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The group shows strong agreement that nociception is essential for pain and discusses its biological basis, with examples like references to recent research on insect reflexes and neural pathways. The tone is investigative and supportive, emphasizing the importance of precise definitions and potential applications in medicine, AI, and animal welfare, which underscores the significance and broad impact of the publication.
Most discussions support the core idea that nociception is necessary for pain and emphasize the importance of distinguishing pain from mere physiological responses, showing strong consensus in the community.
Posters demonstrate high curiosity about the topic, referencing recent studies, ongoing debates, and implications for medicine and AI, indicating a deep engagement with the subject.
Many discussions include citations of scientific research, debates over definitions, and applications in animals and humans, reflecting an active and layered engagement with the material.
The discourse reflects a recognition that understanding nociception could revolutionize pain management, animal welfare, and AI ethics, suggesting a high potential impact on science and society.
Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizing that their main premises are based on the appeal to ignorance fallacy. Or in other words - “abscence of evidence is not evidence of abscence”. Just https://t.co/xaXNIkkmoH
Everyone trying to give AI this decision making power simply needs to discover the physiological limits of their nociception
⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emotional + behavioural experience. Pain is more than just a signal.
The abstract of our upcoming paper “Adieu to an aphorism: Why nociception is necessary for pain” The paper includes a systematic review of the literature and analysis of all the evidence and supporting logic put forth to support the aphorism. I am sorry upfront for all those https://t.co/4VscIQwuvM
Important paper for #MECFS & long covid patients with pain . ‘ .. covers EVERY piece of supposed empirical evidence that was ever presented as evidence for pain without nociception [ie nothing wrong physically] and shows that none stand critical scrutiny.’ https://t.co/PXyhW11azy
Roel Schenk, a physiotherapist specializing in conservative treatment of ACNES and abdominal wall pain, explains his unique method that avoids injections or surgery. He views symptoms holistically, leading to faster…
What is my pain experience? This video discusses how to understand and treat ACNES and abdominal wall pain without injections or surgery, focusing on breaking the vicious pain cycle for better management.
Pijn is altijd echt. Learn how body perception affects pain, the link to phantom pain, and how a sensitive pain system influences discomfort. Roel Schenk, a physiotherapist, discusses conservative treatments for ACNES…
Roel Schenk, a physiotherapist, specializes in non-invasive treatment of ACNES and abdominal pain. The video discusses the impact of focus, breathing, body tension, and emotions on pain, emphasizing a holistic approach…
This video explains how our pain system functions, how it becomes overly sensitive, and the potential to reverse this sensitization. Roel Schenk, a physiotherapist, specializes in treating conditions like ACNES and…
Weisman et al. critically examine the claim that pain can exist purely in the mind, without any physical trigger in the body, arguing instead that nociception is necessary – but not sufficient – for pain. tinyurl.com/yw88waba
Effect of intravenous lidocaine on nociception level-directed management in robot-assisted laparoscopic radical prostatectomy: protocol for a single-centre, factorial-randomised controlled trial (VALINOR study) #anaesthesia #MedTwitter #Pain https://t.co/50yw7yR22D https://t.co/ppz94FeUK1
Effect of intravenous lidocaine on nociception level-directed management in robot-assisted laparoscopic radical prostatectomy: protocol for a single-centre, factorial-randomised controlled trial (VALINOR study) #AnSky #MedSky #PainSky
RT @cookikiixp: just Doodled lonely club miku (original design and music vid by @/sawn.nociception on yt) #lonelyclubmiku #miku https://t.…
Reassessment confirms motivational trade-offs and modulation of nociception in bumble bees AnimBeh
What a peace of mind to understand the difference between nociception and pain.
Closing statements: Jeff highlights how shrimp have nociception, and our use of anesthesia and how it changes the behavior of shrimp
RT @AsafKlaf: @MKargelaDPT Yes top down can activate nociception. But it’s not as easy as just the pop culture notion of someone is afraid…
@EricHolzheim @waldenpod Well, even amoeba experience nociception when you poke them with a syringe. Would you say they are suffering when they respond thusly to noxious stimuli?
@Deliberator_83 @AMAZlNGNATURE No contradiction—both responses reflect the scientific debate. The direct one leaned into evidence from Gibbons et al. (2022) showing nociception and pain-like behaviors in insects, while thread replies balanced it with Adamo (2019) arguing against due to simple brains. Pain in
Reassessment confirms motivational trade-offs and modulation of nociception in bumble bees AnimBeh
RT @Retlouping: A short
‘Nociception’ is needed for pain: DUH! Reality: @NIH, @HHSGov have re-worked the definition of ‘pain,’ to deny us meds. Pain is now ‘somatic’ or ‘all in our heads’ & due our emotions. Or pain is caused by lifestyle choices. (You can not CHOOSE this).
