Non-destructive Determination of Disintegration Time and Dissolution in Immediate Release Tablets by Terahertz Transmission Measurements.

Daniel Markl, Johanna Sauerwein, Daniel J Goodwin, Sander van den Ban, J Axel Zeitler

May 2017 Pharm Res

Synopsis of Social media discussions

The discussions include examples like praise for researchers working on terahertz spectroscopy and mentions of efforts to develop real-time, non-destructive dissolution assays, revealing enthusiasm and recognition of the research’s potential. The tone and choice of words such as ‘developing,’ ‘fast,’ and ‘promising’ emphasize a forward-looking perspective and perceived importance of the findings.

A
Agreement
 Moderate agreement

Most discussions reflected positive recognition of the research's significance, highlighting breakthroughs in non-destructive testing for tablets and emphasizing its potential benefits.

I
Interest
 High level of interest

The conversations demonstrate high interest, with multiple mentions of the technology's applications and praise for the researchers' achievements, indicating active engagement with the material.

E
Engagement
 Moderate level of engagement

Participants reference specific methods, institutions, and future applications, showing moderate to deep engagement which indicates they are reflecting on its implications beyond surface-level appreciation.

I
Impact
 Moderate level of impact

The enthusiasm for the technology and its potential to transform pharmaceutical manufacturing suggest that the discussions view this research as having a meaningful impact on the industry.

Social Mentions

YouTube

2 Videos

Facebook

2 Posts

Twitter

8 Posts

Metrics

Video Views

3,386

Total Likes

57

Extended Reach

10,141

Social Features

12

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Non-destructive Terahertz Method for Pharmaceutical Tablet Porosity and Quality

Non-destructive Terahertz Method for Pharmaceutical Tablet Porosity and Quality

This method rapidly measures tablet porosity noninvasively, correlating with hardness, disintegration, and dissolution. It enables real-time quality assessment without sample preparation, suitable for integration into manufacturing processes.

Terahertz Applications Group Cambridge

November 2, 2019

1,974 views

Impact of Tablet Manufacturing on Pharmaceutical Quality and Disintegration

Impact of Tablet Manufacturing on Pharmaceutical Quality and Disintegration

Presentation by Dr Prince Bawuah at the IFPAC 2021 virtual meeting discusses how process variations affect tablet disintegration and drug release using non-destructive terahertz spectroscopy for quality assessment.

Terahertz Applications Group Cambridge

March 3, 2021

1,412 views

  • Najnin Sharmin
    @SharminNajnin (Twitter)

    Great to see one of our senior from @UniEastFinland working at @Cambridge_Uni on Terahertz Spectroscopy Great job @PrinceBawuah...keep it up Non-destructive Porosity Testing Method for Pharmaceutical Tablets Based... https://t.co/PSVd9KZXZc via @YouTube
    view full post

    November 4, 2019

  • Dr Maggie Cunningham
    @MagRoseCun (Twitter)

    RT @PSSRCNews: #PharmSci360 Poster M1330-06-40 on Monday, 4 Nov: Developing a Fast, Non-Destructive Terahertz Dissolution Assay of Tablets…
    view full post

    November 3, 2019

    9

  • Terahertz Cambridge
    @THzCambridge (Twitter)

    @Quantumbutadyne presenting latest work on developing #sensor for real time #nondestructive #dissolution assay for #pharmaceutical industry at #PharmSci360 this week - M1330-06-40 Monday 1.30 pm. Link to the #abstract in video description #thzdoesitbetter https://t.co/jGdjRXWvg2
    view full post

    November 3, 2019

    5

  • TeraView
    @TeraView (Twitter)

    RT @PSSRCNews: #PharmSci360 Poster M1330-06-40 on Monday, 4 Nov: Developing a Fast, Non-Destructive Terahertz Dissolution Assay of Tablets…
    view full post

    November 2, 2019

    9

  • StrathPharm&Bio
    @SIPBS_Strath (Twitter)

    RT @PSSRCNews: #PharmSci360 Poster M1330-06-40 on Monday, 4 Nov: Developing a Fast, Non-Destructive Terahertz Dissolution Assay of Tablets…
    view full post

    November 2, 2019

    9

  • Terahertz Cambridge
    @THzCambridge (Twitter)

    RT @PSSRCNews: #PharmSci360 Poster M1330-06-40 on Monday, 4 Nov: Developing a Fast, Non-Destructive Terahertz Dissolution Assay of Tablets…
    view full post

    November 2, 2019

    9

  • Daniel Markl
    @DanielMarkl (Twitter)

    RT @PSSRCNews: #PharmSci360 Poster M1330-06-40 on Monday, 4 Nov: Developing a Fast, Non-Destructive Terahertz Dissolution Assay of Tablets…
    view full post

    November 2, 2019

    9

  • The PSSRC
    @PSSRCNews (Twitter)

    #PharmSci360 Poster M1330-06-40 on Monday, 4 Nov: Developing a Fast, Non-Destructive Terahertz Dissolution Assay of Tablets During Manufacture @AAPSComms @TeraView @SIPBS_Strath @EPSRC_CMAC @GSK @innovateuk @cebcambridge #pat #qbd #dissolution #terahertz https://t.co/3iUHYXB2jY
    view full post

    November 2, 2019

    12

    9

Abstract Synopsis

  • This study demonstrates that terahertz (THz) transmission measurements can be used nondestructively to predict disintegration time and active ingredient dissolution in commercial tablets, specifically after 15, 20, and 25 minutes.
  • By analyzing 18 batches of tablets produced through various process conditions, researchers found a strong linear correlation between the effective refractive index (n) measured by THz and both disintegration time and dissolution after 15 minutes, outperforming traditional hardness tests.
  • The findings suggest that THz measurements, due to their high penetration power and contactless nature, are promising tools for monitoring key quality attributes during tablet manufacturing without the need for sample destruction.]