Topical treatment of green tea polyphenols emulsified in carboxymethyl cellulose protects against acute ultraviolet light B-induced photodamage in hairless mice.

Abstract in brief

• The study explores how green tea polyphenols (GTPs), when stabilized with carboxymethyl cellulose sodium (CMCNa), can protect hairless mice skin from damage caused by ultraviolet B (UVB) radiation, which can lead to skin inflammation, oxidative stress, and increased skin cancer risk.
• GTPs normally have issues with stability and low absorption in the body, but CMCNa helps preserve them, enhancing their protective effects.
• The topical application of GTPs emulsified in CMCNa reduces UVB-induced skin damage by decreasing inflammation, oxidative stress, and promoting protective cellular responses like nuclear Nrf2 activation, supporting GTPs’ potential use in skin protection against UV damage.]