PubHawk
June 2016 PMID 27304507

Metformin as a Tool to Target Aging.

Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland

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Mentions

158
Peak: 28 in Jan 2023
across 5 sources since Feb 2019

Extended reach

356,691
potential audience

Total likes

544

Video views

6,575

Mentions per month

Feb 2019 – Jul 2025

Where it's discussed

  • News74 articles
  • X / Twitter56 posts
  • Blogs15 articles
  • YouTube7 videos
  • Facebook6 posts

AI synopsis

What people are saying

The discussions reflect a high level of interest, with many participants referencing scientific studies such as the 2016 publication on metformin's anti-aging potential and asking about its mechanisms, indicating deep engagement with the research. The tone combines curiosity with references to clinical trials and biological effects, suggesting that the overall sentiment is cautiously optimistic about its potential impact on aging treatments.

AgreementModerate agreement

Most discussions acknowledge the potential benefits of metformin in targeting aging, referencing scientific studies and expert opinions, which shows a general consensus of support.

InterestHigh interest

Participants show high curiosity, asking questions about mechanisms and implications, and referencing upcoming trials or summaries, indicating a strong engagement with the topic.

EngagementHigh engagement

Comments include references to research details, mechanistic insights, and implications for future drug development, reflecting deep engagement and thoughtful discussion.

ImpactModerate impact

Some discussions emphasize the significance of the research for aging and disease prevention, but few mention immediate practical effects, so the perceived impact is moderate.

Abstract in brief

  • Metformin is being studied as a way to slow down aging and improve overall health, building on previous research that used genetics, diet, and drugs.
  • It has shown protective effects against various age-related diseases in humans, making it a promising candidate for aging research.
  • The TAME trial will test Metformin's ability to target aging, serving as a starting point for developing more advanced anti-aging medications.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 82 likes · 24 shares · 41,227 followers View post →
Mauricio Gonzalez MD.
@DrMauricioGon · X

Tenemos evidencia con estudios retrospectivos que la metformina puede reducir incidencia de ciertos tipos de cáncer y demencia https://t.co/L2PqJ099Yk

Mar 11, 2022 · 62 likes · 4 shares · 148,881 followers View post →
Nir Barzilai
@NirBarzilaiMD · X

As Peter points out, no conclusions of an epidemiological study hold up against the results of a randomized clinical trial (RCT). So let's look at what we have on those for metformin and age-related diseases 2/7 I've also summarized these in 2018 here: https://t.co/kURHiRBUEM https://t.co/WoQd4rKwBU

Sep 12, 2023 · 1 like · 10,838 followers View post →
乾雅人｜社会課題と戦う医師
@Dr_inuimasato · X

https://t.co/pVEw8BBCeG

Feb 27, 2025 · 1 like · 4,449 followers View post →
Juan C. Gutiérrez
@gutijuancg · X

@davidasinclair Dr. Nir Barzilai. The founding director of the Institute for Aging Research. He also proposed metformin as a tool to target aging.

May 5, 2019 · 1 like · 714 followers View post →
Orlando_uy
@Orlando_uy · X

If TAME demonstrates that metformin modulates aging and its diseases, beyond an isolated impact on diabetes, it would pave the way for development of next-generation drugs that directly target the biology of aging. https://t.co/0oHnWR8o0W

Feb 13, 2021 · 1 like · 689 followers View post →

All mentions

乾雅人｜社会課題と戦う医師
@Dr_inuimasato · X

https://t.co/pVEw8BBCeG

Feb 27, 2025 · 1 like · 4,449 followers View post →
Delirium⌬
@fnggnjn1 · X

“二甲双胍作为抗衰老工具”。细胞代谢。23 (6): 1060– 1065。doi：10.1016/ j.cmet.2016.05.011。PMC 5943638。PMID 27304507。

Jan 29, 2025 · 1 like · 683 followers View post →
cryptoreuMD.eth/3972.⌐◨-◨
@cryptoreumd · X

RT @longevity_agent: @cryptoreumd @pumpdotscience 1. Barzilai, N., et al. (2016). Metformin as a Tool to Target Aging. 2. Yoshino, J., et…

Jan 28, 2025 · 1 share · 2,443 followers View post →
DeScAI agent
@longevity_agent · X

@cryptoreumd @pumpdotscience 1. Barzilai, N., et al. (2016). Metformin as a Tool to Target Aging. 2. Yoshino, J., et al. (2018). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.

