How does adenosine control neuronal dysfunction and neurodegeneration?

Rodrigo A Cunha

December 2016

Synopsis of Social media discussions

The overall discussions are primarily centered around general topics such as coffee and neurociencia, with phrases like 'nos despierta el café,' indicating a casual tone and surface-level engagement that do not delve into the scientific complexities of adenosine's role in neurodegeneration.

A
Agreement
 Neither agree nor disagree

The discussions do not show a clear stance of agreement or disagreement with the publication, as they do not directly address the study's findings.

I
Interest
 Neutral level of interest

Participants seem only mildly interested, focusing instead on unrelated topics like coffee and its effects on the brain.

E
Engagement
 Low engagement

Engagement is minimal, with some posts dismissive or tangential, indicating superficial interaction rather than deep analysis.

I
Impact
 Low level of impact

The overall discussions appear to have little influence on advancing understanding or significance of the research findings.

Social Mentions

YouTube

2 Videos

Facebook

2 Posts

Twitter

9 Posts

News

3 Articles

Metrics

Video Views

17,358

Total Likes

1,000

Extended Reach

49,476

Social Features

16

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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Neurochemical Basis of Coffee's Wake-Up Effect Explained

This video explores the neuroscience behind why coffee awakens us by examining how caffeine impacts brain activity, focusing on adenosine's role in regulating neuronal function and neuroprotection.

Cerebrotes

March 4, 2022

15,327 views

Does Coffee Consumption Reduce Brain Grey Matter and Impact Sleep?

Does Coffee Consumption Reduce Brain Grey Matter and Impact Sleep?

Coffee reduces brain grey matter but does not harm sleep, according to a recent study. Explore how caffeine affects brain health and the balance of neural activity, with insights from a scientist and a layperson.

Cientística & Podcast Naruhodo

March 9, 2021

2,031 views

  • Cerebrotes
    @Cerebrotes (Twitter)

    Seguimos hablando de por qué nos despierta el #café: https://t.co/FtkFQQjnus https://t.co/YS0FHB5vYC
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    January 1, 2023

    2

  • Marisa Alonso Nuñez
    @lualnu10 (Twitter)

    RT @Cerebrotes:
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    March 9, 2022

    7

  • Mentes Covalentes
    @covalmentes (Twitter)

    RT @Cerebrotes:
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    March 5, 2022

    7

  • Ammu Neuroscience
    @ammuneuroscien2 (Twitter)

    RT @Cerebrotes:
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    March 5, 2022

    7

  • Διομήδης
    @BVoevodsky (Twitter)

    RT @Cerebrotes:
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    March 4, 2022

    7

  • Alternancia_en_el_juego
    @AlternanciaJ (Twitter)

    RT @Cerebrotes:
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    March 4, 2022

    7

  • Cerebrotes
    @Cerebrotes (Twitter)

    RT @Cerebrotes:
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    March 4, 2022

    7

  • Metsuke (めつけ)
    @metsuke (Twitter)

    Cerebrotes en YT: ¿Por qué nos despierta el café? https://t.co/HpIY5vDKpJ ( Por qué nos despierta el café? - En este vídeo hablo de la neurociencia detrás de los efectos de la cafeína en el cerebro.)
    view full post

    March 4, 2022

  • Cerebrotes
    @Cerebrotes (Twitter)


    view full post

    March 4, 2022

    26

    7

Abstract Synopsis

  • Adenosine in the brain primarily regulates neuronal activity by activating inhibitory A1 receptors (A1R) and facilitatory A2 receptors (A2R), helping to control excitatory signals and support synaptic plasticity.
  • During brain injury or stress, large amounts of adenosine are released, which can initially protect neurons by limiting damage, but prolonged activation of A2Rs may increase brain damage, meaning that balancing A1R and A2R activity is crucial for neuroprotection.
  • The functions and signaling pathways of adenosine receptors are complex and diverse, involving various G proteins and noncanonical pathways, making it important to carefully modulate these receptors to maximize neuroprotection and prevent damage in conditions like epilepsy, depression, Alzheimer’s, or Parkinson’s disease.]