September 2016 PMID 27219125

Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage.

Felipe Damas, Stuart M Phillips, Cleiton A Libardi, Felipe C Vechin, Manoel E Lixandrão, Paulo R Jannig, Luiz A R Costa, Aline V Bacurau, Tim Snijders, Gianni Parise, Valmor Tricoli, Hamilton Roschel, Carlos Ugrinowitsch

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Mentions

88
Peak: 12 in Nov 2024
across 5 sources since Mar 2019

Extended reach

654,241
potential audience

Total likes

6,981

Video views

147,147

Mentions per month

Mar 2019 – Sep 2025

Where it's discussed

  • X / Twitter51 posts
  • Facebook28 posts
  • News5 articles
  • YouTube3 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The overall tone reflects high interest and engagement, with examples like discussions on how muscle damage affects hypertrophy and the importance of attenuation over time, using precise scientific terminology to emphasize the relevance of these findings. Words like 'correlates,' 'attenuation,' and 'measurement' show an analytical and detailed approach, indicating these discussions could influence future research and fitness practices.

AgreementModerate agreement

Most discussions agree that muscle damage attenuation is crucial for hypertrophy, citing evidence that shows muscle growth correlates with reduced muscle damage after initial training phases.

InterestHigh interest

The topic of muscle protein synthesis and the effects of muscle damage garners high interest, with many social discussions referencing detailed mechanisms and long-term implications.

EngagementHigh engagement

Posts demonstrate deep engagement by referencing scientific studies, discussing measurement methods, and debating the relevance of various measures over different time frames.

ImpactModerate impact

While some see this as an important clarification in training protocols, the overall impact is moderate, influencing how trainers and scientists interpret muscle growth processes.

Top posts

Most liked on X and Bluesky
Brad Schoenfeld, PhD
@BradSchoenfeld · X

@SamaHoole Edema is a non-issue after a few weeks of training due to the repeated bout effect. Multiple lines of evidence showing no effect (e.g., https://t.co/gDWZHsrMk0; https://t.co/1VnSIITMRp; https://t.co/ZdileZeslS) You are getting your info from the wrong influencers

Sep 19, 2025 · 70 likes · 1 share · 95,597 followers View post →
Jozo Grgic
@Jozo_Grgic · X

Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage https://t.co/R9OjpovLCC

Jul 29, 2023 · 49 likes · 8 shares · 5,473 followers View post →
Jozo Grgic
@Jozo_Grgic · X

Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage https://t.co/R9Ojpowjsa https://t.co/RwoIZc9Wpe

Nov 13, 2024 · 43 likes · 13 shares · 5,473 followers View post →
Daniel Rowland
@dwrowland · X

Recovery to adapt to training: "We conclude that muscle hypertrophy is the result of accumulated intermittent changes in MyoPS post-RE in RT, which coincides with progressive attenuation of muscle damage." https://t.co/vLJI0iqPWk

Dec 4, 2024 · 17 likes · 2 shares · 6,467 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@DrMikeRoberts @AbigailMackey1 @kaesser @HornbergerLab True growth after 10wk. Anything early is confounded by edema in our view. https://t.co/xvyGLorKkb

Apr 25, 2021 · 10 likes · 2 shares · 55,987 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@rfloh @proftipper @NanciGuestRDPhD @RobMorton23 @SFZoe014 @meatiermcsorley @Nutradvance @AviBittMD MPS isn't strength. MPS is muscle, when measured appropriately https://t.co/f5JkKXklc8

Dec 12, 2020 · 9 likes · 2 shares · 55,987 followers View post →

All mentions

pitifulcmnd
@pitifulcmnd · X

RT @BradSchoenfeld: @SamaHoole Edema is a non-issue after a few weeks of training due to the repeated bout effect. Multiple lines of eviden…

Sep 19, 2025 · 1 share · 9 followers View post →
Brad Schoenfeld, PhD
@BradSchoenfeld · X

