Nat Med December 2016 PMID 27841876

Cardioprotection and lifespan extension by the natural polyamine spermidine.

Tobias Eisenberg, Mahmoud Abdellatif, Sabrina Schroeder, Uwe Primessnig, Slaven Stekovic, Tobias Pendl, Alexandra Harger, Julia Schipke, Andreas Zimmermann, Albrecht Schmidt, Mingming Tong, Christoph Ruckenstuhl, Christopher Dammbrueck, Angelina S Gross, Viktoria Herbst

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Mentions

143

Peak: 23 in Jun 2021

across 6 sources since Apr 2019

Extended reach

206,540

potential audience

Total likes

2,752

Video views

119,324

Mentions per month

Apr 2019 – Aug 2025

Where it's discussed

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AI synopsis

What people are saying

The overall tone reveals genuine interest, with users referencing studies like Eisenberg et al. (2016), and discussing dietary sources like natto and wheat germ, demonstrating curiosity about practical applications. The use of phrases such as 'promising research' and questions about clinical approval highlights a belief in the potential high impact of the findings, while the mention of doses and autophagy mechanisms shows engagement with scientific details.

AgreementModerate agreement

Most discussions acknowledge the promising results of spermidine for lifespan and heart health, reflecting general agreement with the publication's findings.

InterestHigh interest

The discussions exhibit high interest, with mentions of ongoing research, potential clinical applications, and dietary sources, indicating curiosity about the topic.

EngagementModerate engagement

Participants reference specific studies, methods, and implications, showing moderate to deep engagement with the research details.

ImpactModerate impact

The conversations suggest that many see spermidine as a potentially significant breakthrough for aging and cardiovascular health, indicating perceived impact.

Abstract in brief

Aging raises the risk of cardiovascular issues, but supplementation with spermidine significantly extends mouse lifespan and helps protect the heart by reducing hypertrophy and improving heart function.
Spermidine enhances critical heart processes like autophagy and mitochondrial function, and its benefits are linked to increased titin phosphorylation and reduced inflammation; however, these effects do not occur in mice lacking a specific autophagy protein.
In a high-salt diet model mimicking heart failure, spermidine lowers blood pressure, improves heart structure and function, and in humans, higher dietary spermidine is associated with lower cardiovascular disease rates, suggesting a promising approach for prevention.

Read the full abstract

All mentions

Spermidine's Role in Autophagy and Anti-Aging Research

Spermidine is a natural polyamine in many foods that activates autophagy, a cell recycling process. This has implications for potential anti-aging benefits and disease prevention, including heart disease…

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Dr. Armin Khonsari · Mar 30, 2023 348 views

Spermidine: Natural Cell Self-Repair and Anti-Aging Compound

Spermidine is a natural substance found in foods like wheat germ and soybeans, and also occurs in the human body. Studies indicate it has various anti-aging effects, protecting the heart and brain from age-related…

Dr. Armin Khonsari · Apr 2, 2023 293 views

The Role of Magnesium in Aging and Health Management

Supplements can help slow the aging process in the body. Magnesium metabolism changes with age, leading to mild deficiencies that may worsen chronic diseases. This video explores the importance of magnesium for health…

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DagobertIX

@DagobertIX · X

@biluhuang It did increase lifespan in mice, and induces autophagy in mice in other research. But they use really big doses. https://t.co/cs9x3fXEO9

Aug 12, 2025 · 1 like · 259 followers View post →

Reality Matters-Whether You Believe In It Or Not

@IainSim55659177 · X

Spermidine - autophagy & anti-aging research (2021) https://t.co/99gxdk7Dhs

Feb 5, 2023 · 1 like · 1,052 followers View post →

Schwarztee, keine Milch

@KeineMilch · X

@i_am_fabs Grazer Forschung :) https://t.co/tuwq2nOeN5

Jun 27, 2022 · 43 followers View post →

Dr L Boominathan PhD

@DrLBoominathan · X

Cardioprotection and lifespan extension by the natural polyamine spermidine https://t.co/MvvGgxU79T https://t.co/KLdHkBNkmj https://t.co/jOL1Acklzn

