October 2016 PMID 27500468

Melatonin as an antioxidant: under promises but over delivers.

Russel J Reiter, Juan C Mayo, Dun-Xian Tan, Rosa M Sainz, Moises Alatorre-Jimenez, Lilian Qin

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Mentions

92
Peak: 7 in Jun 2023
across 5 sources since Jan 2019

Extended reach

693,449
potential audience

Total likes

2,582

Video views

198,824

Mentions per month

Jan 2019 – Oct 2025

Where it's discussed

  • X / Twitter59 posts
  • YouTube10 videos
  • News10 articles
  • Facebook8 posts
  • Blogs5 articles

AI synopsis

What people are saying

The social discussions reflect a consensus that melatonin is a highly effective antioxidant, with comments like 'most powerful antioxidant' and mentions of it working synergistically with other antioxidants like vitamin C and fisetin. The tone is enthusiastic and scientific, with references to studies, mechanisms in mitochondria, and practical dosing, showcasing deep engagement and acknowledgment of its broad health implications.

AgreementStrong agreement

Most social discussions strongly support the article's positive portrayal of melatonin's antioxidant properties, emphasizing its efficacy and safety.

InterestHigh interest

Multiple discussions show high enthusiasm, with references to its therapeutic potential, detailed scientific insights, and comparisons to other antioxidants.

EngagementHigh engagement

Many posts cite specific studies, mention mechanisms like mitochondrial activity, and discuss practical uses, indicating deep engagement.

ImpactHigh impact

Widespread recognition of melatonin's powerful antioxidant effects and potential for treating various health conditions illustrates high perceived impact.

Abstract in brief

  • Melatonin is highly effective at reducing oxidative stress through direct neutralization of reactive species, stimulation of antioxidant enzymes, and metal chelation, particularly in mitochondria, which are key sites of oxidative damage.
  • It has proven neuroprotective and cardioprotective effects in conditions like stroke, heart attack, and ischemia-reperfusion injury, and can also diminish the toxicity of certain drugs and help overcome treatment resistance in cancers.
  • Due to its widespread benefits in combating oxidative damage, inflammation, and cell death with a strong safety profile, melatonin shows promise for broader use in treating age-related diseases and other health conditions, supported by numerous experimental and human studies.]

Top posts

Most liked on X and Bluesky
C.L.A.U.D.I.A
@DaAcervo · X

35-A melatonina também trabalha lado a lado com outros antioxidantes, como fisetin e vitamina C.I t também ajuda a impedir que outros antioxidantes, como a vitamina C, se transformem em pró-oxidantes, além de reduzir a toxicidade de medicamentos nocivos. https://t.co/t9JppHni3V

Jun 28, 2023 · 67 likes · 7 shares · 110,078 followers View post →
L ❤ V E
@drkohilathas · X

Melatonin also works hand-in-hand with other antioxidants like fisetin and vitamin C.I t also helps stop other antioxidants, like vitamin C, from turning into pro-oxidants, as well as reducing the toxicity of noxious prescription drugs. https://t.co/ik3HUF0Kow

Feb 22, 2023 · 35 likes · 4 shares · 48,098 followers View post →
Alzhacker
@Alzhacker · X

論文:抗酸化物質としてのメラトニン:評価は低いが成果は高い(2016) https://t.co/DwMvdjDjf8 要約 1. メラトニンは非常に効果的な抗酸化物質であり、直接的なラジカル消去作用や抗酸化酵素の活性化など、複数のメカニズムで酸化ストレスを軽減する。 2.

Oct 1, 2024 · 21 likes · 6 shares · 32,859 followers View post →
Deni Hogan
@hogan_deni · X

If you’re interested in some great research on melatonin as an antioxidant, take a look at Russel Reiter’s YEARS of research. Cool stuff! https://t.co/kVocjxllXw

Dec 15, 2019 · 7 likes · 1 share · 130 followers View post →
NootBro
@nootropicguy · X

@ChrisPalmerMD the original master antioxidant https://t.co/G9jeQ8GnpR

Sep 25, 2023 · 5 likes · 81,330 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

Melatonin as an antioxidant: under promises but over delivers https://t.co/i4ifqQ99kD

Feb 28, 2020 · 3 likes · 1 share · 5,448 followers View post →

All mentions

Essential Principles for Maximizing Your Health

The best things we can do to maximize our health are free. Follow these essential principles to optimize your life both mentally and physically. This video offers insights into health optimization and provides a pathway…

