Annu Rev Virol September 2016 PMID 27578435

Structure, Function, and Evolution of Coronavirus Spike Proteins.

Fang Li

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234

Peak: 41 in Dec 2023

across 5 sources since Jan 2020

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AI synopsis

What people are saying

This collection of discussions reveals a mixture of support, curiosity, and skepticism regarding the structure and function of coronavirus spike proteins, with posts referencing detailed scientific studies, theories about immune responses like IgG4 dynamics, and potential implications for vaccination strategies. The tone varies from analytical to cautionary, highlighting both scientific interest and concern over possible health impacts.

AgreementModerate agreement

Most discussions support the importance of understanding the structure and functions of coronavirus spike proteins, with many referencing the peer-reviewed publication from 2016 and emphasizing the relevance of spike protein research.

InterestHigh interest

The discussions show high interest, especially around topics like IgG4 antibodies, Galectin 3, and vaccine implications, indicating engagement with complex immunological concepts.

EngagementModerate engagement

Conversations involve referencing scientific studies, speculating on mechanisms like frameshifting, and sharing links to detailed research, demonstrating a moderate level of deep engagement.

ImpactModerate impact

There is a recognition of the publication’s potential significance, especially by those connecting spike protein features to vaccine effects and disease processes, suggesting a perceived moderate overall impact.

Abstract in brief

The coronavirus spike protein is essential for viral entry into host cells, binding to receptors via its S1 subunit and facilitating membrane fusion through its S2 subunit.
Two domains in the spike protein's S1 subunit can recognize various host receptors, allowing for viral attachment and influencing how different coronaviruses interact with their hosts.
The article dives into the structural changes of the spike protein, including its prefusion and postfusion states, and explores how these transformations and receptor interactions have evolved in comparison to other viruses and host cell mechanisms.

Read the full abstract

All mentions

IgG4 and Galectin 3: Insights into mRNA Vaccine Side Effects and Protein Similarities

Latest evidence shows IgG4 antibody production in mRNA vaccinated individuals, shedding light on unusual immune responses and potential links to IgG4-related diseases. This research examines how spike protein…

Merogenomics · Dec 6, 2023 52,217 views

Analysis of Covid-19 Vaccination Myths and Scientific Evidence

This is Part 1 of a two-part series addressing claims and controversies surrounding Covid-19 and vaccines. It offers a nuanced, evidence-based discussion aiming to inform and prevent conspiracy theory absorption.

Great Teacher Appoota · Dec 20, 2020 227 views

Understanding COVID-19: Spike Protein Structure and Function

This video explains the essential role of the coronavirus spike protein in viral entry, including its interaction with host cell receptors, structural changes during infection, and evolutionary adaptations that…

Maya Deshmukh · Apr 27, 2020 167 views

Understanding Coronavirus Spike Proteins Structure and Function

This video addresses claims and controversies surrounding Covid 19 and vaccines, providing a nuanced evidence-based discussion. It covers the structure, function, and evolution of coronavirus spike proteins, essential…

Great Teacher Appoota · Dec 20, 2020 102 views

Comparing Spike Proteins in Human and Animal SARS-CoV-2 Strains

This video explores the emergence of SARS-CoV-2, responsible for the global COVID-19 outbreak, including its characteristics, symptoms, transmission, and potential origins from bats and pangolins, highlighting ongoing…

Shia Fisher · Nov 23, 2020 65 views

Fredy 13

@Fredy13_Backup · X

@BrianLenzkes Might be a long shot , has several study links in description . @CoyoteSanctuary https://t.co/zEHPGQTrxU https://t.co/OQfmEicEIK

Feb 28, 2025 · 380 followers View post →

Christoph Engelhardt, M.D.☤

@ChristophE55272 · X

@AlexBerenson Is this T-cell (cellular-mediated) “exhaustion” related to unusually high levels of IgG4 (humoral-modulation)? Are you guys following this? https://t.co/eLLLh07RPz

