Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate.
Sama F Sleiman, Jeffrey Henry, Rami Al-Haddad, Lauretta El Hayek, Edwina Abou Haidar, Thomas Stringer, Devyani Ulja, Saravanan S Karuppagounder, Edward B Holson, Rajiv R Ratan, Ipe Ninan, Moses V Chao
June 2016Synopsis of Social media discussions
The collective comments demonstrate high agreement and curiosity regarding how exercise elevates BDNF via β-hydroxybutyrate, with posts referencing detailed mechanisms like HDAC inhibition and neurotransmitter release, illustrating both scientific engagement and enthusiasm for the topic.
Agreement
Strong agreementMost discussions strongly support the article's claims, emphasizing the beneficial role of exercise and ketone bodies in brain health.
Interest
High level of interestPosts show high interest by exploring detailed mechanisms and asking questions about broader implications.
Engagement
High engagementMany users engage deeply by referencing specific studies, discussing molecular pathways, and sharing related personal insights.
Impact
Moderate level of impactThe discussions highlight significant potential for influence on health practices and scientific understanding, though some debate remains about the practical application.
Social Mentions
YouTube
2 Videos
29 Posts
39 Posts
Blogs
10 Articles
News
188 Articles
Metrics
Video Views
794
Total Likes
65
Extended Reach
282,202
Social Features
268
Timeline: Posts about article
Top Social Media Posts
JT | Jerry Teixeira
Many prefer to not eat low carb, but you can still get the health benefits of ketone bodies through exercise without “eating keto”
We know exercise has myriad health benefits
How many come from exercise enduced ketone production?
Here is one
view full post
VT LG56
Source 4: Jiménez-Maldonado et al. 2014 (PLOS ONE) – https://t.co/r7X122jFBu
Source 5: Sleiman et al. 2016 (eLife) – https://t.co/RAzeUDjuSr
Source 6: Niemann et al. 2014 (Frontiers in Aging Neuroscience) – https://t.co/G7gXecTZm6
view full post
Dr Mark D'Arcy
An interesting mechanism that seems to show that BDNF (brain derived growth factor), which improves neuronal connectivity (brain health), is stimulated by β-hydroxybutyrate. This is produced during exercise or when engaging in a ketogenic diet #Science
https://t.co/nk4BpPrd4i
view full post
Nick Norwitz MD PhD
@KetoCarnivore @upyrbike @HermanPontzer @Travis_Statham @TuckerGoodrich @paulmelzer1 @throwingspears @LowCarbVet @p70S6K @bendormiki @CarnivoreMD @KenDBerryMD @DrPaulMason @SBakerMD @KetoDocCLT @KevinH_PhD @ProfTimNoakes @Ad_SotoMota @vybarr @Kevin65379773 This is best paper on the topic, in my opinion https://t.co/T2Z4FCfQdf
Mice expirements --> Exercise elevates circulating ketones. ketones HDAC2 and HDAC3 and, thereby, induces BDNF gene expression in the hippocampus. ...
view full post
Dr. Myohead
@B_Holmer @JWLevitt I got down this rabbit hole in the PhD. I think it might have to do with β-hydroxybutyrate inducing BDNF in the hippocampus
Fascinating topic in general
See here:
https://t.co/9GX5QP1qhc
https://t.co/7bs3stufXR
view full post
Posts referencing the article
Exploring the Impact of Exercise on Mental Health
This video investigates the release of hormones and neurotransmitters in the brain during physical activity, highlighting their roles in mood enhancement and stress reduction. Group members Hanna Tilahun Solomon, Jenny Lu, Maryam Qader, and Aya dive into key physiological responses.
August 23, 2024
726 views
Understanding the Link Between the Ketogenic Diet and Brain Health Improvements
The ketogenic diet benefits cognition by increasing ketone availability and reducing inflammation, potentially improving brain function and neuroprotection.
November 7, 2023
68 views
-
Source 4: Jiménez-Maldonado et al. 2014 (PLOS ONE) – https://t.co/r7X122jFBu Source 5: Sleiman et al. 2016 (eLife) – https://t.co/RAzeUDjuSr Source 6: Niemann et al. 2014 (Frontiers in Aging Neuroscience) – https://t.co/G7gXecTZm6
view full postSeptember 12, 2025
11
-
Dr. Myohead
@DrMyohead (Twitter)@B_Holmer @JWLevitt I got down this rabbit hole in the PhD. I think it might have to do with β-hydroxybutyrate inducing BDNF in the hippocampus Fascinating topic in general See here: https://t.co/9GX5QP1qhc https://t.co/7bs3stufXR
view full postMarch 16, 2024
3
-
タローマン
@tomo_pika0217 (Twitter)Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate https://t.co/qLZNtQgeJB
view full postNovember 16, 2023
-
Jonathan Ruiz (Taylor's Version)
@ruizjc99 (Twitter)@hugocorralesMD Además, hay que insistir en que la actividad física sea agradable para quien la realiza. Múltiples estudios en animales y humanos sobre los efectos del ejercicio muestran resultados dispares cuando esta actividad es voluntaria o no. Aquí un ejemplo: https://t.co/aJ5InD1PqZ
view full postSeptember 27, 2023
-
Pan Janek
@psych_janek (Twitter)@wszczeklik @Igor_psycholog Aktywność fizyczna również dobrze wpływa na głowę, zwiększa BDNF,a na starość jest czynnikiem chroniącym przed otępieniem. Ale trening poznawczy też zwiększa BDNF.
