N Engl J Med September 2016 PMID 27571048

CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea.

R Doug McEvoy, Nick A Antic, Emma Heeley, Yuanming Luo, Qiong Ou, Xilong Zhang, Olga Mediano, Rui Chen, Luciano F Drager, Zhihong Liu, Guofang Chen, Baoliang Du, Nigel McArdle, Sutapa Mukherjee, Manjari Tripathi

Mentions

178
Peak: 4 in Mar 2023
across 6 sources since Feb 2019

Extended reach

84,541
potential audience

Total likes

46

Video views

708

Mentions per month

Feb 2019 – Feb 2025

Where it's discussed

  • News92 articles
  • Facebook45 posts
  • X / Twitter23 posts
  • Blogs14 articles
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

The discussions reflect a careful consideration of the study's findings, mentioning the trial's negative results on cardiovascular prevention despite improvements in symptoms, and addressing factors like treatment adherence and patient risk profiles, which indicates thoughtful engagement and recognition of its significance in sleep medicine and cardiovascular health.

AgreementModerate agreement

Most discussions highlight the trial's findings that CPAP did not significantly prevent cardiovascular events, indicating general consensus or acknowledgment of these results.

InterestModerate interest

Participants show moderate interest, with some expressing curiosity and highlighting the importance of improving therapies and identifying high-risk groups.

EngagementModerate engagement

Many posts reference specific research details, such as trial results and compliance issues, showing an active engagement with the study data.

ImpactModerate impact

The discourse underscores the study's influence on clinical understanding and future research directions, emphasizing the need for better treatment strategies.

Abstract in brief

  • This study investigated whether using CPAP (continuous positive airway pressure) can prevent major cardiovascular events like heart attacks and strokes in adults with moderate to severe obstructive sleep apnea (OSA) and existing cardiovascular disease.
  • After about 3.7 years of follow-up, the results showed no significant difference in preventing cardiovascular events between those who used CPAP and those who received usual care, although CPAP did help reduce snoring, daytime sleepiness, and improve quality of life.
  • Overall, the findings suggest that CPAP therapy may not effectively prevent cardiovascular events in this patient group, despite improving some symptoms related to sleep apnea.]

Top posts

Most liked on X and Bluesky
Tanja Dudenbostel, MD, FASH, FAHA
@DrDudenbostel · X

add on to Q14/A14 : Some studies define CPAP use as min of 4 hrs, -> patients are 1/2 night off CPAP but considered on CPAP which may contribute to conflicting results #HYPHIP @HyperAHA @DrDudenbostel @MaierLauren @CraigSteinback https://t.co/RoFp9zVmsP

Mar 8, 2023 · 6 likes · 3 shares · 1,511 followers View post →
Primary Care Chat
@primarycarechat · X

Though it did not prevent CV events in pts with mod-severe #OSA +CVD, #CPAP significantly reduced #snoring and daytime #sleepiness and improved health-related QOL and mood. SAVE Trial. #PrimaryCareChat #SleepMatters https://t.co/Bz0goLEHM7

Oct 17, 2019 · 5 likes · 2,924 followers View post →
Andrew Sharp
@drandrewsharp · X

@SukhNijjer @DrVikasKapil - any thoughts on this trial? https://t.co/poK9Fa4RZZ

Jul 13, 2020 · 4 likes · 2 shares · 6,891 followers View post →
Max Jordan Nguemeni
@MaxJordan_N · X

@ProfHayward ah I saw the SAVE trial found ppl in CPAP group report fewer days off work for health-related reasons, think that's a worthwhile outcome (if people like to go to work!) lol fairly tight confidence interval too. 0.82 (0.80-0.85) @AlexChaitoff @JeremySussman https://t.co/zjDTLeMTeX

Feb 1, 2022 · 3 likes · 19,822 followers View post →
Paul Langton
@WALangProf · X

@Dominik_Linz @AHAScience @ReenaMehra0203 @PrashSanders @SusanRedline @NancySRed @Vaish1986 @EP_mom1 @CircAHA @J_Hendriks1 @DavidDuncker @DrDave01 @escardio @CARIMMaastricht @adribaran @Elliott_AD @MDTolgaAksu @EmmaSvennberg @ChristianHeeger Interesting theory. But the major (Industry sponsored) SAVE trial showed no CV or other major benefit from treating OSA with CPAP? #awkward https://t.co/VScbf8eqTQ