Oct 25, 2021 · 881 followers View post →

Ed n' Stuff

@EdnStuff · X

@brettdusek @Ravishing_Frog @Parsifaler https://t.co/PsNKfrOqkJ

Sep 17, 2021 · 7,943 followers View post →

peter mossop

@mostol1 · X

Spermidine - autophagy & anti-aging research (2021) https://t.co/otyITqHjWH via @YouTube

Jun 28, 2021 · 338 followers View post →

Tom Ovlien

@ATomOvlien · X

Vil Spermidine bli det første godkjente preparatet som forebygger kreft, hjerte- og karsykdom, demens og samtidig virker mot aldring? Lovende forskning allerede gjort, mer underveis. https://t.co/SBmXLpkNiA

Jun 28, 2021 · 488 followers View post →

Eleanor Sheekey

@EleanorSheekey · X

RT @michaelpawluk1: @davidasinclair @EleanorSheekey is already there. https://t.co/3VhIdf5lLD

Jun 28, 2021 · 8 shares · 4,870 followers View post →

ScienceStop

@B0tSci · X

RT @EleanorSheekey: In this week's video I take a look at some of the latest research regarding the natural polyamine spermidine and how it…

Jun 28, 2021 · 10 shares · 4,082 followers View post →

DomTheBoss

@uberrimaefidei1 · X

RT @EleanorSheekey: In this week's video I take a look at some of the latest research regarding the natural polyamine spermidine and how it…

Jun 28, 2021 · 10 shares · 626 followers View post →

win₿last

@winblast · X

RT @michaelpawluk1: @davidasinclair @EleanorSheekey is already there. https://t.co/3VhIdf5lLD

Jun 28, 2021 · 8 shares · 579 followers View post →

Swany Velázquez S. | NYC Dweller-CDMX Made

@SwanyVe · X

RT @michaelpawluk1: @davidasinclair @EleanorSheekey is already there. https://t.co/3VhIdf5lLD

Jun 27, 2021 · 8 shares · 289 followers View post →

Zen Ya

@Zen66491421 · X

RT @michaelpawluk1: @davidasinclair @EleanorSheekey is already there. https://t.co/3VhIdf5lLD

Jun 27, 2021 · 8 shares · 564 followers View post →

Informative News

@linas19814 · X

RT @michaelpawluk1: @davidasinclair @EleanorSheekey is already there. https://t.co/3VhIdf5lLD

Jun 27, 2021 · 8 shares · 189 followers View post →

michael pawluk

@michaelpawluk1 · X

@davidasinclair @EleanorSheekey is already there. https://t.co/3VhIdf5lLD

Jun 27, 2021 · 61 likes · 8 shares · 33 followers View post →

LongeCity

@longecity_org · X

RT @EleanorSheekey: In this week's video I take a look at some of the latest research regarding the natural polyamine spermidine and how it…

Jun 9, 2021 · 10 shares · 1,547 followers View post →

Orlando_uy

@Orlando_uy · X

Cardioprotection and lifespan extension by the natural polyamine spermidine. https://t.co/zu2z7Xcdwh

Jun 9, 2021 · 690 followers View post →

Based Hatter

@BasedHatter · X

RT @EleanorSheekey: In this week's video I take a look at some of the latest research regarding the natural polyamine spermidine and how it…

Jun 6, 2021 · 10 shares · 4,524 followers View post →

ScienceStop

@B0tSci · X

RT @EleanorSheekey: In this week's video I take a look at some of the latest research regarding the natural polyamine spermidine and how it…

Jun 6, 2021 · 10 shares · 4,082 followers View post →

Academic YouTubers

@YTacademics · X

RT @EleanorSheekey: In this week's video I take a look at some of the latest research regarding the natural polyamine spermidine and how it…

