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Several posts emphasize the questionable efficacy of SSRIs, quoting meta-analyses and pointing out high risks of bias, with words like 'junk' and 'questionable' implying distrust. The tone and context reveal a critical stance, illustrating the ongoing debate about the true benefits and harms of these medications, ultimately fostering a nuanced understanding of their limited clinical impact.
Many discussions highlight skepticism about the effectiveness of SSRIs, suggesting a tendency toward disagreement with their clinical utility.
The topic clearly sparks strong curiosity and concern, with numerous posts analyzing study details and implications.
Posts show deep engagement through referencing meta-analyses, discussing biases, and debating clinical significance, indicating active participation in the topic.
While some posts question the clinical relevance, overall the discussions raise awareness about the limitations and risks associated with SSRIs, highlighting moderate impact.
En 2017 se publicó un metaanálisis sobre la eficacia de los antidepresivos (otro más, habría que decir). Es un tema que no cesa precisamente porque no está nada claro. Aquí va el enlace. https://t.co/OZarlA9L7C
@Beautyjunkie21 @babycatcalla @ToBornin @AngelAlma10 @GirlWarehouse @Quin4Trump @ramsey_lewis007 @S51781902 @Gigi69030829 @Visitor22 @justavtr @FroniterLyn @traveler002 @jackiejones632 @MarilynLavala @diggihop @larry_mcelhiney @HarryMi47749146 @CowboysRunWest @JOHNIE11402 @ICanPlainlySee @heathrodgirs @Una_Alta_Volta @Tomerallen31 @robcarlson20 @kcinor @Rabiddogg @Wahboom @AntiProgreWorld @MAGAgpsmith @1AuburnAllie @Rosemar06585176 @Mike_Pence @JackieSearsshh @Bella_ItalianM @realDonaldTrump @Jim_Jordan @SpeakerMcCarthy @SpeakerPelosi @DbbTom @TonyClimate I agree. It’s still hotly debated whether they actually work, how they work, not to mention potential adverse side effects. I feel for people who suffer. The best I can say about SSRIs is they appear to blunt emotions.
Sobre lo dicho de la eficacia clínica de los antidepresivos: https://t.co/TTtlcd56jl
@AKECassels @Drug_Evidence @amtejani @LessIsMoreMed @DrRitaMc From the usually brilliant @Drug_Evidence this is pretty sub-par, taking the highly misleading Cipriani 2018 review as the basis for its evidence. https://t.co/ICuBfVAlJ9. Better to look at clin relevant effects with qual appraisal https://t.co/6HO95a04lk Disappointing
@Martin_Ploederl Moreover, according to Jakobsen et al only 6 of 131 SSRI trials reported a QoL outcome, though arguably most included such a measure. So outcome reporting bias likely a very big issue here. There is certainly a reason why QoL is so rarely reported... https://t.co/JOf6I3wXTk
@Rose_Marie_Holt @DrMcFillin_PsyD @krisgracehely Really, no question? https://t.co/zDmk2qnN3e
In an interview for Changing Our Minds, Dr. Peter Breggin discusses effective depression therapies and the truth about the adverse effects of SSRIs and other antidepressants. He emphasizes the importance of empathetic…
In this podcast episode, Dr. Sabrina Mörkl discusses the gut-brain axis and gut microbiome's influence on well-being and mental health. She also explores fasting, the food industry’s impact, and how to promote better…
In this video, I address the claim that SSRIs don't work, reviewing research papers and meta-analyses on their effectiveness for mental disorders like depression and anxiety. Findings reveal issues with pharmaceutical…
https://t.co/Lu7xsJGB1L (overprescribing and underperforming)
@berry5474 @honestsabe @emilykmay Oh so you don’t know what a meta-analysis is. Here you go, here’s one on SSRIs. You might find the conclusion illuminating. Btw there is none for vaccines. You’ve made an argument from silence fallacy https://t.co/piJaaZtNAV
I'm happy to discuss the studies directly but they *have* passed peer review - pubmed.ncbi.nlm.nih.gov/28178949/ pmc.ncbi.nlm.nih.gov/articles/PMC...
@fightwithmemes Meta-analyses have shown SSRIs to be at best ineffective and at worst dangerous: https://t.co/fPISeN1yNS https://t.co/yX7Yjt3UB1
@darmardare https://t.co/LxfS96yiA8
@theBrianaMills @iatrogenic_harm @Industryideator @joannamoncrieff @HengartnerMP @markhoro “SSRIs might have statistically significant effects on depressive symptoms, but all trials were at high risk of bias and the clinical significance seems questionable. SSRIs significantly increase the risk of both serious and non-serious adverse events.” https://t.co/cGP5YrpZEP
@KosterNews @kryscina_by 1) зверобой официально является СИОЗС. 2) разные препараты, для разных пациентов, кому-то помогает, кому-то нет, по этому и выбор есть. 3) официальная эффективность того же сертрадина существенно выше чем плацебо: https://t.co/SjyIf8zMwH 4) вместо писания хуйни, учись!