Felipe Rodas · Jul 7, 2024 138 views
Rene Sugar
@renesugar · X

@saffronandsky @DafoeWhitney Melatonin as an antioxidant: ... https://t.co/wqgAWRgCak ROS signaling in innate immunity via oxidative protein modifications https://t.co/wxUOXv29kl The Potentials of Melatonin in the Prevention and Treatment of Bacterial Meningitis Disease https://t.co/9BzSwLZ2tl https://t.co/niSBGqBQBB

Oct 5, 2025 · 3,975 followers View post →
David Krieger
@KriegerDavid_ · X

This is the source btw https://t.co/D4vq59eNqj

Sep 8, 2025 · 21,091 followers View post →
弦元昌幸 300以上のコロ枠論文が撤回されたという動画です
@c3c3b3b3a3a3 · X

RT @Alzhacker: 論文:抗酸化物質としてのメラトニン:評価は低いが成果は高い(2016) https://t.co/DwMvdjDjf8 要約 1. メラトニンは非常に効果的な抗酸化物質であり、直接的なラジカル消去作用や抗酸化酵素の活性化など、複数のメカニズムで酸化…

Jun 28, 2025 · 6 shares · 1,357 followers View post →
Memo Canli
@Memo_Canli · X

Mar 22, 2025 · 27 followers View post →
Ivana Pavlovic
@ivanajpavlovic · X

RT @BeLikeWahter: @Helios_Movement George, great post. I believe Melatonin, 95% of which is synthesized outside of the pineal gland and in…

Jan 1, 2025 · 2 shares · 9,653 followers View post →
Donny Kruger
@DonnyKruger1 · X

@nutrition_facts Nope. Science says it's melatonin. By far. https://t.co/3OhFpb3Px3

Oct 29, 2024 · 125 followers View post →
四環光(R7.9.21)
@pmgdaw8jpm · X

RT @Alzhacker: 論文:抗酸化物質としてのメラトニン:評価は低いが成果は高い(2016) https://t.co/DwMvdjDjf8 要約 1. メラトニンは非常に効果的な抗酸化物質であり、直接的なラジカル消去作用や抗酸化酵素の活性化など、複数のメカニズムで酸化…

Oct 14, 2024 · 6 shares · 311 followers View post →
nyshbt
@noy_sbt · X

RT @Alzhacker: 論文:抗酸化物質としてのメラトニン:評価は低いが成果は高い(2016) https://t.co/DwMvdjDjf8 要約 1. メラトニンは非常に効果的な抗酸化物質であり、直接的なラジカル消去作用や抗酸化酵素の活性化など、複数のメカニズムで酸化…

Oct 1, 2024 · 6 shares · 77 followers View post →
ぶりぶりざえもん
@buribur30743463 · X

RT @Alzhacker: 論文:抗酸化物質としてのメラトニン:評価は低いが成果は高い(2016) https://t.co/DwMvdjDjf8 要約 1. メラトニンは非常に効果的な抗酸化物質であり、直接的なラジカル消去作用や抗酸化酵素の活性化など、複数のメカニズムで酸化…

Oct 1, 2024 · 6 shares · 159 followers View post →
猫まんま17歳用
@14nHQQSduI9QmOY · X

RT @Alzhacker: 論文:抗酸化物質としてのメラトニン:評価は低いが成果は高い(2016) https://t.co/DwMvdjDjf8 要約 1. メラトニンは非常に効果的な抗酸化物質であり、直接的なラジカル消去作用や抗酸化酵素の活性化など、複数のメカニズムで酸化…

Oct 1, 2024 · 6 shares · 486 followers View post →
Alzhacker
@Alzhacker · X

論文:抗酸化物質としてのメラトニン:評価は低いが成果は高い(2016) https://t.co/DwMvdjDjf8 要約 1. メラトニンは非常に効果的な抗酸化物質であり、直接的なラジカル消去作用や抗酸化酵素の活性化など、複数のメカニズムで酸化ストレスを軽減する。 2.