view full postAugust 16, 2023
1
-
Christos Tsakmakis
@khristaki (Twitter)Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate https://t.co/hZflp5FwGM
view full postJanuary 20, 2023
-
@Orlando_uy (Twitter)Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. https://t.co/jaUpKqMEJg
view full postJanuary 11, 2023
-
Erin H
@erin0567 (Twitter)#Exercise promotes the expression of Brain Derived Neurotrophic Factor (BDNF) which plays an important role in neuronal survival and growth. https://t.co/BE1SaPoE52
view full postSeptember 6, 2022
1
-
david p
@deyanp1 (Twitter)Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate https://t.co/4n31YO3RsP
view full postFebruary 2, 2022
-
Manga Panel
@nEmezyz_bytes (Twitter)menarique, olahrga bisa bikin peningkatan kognisi? jadi sebelum belajar jngan lupa angkat bban dlu wkwk.clear mistrinya Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate https://t.co/Em5IWR4vyW
view full postOctober 25, 2021
-
ingeborg oppenheimer
@ingeoppenheimer (Twitter)interested in the p's and q's behind the mental benefits of regular working out? read this LENGTHY article: Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate https://t.co/ce8CtDMYU0
view full postJune 5, 2021
1
-
Inwazja Śrubek
@ISrubek (Twitter)@CSwiata Aktywność fizyczna zwiększa produkcję kwasu 3-hydroksymasłowego w wątrobie, ten wraz z krwiobiegiem dostaje się do mózgu i hamuje pewną deacetylazę histonową, której rolą jest hamowanie ekspresji genu BDNF. Przynajmniej u myszy. https://t.co/v2woL3vv0C
view full postMay 28, 2021
1
-
Neurometabolism
@Neurometabolis1 (Twitter)RT @markoftheD: An interesting mechanism that seems to show that BDNF (brain derived growth factor), which improves neuronal connectivity (…
view full postMay 3, 2021
5
-
Richard Halliwell
@rmthalliwell (Twitter)RT @markoftheD: An interesting mechanism that seems to show that BDNF (brain derived growth factor), which improves neuronal connectivity (…
view full postMay 2, 2021
5
-
koheitag ᴾʳᵒᵒᶠ of staying for all ⁷
@GentTracy (Twitter)RT @markoftheD: An interesting mechanism that seems to show that BDNF (brain derived growth factor), which improves neuronal connectivity (…
view full postMay 2, 2021
5
-
Dr Mark D'Arcy
@markoftheD (Twitter)RT @markoftheD: An interesting mechanism that seems to show that BDNF (brain derived growth factor), which improves neuronal connectivity (…
view full postMay 2, 2021
5
-
Nicholas Shaw
@Lambdoid (Twitter)RT @markoftheD: An interesting mechanism that seems to show that BDNF (brain derived growth factor), which improves neuronal connectivity (…
view full postMay 1, 2021
5
-
Dr Mark D'Arcy
@markoftheD (Twitter)An interesting mechanism that seems to show that BDNF (brain derived growth factor), which improves neuronal connectivity (brain health), is stimulated by β-hydroxybutyrate. This is produced during exercise or when engaging in a ketogenic diet #Science https://t.co/nk4BpPrd4i
view full postMay 1, 2021
9
5
-
Integrated Manual Medicine UK ltd
@immltduk (Twitter)Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate https://t.co/TWLdbdscFI
view full postApril 4, 2021
-
Rene Sugar
@renesugar (Twitter)Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate https://t.co/FXKxqaHNO8 "β-hydroxybutyrate causes an increase in neurotransmitter release, which is dependent upon the TrkB receptor."
view full postMarch 27, 2021
-
Rene Sugar
@renesugar (Twitter)Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate https://t.co/FXKxqaHNO8 "action of β-hydroxybutyrate is specifically upon HDAC2 and HDAC3, which act upon selective Bdnf promoters."