@SamaHoole Edema is a non-issue after a few weeks of training due to the repeated bout effect. Multiple lines of evidence showing no effect (e.g., https://t.co/gDWZHsrMk0; https://t.co/1VnSIITMRp; https://t.co/ZdileZeslS) You are getting your info from the wrong influencers

Sep 19, 2025 · 70 likes · 1 share · 95,597 followers View post →
tokatti
@tokatti_ · X

ダメージが多くても筋肉は増えなかった https://t.co/jsu7MB95Z8 2016年の実験 筋トレ初心者を対象にした トレーニングを開始してから3週間後は筋肉痛が多い方がタンパク質合成が増えたが、筋肉のダメージが治ったあとは全く関係がなくなった https://t.co/A6GnArHokr

May 19, 2025 · 178 followers View post →
João M
@nababu.toot.community.ap.brid.gy · Bluesky

Anti-inflamatório atrapalha a musculação? https://www.youtube.com/watch?v=-os4fi_5AJ0

Feb 3, 2025 View post →
Prof. Nasser Alzerwi
@NAlzerwi · X

RT @dwrowland: Recovery to adapt to training: "We conclude that muscle hypertrophy is the result of accumulated intermittent changes in M…

Dec 5, 2024 · 2 shares · 1,742 followers View post →
ionber
@ion_bermejo · X

RT @dwrowland: Recovery to adapt to training: "We conclude that muscle hypertrophy is the result of accumulated intermittent changes in M…

Dec 4, 2024 · 2 shares · 544 followers View post →
Daniel Rowland
@dwrowland · X

Recovery to adapt to training: "We conclude that muscle hypertrophy is the result of accumulated intermittent changes in MyoPS post-RE in RT, which coincides with progressive attenuation of muscle damage." https://t.co/vLJI0iqPWk

Dec 4, 2024 · 17 likes · 2 shares · 6,467 followers View post →
Joss
@JoselynNoriega1 · X

RT @Jozo_Grgic: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Nov 15, 2024 · 13 shares · 214 followers View post →
A. Noal
@riannoal · X

RT @Jozo_Grgic: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Nov 15, 2024 · 13 shares · 57 followers View post →
Roger Olsen
@ReineRoger · X

RT @Jozo_Grgic: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Nov 14, 2024 · 13 shares · 68 followers View post →
Javed Alam
@jalam1001 · X

Here are more detailed summaries, main findings, and conclusions based on the document: Article 1 Title: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage Authors: Felipe Damas, https://t.co/eCaCjWydep https://t.co/LT8GVaje12

Nov 14, 2024 · 993 followers View post →
Prof. Nasser Alzerwi
@NAlzerwi · X

RT @Jozo_Grgic: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Nov 14, 2024 · 13 shares · 1,742 followers View post →
YURI PAUCAR
@ypaucar · X

RT @Jozo_Grgic: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Nov 14, 2024 · 13 shares · 1,214 followers View post →
GDLeahy
@GDLeahy · X

RT @Jozo_Grgic: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Nov 14, 2024 · 13 shares · 680 followers View post →
William Amaral
@_sempreguica · X

RT @Jozo_Grgic: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Nov 14, 2024 · 13 shares · 122 followers View post →
Kristopher Mendes de Souza
@KristopherDoc · X

RT @Jozo_Grgic: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Nov 14, 2024 · 13 shares · 67 followers View post →
Zack
@keychupkicap · X

RT @Jozo_Grgic: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Nov 14, 2024 · 13 shares · 388 followers View post →
Abramo coach
@coach_abramo · X

RT @Jozo_Grgic: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Nov 14, 2024 · 13 shares · 74 followers View post →
Jozo Grgic
@Jozo_Grgic · X

Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage https://t.co/R9Ojpowjsa https://t.co/RwoIZc9Wpe

Nov 13, 2024 · 43 likes · 13 shares · 5,473 followers View post →
tokatti
@tokatti_ · X