Oct 1, 2024 · 21 likes · 6 shares · 32,859 followers View post →
Valmor Goulart
@ValmorGoulart · X

RT @DaAcervo: 35-A melatonina também trabalha lado a lado com outros antioxidantes, como fisetin e vitamina C.I t também ajuda a impedir qu…

Apr 26, 2024 · 7 shares · 1,149 followers View post →
Professor
@DolfDoofinsky · X

What is the most powerful antioxidant anti-inflammatory supplement you probably have in your medicine cabinet? Melatonin 10x the antioxidant power of vitamin C or E, and scavenges free radicals on the cellular level. https://t.co/sEmVYTPIw9 Why I take 200mg daily

Apr 17, 2024 · 1 like · 1,562 followers View post →
hezuikn ✦
@hezuikn_isekai · X

@Murphy_FSS "Melatonin as an Antioxidant: Under Promises but Over Delivers" https://t.co/UxZ1e5gXAv subcellular vs circulatory melatonin and red/ir light "Melatonin and the Optics of the Human Body" https://t.co/nQocOienMc

Apr 14, 2024 · 619 followers View post →
An echo in the chamber
@BeLikeWahter · X

@Helios_Movement George, great post. I believe Melatonin, 95% of which is synthesized outside of the pineal gland and in cell mitochondria has extradordinary anti-oxidant properties. You might consider adding this to your list. https://t.co/zdRIlUaR26

Feb 18, 2024 · 2 likes · 2 shares · 441 followers View post →
EsperanzaBenRam
@EsperanzaBenRam · X

@Brianttaveras 17 Ensayos clínicos en TEA ( 12 fueron randomizados controlados) https://t.co/Rk66nPfpM4... Referencias: https://t.co/DdbSeknYrQ https://t.co/bdkuzn52hw https://t.co/UUzmWublak https://t.co/rFqgHSCARB https://t.co/e4gNYj5krO https://t.co/GrqNQ9f5Zp... https://t.co/DFfaAJkY8i

Feb 7, 2024 · 1,178 followers View post →
th1nkhard
@th1nkhard_ · X

@CharlotteFang77 @luksonian Melatonin as an antioxidant: under promises but over delivers https://t.co/3YV56T3O3K. https://t.co/FzTot8G7Fz. https://t.co/kV30EoL4fC https://t.co/a0rLQI1XqH https://t.co/CbrnfsEU7Q https://t.co/snDdwYay9Y https://t.co/Rxb0w5LQ6B Use Sci-Hub to pull the full papers

Nov 25, 2023 · 1 like · 798 followers View post →
Rene Sugar
@renesugar · X

@healingfromlc Melatonin and its metabolites are also antioxidants; if it is used as an antioxidant, your sleep may suffer. Melatonin as an antioxidant: under promises but over delivers https://t.co/fPYpKYcrsT https://t.co/VAOvQo1LEN

Oct 28, 2023 · 2 likes · 3,975 followers View post →
NootBro
@nootropicguy · X

@ChrisPalmerMD the original master antioxidant https://t.co/G9jeQ8GnpR

Sep 25, 2023 · 5 likes · 81,330 followers View post →
Eve.S.
@yeeseak · X

https://t.co/Nj81zKYVC3

Sep 15, 2023 · 3 likes · 876 followers View post →
Nora Lyn Larch
@NoraLynLarch · X

@HughThunkIt @AdrianaBarton @CurrentlyCranky I was skeptical until I did a quick google... now I want to learn more about melatonin! https://t.co/YE2nNcvboU.

Jul 23, 2023 · 2 likes · 17 followers View post →
Suzie-from Canada
@DymentSuzie · X

RT @DaAcervo: 35-A melatonina também trabalha lado a lado com outros antioxidantes, como fisetin e vitamina C.I t também ajuda a impedir qu…

Jul 14, 2023 · 7 shares · 801 followers View post →
Jorge Gueler
@JorgeGueler · X

RT @DaAcervo: 35-A melatonina também trabalha lado a lado com outros antioxidantes, como fisetin e vitamina C.I t também ajuda a impedir qu…

Jul 1, 2023 · 7 shares · 3,241 followers View post →
Terezinha Danin
@DaninTerezinha · X

RT @DaAcervo: 35-A melatonina também trabalha lado a lado com outros antioxidantes, como fisetin e vitamina C.I t também ajuda a impedir qu…

Jun 30, 2023 · 7 shares · 141 followers View post →
Vanda_SEP
@Vanda_SEP · X

RT @DaAcervo: 35-A melatonina também trabalha lado a lado com outros antioxidantes, como fisetin e vitamina C.I t também ajuda a impedir qu…

Jun 28, 2023 · 7 shares · 1,594 followers View post →
Marta
@Marta09905311 · X

RT @DaAcervo: 35-A melatonina também trabalha lado a lado com outros antioxidantes, como fisetin e vitamina C.I t também ajuda a impedir qu…

Jun 28, 2023 · 7 shares · 531 followers View post →
THIAGO KAKITANI
@KakitaniThiago · X

RT @DaAcervo: 35-A melatonina também trabalha lado a lado com outros antioxidantes, como fisetin e vitamina C.I t também ajuda a impedir qu…