Aug 1, 2022 · 3 likes · 234 followers View post →
Carl-Magnus Broden
@BrodenCarl · X

@AbdTahrani @MichaelAlbertMD Exactly: https://t.co/Od4mn3g5mY

Feb 20, 2022 · 2 likes · 335 followers View post →

All mentions

Carlos F. Matute-Martínez
@Felipe_Matute · X

CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea | New England Journal of Medicine https://t.co/0tKbAqIvVj

Feb 15, 2025 · 221 followers View post →
Seong Chin
@sc2910 · X

@H0B0_elite Snoring can be adaptive/protective to secure venous return while sleeping. Cardiac events, even death, from poor venous return during severe stress. CPAP doesn't provide cardiac protection contrary to common belief. Many allergy sx seem protective. https://t.co/NZ6xcIQVmn

Jan 4, 2025 · 2 likes · 33 followers View post →
Dr.Paper
@paper_DrDr · X

「CPAPを3時間以上使用しても心血管イベントを予防できなかった。日中の眠気やQOLはCPAP利用群で有意に改善した。」 CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea NEJM September 8, 2016 R. Doug McEvoy, M.D.

Dec 4, 2023 · 14 followers View post →
Willy Frick
@willyhfrick · X

@MohitHarshMD I’ll admit, I’m a little pessimistic about the benefits of CPAP. Clear benefit in daytime sleepiness. CV benefits seem less clear. But I do always address it. https://t.co/iLuEi70Wbs

Aug 21, 2023 · 4,058 followers View post →
Sovetorax Tips
@tipssovetorax · X

En la charla del doctpr Malhotra recuerda el trabajo de NEJM de 2016 donde se concluye en ese entonces que para son necesarioñ mejores terapias y adherencia, identificar mejor pacientes de alto riesgo y mas inestigacion basica 2 https://t.co/AmUsvXJ5w1

Jun 24, 2023 · 1 like · 3,237 followers View post →
Hypertension
@HyperAHA · X

RT @DrDudenbostel: add on to Q14/A14 : Some studies define CPAP use as min of 4 hrs, -> patients are 1/2 night off CPAP but considered on C…

Mar 8, 2023 · 3 shares · 10,864 followers View post →
Francisco Rios
@fjorios · X

RT @DrDudenbostel: add on to Q14/A14 : Some studies define CPAP use as min of 4 hrs, -> patients are 1/2 night off CPAP but considered on C…

Mar 8, 2023 · 3 shares · 635 followers View post →
Guto Montezano
@guto_montezano · X

RT @DrDudenbostel: add on to Q14/A14 : Some studies define CPAP use as min of 4 hrs, -> patients are 1/2 night off CPAP but considered on C…

Mar 8, 2023 · 3 shares · 1,311 followers View post →
Tanja Dudenbostel, MD, FASH, FAHA
@DrDudenbostel · X

add on to Q14/A14 : Some studies define CPAP use as min of 4 hrs, -> patients are 1/2 night off CPAP but considered on CPAP which may contribute to conflicting results #HYPHIP @HyperAHA @DrDudenbostel @MaierLauren @CraigSteinback https://t.co/RoFp9zVmsP

Mar 8, 2023 · 6 likes · 3 shares · 1,511 followers View post →
Kookaburra cove
@kookcove · X

@bobepidemiology This is another multi centre study, trying to assess the benefits on cardiovascular events. When you read through the study, compliance to the treatment impacted effectiveness. https://t.co/X3hgLGelM9

Feb 26, 2023 · 450 followers View post →
Paul Langton
@WALangProf · X

@taipan168 There's a special irony in the fact that the only large trial of CPAP masks showed they don't work... "CPAP + usual care vs. usual care alone did not prevent cardiovascular events in patients with moderate-severe obstructive sleep apnea & CV disease" https://t.co/VScbf7XnRQ