Feb 19, 2025 · 1,718 followers View post →

KD51

@CarlPal32991716 · X

RT @dezzie_rezzie: 12

Feb 3, 2025 · 6 shares · 175 followers View post →

KD51

@CarlPal32991716 · X

RT @dezzie_rezzie: 8

Feb 3, 2025 · 7 shares · 175 followers View post →

Kim Walther

@kpossible0212 · X

RT @dezzie_rezzie: 12

Feb 2, 2025 · 6 shares · 331 followers View post →

Kim Walther

@kpossible0212 · X

RT @dezzie_rezzie: 8

Feb 2, 2025 · 7 shares · 331 followers View post →

@Helaway · X

https://t.co/M9LV67GRbZ

Sep 25, 2024 · 372 followers View post →

Valérie FERRIER

@ferrierv2502 · X

@0xDanielBgt @AnneliseBocquet @VictorSinclair3 Non. De précédentes souches de coronavirus humains étaient déjà équipés de protéines spike. https://t.co/ISNjNGWP5E https://t.co/zqFBLdFVY4

Aug 12, 2024 · 1 like · 1,005 followers View post →

Vance

@VanceMeister · X

@RealDrJaneRuby It's a coronavirus. https://t.co/lX8gK7oOyC https://t.co/D0lKvjwNwv https://t.co/m7P0sshNvb. https://t.co/3WQKY1Weod

May 6, 2024 · 337 followers View post →

Merogenomics

@merogenomics · X

@HouseLyndseyRN https://t.co/QqyR8yEybL

Mar 10, 2024 · 2,808 followers View post →

Fredy13

@Goofygrandpa · X

@Pinzie I park these , around Galectin 3 https://t.co/noDsl7cyFd https://t.co/wpKcrGhVYs https://t.co/59E9U2xHgt https://t.co/eeNB2sr2t6 https://t.co/HURc6jFVsC couple more links here

Mar 4, 2024 · 1 like · 426 followers View post →

Free56

@Free5620 · X

@CartlandDavid @DrEliDavid @DrJohnCampbell3 @DrEricDing @DrLoupis @DrSuneelDhand @Fynnderella1 @goddeketal @mercola @LaraAmoako @Christii3131 @AnnaForFlorida @naomirwolf @drbeen_medical https://t.co/dVzpc1ATVg https://t.co/800fLEmcHO

Feb 1, 2024 · 191 followers View post →

roger carey

@rogerca77506469 · X

IgG4 + surprise theory of Galectin 3 (IgG4 part 8, update118) https://t.co/voPVJ0dIbg via @YouTube

Jan 15, 2024 · 1 like · 876 followers View post →

Carlo Alessio

@CarloAlessio2 · X

https://t.co/NfJcFxjyRm

Dec 24, 2023 · 282 followers View post →

Open your eyes.

@AlmightyKelly · X

@LJtheamazing @FatEmperor https://t.co/onRt7XMBjq

Dec 22, 2023 · 446 followers View post →

Open your eyes.

@AlmightyKelly · X

@BoschEyes @unhealthytruth @HerbsandDirt @Claireashb25012 Wake up. https://t.co/onRt7XMBjq

Dec 22, 2023 · 446 followers View post →

Fredy13

@Goofygrandpa · X

@trainerrueben Seen this one : https://t.co/EhxBRYzcuD

Dec 20, 2023 · 2 likes · 423 followers View post →

John Keighron. A doves feather

@keighron_s · X

RT @keighron_s: https://t.co/kv4FU4GJkP

Dec 20, 2023 · 1 share · 13,024 followers View post →

John Keighron. A doves feather

@keighron_s · X

https://t.co/kv4FU4GJkP

Dec 20, 2023 · 1 like · 1 share · 13,024 followers View post →

Tres Leches

@eneldiluvio · X

@janiesaysyay Have you watched this recent vid https://t.co/NX4fZlnhQe Seems the IgG4 switch may be an attempt to avoid fibrotic activity brought on by gain of function situation. So nuts

Dec 19, 2023 · 1 like · 1,373 followers View post →

Fredy13

@Goofygrandpa · X

@LexiGirlDog @Parsifaler Or invert it , the lack of taste leads to overeating / use of sugars . Now @merogenomics had a connection to Galectin 3 using the same pathways as some cancers . All with IgG 4 cross connections in patients with multiple shots . https://t.co/EhxBRYzKkb