view full postMarch 27, 2021
-
DesignedByNature
@DesignedNature (Twitter)I just posted "Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate (2016)" on Reddit https://t.co/rJfGUnBiPX
view full postMarch 23, 2021
-
Akshay D
@Akshz13 (Twitter)@pankaj https://t.co/Jamp6sTGIs
view full postFebruary 18, 2021
1
-
Kevin
@Kevindanielpg (Twitter)RT @AKA_Sadrien: @jerryteixeira "Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ket…
view full postDecember 23, 2020
2
-
melissa
@melisssav_xo (Twitter)RT @AKA_Sadrien: @jerryteixeira "Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ket…
view full postNovember 20, 2020
2
-
@AKA_Sadrien (Twitter)@jerryteixeira "Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate" https://t.co/h12jgXzuNH
view full postNovember 20, 2020
3
2
-
Nick Norwitz MD PhD
@nicknorwitz (Twitter)@KetoCarnivore @upyrbike @HermanPontzer @Travis_Statham @TuckerGoodrich @paulmelzer1 @throwingspears @LowCarbVet @p70S6K @bendormiki @CarnivoreMD @KenDBerryMD @DrPaulMason @SBakerMD @KetoDocCLT @KevinH_PhD @ProfTimNoakes @Ad_SotoMota @vybarr @Kevin65379773 This is best paper on the topic, in my opinion https://t.co/T2Z4FCfQdf Mice expirements --> Exercise elevates circulating ketones. ketones HDAC2 and HDAC3 and, thereby, induces BDNF gene expression in the hippocampus. ...
view full postJune 28, 2020
5
-
@AKA_Sadrien (Twitter)@wellboy Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate https://t.co/LLy3pANGvF https://t.co/KMnX6Z5cIO
view full postSeptember 23, 2019
1
-
@AKA_Sadrien (Twitter)@AntoineJonatha5 @gthomas_ssb @Dick_Muller @HodkinsonAlice @Sugar51976529 @tkilgour11 @carrieph2 @ProfTimNoakes @zoeharcombe @Riverpixie1 @VTLandau @imsiddharthm @bigfatsurprise @DrAseemMalhotra @aarc_tweets @PulmonaryNews @RobertLustigMD @KenDBerryMD @FatEmperor "Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate" https://t.co/LLy3pANGvF
view full postSeptember 1, 2019
1
-
@AKA_Sadrien (Twitter)https://t.co/mVvDjIYgQe "Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate" https://t.co/ruKAso8v5V "Modulation of Autophagy by BDNF Underlies Synaptic Plasticity" https://t.co/4E23SnltmT
view full postAugust 23, 2019
-
AllIn Computer (Esther)
@estocanam2 (Twitter)Exercise promotes the expression of the brain derived neurotrophic factor (BDNF) https://t.co/tUkHP29kfa https://t.co/KHAAlKkCk8
view full postAugust 21, 2019
-
Mass Migration
@BChinatti (Twitter)Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate. https://t.co/K5xEYPnCtX
view full postAugust 18, 2019
1
-
Chuy Garza
@Chuygzaa (Twitter)"Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate"(Sleiman 2016). What this basically means is that #exercise + #ketosis promotes the growth of new brain cells. Exercise and diet make you smarter!
view full postAugust 6, 2019
1
-
Vet Goed
@VetGoed (Twitter)RT @jerryteixeira: Many prefer to not eat low carb, but you can still get the health benefits of ketone bodies through exercise without “ea…
view full postJuly 20, 2019
3
-
Kate Dringman
@k8sdream (Twitter)RT @jerryteixeira: Many prefer to not eat low carb, but you can still get the health benefits of ketone bodies through exercise without “ea…
view full postJuly 19, 2019
3
-
Ana Cláudia
@Anawsantos (Twitter)RT @jerryteixeira: Many prefer to not eat low carb, but you can still get the health benefits of ketone bodies through exercise without “ea…
view full postJuly 18, 2019
3
-
JT | Jerry Teixeira
@jerryteixeira (Twitter)Many prefer to not eat low carb, but you can still get the health benefits of ketone bodies through exercise without “eating keto” We know exercise has myriad health benefits How many come from exercise enduced ketone production? Here is one
view full postJuly 18, 2019
20
3
-
alan
@alangarciaexe (Twitter)https://t.co/OqzKJGrqrQ
view full postJune 18, 2019
-
Bayard T. Horton
@bayard_horton (Twitter)#Exercise promotes the expression of brain derived neurotrophic factor (#BDNF) through the action of the #ketone body β-hydroxybutyrate. https://t.co/FqHsabZINV https://t.co/xJG7CRxCcL
view full postJanuary 10, 2019
Abstract Synopsis
- Exercise promotes brain health by increasing BDNF, a protein linked to improved cognition and reduced depression and anxiety.
- The specific ways that exercise boosts BDNF gene expression are not well understood, but recent findings suggest that the metabolite β-hydroxybutyrate released during prolonged exercise may play a key role.
- β-hydroxybutyrate enhances BDNF activity by targeting specific histone deacetylases (HDAC2 and HDAC3) and is linked to increased neurotransmitter release, indicating a natural mechanism through which exercise benefits brain function.
VT LG56
@lowgravity56 (Twitter)