J Psychosoc Nurs Ment Health Serv September 2016 PMID 27576224

Methylene Blue: The Long and Winding Road from Stain to Brain: Part 1.

Robert H Howland

Mentions

21
Peak: 6 in Mar 2023
across 4 sources since Apr 2021

Extended reach

164,483
potential audience

Total likes

98

Video views

272

Mentions per month

Apr 2021 – Sep 2025

Where it's discussed

  • X / Twitter14 posts
  • News4 articles
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions reflect a broad range of perspectives, from historical highlights like its role as one of the first synthetic drugs to more technical points about its use in tissue staining, exemplified by posts mentioning its 'colourful history' and its importance in histology. While some comments show curiosity and basic understanding, others are dismissive or personal, highlighting varied levels of engagement with the article's significance.

AgreementNeither agree nor disagree

The discussions are mixed; some posts emphasize the historical and scientific significance, while others dismiss or make personal remarks, resulting in neutral overall agreement.

InterestModerate interest

Posts generally show a mild interest, especially in historical context and applications, but some comments lack depth and engagement with the scientific content.

EngagementModerate engagement

The posts vary from superficial mentions to technical comments, indicating some active engagement but not deep or sustained discussion.

ImpactNeutral impact

The overall impact appears modest, with some recognition of the molecule's historical importance but little evidence of widespread influence or practical implications being emphasized.

Abstract in brief

  • Methylene blue was originally discovered and used as a textile dye, but its unique properties led to its early use in biological staining and as one of the first synthetic drugs for treating malaria over a century ago.
  • It played a significant role in medicine, being used to treat psychosis at the end of the 19th century and contributing to the development of antipsychotic drugs, as well as being studied for bipolar disorder and neurodegenerative diseases in recent years.
  • The evolution of methylene blue from a dye to a therapeutic agent exemplifies how scientific understanding, clinical needs, and interdisciplinary insights can shape a drug's application over time through observation and serendipity.

Top posts

Most liked on X and Bluesky
L ❤ V E
@drkohilathas · X

Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used as a dye in the textile industry. https://t.co/pwaPwAZY3a

Mar 4, 2023 · 75 likes · 12 shares · 47,938 followers View post →
Vance
@VanceE · X

@john316andax210 https://t.co/YM9bllWN96 https://t.co/lVYwoFfkge https://t.co/PEU92cZKWV https://t.co/jaF3emIaZK https://t.co/BGOiePsLa9 https://t.co/pnzuQubjDI https://t.co/wCDqQvxenm

Aug 19, 2023 · 5 likes · 44,392 followers View post →
Meraki Blue Tongues
@Merakimedicinal · X

Jun 21, 2023 · 3 likes · 21,562 followers View post →
Rosemary Frei
@RosemaryFreiTO · X

@HughBoone9 Methylene blue is used on fixed tissue sections - ie on tissue that has been embedded in paraffin and sliced. Toxicity is completely irrelevant. I suggest you learn about histology. I also found this paper, which looks kinda cool.https://t.co/QjIl2jGzsQ https://t.co/0oJRVw5drD

Apr 6, 2021 · 1 like · 4,987 followers View post →
Nabil H The Peacemaker ⚛️☮️
@inabster · X

RT @drkohilathas: Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used…

Feb 17, 2025 · 12 shares · 37,955 followers View post →
Renewables| #teamelon |#Tesla| Ethical hacker
@AstraHackr · X

RT @drkohilathas: Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used…

Nov 26, 2023 · 12 shares · 2,446 followers View post →

All mentions

mary
@roughrider994.bsky.social · Bluesky

pubmed.ncbi.nlm.nih.gov/27576224/

May 18, 2025 View post →
Thor
@Thor34460522 · X

@DrNeilStone You really have no soul

May 13, 2025 · 172 followers View post →
Nabil H The Peacemaker ⚛️☮️
@inabster · X

RT @drkohilathas: Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used…

Feb 17, 2025 · 12 shares · 37,955 followers View post →
Renewables| #teamelon |#Tesla| Ethical hacker
@AstraHackr · X

RT @drkohilathas: Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used…

Nov 26, 2023 · 12 shares · 2,446 followers View post →
Meryl Hepburn
@MerylHepburn · X

RT @drkohilathas: Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used…

Sep 4, 2023 · 12 shares · 169 followers View post →
Æ-LEX
@TurboWealthLex · X

RT @drkohilathas: Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used…

Sep 4, 2023 · 12 shares · 1,877 followers View post →
Vance
@VanceE · X

@john316andax210 https://t.co/YM9bllWN96 https://t.co/lVYwoFfkge https://t.co/PEU92cZKWV https://t.co/jaF3emIaZK https://t.co/BGOiePsLa9 https://t.co/pnzuQubjDI https://t.co/wCDqQvxenm

Aug 19, 2023 · 5 likes · 44,392 followers View post →
Meraki Blue Tongues
@Merakimedicinal · X

Jun 21, 2023 · 3 likes · 21,562 followers View post →
wk.valentina
@Wk_1971 · X

RT @drkohilathas: Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used…

Mar 9, 2023 · 12 shares · 214 followers View post →
VéioMatraca
@VeioMatraca · X

RT @drkohilathas: Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used…

Mar 8, 2023 · 12 shares · 685 followers View post →
kike
@FUENTESMANZULLI · X

RT @drkohilathas: Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used…

Mar 6, 2023 · 12 shares · 249 followers View post →
Alejandro Zoccola
@zoccosunlight · X

RT @drkohilathas: Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used…

Mar 5, 2023 · 12 shares · 231 followers View post →
Rhonda Simms
@SimmsRls · X

RT @drkohilathas: Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used…

Mar 4, 2023 · 12 shares · 1,095 followers View post →
L ❤ V E
@drkohilathas · X

Methylene blue (MB) has a colourful history, having been the first synthetic drug used in medicine as well as being used as a dye in the textile industry. https://t.co/pwaPwAZY3a

Mar 4, 2023 · 75 likes · 12 shares · 47,938 followers View post →
Rosemary Frei
@RosemaryFreiTO · X

@HughBoone9 Methylene blue is used on fixed tissue sections - ie on tissue that has been embedded in paraffin and sliced. Toxicity is completely irrelevant. I suggest you learn about histology. I also found this paper, which looks kinda cool.https://t.co/QjIl2jGzsQ https://t.co/0oJRVw5drD

Apr 6, 2021 · 1 like · 4,987 followers View post →