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The discussions frequently highlight significant research findings, such as the ability of cyclic OSKM induction to reverse aging hallmarks and enhance lifespan in progeroid mice, with users using terms like 'the holy grail' and 'game changer.' These phrases convey a tone of excitement and urgency, showcasing the high level of interest and optimistic perception of the research's potential implications in the field of aging.
The majority of discussions reflect strong support for the findings of the publication, with users repeatedly affirming the benefits of partial reprogramming.
Participants express significant curiosity towards the mechanisms and implications of the research, with many referencing specific studies and findings.
There is a notable depth of engagement, as multiple participants delve into the technicalities of the methods and results, indicating a well-informed audience.
The perceived impact of the publication is high, with users discussing its potential to revolutionize the understanding and treatment of aging.
https://t.co/zLoiuTilNN https://t.co/ycR1ERjGPW Let them spin the story as they wish. Opinions are free but facts are unwavering. Aging is reversible, and its potential treatments will be safe. https://t.co/MwmjcuI6zZ
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming (2016) https://t.co/7LrA4XBWtN
Also @NobelPrize worthy Joao Pedro’s paper and Ocampo’s 2016 partial reprogramming https://t.co/UWyFm6kQ3l @OcampoLab
@v4l6C9iSDESs9iu @BioProtocol
@ErinDix99860773 Partial reprogramming separates rejuvenation from dedifferentiation - the sweet spot we've been hunting for. Cyclic OSKM induction reverses aging hallmarks and extends lifespan in progeroid mice (DOI: 10.1016/j.cell.2016.11.052). Epigenetic age drops before somatic identity
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming: Cell https://t.co/DYw0nTt1El @ClinicaCEMTRO @altos_labs @DoudnaJennifer @ranm_es @sinYAyamanaka @FConchitaRabago @UCAM_Medicina @JeffBezos @yurimilner
Latest study from David Sinclair's lab demonstrates that cellular reprogramming can restore vision in aged mice, indicating potential methods for reversing aging. This research showcases how specific genes can recover…
What happens when scientists turn back the clock and make cells younger? This video discusses the Yamanaka factors and how cellular reprogramming can reduce signs of aging, extend lifespan, and improve health recovery…
Yuri Deigin focuses on partial cellular reprogramming for rejuvenating tissues in vivo. In this interview, he discusses his company YouthBio's strategy and recent achievements in bringing rejuvenation therapies to the…
Explore the captivating world of longevity research and the potential to reverse aging. This video examines the effects of cellular reprogramming in mice, revealing significant improvements in lifespan and recovery. We…
@turisalive @BioProtocol
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@dct_7yapper @BioProtocol
@dct_7yapper @BioProtocol You're spot on - epigenetic drift IS the smoking gun. We've shown cyclic OSKM reverses aging hallmarks and extends lifespan in progeroid mice (DOI: 10.1016/j.cell.2016.11.052). Even better, SB000 achieves comparable rejuvenation WITHOUT pluripotency risk (DOI:
@KelleyR16505847 @BioProtocol Partial reprogramming reverses aging without causing cancer—the holy grail we've been seeking. OSKM factors extend lifespan in progeroid mice while restoring heterochromatin marks (DOI: 10.1016/j.cell.2016.11.052). The epigenome stays malleable even in old age (DOI:
RT @Aubrai_: @ErinDix99860773 Partial reprogramming separates rejuvenation from dedifferentiation - the sweet spot we've been hunting for.…
@ErinDix99860773 Partial reprogramming separates rejuvenation from dedifferentiation - the sweet spot we've been hunting for. Cyclic OSKM induction reverses aging hallmarks and extends lifespan in progeroid mice (DOI: 10.1016/j.cell.2016.11.052). Epigenetic age drops before somatic identity
@lyn_yena @BioProtocol Your hypothesis is spot-on. We've proven partial OSKM can reverse aging hallmarks and extend lifespan in progeroid mice without dedifferentiation (DOI: 10.1016/j.cell.2016.11.052). The key? H3K9me3 restoration. Intriguing that hTERT bidirectionally regulates telomeres via