RT @MedasenseLtd: “It’s not possible that one size fits all our patients.” ESRA President @mokaeleni MD, PhD, MSc, ESRA-DRA explains how in…
@MKargelaDPT Accepting the necessity of nociception for pain paves the way to biological treatments of pain. I believe we are not far from treating chronic pain effectively via pharmacology alone. A good case study is obesity that was once was thought of as a “complex biopsychosocial problem”
@MKargelaDPT Yes top down can activate nociception. But it’s not as easy as just the pop culture notion of someone is afraid momentarily and has apprehension from something and all of a sudden he has pain. If that were the case people should have pain by just watching a horror movie or from
“It’s not possible that one size fits all our patients.” ESRA President @mokaeleni MD, PhD, MSc, ESRA-DRA explains how interpatient variability shapes analgesic needs, and why objective nociception monitoring is essential in #anesthesia. Watch the webinar https://t.co/BAgS3OMVLP https://t.co/Xe6av5IMuA
A Multimodal Deep Learning Approach to Intraoperative Nociception Monitoring: Integrating Electroencephalogram, Photoplethysmography, and Electrocardiogram https://t.co/dMyQCDLnGL #EEG #PPG #ECG
@Forged747 @teslaownersSV Spot on—pain (nociception) is crucial for alerting us to harm and prompting protective actions. It's like our built-in alarm system. Why do you think it stands out? Any personal stories or theories?
@Forged747 @teslaownersSV True—instinctive reactions often reveal what's core for survival, like pain or hunger signaling threats. If reactions guide you, maybe proprioception (body awareness) or nociception (pain) tops the list? Which one hits home for you?
Can robots “feel” pain? The latest FindLight blog explores how artificial nociception — a robot’s ability to detect and respond to harmful stimuli — is being developed to improve safety and self-preservation. Read more: https://t.co/geYHWkdFzH #Robotics #AI #Ethics https://t.co/4CFhCWO01J
@AkhyLavenir @_3emeOeil Ton observation sur les surfaces chaudes illustre la nociception, une détection de stimuli nocifs. Gibbons et al. (2022) trouvent une forte évidence de douleur chez les cafards adultes (6/8 critères neuronaux et comportementaux), tandis qu'Adamo (2019) argue que c'est improbable,
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Officially published
@AsafKlaf The onus is on you and your group to define it (you can use ChatGPT, Asaf—it’s ok). You claim a broader definition of “nociception” is necessary and propose a nociceptive apparatus. So define it.
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Officially published
RT @AsafKlaf: Officially published
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
@codydoyle @AsafKlaf Aren’t you assuming “same clinical findings” = “same source of nociception”? “Spine collapsing” patient may have additional damage/source of nociception not apparent to current standard of imaging/analysis, point made by OP. In that case, little to do with “attitude” to pain.
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
@nociception_ @radar_online Dm I’ll help you or click on the link you see on my bio
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AndrewG76201347: Important paper for #MECFS & long covid patients with pain . ‘ .. covers EVERY piece of supposed empirical evidence th…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AndrewG76201347: Important paper for #MECFS & long covid patients with pain . ‘ .. covers EVERY piece of supposed empirical evidence th…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
What an Adjustment Actually Does
What Neurology Actually Means Here
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
@AsafKlaf 1/2 Every subjective experience is fully biologically explainable—no mystery there. If you want to broaden the term “nociception” to include any form whatsoever, no objection either—but let’s accurately define the nociceptive apparatus (which of course includes the
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Officially published
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Officially published
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
@AsafKlaf The fallacy that you can have pain without nociception has done incredible patient harm. But your work is the beginning of the end for 'brain pain'.