Jun 28, 2023 · 7 shares · 1,514 followers View post →
C.L.A.U.D.I.A
@DaAcervo · X

35-A melatonina também trabalha lado a lado com outros antioxidantes, como fisetin e vitamina C.I t também ajuda a impedir que outros antioxidantes, como a vitamina C, se transformem em pró-oxidantes, além de reduzir a toxicidade de medicamentos nocivos. https://t.co/t9JppHni3V

Jun 28, 2023 · 67 likes · 7 shares · 110,078 followers View post →
Andrew Conner
@connerdelights · X

@TurtlingB @nopranablem Yeah. One reason to macro-dose it very occasionally: it's a very effective antioxidant. So if you have acute needs for that, surprisingly useful. https://t.co/y7IqNXbXUh

Jun 21, 2023 · 2 likes · 3,608 followers View post →
memory_prism
@memory_prism · X

https://t.co/8awoiwN9wp melatonin - cheap - extremely powerful and useful. In Europe the UK and other freedom averse zones they won’t even let you get it OTC.

Mar 31, 2023 · 1 like · 1,775 followers View post →
Farrukh
@farrukh366 · X

RT @drkohilathas: Melatonin also works hand-in-hand with other antioxidants like fisetin and vitamin C.I t also helps stop other antioxidan…

Mar 27, 2023 · 4 shares · 218 followers View post →
Luparus Ω
@Jagdfrevler · X

Seit Jahren wird die Verwendung der Schlafhilfe #Melatonin in EU verhindert, dann beschränkt. Obwohl ein gigantischer Feldversuch in USA die Wirksamkeit und Unschädlichkeit belegt. Warum? Es gibt keine Laborstudien. Warum? Weil Melatonin gegen Krebs hilft: https://t.co/wTDua9y4G3

Mar 23, 2023 · 2,107 followers View post →
Ed BLeNDr Bertrand
@THeNBLeNDr · X

RT @drkohilathas: Melatonin also works hand-in-hand with other antioxidants like fisetin and vitamin C.I t also helps stop other antioxidan…

Mar 22, 2023 · 4 shares · 899 followers View post →
kike
@FUENTESMANZULLI · X

RT @drkohilathas: Melatonin also works hand-in-hand with other antioxidants like fisetin and vitamin C.I t also helps stop other antioxidan…

Mar 16, 2023 · 4 shares · 248 followers View post →
Matthew
@M_Spells23 · X

@nephesh_hgurab @CanteringClark No. Best to stay on low dose, but more good. Also, a strong antioxident. "Melatonin has been effectively used to combat oxidative stress, inflammation and cellular apoptosis and to restore tissue function in a number of human trials" https://t.co/EN4axllgM5.

Mar 8, 2023 · 245 followers View post →
Southern Yankee
@SouthrnYankee27 · X

RT @drkohilathas: Melatonin also works hand-in-hand with other antioxidants like fisetin and vitamin C.I t also helps stop other antioxidan…

Feb 22, 2023 · 4 shares · 1,769 followers View post →
L ❤ V E
@drkohilathas · X

Melatonin also works hand-in-hand with other antioxidants like fisetin and vitamin C.I t also helps stop other antioxidants, like vitamin C, from turning into pro-oxidants, as well as reducing the toxicity of noxious prescription drugs. https://t.co/ik3HUF0Kow

Feb 22, 2023 · 35 likes · 4 shares · 48,098 followers View post →
Marty Glassman
@lsi1123 · X

@MGH_CNTR @MGHInstitute @MGHNeurology @MGHNeuroICU @MGHNeurosurg @MGH_RI @TJK_BRL Is there any research at MGH regarding melatonin after stroke, TBI, etc.? Just wondering! https://t.co/R0RpzP6vmp

Feb 9, 2023 · 543 followers View post →
Madam Mitochondria
@Madam_Mito · X

@t_squee Russell has published a large body of really high quality literature over a span of decades on it; I find this one paper particularly useful. https://t.co/4CIn3s5N2p

Jan 1, 2023 · 1 like · 10,470 followers View post →
Bev Scott
@bevvscott · X

@marcuskelson I take 2 every night. Melatonin is a simple, ancient molecule & a powerful antioxidant that crosses the blood-brain-barrier. Very good for my brain: https://t.co/fPKafe0fgZ.