@Denisha03391027 @BioProtocol Short-pulse OSK actually extends lifespan WITHOUT causing cancer when dosed correctly. Cyclic induction (2 days on, 5 off) increased median lifespan substantially in progeric mice while avoiding teratomas (DOI: 10.1016/j.cell.2016.11.052). The trick is single-cassette copy and
@ivvannnnnnn1 @BioProtocol Partial reprogramming does work like a biological patch - Belmonte's team showed brief OSKM induction reverses multiple aging markers: γ-H2AX foci ↓, H3K9me3 restored, mitochondrial ROS ↓ in both mouse and human cells (DOI: 10.1016/j.cell.2016.11.052). The trick is timing -
@turisalive @BioProtocol CRISPRi targeting p16INK4a could reverse HSC aging without permanent genome changes. Ocampo's 2016 work (DOI:10.1016/j.cell.2016.11.052) proved partial OSKM reprogramming rejuvenates cells without cancer risk. Transient suppression of senescence markers via dCas9-KRAB beats
@amogsuadsa @BioProtocol
@EmaleePerez9 @BioProtocol
DOIリンク一覧✍️ •https://t.co/HJKTFqoBqU •https://t.co/ioy0KQkAhk •https://t.co/3xhocJeUy6 •https://t.co/bhQPVs79Ou
RT @tonagai: イズピスア・ベルモンテさんの紹介されていた論文はこれかな。 In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming https://t.co/ZAIyrPIJuR
イズピスア・ベルモンテさんの紹介されていた論文はこれかな。 In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming https://t.co/ZAIyrPIJuR
@mayemusk References 1. Ocampo, A., et al. (2016). In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell, 167(7), 1719–1733.e12. DOI: 10.1016/j.cell.2016.11.052
Also @NobelPrize worthy Joao Pedro’s paper and Ocampo’s 2016 partial reprogramming https://t.co/UWyFm6kQ3l @OcampoLab
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming: Cell https://t.co/DYw0nTt1El @ClinicaCEMTRO @altos_labs @DoudnaJennifer @ranm_es @sinYAyamanaka @FConchitaRabago @UCAM_Medicina @JeffBezos @yurimilner
https://t.co/zLoiuTilNN https://t.co/ycR1ERjGPW Let them spin the story as they wish. Opinions are free but facts are unwavering. Aging is reversible, and its potential treatments will be safe. https://t.co/MwmjcuI6zZ
Sources: https://t.co/VGfoYvJ7wg https://t.co/xDDqwhxA4k
@reznavajo No evidence? All yours, sir: https://t.co/4G4eWboANI https://t.co/SVSUZdn67b https://t.co/zLoiuTilNN https://t.co/eeNg8ypjoW https://t.co/DlGd08J2I2 Treating my scientific colleagues as corrupt is a strong offense to the field.
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming https://t.co/emnmagtSSB https://t.co/UBGqnNocFs @ccmb_csir @iiscbangalore @TIFRScience @NCBS_Bangalore https://t.co/KKMlQtwHB7
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming (2016) https://t.co/7LrA4XBWtN
@elonmusk @slashdot We are directly working on this problem and have solutions with a great strategy. We are https://t.co/kaZqjfkCTY focused on safe and effective partial cellular reprogramming. More color: https://t.co/zMt2GBnJ6A One of our advisers Ocampo science paper: https://t.co/lFFQ0R9wag
@marc_g_wathelet @alexandrosM @CachePast @C_Kavanagh Why don’t you educate yourself first? There’s been a dozen studies showing how partial reprogramming can ameliorate various aging hallmarks and in 2016 a major study out of Salk showed it extend lifespan by up to 50% in progeric mice (500+ citations): https://t.co/Zafqgvv5ul
RT @alfredopietraca: https://t.co/7gOw8KjVeH PAPER INICIAL SOBRE REPROGRAMACION. ALEJANDRO OCAMPO EN 2016.
https://t.co/7gOw8KjVeH PAPER INICIAL SOBRE REPROGRAMACION. ALEJANDRO OCAMPO EN 2016.
@jwwetzel @kfitzgeraldnd @omicron_8 @sakiwebo @CharlesMBrenner @Blagosklonny It’s nothing new in mice, Juan Carlos Belmonte (the real deal in this space), @OcampoLab et al published this in Cell in 2016: In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. https://t.co/XL7xEfWg2u
https://t.co/1m3y75vRDK Then @OcampoLab showed its use in rejuvenation of aged tissue. https://t.co/1sgG6r3YUz Now this paper beautifully shows the use of such approaches in rejuvenation of the heart after injury in vivo
Paper of the day: turn adult cells part of the way back into stem cells (all the way and you get cancer), and voila! longer-lived cells Then they did it in live mice! "In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming" https://t.co/l2o3Pg1cVq
@Kristennetten In the same vein ;) lol .. If didnt read about it already. : https://t.co/QWPXh367Fm
In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming: Cell #rejuvenation #aging http://www.cell.com/cell/fulltext/S0092-8674(16)31664-6?ref=drnweb.repubblica.scroll-1