@RevRDracoAuthor @statwonk @2Hater2Ade @justin_garson @AlastairMcA30 There are many. Important that the studies that qualify for inclusion must have an active placebo, one that gives some mild symptoms to truly blind the participants from knowing which they've got. Most studies are junk. https://t.co/XFYSeYNjMm
@yoshkapundrick @PierreKory Right, lets really get into the data then. SSRI's effects are not clinical significant, remission was higher in SSRI users, and adverse outcomes were significantly higher. And of course they are the drug of choice, they are the best we've currently got. https://t.co/glmbfku53e
https://t.co/naOcf41XNC https://t.co/wihskzLIsm https://t.co/1gjkINhIsj
@stopharmingus @tylerblack32 @elonmusk Like I said, it's been awhile since I looked at this topic, and the research is not terribly supportive. Pubmed, Meta analysis, "SSRI AND depression." https://t.co/BrbhaGZmzi
RT @kithercbaby: @Beautyjunkie21 @babycatcalla @ToBornin @AngelAlma10 @GirlWarehouse @Quin4Trump @ramsey_lewis007 @S51781902 @Gigi69030829…
RT @kithercbaby: @Beautyjunkie21 @babycatcalla @ToBornin @AngelAlma10 @GirlWarehouse @Quin4Trump @ramsey_lewis007 @S51781902 @Gigi69030829…
RT @kithercbaby: @Beautyjunkie21 @babycatcalla @ToBornin @AngelAlma10 @GirlWarehouse @Quin4Trump @ramsey_lewis007 @S51781902 @Gigi69030829…
@OTirmizi @iam_emilyanne @thelowcarb_rd https://t.co/HTzHJHCjVE https://t.co/HdqXBOYEYN
@iminhobengoshi @shinychrome78 https://t.co/HTzHJHCjVE
RT @kithercbaby: @Beautyjunkie21 @babycatcalla @ToBornin @AngelAlma10 @GirlWarehouse @Quin4Trump @ramsey_lewis007 @S51781902 @Gigi69030829…
RT @kithercbaby: @Beautyjunkie21 @babycatcalla @ToBornin @AngelAlma10 @GirlWarehouse @Quin4Trump @ramsey_lewis007 @S51781902 @Gigi69030829…
RT @kithercbaby: @Beautyjunkie21 @babycatcalla @ToBornin @AngelAlma10 @GirlWarehouse @Quin4Trump @ramsey_lewis007 @S51781902 @Gigi69030829…
RT @kithercbaby: @Beautyjunkie21 @babycatcalla @ToBornin @AngelAlma10 @GirlWarehouse @Quin4Trump @ramsey_lewis007 @S51781902 @Gigi69030829…
@Beautyjunkie21 @babycatcalla @ToBornin @AngelAlma10 @GirlWarehouse @Quin4Trump @ramsey_lewis007 @S51781902 @Gigi69030829 @Visitor22 @justavtr @FroniterLyn @traveler002 @jackiejones632 @MarilynLavala @diggihop @larry_mcelhiney @HarryMi47749146 @CowboysRunWest @JOHNIE11402 @ICanPlainlySee @heathrodgirs @Una_Alta_Volta @Tomerallen31 @robcarlson20 @kcinor @Rabiddogg @Wahboom @AntiProgreWorld @MAGAgpsmith @1AuburnAllie @Rosemar06585176 @Mike_Pence @JackieSearsshh @Bella_ItalianM @realDonaldTrump @Jim_Jordan @SpeakerMcCarthy @SpeakerPelosi @DbbTom @TonyClimate I agree. It’s still hotly debated whether they actually work, how they work, not to mention potential adverse side effects. I feel for people who suffer. The best I can say about SSRIs is they appear to blunt emotions.
