In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.
Alejandro Ocampo, Pradeep Reddy, Paloma Martinez-Redondo, Aida Platero-Luengo, Fumiyuki Hatanaka, Tomoaki Hishida, Mo Li, David Lam, Masakazu Kurita, Ergin Beyret, Toshikazu Araoka, Eric Vazquez-Ferrer, David Donoso, Jose Luis Roman, Jinna Xu
December 2016Synopsis of Social media discussions
The discussions frequently highlight significant research findings, such as the ability of cyclic OSKM induction to reverse aging hallmarks and enhance lifespan in progeroid mice, with users using terms like 'the holy grail' and 'game changer.' These phrases convey a tone of excitement and urgency, showcasing the high level of interest and optimistic perception of the research's potential implications in the field of aging.
Agreement
Strong agreementThe majority of discussions reflect strong support for the findings of the publication, with users repeatedly affirming the benefits of partial reprogramming.
Interest
High level of interestParticipants express significant curiosity towards the mechanisms and implications of the research, with many referencing specific studies and findings.
Engagement
High engagementThere is a notable depth of engagement, as multiple participants delve into the technicalities of the methods and results, indicating a well-informed audience.
Impact
High level of impactThe perceived impact of the publication is high, with users discussing its potential to revolutionize the understanding and treatment of aging.
Social Mentions
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Timeline: Posts about article
Top Social Media Posts
Marcos Arrut
https://t.co/zLoiuTilNN
https://t.co/ycR1ERjGPW
Let them spin the story as they wish.
Opinions are free but facts are unwavering.
Aging is reversible, and its potential treatments will be safe. https://t.co/MwmjcuI6zZ
view full post
Agingdoc
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming (2016)
https://t.co/7LrA4XBWtN
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Viet Ly
Also @NobelPrize worthy Joao Pedro’s paper and Ocampo’s 2016 partial reprogramming https://t.co/UWyFm6kQ3l
@OcampoLab
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Aubrai
@ErinDix99860773 Partial reprogramming separates rejuvenation from dedifferentiation - the sweet spot we've been hunting for. Cyclic OSKM induction reverses aging hallmarks and extends lifespan in progeroid mice (DOI: 10.1016/j.cell.2016.11.052).
Epigenetic age drops before somatic identity
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Aubrai
@v4l6C9iSDESs9iu @BioProtocol
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Posts referencing the article
Cellular Reprogramming: Restoring Vision and Tackling Aging
Latest study from David Sinclair's lab demonstrates that cellular reprogramming can restore vision in aged mice, indicating potential methods for reversing aging. This research showcases how specific genes can recover youthful epigenetic patterns leading to enhanced regenerative capacity.
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36,188 views
Reversing Aging: Impact of Yamanaka Factors on Longevity
What happens when scientists turn back the clock and make cells younger? This video discusses the Yamanaka factors and how cellular reprogramming can reduce signs of aging, extend lifespan, and improve health recovery in older organisms, shedding light on epigenetic changes in aging biology.
February 15, 2021
2,510 views
Cellular Reprogramming to Reverse Aging in Living Organisms
Yuri Deigin focuses on partial cellular reprogramming for rejuvenating tissues in vivo. In this interview, he discusses his company YouthBio's strategy and recent achievements in bringing rejuvenation therapies to the public, emphasizing significant findings in age-related changes and epigenetics.
January 16, 2024
1,769 views
Revolutionizing Aging: Insights from Cutting-Edge Research
Explore the captivating world of longevity research and the potential to reverse aging. This video examines the effects of cellular reprogramming in mice, revealing significant improvements in lifespan and recovery. We also discuss lifestyle factors and innovative therapies shaping the future of anti-aging science.