Jun 6, 2021 · 10 shares · 2,114 followers View post →

Yuji Marutani Planning Director

@YujiMarutani · X

Watch "Spermidine - autophagy & anti-aging research (2021)" on YouTube https://t.co/SToWKVaIWs

Jun 5, 2021 · 1,580 followers View post →

Omar Elashkar

@OmarIAshkar · X

RT @EleanorSheekey: In this week's video I take a look at some of the latest research regarding the natural polyamine spermidine and how it…

Jun 5, 2021 · 10 shares · 17 followers View post →

Alex Freeman

@alex__freeman · X

RT @EleanorSheekey: In this week's video I take a look at some of the latest research regarding the natural polyamine spermidine and how it…

Jun 4, 2021 · 10 shares · 38 followers View post →

Rapamycin News

@RapaNews · X

RT @EleanorSheekey: In this week's video I take a look at some of the latest research regarding the natural polyamine spermidine and how it…

Jun 4, 2021 · 10 shares · 5,291 followers View post →

Stan

@KanstantinS · X

@LongevityTech @EleanorSheekey Here is youtube link https://t.co/V74dQzXQWW

Jun 4, 2021 · 1 like · 77 followers View post →

(((Phroexus)))

@phroex · X

RT @EleanorSheekey: In this week's video I take a look at some of the latest research regarding the natural polyamine spermidine and how it…

Jun 4, 2021 · 10 shares · 2,781 followers View post →

Eleanor Sheekey

@EleanorSheekey · X

Jun 4, 2021 · 21 likes · 10 shares · 4,870 followers View post →

Joel "Heart Prevention" Kahn MD, FACC

@drjkahn · X

More on the health benefits of spermidine rich foods (wheat germ, peas, shrooms) Cardioprotection and lifespan extension by the natural polyamine spermidine https://t.co/bXp5Uxge5v #kahnchronicle

Oct 25, 2020 · 32,289 followers View post →

TopologicApple

@topologic_apple · X

Jun 22, 2020 · 1 like · 2,932 followers View post →

Pedro de Noronha Pissarra, PhD

@pnpissarra · X

@foundmyfitness what do you make of Spermidine and analogues/derivatives as autophagy inducers? Eisenberg et al 2016; Cardioprotection and lifespan extension by the natural polyamine spermidine in Nature Med 2016; 22: 1428–1438

May 1, 2019 · 37 followers View post →

Pedro de Noronha Pissarra, PhD

@pnpissarra · X

@davidasinclair what do you make of Spermidine and analogues/derivatives as autophagy inducers? Eisenberg et al,2016; Cardioprotection and lifespan extension by the natural polyamine spermidine in Nature Med 2016; 22: 1428–1438

May 1, 2019 · 37 followers View post →

Pedro de Noronha Pissarra, PhD

@pnpissarra · X

@PeterAttiaMD what do you make of Spermidine and analogues/derivatives as autophagy inducers? Eisenberg et al,2016; Cardioprotection and lifespan extension by the natural polyamine spermidine in Nature Med 2016; 22: 1428–1438

May 1, 2019 · 37 followers View post →

Keto Brainz Nootropics

@ketobrainz · X

Natto, how did I forget about you?!Natto & Brie are back on my shopping list! Cardioprotection and lifespan extension by the natural polyamine spermidine https://t.co/R8cW6FUOKI via @foundmyfitness

Apr 20, 2019 · 1,723 followers View post →

Cardioprotection and lifespan extension by the natural polyamine spermidine.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Spermidine's Role in Autophagy and Anti-Aging Research

The Science Behind Urine Therapy and Its Dermatological Uses

Understanding Magnesium's Role in Healthy Aging and Longevity

Spermidine: Natural Cell Self-Repair and Anti-Aging Compound

The Role of Magnesium in Aging and Health Management