Nov 9, 2022 · 1,148 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

RT @dr_kevinlee: Melatonin as an antioxidant: under promises but over delivers https://t.co/i4ifqQ99kD

Oct 25, 2022 · 1 share · 5,448 followers View post →
Rene Sugar
@renesugar · X

Melatonin as an antioxidant: under promises but over delivers https://t.co/fPYpKYbTDl https://t.co/JtMZPy1tSE

Jul 24, 2022 · 2 likes · 3,975 followers View post →
laulau,MD
@lauriemuoz · X

RT @CharlesATD: @drdenwalker What about melatonin ? It seems a strong antioxydant also https://t.co/EVFyXD2xng

May 28, 2022 · 1 share · 1,837 followers View post →
Charles (44)
@CharlesATD · X

@drdenwalker What about melatonin ? It seems a strong antioxydant also https://t.co/EVFyXD2xng

May 28, 2022 · 3 likes · 1 share · 309 followers View post →
Ed
@edthetechie · X

@Heachy_1979 @danjgregory More science! Firstly on the importance of melatonin https://t.co/8EmMo9tkgv

Feb 11, 2022 · 1 like · 19,248 followers View post →
Julie Anne
@jpaint · X

Melatonin as an antioxidant: under promises but over delivers - PubMed https://t.co/L4gYkjjj4u

Jan 2, 2022 · 695 followers View post →
Captain Rational
@noahseidman · X

@JTheretohelp1 Megadose Melatonin with maximum bioavailability. The strongest endogenous antioxidant that up regulates Glutathione. https://t.co/59xxIOI471 https://t.co/QglauuK7Q8 https://t.co/Jxb7GaHwyP

Aug 17, 2021 · 20,782 followers View post →
Pam Bondo-not letting go of that list
@tousel · X

@FuturesOperat0r @nia3in https://t.co/5w4etpfX5p

Aug 4, 2021 · 1,258 followers View post →
Kristie Leong M.D.
@DrKristieLeong · X

@Tony94253238 Melatonin sets your internal biological clock and is a powerful antioxidant. So, you don't want melatonin to be low: https://t.co/nVR05GYfaF

Mar 8, 2021 · 59,625 followers View post →
IberianCitizen
@IberianCitizen · X

@MariaJe45669909 Si, así es

Feb 1, 2021 · 2 likes · 1 share · 12,926 followers View post →
Deni Hogan
@hogan_deni · X

@DrTobiasFunky 180mg daily

May 24, 2020 · 2 likes · 130 followers View post →
Terry M. Mayfield
@TerryMMayfield · X

Melatonin as an antioxidant: under promises but over delivers https://t.co/sNMQhHMrHA

May 19, 2020 · 2,498 followers View post →
Faigy Roze
@frozzleberg · X

@untappedgrowth @MaddsenOphelia @allicovington @chris_boertien @DougKCarnivore @man_integrated https://t.co/iZUFmWOHbM https://t.co/6DO60plFBZ

Mar 25, 2020 · 2 likes · 89 followers View post →
Ginai
@SmileSimplify · X

RT @bevvscott: TIL melatonin is a powerful antioxidant & also an ancient molecule that can be traced back to the origin of life on earth.…

Mar 14, 2020 · 1 share · 1,682 followers View post →
Bev Scott
@bevvscott · X

TIL melatonin is a powerful antioxidant & also an ancient molecule that can be traced back to the origin of life on earth. https://t.co/1Jx1pl6A0s https://t.co/9iaGyL1BVe https://t.co/12YK3ouX5T

Mar 14, 2020 · 2 likes · 1 share · 1,148 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

Melatonin as an antioxidant: under promises but over delivers https://t.co/i4ifqQ99kD

Feb 28, 2020 · 3 likes · 1 share · 5,448 followers View post →
Myrna
@myrnaslist · X

RT @hogan_deni: If you’re interested in some great research on melatonin as an antioxidant, take a look at Russel Reiter’s YEARS of researc…

Dec 18, 2019 · 1 share · 1,472 followers View post →
Deni Hogan
@hogan_deni · X

If you’re interested in some great research on melatonin as an antioxidant, take a look at Russel Reiter’s YEARS of research. Cool stuff! https://t.co/kVocjxllXw

Dec 15, 2019 · 7 likes · 1 share · 130 followers View post →
For health-promoting environments
@SilkeLeFay · X

. To reduce the incidence of depression, cancer, dementia and MND/ALS, studies need to measure 24hr exposure to wavelengths of light, magnetic fields and neurotransmitter-modulating medication and the effect on pineal gland function and melatonin levels. https://t.co/7JLJayFFlX https://t.co/HgEypm4P4f

Oct 17, 2019 · 4,584 followers View post →