Oct 10, 2022 · 2 likes · 234 followers View post →
Paul Langton
@WALangProf · X

@Dominik_Linz @AHAScience @ReenaMehra0203 @PrashSanders @SusanRedline @NancySRed @Vaish1986 @EP_mom1 @CircAHA @J_Hendriks1 @DavidDuncker @DrDave01 @escardio @CARIMMaastricht @adribaran @Elliott_AD @MDTolgaAksu @EmmaSvennberg @ChristianHeeger Interesting theory. But the major (Industry sponsored) SAVE trial showed no CV or other major benefit from treating OSA with CPAP? #awkward https://t.co/VScbf8eqTQ

Aug 1, 2022 · 3 likes · 234 followers View post →
Rafael Bravo
@rafabravo · X

@Carcos2 @KikeCimas y el clásico https://t.co/hAGrYxnOIL?

Jun 11, 2022 · 16,957 followers View post →
Carl-Magnus Broden
@BrodenCarl · X

@AbdTahrani @MichaelAlbertMD Exactly: https://t.co/Od4mn3g5mY

Feb 20, 2022 · 2 likes · 335 followers View post →
Max Jordan Nguemeni
@MaxJordan_N · X

@ProfHayward ah I saw the SAVE trial found ppl in CPAP group report fewer days off work for health-related reasons, think that's a worthwhile outcome (if people like to go to work!) lol fairly tight confidence interval too. 0.82 (0.80-0.85) @AlexChaitoff @JeremySussman https://t.co/zjDTLeMTeX

Feb 1, 2022 · 3 likes · 19,822 followers View post →
Peter Jackson
@PDjack1984 · X

@MaxJordan_N @BenMazer Good questions, check out the SAVE trial NEJM https://t.co/NaQl7M1OON they tried to find the highest risk group to see mortality or composite CV event benefit. Unfortunately no difference.

Feb 1, 2022 · 1 like · 274 followers View post →
Lavinia Gabara
@DrLaviniaGabara · X

RT @drandrewsharp: @SukhNijjer @DrVikasKapil - any thoughts on this trial? https://t.co/poK9Fa4RZZ

Jul 14, 2020 · 2 shares · 345 followers View post →
Aaysha Cader
@aayshacader · X

RT @drandrewsharp: @SukhNijjer @DrVikasKapil - any thoughts on this trial? https://t.co/poK9Fa4RZZ

Jul 13, 2020 · 2 shares · 9,105 followers View post →
Andrew Sharp
@drandrewsharp · X

@SukhNijjer @DrVikasKapil - any thoughts on this trial? https://t.co/poK9Fa4RZZ

Jul 13, 2020 · 4 likes · 2 shares · 6,891 followers View post →
Carlos Coscollar
@Carcos2 · X

@rafabravo Curioso resultado, en pacientes de muy alto riesgo CV. Quizá el tiempo medio de uso de CPAP (2,78 h/noche) puede influir. Pero en el análisis ajustado a cumplimiento tampoco parece afectar el resultado. Ya había datos que ponían en cuestión el beneficio CV https://t.co/KY0SxQTYPh

Dec 30, 2019 · 1 like · 1,166 followers View post →
Primary Care Chat
@primarycarechat · X

Though it did not prevent CV events in pts with mod-severe #OSA +CVD, #CPAP significantly reduced #snoring and daytime #sleepiness and improved health-related QOL and mood. SAVE Trial. #PrimaryCareChat #SleepMatters https://t.co/Bz0goLEHM7

Oct 17, 2019 · 5 likes · 2,924 followers View post →
Pablo
@PabloaVegao · X

@pcorrea78 @elespectador https://t.co/HR8jInihXm No sabía que no se podían enviar PDF por aquí, pero este es el link ya esta libre. https://t.co/b2WgVWbMJy

Mar 16, 2019 · 118 followers View post →
坂田 昌嗣 Masa Sakata, PhD
@MasatsuguSakata · X

CPAPで心血管イベントを防ぐことはできませんぜ、って文献をクリティカルに読むことになった。 CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea | NEJM https://t.co/9NH8K9tzzW

Feb 5, 2019 · 3,059 followers View post →