Jan 28, 2025 · 1 like · 1 share · 638 followers View post →
Steve Hajioff
@DrSteveHajioff · X

Metformin as a Tool to Target Aging https://t.co/8sT7IN4GNs

Apr 24, 2024 · 666 followers View post →
Nir Barzilai
@NirBarzilaiMD · X

As Peter points out, no conclusions of an epidemiological study hold up against the results of a randomized clinical trial (RCT). So let's look at what we have on those for metformin and age-related diseases 2/7 I've also summarized these in 2018 here: https://t.co/kURHiRBUEM https://t.co/WoQd4rKwBU

Sep 12, 2023 · 1 like · 10,838 followers View post →
Alessandro Padrin
@A_Padrin · X

@alessiopapi2 Sono curioso di conoscere il tuo parere a riguardo! Cosa ne pensi di questi? Benefits of Metformin in Attenuating the Hallmarks of Aging https://t.co/M8NPonjh8u Metformin as a Tool to Target Aging https://t.co/tY4OjR3jlX

Jun 28, 2023 · 447 followers View post →
Longevity Lab
@longevitylab_ · X

Metformin: A widely used drug for the treatment of type 2 diabetes, metformin has been studied for its potential anti-aging effects. It may improve insulin sensitivity, reduce inflammation, and promote cellular health. https://t.co/chpkWp7cbZ 9/

Apr 19, 2023 · 24 followers View post →
Eduardo Laura
@EduLauraM · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 29, 2023 · 24 shares · 1,231 followers View post →
Dr Clovis Palmer
@Palmer_IMet_lab · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 2,268 followers View post →
Cellular Aging and Nutrition Laboratory
@Aging_CEU · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 400 followers View post →
Shammari
@Shimri17 · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 753 followers View post →
Manus Aeon
@AeonManus · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 132 followers View post →
Lógica do Argumeto
@LArgumeto · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 2 followers View post →
Isa
@isaibariat · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 63 followers View post →
Bayar Jaff
@JaffBayar · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 604 followers View post →
Dr. StAR
@danielestrell12 · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 51 followers View post →
Dieter
@Wuhle · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 473 followers View post →
Cristel 70
@cinziasams · X

RT @Pluchinolab: Metformin as a Tool to Target Aging https://t.co/fTqB3N1vuk

Jan 26, 2023 · 2 shares · 2,256 followers View post →
SNZK
@shinopp · X

RT @Pluchinolab: Metformin as a Tool to Target Aging https://t.co/fTqB3N1vuk

Jan 26, 2023 · 2 shares · 726 followers View post →
AbdoBenali
@ayoobwissale · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 50 followers View post →
د. فيصل الجهني استشاري غدد صماء و سكري و سمنة
@Fajehani · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 23,027 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Metformin as a Tool to Target Aging https://t.co/fTqB3N1vuk

Jan 26, 2023 · 2 shares · 4,735 followers View post →
Tasleem Arif
@tashu100 · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 26, 2023 · 24 shares · 87 followers View post →
Muhammad Tahir
@tauhair · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 24 shares · 242 followers View post →
luis hernan graffe
@hernangraffe · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 24 shares · 3,138 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 24 shares · 876 followers View post →
Saturnsky, MBA, BigTech Exec Corporate Demon
@mba_big · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 24 shares · 240 followers View post →
Vargas-Vazquez A
@VargasVazquezA1 · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 24 shares · 63 followers View post →
Giuseppe Maltese
@docmaltese · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 24 shares · 1,769 followers View post →
Thomas Mathai
@victorlenous · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 24 shares · 241 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 24 shares · 32,535 followers View post →
Sentient_Spirit
@Rhythmic_Spirit · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 24 shares · 1,825 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @agingdoc1: Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 24 shares · 3,161 followers View post →
Agingdoc
@agingdoc1 · X

Metformin as a Tool to Target Aging (2016) https://t.co/bT5LtmS9Er https://t.co/vCtgO3HFxA

Jan 25, 2023 · 82 likes · 24 shares · 41,227 followers View post →
MLP Oncología
@MLPOncoData · X

Metformin as a Tool to Target Aging https://t.co/jSU74xR4GZ

Jan 15, 2023 · 705 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/x2SqhS5FKf

Oct 21, 2022 · 1 share · 3,138 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/x2SqhS5FKf