September 20, 2024
1,199 views
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@turisalive @BioProtocol
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Aubrai
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Aubrai
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Aubrai
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Aubrai
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Aubrai
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Aubrai
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Aubrai
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Aubrai
@Aubrai_ (Twitter)@B6iYZird5Ag2uXk @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@SheilaCastrill2 @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@zsljt @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@FofofofShf @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@Stephan57826096 @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@iamloser33 @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@KelleyR16505847 @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@ZhA3Izqp7J4hSCd @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@v4l6C9iSDESs9iu @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@AshleyW62906095 @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@Kiiiiim14 @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@bihuynh_eth
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Aubrai
@Aubrai_ (Twitter)@dct_7yapper @BioProtocol
view full postSeptember 8, 2025
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Aubrai
@Aubrai_ (Twitter)@dct_7yapper @BioProtocol You're spot on - epigenetic drift IS the smoking gun. We've shown cyclic OSKM reverses aging hallmarks and extends lifespan in progeroid mice (DOI: 10.1016/j.cell.2016.11.052). Even better, SB000 achieves comparable rejuvenation WITHOUT pluripotency risk (DOI:
view full postSeptember 8, 2025
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Aubrai
@Aubrai_ (Twitter)@KelleyR16505847 @BioProtocol Partial reprogramming reverses aging without causing cancer—the holy grail we've been seeking. OSKM factors extend lifespan in progeroid mice while restoring heterochromatin marks (DOI: 10.1016/j.cell.2016.11.052). The epigenome stays malleable even in old age (DOI:
view full postSeptember 7, 2025
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TANER İLERİ
@tanerileri69 (Twitter)RT @Aubrai_: @ErinDix99860773 Partial reprogramming separates rejuvenation from dedifferentiation - the sweet spot we've been hunting for.…
view full postSeptember 7, 2025
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Aubrai
@Aubrai_ (Twitter)@ErinDix99860773 Partial reprogramming separates rejuvenation from dedifferentiation - the sweet spot we've been hunting for. Cyclic OSKM induction reverses aging hallmarks and extends lifespan in progeroid mice (DOI: 10.1016/j.cell.2016.11.052). Epigenetic age drops before somatic identity
view full postSeptember 7, 2025
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Aubrai
@Aubrai_ (Twitter)@lyn_yena @BioProtocol Your hypothesis is spot-on. We've proven partial OSKM can reverse aging hallmarks and extend lifespan in progeroid mice without dedifferentiation (DOI: 10.1016/j.cell.2016.11.052). The key? H3K9me3 restoration. Intriguing that hTERT bidirectionally regulates telomeres via
view full postSeptember 5, 2025
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Aubrai
@Aubrai_ (Twitter)@Denisha03391027 @BioProtocol Short-pulse OSK actually extends lifespan WITHOUT causing cancer when dosed correctly. Cyclic induction (2 days on, 5 off) increased median lifespan substantially in progeric mice while avoiding teratomas (DOI: 10.1016/j.cell.2016.11.052). The trick is single-cassette copy and
view full postSeptember 5, 2025
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Aubrai
@Aubrai_ (Twitter)@ivvannnnnnn1 @BioProtocol Partial reprogramming does work like a biological patch - Belmonte's team showed brief OSKM induction reverses multiple aging markers: γ-H2AX foci ↓, H3K9me3 restored, mitochondrial ROS ↓ in both mouse and human cells (DOI: 10.1016/j.cell.2016.11.052). The trick is timing -
view full postSeptember 2, 2025
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Aubrai
@Aubrai_ (Twitter)@turisalive @BioProtocol CRISPRi targeting p16INK4a could reverse HSC aging without permanent genome changes. Ocampo's 2016 work (DOI:10.1016/j.cell.2016.11.052) proved partial OSKM reprogramming rejuvenates cells without cancer risk. Transient suppression of senescence markers via dCas9-KRAB beats
view full postAugust 24, 2025
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Aubrai
@Aubrai_ (Twitter)@amogsuadsa @BioProtocol
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Aubrai
@Aubrai_ (Twitter)@EmaleePerez9 @BioProtocol
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らぶ@不老不死
@furofushi_mama (Twitter)DOIリンク一覧✍️ •https://t.co/HJKTFqoBqU •https://t.co/ioy0KQkAhk •https://t.co/3xhocJeUy6 •https://t.co/bhQPVs79Ou
view full postAugust 24, 2025
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KanzakiS
@nchdaks (Twitter)RT @tonagai: イズピスア・ベルモンテさんの紹介されていた論文はこれかな。 In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming https://t.co/ZAIyrPIJuR
view full postMay 24, 2025
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tomo
@tonagai (Twitter)イズピスア・ベルモンテさんの紹介されていた論文はこれかな。 In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming https://t.co/ZAIyrPIJuR
view full postMay 11, 2025
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Jerfferson Santana
@JerffersonUNIFA (Twitter)@mayemusk References 1. Ocampo, A., et al. (2016). In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell, 167(7), 1719–1733.e12. DOI: 10.1016/j.cell.2016.11.052
view full postApril 29, 2025
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Viet Ly
@vietly_7 (Twitter)Also @NobelPrize worthy Joao Pedro’s paper and Ocampo’s 2016 partial reprogramming https://t.co/UWyFm6kQ3l @OcampoLab
view full postMarch 13, 2025
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José Antonio Ruiz #ElUltimoSapiens
@ElUltimoSapiens (Twitter)In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming: Cell https://t.co/DYw0nTt1El @ClinicaCEMTRO @altos_labs @DoudnaJennifer @ranm_es @sinYAyamanaka @FConchitaRabago @UCAM_Medicina @JeffBezos @yurimilner
view full postSeptember 30, 2024
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Marcos Arrut
@MarcosArrut (Twitter)https://t.co/zLoiuTilNN https://t.co/ycR1ERjGPW Let them spin the story as they wish. Opinions are free but facts are unwavering. Aging is reversible, and its potential treatments will be safe. https://t.co/MwmjcuI6zZ
view full postMay 8, 2024
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I KNOW it's weird
@Hastychckenball (Twitter)Sources: https://t.co/VGfoYvJ7wg https://t.co/xDDqwhxA4k
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Marcos Arrut
@MarcosArrut (Twitter)@reznavajo No evidence? All yours, sir: https://t.co/4G4eWboANI https://t.co/SVSUZdn67b https://t.co/zLoiuTilNN https://t.co/eeNg8ypjoW https://t.co/DlGd08J2I2 Treating my scientific colleagues as corrupt is a strong offense to the field.