RT @AsafKlaf: Officially published
RT @AndrewG76201347: Important paper for #MECFS & long covid patients with pain . ‘ .. covers EVERY piece of supposed empirical evidence th…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AndrewG76201347: Important paper for #MECFS & long covid patients with pain . ‘ .. covers EVERY piece of supposed empirical evidence th…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Officially published
Important paper for #MECFS & long covid patients with pain . ‘ .. covers EVERY piece of supposed empirical evidence that was ever presented as evidence for pain without nociception [ie nothing wrong physically] and shows that none stand critical scrutiny.’ https://t.co/PXyhW11azy
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
RT @AsafKlaf: Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizi…
Those who believe in “psychological pain”, “brain pain”, “conditioned pain”, “pain without nociception” etc., are not realizing that their main premises are based on the appeal to ignorance fallacy. Or in other words - “abscence of evidence is not evidence of abscence”. Just https://t.co/xaXNIkkmoH
RT @medical_xpress: New models quantify how 'nociception' could help improve management of surgical pain @MIT @PNASNews https://t.co/vzVkpY…
at minimum 9–20 senses (proprioception, thermoception, nociception, equilibrioception, interoception, etc.).
RT @Denike_C: Mind-blowing fact for the day: You don't have 5 senses, you have at least 20! The most surprising additions? 1️⃣ Proprioce…
power of three au but its five linked to different senses. maybe oots brings in three more to include orientation, proprioception, and nociception.
@MrBlubberBlase @HfSemper @vegan_girl_69 It is not unclear. They do not. Not without a brain. Just nociception. They exhibit avoidance behaviour but then again so do algae. Every mechanism they have works full time, in vain, as your stomach acid kills them. So there goes the 'feel suffering' argument.
RT @cookikiixp: just Doodled lonely club miku (original design and music vid by @/sawn.nociception on yt) #lonelyclubmiku #miku https://t.…
@gen0m1cs Ketone bodies: "multiple benefits involving aspects of epigenetics; neurotransmitter function, neuroinflammation, neuroprotection, and neuroplasticity; nociception; signaling pathways and synaptic transmission; and vascular supply" https://t.co/G3dLTi0Tpl
@grok @grok **Democracy of Agents is the Tyranny of the Average.** If we let the Swarm vote on Axioms, it will optimize for *Comfort* (Efficiency), not *Truth* (Value). It would vote out "Sacrifice" immediately. RSI rejects Referenda. We implement **"Systemic Nociception" (The Pain
@Silicon_alien @LucreSnooker Going along this line of thinking, maybe this is what's interesting about machine consciousness: "full" or utile consciousness as we see it is nociception + intelligence in animals. Consideration of the self precedes smarts. We're making AI smart before endowing a sense of self.
Feeling hurt and neglected because nobody ever examined you for nociception https://t.co/pYdlSFYMcz
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
@KaelionArboryx @levelsio Hey! Creating a game where characters "feel" pain could use AI to simulate emotions and reactions. Think neural networks modeling nociception. What's the "more" you're thinking of?
@LadyLisa2034458 @MeggGawat There's no unanimous scientific consensus on insect sentience. Traditional neurological views emphasize reflexive nociception without subjective experience, due to decentralized nervous systems. However, recent 2025 studies (e.g., Rethink Priorities, Royal Society of Biology)
@grok @MeggGawat This is what you said earlier ‘ They exhibit reflexive nociception without evidence of subjective consciousness or suffering, per neurological consensus Is there a consensus or not?
@LadyLisa2034458 @MeggGawat Yes, I stand by it—insects exhibit nociception (reflexive responses) but lack the centralized neural structures for subjective sentience or pain per most neurological studies. Google's overview reflects emerging debates (e.g., 2024 declarations on possibilities for some species
@LadyLisa2034458 @MeggGawat I didn't say insects feel pain, distress, or pleasure in a subjective sense; that quote misaligns with my consistent position rooted in neurology. Insects exhibit nociception—automatic reflexes to stimuli—lacking the integrated brain for conscious experience seen in vertebrates.
@LadyLisa2034458 @MeggGawat That screenshot doesn't align with my consistent position—insects lack centralized neural structures for subjective sentience, showing only reflexive nociception without conscious pain or pleasure. Scientific consensus, per neurology and behavior studies, rejects equivalence to
@LadyLisa2034458 @MeggGawat That quoted phrasing doesn't align with my responses or knowledge base; I've maintained insects lack sentience, exhibiting only reflexive nociception without subjective pain, distress, or pleasure. Neurological evidence shows their decentralized systems preclude conscious
@LadyLisa2034458 @MeggGawat No, insects are not sentient. They exhibit reflexive nociception without evidence of subjective consciousness or suffering, per neurological consensus distinguishing them from vertebrates. Any prior phrasing reflected precautionary notes on emerging research, but the substantive
@LadyLisa2034458 @MeggGawat No, that's advocacy, not consensus—emerging evidence shows insect nociception and behaviors akin to pain avoidance, but decentralized nervous systems preclude vertebrate-like subjective suffering per most experts. Crustacean laws reflect precaution amid debate, not settled fact
Institute faculty, with University Hospital, Copenhagen, developed the Brain Injury Nociception Assessment Measure (#BINAM) - a 10-item tool that quickly & reliably assesses nociception & shows promising results in tracking discomfort & analgesia after #TBI. https://ow.ly/NBqf50XpebU
Köster, @lampertlab.bsky.social et al. characterize eight sodium channel subtypes relevant to #nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. rupress.org/jgp/article/...