@RyanShead There is no empirical evidence whatsoever that SSRIs, like Prozac, are even effective, let alone save lives. Don’t combat bad information with more bad information Source: https://t.co/iPwiPE9BVG
@psy_massondavid J'aime bien celle là : https://t.co/Oz3Ie4NW8j
@jaldy_ @nurse_gracie_pi @Caulimovirus https://t.co/S2k785R62y
@predictevo @BowTiedUM Check out the conclusion of this recent meta-analysis… https://t.co/EuXw5xt1Ux
@DecrimSf @Morgan_Rynor @Scott_Wiener Let’s hope they work better than SSRIs. https://t.co/FwKdcaT0gR
@ProfRobHoward @pash22 The same effect size for antidepressant in depression...wouah! https://t.co/TV7shfEajn
@HabitosAlfa https://t.co/lgZmSaZ4U4 https://t.co/38sVwxIFkf https://t.co/X50uWio6hW
Degelijk kritisch leesvoer: ‘Te weinig serotonine’ hypothese is voor de prullenmand: https://t.co/XMiRLa4hNm 131 SSRI RCTs bij 27.500 mensen, en wat leren we? https://t.co/pF1ClG4Vv4
Someone claiming this is untrue on FB has provided the following studies as evidence! https://t.co/WuzfjYJP4I https://t.co/zSUeXynm5R
@ENirenberg I agree with your point, but would add that the clinical data isn't nearly as straightforward as we'd hope, either. Rampant publication bias, blinding problems, etc. https://t.co/x9MbxZ5x6O https://t.co/HUfBmpginB
@SteveTobak @CassandraRules Most of the statistics and data on SSRI outcomes not sponsored by drug companies show otherwise... Just because you read a headline or tidbit on something does not make you versed on the topic https://t.co/CFxdj9HSFt https://t.co/Z3Vb1X25rU
@AndersHansen74 Vad är din åsikt gällande dessa metastudier? https://t.co/OmHRjtK7XL https://t.co/WzgBzeh625
@nealkhosla @morgancheatham Agree. Not a lot of great longitudes effectiveness evidence on SSRIs to begin with… esp. w/ pharma marketing machine https://t.co/nJA2eEq37v SSRIs are not on the same level of addictiveness as opioids but withdrawal symptoms - yes (very few studies on this - wonder why!)
@Matthewtheshep @KatelynTweeter @MattWalshBlog “The potential small beneficial effects seem to be outweighed by harmful effects.” https://t.co/yh4hRQ3rzU
@simplyseitanic I would never recommend stopping something that is working for someone and I would *never* recommend quitting cold turkey. But SSRIs are placebos with significant side effects: https://t.co/cTbDrIKfan
@Pavel_Asparagus "SSRIs might have statistically significant effects on depressive symptoms, but all trials were at high risk of bias and the clinical significance seems questionable. SSRIs significantly increase the risk of both serious and non-serious adverse events… https://t.co/nJA2eEq37v
@wr0ngf1t @snowfairielove https://t.co/ttzVggO2IH
@jjigglypuffff This study looks at the bias of SSRI trials even w generally better outcomes in terms of symptoms & how the adverse events were still greater in the SSRI group. https://t.co/pzt2Csk1O8
#zoloft Follow the science https://t.co/TB4qb3Jfxp
@Rose_Marie_Holt @DrMcFillin_PsyD @krisgracehely Really, no question? https://t.co/zDmk2qnN3e
RT @markhoro: @AKECassels @Drug_Evidence @amtejani @LessIsMoreMed @DrRitaMc From the usually brilliant @Drug_Evidence this is pretty sub-pa…
@AKECassels @Drug_Evidence @amtejani @LessIsMoreMed @DrRitaMc From the usually brilliant @Drug_Evidence this is pretty sub-par, taking the highly misleading Cipriani 2018 review as the basis for its evidence. https://t.co/ICuBfVAlJ9. Better to look at clin relevant effects with qual appraisal https://t.co/6HO95a04lk Disappointing
RT @literalbanana: five points on the beck seems to be a LOT more than antidepressants can manage! https://t.co/VSbHzxA0bo / https://t.co/H…
@derekcaelin be careful, SSRIs may be helpful for a few months, but longterm effects are ... different: https://t.co/JbygRjbUJw https://t.co/vDUOTnDXoE (from minute 48 on)
@natnie @CritFacts https://t.co/G4x7wVogYh
@DrSaripanidis @BrageKraft @evahilland @cktamnes @LAMaglanoc @NeuroJonassen @Psykologiskinst "no noticeable benefit compared with placebo" is a bit oversimplified imo; reviews and meta analyses support anything from d=0.3 to "significant but not clinically significant" 1) https://t.co/cVEuMB2TWF 2) https://t.co/1moWcCwwyj
@Martin_Ploederl Moreover, according to Jakobsen et al only 6 of 131 SSRI trials reported a QoL outcome, though arguably most included such a measure. So outcome reporting bias likely a very big issue here. There is certainly a reason why QoL is so rarely reported... https://t.co/JOf6I3wXTk