Dec 19, 2023 · 1 like · 423 followers View post →

Nordenslys #EalaFreaFresena - #StemZeWeg

@Nordenslys · X

Wederom een onderzoek wat aantoont dat er een (flinke) toename van IgG4 antilichamen is na mrna boosterprikken. Waarom dan gewoon doorgaan met prikrondes @minVWS @ministerVWS? https://t.co/vXUfd2qzMT

Dec 18, 2023 · 2,508 followers View post →

EpitomeTheBurnkid (OK, Copernicus/473x4ndr14)

@BurnkidV · X

IgG4 + surprise theory of Galectin 3 (IgG4 part 8, update118) https://t.co/hcassmqHJL via @YouTube If videos like this interest you, please look for my show #youtuberecommendedchronicles

Dec 16, 2023 · 1,626 followers View post →

EpitomeTheBurnkid (OK, Copernicus/473x4ndr14)

@BurnkidV · X

IgG4 + surprise theory of Galectin 3 (IgG4 part 8, update118) https://t.co/LSpqazsMrV via @YouTube If videos like this interest you, please look for my show #youtuberecommendedchronicles

Dec 16, 2023 · 1,626 followers View post →

khellstr

@kHellstr · X

@MikaelNiku @WayneSelanne @olliposti @IsoHenkka @OssiTiihonen @IPiikki @ystheppu @SamiAntinniemi @odefinn @Pesakauha @Veera_Fager @edvpml @Terrrieri @mtmalinen @zirkkeli1 Ja sitten on vaikka tälläisiä juttuja että piikkiproteiini muistuttaa joltain osin ihmisen omaa Galectin 3 proteiinia, joka säätelee soiluissa juttaja ja liittyy IgG4 proteiinin tuotantoon. Miten vaikka Framshifting vaikuttaa tähän? https://t.co/CDt6TUGARo

Dec 15, 2023 · 1,174 followers View post →

highroadwins

@canoecurves · X

IgG4 + surprise theory of Galectin 3 (IgG4 part 8, update118) https://t.co/FS9nv4dLWq via @YouTube @AlexBerenson

Dec 13, 2023 · 275 followers View post →

khellstr

@kHellstr · X

@JesslovesMJK @bell00david @Kevin_McKernan @AdhesionsOrg @Parsifaler @NestCommander @DrJBhattacharya Could frame shifting make this similarity more harmful ? https://t.co/LOCwkC6MDW https://t.co/CVdI2BYpyb

Dec 13, 2023 · 1,174 followers View post →

khellstr

@kHellstr · X

@ystheppu Toimiiko tää: https://t.co/WO9JlmW1cw

Dec 13, 2023 · 1,174 followers View post →

khellstr

@kHellstr · X

@KangaDMC @USMortality Here is an interesting video, one more possible mechanism for adverse effect. https://t.co/SC8sDMWm6a

Dec 13, 2023 · 1,174 followers View post →

khellstr

@kHellstr · X

Tämä voikin olla sitten vähän huonompi juttu. Ja mites sit käy kun koodi frameshiftaa? https://t.co/txHtjC0U8x https://t.co/4xDEGKswou

Dec 13, 2023 · 1,174 followers View post →

Anne

@Lyall3Lyall · X

https://t.co/MZFoNuDRFT

Dec 13, 2023 · 1 like · 2,207 followers View post →

Carolyn Kennedy

@chillibeetle · X

@HopeRising19 This is interesting too, re igG4 increase in mNra vaxed, galectin 3, and that Ivermectin inhibits galectin 3. https://t.co/4uikShqlgR

Dec 12, 2023 · 11 followers View post →

Carolyn Kennedy

@chillibeetle · X

@winstonpeters Most recent important paper discussions.. Ribosome slip & igG4 https://t.co/4NG5hHFmfL https://t.co/pkRpURVpyG https://t.co/4NG5hHFmfL https://t.co/4uikShqlgR