筋肉痛が起きないようにする方法 身の丈に合った負荷で少しずつトレーニング量を増やすのが基本 https://t.co/A6GnArHokr #自分用メモ

Jul 7, 2024 · 178 followers View post →
Alex Leaf
@AlexJLeaf · X

@PlantBasedLift1 There is some evidence that shows MPS correlates to muscle growth, but only after 3 weeks of training. https://t.co/VQ541fffCt

Dec 20, 2023 · 1 like · 4,035 followers View post →
Lorenzo S.Wayne
@LorenzoSWayne · X

RT @Jozo_Grgic: Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Jul 30, 2023 · 8 shares · 51 followers View post →
andrea avila
@andrea_avilab · X

RT @Jozo_Grgic: Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Jul 30, 2023 · 8 shares · 340 followers View post →
Joe Collins
@JD_Collins7 · X

RT @Jozo_Grgic: Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Jul 30, 2023 · 8 shares · 340 followers View post →
Kate M.
@KateM000000 · X

RT @Jozo_Grgic: Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Jul 30, 2023 · 8 shares · 158 followers View post →
Dr. Michael Sagner, MD
@DrMichaelSagner · X

RT @Jozo_Grgic: Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Jul 30, 2023 · 8 shares · 5,359 followers View post →
Jeffery Heileson
@jheilesonRD · X

RT @Jozo_Grgic: Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Jul 30, 2023 · 8 shares · 805 followers View post →
Kineblasto
@Kineblasto · X

RT @Jozo_Grgic: Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Jul 29, 2023 · 8 shares · 111 followers View post →
Jozo Grgic
@Jozo_Grgic · X

Resistance training‐induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage https://t.co/R9OjpovLCC

Jul 29, 2023 · 49 likes · 8 shares · 5,473 followers View post →
Jacob Rauch
@JTRAUCH · X

Links to some of the papers discussed: https://t.co/dzBmbjc67Z https://t.co/fFikEETBPd

May 26, 2023 · 1 like · 400 followers View post →
Poole Fitness
@PooleFitness · X

@orth0girl Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect PMID: 27782911 Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage PMID: 27219125

May 9, 2023 · 110 followers View post →
Poole Fitness
@PooleFitness · X

@ChumaFitness Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect PMID: 27782911 Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage PMID: 27219125

May 6, 2023 · 110 followers View post →
Grayson Smith
@JWL63 · X

@Naomi_D_Harvey @ChrisMasterjohn @RBImGuy Often see an exaggerated response with increase inflammatory markers, muscle damage, etc. Only to see that response be down regulated & show benefits many weeks later. https://t.co/HJRNBhZotd

Mar 4, 2023 · 77 followers View post →
Henning Langer
@HenningLanger · X

Stu, any chance you have some biopsy samples left from this one you want to send me?

Dec 23, 2022 · 1,710 followers View post →
Jimmy
@dwightnyamouth · X

@DylanSpina61 https://t.co/tZjU3Xcgwi

Jun 11, 2022 · 109 followers View post →
Training Well | TE AYUDO A CAMBIAR TU FISICO
@TrainingWellOfi · X

Destacando que, un excesivo daño muscular puede reducir el crecimiento muscular.

Apr 23, 2022 · 40 followers View post →
Saburo Hagihara
@saburo_hagihara · X

別の研究では、 全く逆の結論に至っているものを見つけました。 これは、研究している手段が違いから、それぞれ出した結果から基づく結論が全く違うことになったのかなと思います。 色々と出てくる情報をしっかり自分なりに噛み砕いて、精査する必要は常にあります。 https://t.co/sZlAlt8nzb

Nov 12, 2021 · 2 likes · 158 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@JohnG_UK @Alecsplaining @ScepticalDoctor @DrMauricioGon @DBelardoMD @DrOstfeld This paper https://t.co/et93CMYrcc was a measurement made over weeks My reference was to a paper showing that measurements made over days are much more reflective of what happens long-term https://t.co/7ucvWL8uu3 so the 6h paper is not relevant here

