Nat Genet September 2016 PMID 27455349

A thrifty variant in CREBRF strongly influences body mass index in Samoans.

Ryan L Minster, Nicola L Hawley, Chi-Ting Su, Guangyun Sun, Erin E Kershaw, Hong Cheng, Olive D Buhule, Jerome Lin, Muagututi'a Sefuiva Reupena, Satupa'itea Viali, John Tuitele, Take Naseri, Zsolt Urban, Ranjan Deka, Daniel E Weeks

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Mentions

81
Peak: 1 in Feb 2020
across 5 sources since Feb 2020

Extended reach

10,131
potential audience

Total likes

40

Video views

329

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Feb 2020 – Nov 2025

Where it's discussed

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AI synopsis

What people are saying

The discussions reflect curiosity about the ancient origins of the CREBRF gene, exemplified by phrases like 'helped them preserve fat' and references to Polynesian navigation, which evoke interest in evolutionary biology. The tone varies from educational to technical, with mentions of specific genetic variants and visualization methods, indicating both interest and engagement with the scientific content, though the perceived immediate impact remains moderate.

AgreementModerate agreement

Most posts acknowledge the significance of the genetic findings, with some highlighting its evolutionary implications, showing general support for the study's conclusions.

InterestHigh interest

Discussions demonstrate a high level of curiosity about the genetic aspects and historical context, engaging with details like Polynesian voyaging and DNA analysis.

EngagementModerate engagement

Messages include references to scientific visualization and methods, indicating a moderate level of detailed engagement beyond surface-level discussion.

ImpactModerate impact

While some recognize the importance of understanding genetic influences on obesity, the overall perception of immediate societal impact appears moderate, with emphasis on scientific curiosity rather than policy influence.

Abstract in brief

  • The study identified a specific genetic variant, rs373863828 in the CREBRF gene, that significantly influences body mass index (BMI) in Samoans, a population with a high obesity rate.
  • This variant, which is rare in most populations but common in Samoans (about 2.5%), has a much larger effect on BMI than other known risk variants, promoting fat storage and decreasing energy expenditure.
  • The findings support the idea of a "thrifty" genetic variant that may have been positively selected in Samoans, contributing to their susceptibility to obesity by favoring efficient fat storage.]

Top posts

Most liked on X and Bluesky
Daniel E. Weeks
@StatGenDan · X

@claire_ethomas Actually, we found a good reason to present a 3D figure, rotating as a movie, in the Sup Info of this paper - the 2D was misleading: Minster RL et al. A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nat Genet. 2016;48(9):1049–1054. doi:10.1038/ng.3620

Feb 28, 2020 · 1 like · 1,504 followers View post →
issaplant
@issaplant · X

@Rainmaker1973 Fun Fact: It’s due to a gene called “CREBRF”. It’s from long ago when Polynesians were crossing the vast oceans, led by nothing but the stars. That gene helped them preserve fat through times of long travel with little to no food. The more you know

Nov 7, 2025 · 1 like · 535 followers View post →
Joshua G. Schraiber
@jgschraiber · X

RT @StatGenDan: @jgschraiber Imputation “adds” information derived from the correlational structure of the phased reference panel beyond wh…

Jul 13, 2020 · 1 share · 7,750 followers View post →
Haoyi Fu
@HaoyiFu · X

2/ A recently discovered missense variant rs373863828 in CREBRF plays a role in obesity in Samoa. The minor allele of rs373863828 was found to be strongly associated with greater BMI in the Samoan population, using cross-sectional data collected in 2010. https://t.co/w1sjyHTbu1

May 22, 2022 · 12 followers View post →

All mentions

issaplant
@issaplant · X

@Rainmaker1973 Fun Fact: It’s due to a gene called “CREBRF”. It’s from long ago when Polynesians were crossing the vast oceans, led by nothing but the stars. That gene helped them preserve fat through times of long travel with little to no food. The more you know

Nov 7, 2025 · 1 like · 535 followers View post →
Haoyi Fu
@HaoyiFu · X

2/ A recently discovered missense variant rs373863828 in CREBRF plays a role in obesity in Samoa. The minor allele of rs373863828 was found to be strongly associated with greater BMI in the Samoan population, using cross-sectional data collected in 2010. https://t.co/w1sjyHTbu1

May 22, 2022 · 12 followers View post →
Joshua G. Schraiber
@jgschraiber · X

RT @StatGenDan: @jgschraiber Imputation “adds” information derived from the correlational structure of the phased reference panel beyond wh…

Jul 13, 2020 · 1 share · 7,750 followers View post →
Daniel E. Weeks
@StatGenDan · X

@claire_ethomas Actually, we found a good reason to present a 3D figure, rotating as a movie, in the Sup Info of this paper - the 2D was misleading: Minster RL et al. A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nat Genet. 2016;48(9):1049–1054. doi:10.1038/ng.3620

Feb 28, 2020 · 1 like · 1,504 followers View post →