Dec 11, 2023 · 11 followers View post →

@Helaway · X

Hmm, galectin-3 IgG4 YDY! peace! https://t.co/of7UAsTpYf

Dec 11, 2023 · 372 followers View post →

Governmentsandallbanksliekillandstealworldwide6969

@Politicarilazu1 · X

https://t.co/BVtJ1r9tRl

Dec 10, 2023 · 392 followers View post →

nuigui

@Nuigilan · X

IgG4 + surprise theory of Galectin 3 (IgG4 part 8, update118) https://t.co/AN1giR7Cup via @YouTube

Dec 10, 2023 · 2,371 followers View post →

Mark Estabrook

@EuromaidanRev · X

RT @EuromaidanRev: COVID-19 https://t.co/B8UDo0VEM5 #Galectin3 #IgG4 #mRNA #MAB #CCR5 #FDA #NIH #CytokineStorm #Mortality #Vaccination #Pfi…

Dec 9, 2023 · 1 share · 104 followers View post →

Mark Estabrook

@EuromaidanRev · X

COVID-19 https://t.co/B8UDo0VEM5 #Galectin3 #IgG4 #mRNA #MAB #CCR5 #FDA #NIH #CytokineStorm #Mortality #Vaccination #Pfizer #Fauci #Cancer #Immunology #Oncology

Dec 9, 2023 · 1 like · 1 share · 104 followers View post →

Governmentsandallbanksliekillandstealworldwide6969

@Politicarilazu1 · X

https://t.co/XIYUkGHi03

Dec 8, 2023 · 392 followers View post →

Marie.St.Clair

@stmarie_d · X

RT @dezzie_rezzie: 12

Dec 8, 2023 · 6 shares · 239 followers View post →

Marie.St.Clair

@stmarie_d · X

RT @dezzie_rezzie: 8

Dec 8, 2023 · 7 shares · 239 followers View post →

Operation: MindCrime

@sasapokimica · X

@APicuskin Evo i neko geneticar sad po evropi istrazuje to sa nekim docama na tu temu. I vec postoji 6 peer reviewd studija koje to potvrdjuju https://t.co/x1FIbUflhq

Dec 7, 2023 · 598 followers View post →

@AntoBertelli · X

@ChanceGardiner pare che i vaccini a mRNA facciano impazzire, in alcuni soggetti predisposti, diciamo 1 su 4, le IgG4 che portano malattie autoimmuni e cancro se il soggetto ha determinate proteine in eccesso nelle membrane cellulari: https://t.co/7zpjkm3gyB

Dec 7, 2023 · 9 followers View post →

LizS.

@LizzieLouS2 · X

Dr. Raszek explains the findings in an important new paper on the production of IgG4 antibodies in people following Covid mRNA vaccines (as well as possible treatments). https://t.co/qWuspI2ZKI

Dec 7, 2023 · 428 followers View post →

Ruth / רות

@NZalider · X

"Science is normal to introduce incorrect theories. That's how science is suppose to operate." @merogenomics More important material. Don't be an ignorant fool, learn! https://t.co/zge05ZsfWH

Dec 7, 2023 · 123 followers View post →

Refracto

@refractor111 · X

https://t.co/kGa14tTsf5

Dec 6, 2023 · 1,376 followers View post →

Jercuinn

@jercuinn · X

https://t.co/6ZL3oXAkV5

Dec 6, 2023 · 2,010 followers View post →

trainerrueben

@trainerrueben · X

#IGG4 https://t.co/6qXrCtwoNv #galectin3 https://t.co/ehoiUcNfgz

Dec 6, 2023 · 1 like · 948 followers View post →

Fredy13

@Goofygrandpa · X

IgG4 + surprise theory of Galectin 3 (IgG4 part 8, update118) https://t.co/FMR1DgDifo via @YouTube

Dec 6, 2023 · 423 followers View post →

Vernie

@VernWohlgemuth · X

IgG4 diseases in the 3x jabbed. O dear. At least there are scientists out there doing research that should have been done before u freaking jab billions of people! IgG4 + surprise theory of Galectin 3 (IgG4 part 8, update118) https://t.co/PvkrfI7t0d via @YouTube