Oct 21, 2021 · 3 likes · 55,987 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@ScepticalDoctor @Alecsplaining @JohnG_UK @DrMauricioGon @DBelardoMD @DrOstfeld If we'd made acute measure of MPS that paper would be relevant, but that's not what was done: https://t.co/7ucvWL8uu3

Oct 21, 2021 · 2 likes · 55,987 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @mackinprof: @DrMikeRoberts @AbigailMackey1 @kaesser @HornbergerLab True growth after 10wk. Anything early is confounded by edema in our…

Apr 25, 2021 · 2 shares · 404 followers View post →
Abigail Mackey
@AbigailMackey1 · X

RT @mackinprof: @DrMikeRoberts @AbigailMackey1 @kaesser @HornbergerLab True growth after 10wk. Anything early is confounded by edema in our…

Apr 25, 2021 · 2 shares · 3,711 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@DrMikeRoberts @AbigailMackey1 @kaesser @HornbergerLab True growth after 10wk. Anything early is confounded by edema in our view. https://t.co/xvyGLorKkb

Apr 25, 2021 · 10 likes · 2 shares · 55,987 followers View post →
Dr. Myohead
@DrMyohead · X

@grassfedscott Why would MUSCLE protein synthesis track with LBM? Certainly evidence integrated MPS is related to MUSCLE hypertrophy: https://t.co/PRjWfWwt8L Tags for more experts: @mackinprof @proftipper @OllyWitard @LeighBreen @JornTrommelen @saraoikawa @vanvlietphd @BenjaminTWall

Mar 16, 2021 · 6 likes · 1 share · 2,644 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @mackinprof: @rfloh @proftipper @NanciGuestRDPhD @RobMorton23 @SFZoe014 @meatiermcsorley @Nutradvance @AviBittMD MPS isn't strength. MPS…

Mar 1, 2021 · 2 shares · 1,367 followers View post →
Kevin Tipton
@proftipper · X

RT @mackinprof: @rfloh @proftipper @NanciGuestRDPhD @RobMorton23 @SFZoe014 @meatiermcsorley @Nutradvance @AviBittMD MPS isn't strength. MPS…

Dec 13, 2020 · 2 shares · 18,252 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@rfloh @proftipper @NanciGuestRDPhD @RobMorton23 @SFZoe014 @meatiermcsorley @Nutradvance @AviBittMD MPS isn't strength. MPS is muscle, when measured appropriately https://t.co/f5JkKXklc8

Dec 12, 2020 · 9 likes · 2 shares · 55,987 followers View post →
EskeleThor
@EskeleThor · X

RT @Jozo_Grgic: Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after atte…

Jan 9, 2020 · 1 share · 405 followers View post →
Jozo Grgic
@Jozo_Grgic · X

Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage. https://t.co/d8q3xD1fUT

Jan 9, 2020 · 4 likes · 1 share · 5,473 followers View post →
DimeComoSea
@DimeComoSea · X

A todos nos han dicho que "si no duele no sirve" pero ¿realmente eso es verdad? https://t.co/0ixcGGVqBj

Oct 31, 2019 · 3,152 followers View post →
Docteur Fitness
@DocteurFitness · X

Étude examinée : Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage. #Physiologie #Prendredumuscle #musculation #fitfrenchies #fitness #fitgirl #fitnessgirl https://t.co/oujXgOpBLj https://t.co/Xuhi9mdKVT

Sep 13, 2019 · 112 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@kevinnbass @NanciGuestRDPhD @dougkalmanphdrd @DJGolf272 @DStanTheMc @LSpriet @JohnAHawley @LouiseMBurke https://t.co/xvyGLorKkb

Jul 20, 2019 · 2 likes · 55,987 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

@p70S6K Plus the subjects in this study were not very trained, but trained nonetheless https://t.co/x7TnkYZNGU and it only takes 5 bouts of RE for a strong correlation to emerge between MPS and hypertrophy: https://t.co/xvyGLorKkb

Mar 6, 2019 · 55,987 followers View post →