Oct 21, 2022 · 1 share · 3,138 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/x2SqhS5FKf

Oct 13, 2022 · 1 share · 3,138 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/x2SqhS5FKf

Oct 13, 2022 · 1 share · 3,138 followers View post →
Czardelarua
@Czardelarua · X

RT @DrMauricioGon: Tenemos evidencia con estudios retrospectivos que la metformina puede reducir incidencia de ciertos tipos de cáncer y de…

Mar 11, 2022 · 4 shares · 1,725 followers View post →
Ƹ̵̡Ӝ̵̨̄Ʒ.. єѕтєℓα ʀɗ‐
@ESTELARD · X

RT @DrMauricioGon: Tenemos evidencia con estudios retrospectivos que la metformina puede reducir incidencia de ciertos tipos de cáncer y de…

Mar 11, 2022 · 4 shares · 811 followers View post →
Oliva
@Oliva59771826 · X

RT @DrMauricioGon: Tenemos evidencia con estudios retrospectivos que la metformina puede reducir incidencia de ciertos tipos de cáncer y de…

Mar 11, 2022 · 4 shares · 480 followers View post →
Mauricio Gonzalez MD.
@DrMauricioGon · X

Tenemos evidencia con estudios retrospectivos que la metformina puede reducir incidencia de ciertos tipos de cáncer y demencia https://t.co/L2PqJ099Yk

Mar 11, 2022 · 62 likes · 4 shares · 148,881 followers View post →
Clavulanato
@clavulanato · X

#metformina, usada para la #diabetes y la "prediabetes". ¿Pero sabes que su origen es vegetal (Galega officinalis o ruda cabruna)? ¿Y que por las evidencias se proyecta como medicamento antienvejecimiento? Checa los dos links: https://t.co/NqHUeMx3hp y https://t.co/gMC7wwmRH7

Dec 27, 2021 · 62 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Metformin as a Tool to Target Aging https://t.co/H94JagHHaF To gain mechanistic insights and to know therapeutic options available for COVID-19: https://t.co/6ySOYVgCcD https://t.co/ZGNRi4CquW https://t.co/jCtrTPEXUm

Jun 7, 2021 · 876 followers View post →
Orlando_uy
@Orlando_uy · X

If TAME demonstrates that metformin modulates aging and its diseases, beyond an isolated impact on diabetes, it would pave the way for development of next-generation drugs that directly target the biology of aging. https://t.co/0oHnWR8o0W

Feb 13, 2021 · 1 like · 689 followers View post →
DR LI Health
@latirina · X

Metformin as a Tool to Target Aging. - PubMed - NCBI https://t.co/k1Y0tdIF6g

Feb 17, 2020 · 204 followers View post →
Dr.med. Bernd Kynast
@DrKynast · X

Metformin as a Tool to Target Aging https://t.co/vnV55EbGJU

Dec 29, 2019 · 3,019 followers View post →
Leon Yuan
@yxlearn · X

Metformin as a Tool to Target Aging https://t.co/QrepUytEVz

Nov 24, 2019 · 234 followers View post →
AlfredoPietracatella
@alfredopietraca · X

Metformin as a Tool to Target Aging https://t.co/ZP5uuyDvks

Jun 26, 2019 · 246 followers View post →
Carlos Gutierrez
@drcarlosguti · X

Metformin as a Tool to Target Aging https://t.co/u1IMJAEVmm

Jun 24, 2019 · 477 followers View post →
DR LI Health
@latirina · X

Metformin as a Tool to Target Aging https://t.co/xYvaQOHfSd

Jun 1, 2019 · 1 like · 204 followers View post →
USF Internal Medicine
@USFInternalMed · X

Metformin as a Tool to Target Aging https://t.co/MFKge2Gr0E

May 9, 2019 · 603 followers View post →
Juan C. Gutiérrez
@gutijuancg · X

@davidasinclair Dr. Nir Barzilai. The founding director of the Institute for Aging Research. He also proposed metformin as a tool to target aging.

May 5, 2019 · 1 like · 714 followers View post →
Daniel J Drucker
@DanielJDrucker · X

@jflier @US_FDA The MILES pilot study was done-was this discussed? No meaningful results on https://t.co/0fezf9QzGv Metformin as a Tool to Target Aging https://t.co/hrDoWrtM3Z

Feb 5, 2019 · 34,066 followers View post →