Dec 6, 2023 · 153 followers View post →

White Matador

@whitematador · X

RT @dezzie_rezzie: 8

Dec 5, 2023 · 7 shares · 7,095 followers View post →

bubba’s lmn chop shop

@LmBubba · X

RT @dezzie_rezzie: 8

Dec 1, 2023 · 7 shares · 1,769 followers View post →

john watson

@jdwatsonii · X

RT @dezzie_rezzie: 12

Dec 1, 2023 · 6 shares · 374 followers View post →

E4rthFx

@EFxScout1League · X

RT @dezzie_rezzie: 8

Nov 30, 2023 · 7 shares · 14,277 followers View post →

E4rthFx

@EFxScout1League · X

RT @dezzie_rezzie: 12

Nov 30, 2023 · 6 shares · 14,277 followers View post →

Destiny Rezendes

@dezzie_rezzie · X

Nov 30, 2023 · 11 likes · 6 shares · 72,980 followers View post →

Destiny Rezendes

@dezzie_rezzie · X

Nov 30, 2023 · 6 likes · 7 shares · 72,980 followers View post →

Paul Maidowski

@_ppmv · X

@my2pups2 @villagerssn @PatrickHalstead @RealCheckMarker That's an excellent 2016 review article by Dr. Li Fang. https://t.co/M9Iv4BThYG

Sep 11, 2023 · 1 like · 9,083 followers View post →

@kingfisher444 · X

https://t.co/70QxQyOtCP https://t.co/OUWlg3P9ny

Aug 30, 2023 · 1 like · 1,022 followers View post →

A.Kruschke

@a_kruschke · X

@blanc0981 https://t.co/ZWSGIT5kZE

Jul 4, 2023 · 2 likes · 1,495 followers View post →

WASP Society

@crazycorpsman22 · X

@WCCO I still haven't seen reports from Congress that look into the connection with the University of Minnesota with some of the research. They had grants for a spike protein vaccine research years before, and Fang li was working with Wuhan on corona. https://t.co/SUJUIMs9CH

Jun 24, 2023 · 1 like · 2,245 followers View post →

Christopher Wayne Fisher

@ChristopWFisher · X

RT @EnemyInAState: https://t.co/DcYCsW2iFb https://t.co/rVlffNTmXl

May 7, 2023 · 1 share · 3,517 followers View post →

Chris Turnbull

@EnemyInAState · X

https://t.co/DcYCsW2iFb https://t.co/rVlffNTmXl

May 7, 2023 · 7 likes · 1 share · 28,758 followers View post →

Louis Nicolas-Baret

@BaretLouis · X

@CarreHarold @leomainie2 @DrFranckClarot https://t.co/dbEH974RSm et https://t.co/wWmeoKc92z et https://t.co/4Dl2MXz6AC et https://t.co/iPr1IZcAoW et https://t.co/9LgebEQR8E Et des dizaines de publis qui montrent un grand risque de contournement immunitaire.

May 6, 2023 · 1 like · 193 followers View post →

MarianW

@MarianWert · X

RT @BagaiDr: Structure,Function,Evolution of Coronavirus Spike Proteins: spike protein multifunctional molecular machine,mediates coV entry…

Apr 17, 2023 · 2 shares · 71 followers View post →

Serafina

@Serafina83837 · X

RT @BagaiDr: Structure,Function,Evolution of Coronavirus Spike Proteins: spike protein multifunctional molecular machine,mediates coV entry…

Apr 16, 2023 · 2 shares · 373 followers View post →

Prof. Dr. Sanjeev Bagai

@BagaiDr · X

Apr 16, 2023 · 10 likes · 2 shares · 34,759 followers View post →

Annual Reviews

@AnnualReviews · X

Feb 24, 2023 · 12,114 followers View post →

The Politics Archive

@TheArchiveTS · X

Structure, Function, and Evolution of Coronavirus Spike Proteins https://t.co/nXDTgQdLzy https://t.co/aQYq0QddWO

Jan 24, 2023 · 37 followers View post →

BreakthroughMedicine&AdvancedResearchTools

@JayChance12 · X