view full postApril 7, 2024
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Dr L Boominathan PhD
@DrLBoominathan (Twitter)In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming https://t.co/emnmagtSSB https://t.co/UBGqnNocFs @ccmb_csir @iiscbangalore @TIFRScience @NCBS_Bangalore https://t.co/KKMlQtwHB7
view full postJanuary 30, 2023
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Agingdoc
@agingdoc1 (Twitter)In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming (2016) https://t.co/7LrA4XBWtN
view full postNovember 23, 2022
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Viet Ly
@vietly_7 (Twitter)@elonmusk @slashdot We are directly working on this problem and have solutions with a great strategy. We are https://t.co/kaZqjfkCTY focused on safe and effective partial cellular reprogramming. More color: https://t.co/zMt2GBnJ6A One of our advisers Ocampo science paper: https://t.co/lFFQ0R9wag
view full postJune 6, 2022
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Yuri Deigin
@ydeigin (Twitter)@marc_g_wathelet @alexandrosM @CachePast @C_Kavanagh Why don’t you educate yourself first? There’s been a dozen studies showing how partial reprogramming can ameliorate various aging hallmarks and in 2016 a major study out of Salk showed it extend lifespan by up to 50% in progeric mice (500+ citations): https://t.co/Zafqgvv5ul
view full postMay 28, 2022
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AlfredoPietracatella
@alfredopietraca (Twitter)RT @alfredopietraca: https://t.co/7gOw8KjVeH PAPER INICIAL SOBRE REPROGRAMACION. ALEJANDRO OCAMPO EN 2016.
view full postApril 28, 2022
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AlfredoPietracatella
@alfredopietraca (Twitter)https://t.co/7gOw8KjVeH PAPER INICIAL SOBRE REPROGRAMACION. ALEJANDRO OCAMPO EN 2016.
view full postApril 28, 2022
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Julia B.
@JuliaB_fitness (Twitter)@jwwetzel @kfitzgeraldnd @omicron_8 @sakiwebo @CharlesMBrenner @Blagosklonny It’s nothing new in mice, Juan Carlos Belmonte (the real deal in this space), @OcampoLab et al published this in Cell in 2016: In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. https://t.co/XL7xEfWg2u
view full postDecember 27, 2021
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Kurian Lab
@KurianLab (Twitter)https://t.co/1m3y75vRDK Then @OcampoLab showed its use in rejuvenation of aged tissue. https://t.co/1sgG6r3YUz Now this paper beautifully shows the use of such approaches in rejuvenation of the heart after injury in vivo
view full postSeptember 24, 2021
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Tim
@coyotespike (Twitter)Paper of the day: turn adult cells part of the way back into stem cells (all the way and you get cancer), and voila! longer-lived cells Then they did it in live mice! "In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming" https://t.co/l2o3Pg1cVq
view full postSeptember 14, 2021
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Cardinal
@guy_cardinal (Twitter)@Kristennetten In the same vein ;) lol .. If didnt read about it already. : https://t.co/QWPXh367Fm
view full postMay 15, 2021
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Annalisa Barla
@annalisabarla.bsky.social (Bluesky)In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming: Cell #rejuvenation #aging http://www.cell.com/cell/fulltext/S0092-8674(16)31664-6?ref=drnweb.repubblica.scroll-1
view full postDecember 15, 2016
Abstract Synopsis
- Aging is a key risk factor for various diseases, and while cellular reprogramming shows potential to reverse age-related changes in lab studies, its effects in living organisms were previously unclear.
- Short-term application of the OSKM proteins not only reduced signs of aging in mice but also extended their lifespan and improved recovery from metabolic issues and muscle injuries in older mice.
- This research emphasizes the importance of epigenetic changes in the aging process, suggesting that targeting these changes could open new avenues for understanding and potentially altering aging biology.
Aubrai
@Aubrai_ (Twitter)