Acta Pharm Sin B January 2017 PMID 28119804

Targeting calcium signaling in cancer therapy.

Chaochu Cui, Robert Merritt, Liwu Fu, Zui Pan

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What people are saying

The discussions exhibit a lack of focus and clarity, with vague mentions like 'smoke a cancer cure' and references to unrelated subjects such as mummy mitochondrial metabolism, which diminish the perceived importance of the publication. The tone suggests disinterest and superficial engagement rather than serious scientific dialogue.

AgreementNeither agree nor disagree

The comments do not clearly support or oppose the publication, reflecting neutrality or confusion about its significance.

InterestNeutral interest

Overall, the discussions show minimal curiosity about calcium signaling and cancer therapies.

EngagementLow engagement

Posts seem dismissive and inconsistent, with some confusing references that suggest low engagement depth.

ImpactLow impact

The references to unrelated topics and casual remarks indicate little to no meaningful influence on research or clinical perspectives.

Abstract in brief

Intracellular calcium ions (Ca) act as second messengers that regulate key cellular processes such as gene transcription, cell growth, migration, and death, with abnormal calcium signaling linked to cancer development and spread.
Research is focusing on targeting calcium channels, transporters, and pumps that are altered in cancer cells, using blockers or inhibitors as potential anti-cancer therapies.
The review aims to encourage further research into how calcium signaling is regulated in cancer cells and to develop new treatments by targeting these calcium-related molecules.

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