of glial cells. https://t.co/boDUrnh7l1
@jonykipnis @BaptisteLacost3 Sorry... :) https://t.co/ilGHPShZw8 https://t.co/BQNxOB8Zjq
RT @amandameyerphd: There are LESS than 100 billion neurons in the human brain and there are slightly LESS glial cells compared to neurons!…
There are LESS than 100 billion neurons in the human brain and there are slightly LESS glial cells compared to neurons! #neuroanatomy https://t.co/6aXdqA9nDB https://t.co/c1vFkSBKgY
最近では、脳内の神経細胞は推定860億個、グリア細胞はそれとほぼ同じ850億個と推定されているらしい。 グリア細胞は、神経細胞の何十倍も多いと当たり前のように習っているけどアップデートが必要ですね...(これも古くなってる可能性あり) https://t.co/pHdsun0Ndj https://t.co/Vb9FOeaXZj
@BlancheEllisArt Aquí lo tienes. Es un descubrimiento genial de @suzanahh y su equipo en 2009 https://t.co/hupHqt8MTj Artículo de revisión: https://t.co/NRklvGGnTc
@AmarSahay_ Here it is: The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting. https://t.co/qcb69mhg6X
RT @MaraMather: Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that ar…
RT @MaraMather: Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that ar…
RT @MaraMather: Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that ar…
RT @MaraMather: Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that ar…
Apparently there are large individual differences in the number of neurons we each have - "a variance of more than eight times the variance of human body height" https://t.co/unH6okQySg
Turns out the 'fact' that there are many more glial cells than neurons in the brain is one of those textbook claims that are inaccurate. https://t.co/unH6okQySg
Counting neurons rather than sheeps to fall asleep tonight? http://onlinelibrary.wiley.com/doi/10.1002/cne.24040/abstract
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