@SamQari @KindaAspirant @_su_gibi https://t.co/ZkauoFcpZd
@tylerblack32 @Martin_Ploederl @J_F_Hayes 9/1000 people on an SSRI (as compared to pbo) will experience a serious adverse event in short term trials. https://t.co/xUnZipjwMg
@a_lisinski @Sven_Roman @glas_doktor Däremot visar studier som bara jämfört placebokontrollerade studier ingen ökning (e.g., Stone 2009, https://t.co/Y1wT09qDAY, Sharma 2016, https://t.co/1jOxko2JgB, Jakobsen 2017, https://t.co/t2aLmQH8rc)
Sobre lo dicho de la eficacia clínica de los antidepresivos: https://t.co/TTtlcd56jl
RT @ReadReadj: Compelling new review of 131 studies concludes antidepressants no better than placebo, plus major adverse effects. https://t…
@emartinez78987 @MarieCorcoran13 @bookworminma @KellyMartin02 @emb70 @Truthman30 @WeCareAboutMH @JasnaBadzak @LinnyJackson @MeschLinjean @nursewhitebeard @VirtualKnight64 @PsychRecovery @GregBla81247728 @initiallyno @benzosarebad @NMacFa @jill_d35 @ClinpsychLucy @sarafinlayson @DrAlecGrant @wendyburn @Altostrata @alyne_duthie @hatttiegladwell @Sc0ttJenkins @BPelsted @politicasual @annmarcos1 @PlanetJanice @andydalessio2 @youalwaysfindme @recover2renew @Fiddaman @balfe_robert @WatchyaSamantha @peterkinderman @rcpsych @Pandypooch21 @CunliffeSue Erin, I believe this may mean statistical signifiant but not clincially significant (i.e health outcomes may be minor). An oldie opinion piece and a sort of relavent article for your pleasure - https://t.co/FLeJdOeJg6 https://t.co/kfnfWSq5HG
＜システマティックレビュー・メタ解析＞ ●2017年抗うつ薬の有効性が有害事象を上回ったと結論付けた。 https://t.co/Q15xcLP4Z4 ●精神障害の患者に対する作業療法が作業遂行能力と健康度を向上させるとするメタ解析（Ikiugu et al, 2017） ※ただし、うつ病患者に限定していない
RT @HengartnerMP: @KellyMartin02 See also my own evaluation of the Cipriani data https://t.co/T0gKH0H5Y9 or the critical meta-analysis by J…
@HengartnerMP @Martin_Ploederl @therealrthorat Power is lower in Gunnell and Ferguson than in Stone yet you seem to prefer the two former ones. Why? Anyway, we can of course trade references back and forth (eg., https://t.co/qmYtztqQVq). My point is that whether or not ad:s cause suicide and suicide attempts is far from clear
@LasseTKrogsbll @HengartnerMP But the problem then, of course, is that there are so few events that no firm conclusions can be drawn (see e.g., https://t.co/t2aLmQpx2C) - which is exactly were we've been for the last twenty or so years and exactly where we will continue to be for the foreseeable future.
RT @ReadReadj: Compelling new review of 131 studies concludes antidepressants no better than placebo, plus major adverse effects. https://t…
Although reported that #SSRIs had positive effect on depression, "[the] high risk of bias trials tend to overestimate benefits and underestimate harms [of SSRIs]. The ‘true’ effect of SSRIs might not even be statistically significant." https://t.co/qEtwG8LwJT #bmcpsychiatry
@HengartnerMP SSRIs not clinically effective, in a systematic review and meta-analysis of 131 randomised placebo-controlled trials: https://t.co/crAPh0XBeO
RT @JuliaRucklidge: #Press column today challenges us about public funding of "dubious therapies". How about therapies that, as more data c…
RT @eparquiodelgado: En 2017 se publicó un metaanálisis sobre la eficacia de los antidepresivos (otro más, habría que decir). Es un tema qu…
RT @eparquiodelgado: En 2017 se publicó un metaanálisis sobre la eficacia de los antidepresivos (otro más, habría que decir). Es un tema qu…
RT @eparquiodelgado: En 2017 se publicó un metaanálisis sobre la eficacia de los antidepresivos (otro más, habría que decir). Es un tema qu…
RT @eparquiodelgado: En 2017 se publicó un metaanálisis sobre la eficacia de los antidepresivos (otro más, habría que decir). Es un tema qu…
RT @eparquiodelgado: En 2017 se publicó un metaanálisis sobre la eficacia de los antidepresivos (otro más, habría que decir). Es un tema qu…
En 2017 se publicó un metaanálisis sobre la eficacia de los antidepresivos (otro más, habría que decir). Es un tema que no cesa precisamente porque no está nada claro. Aquí va el enlace. https://t.co/OZarlA9L7C
RT @JuliaRucklidge: #Press column today challenges us about public funding of "dubious therapies". How about therapies that, as more data c…
@petergnz your column today challenges us about public funding of "dubious therapies". How about therapies that, as more data comes out, are no longer as good as we thought they were with evidence of harm? Should we continue to fund those? https://t.co/mQi2AXGVlr
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