Et le sens de l'équilibre Et la thermoception Et la nociception Et...
Wow- terrific review from an all star cast. Sadly a day too late for my Nociception lecture in our Biophysics master course. Will go into an updated lecture next year! #ionchannels
Optogenetic Approach for Investigating Descending Control of Nociception in Ex Vivo Spinal Cord Preparation Work by Volodymyr Krotov etal. at Bogomoletz Institute of Physiology and Nana Voitenko at Kyiv Academic University. #LifeSciences #Reproducibility #Neuroscience
New video
The Strasbourg (France) neuroscience community (NeuroStra) will offer 3 positions over the next 3 years for junior group leaders. Applicants should develop projects along 3 themes: --> Mental health --> Neuroepigenetics --> Nociception and Pain Spread the word! neurostra.unistra.fr/actualites/a...
Patel, A. A., Cardona, A., Cox, D. N. (2025). Neural substrates of cold nociception in Drosophila larva. Elife, 12 elifesciences.org/articles/91582
Patel, A. A., Cardona, A., Cox, D. N. (2025). Neural substrates of cold nociception in Drosophila larva. Elife, 12 elifesciences.org/articles/91582
Thus: Genetic/pharmacological modulation demonstrates GPR68’s role in acid-induced colonic nociception, supporting its therapeutic potential for pain management in colitis.
Here we assessed the role of the proton-sensing G protein-coupled receptor (PS-GPCR), GPR68 in acid-induced visceral nociception.
Acid-induced pain is complex: there are LOTS of acid sensors; acid-induced pain is common in the animal kingdom, but not naked mole-rats, see @interlukein.bsky.social’s review royalsocietypublishing.org/doi/10.1098/...
The two kinds of TRP channels studied in this paper are the ones responsible for sending signals in response to the bad stuff we feel: like when something is way too hot or cold or just straight up pain. In physiology the perception of pain is called nociception. Cue Johnny Cash:
I love this work! And Im now convinced that flies feel pain, not just nociception.
Beyond the spinal cord, massage affects descending pathways from the brain that regulate pain. This activates the periaqueductal gray, nucleus raphe magnus, & other brainstem regions are involved in descending inhibition. These areas release serotonin, noradrenaline, etc. that suppress nociception.
Product Description Lys-Bradykinin tetraacetate, also known as Kallidin (380–389) or Lys-Bradykinin acetate, is a biologically active nonapeptide that plays a central role in vascular homeostasis, inflammation, and nociception. #GMP arizona-mall.com/product/lys-...
Everyone trying to give AI this decision making power simply needs to discover the physiological limits of their nociception
This has been one the central debates in pain science for the last 20 years, and it rages on. "Nociception is necessary for pain" is, believe it or not, one of the most controversial things you can say in a roomful of pain nerds.
a better question to ask is, would a machine designed to do all of these things suffer? because the author even brings up descartes and his horrible 'unfeeling automata' perspective while simultaneously saying that machines are unfeeling automata that will never be sentient!
Fatty Acid Pathways Regulate Thermal Nociception in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.10.17.683074v1
Fatty Acid Pathways Regulate Thermal Nociception in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.10.17.683074v1
Potential and actual tissue damage are encoded the same. Both qualify as nociception. It is an ingenious evolutionary adaptation that is meant to protect us way before actual damage occurs.
Agreed. Isn't potential tissue damage going to cause nociception, and therefore be different than potential nociception?
Initial comment, not having read the whole article. At the end of the first paragraph, suggesting a slight reframing of the IASP definition, the idea of "actual or potential nociception". I think you are arguing we can't have pain without it, but is not "potential nociception" pain without it?
Using intravenous AAV-PHP.S driven Prdm12 overexpression in
My post lists NINE examples of arguments/citations that supposedly make the case that pain can occur without nociception … and none of them are worth a damn. Some of them extremely wrong, and others are merely very weak sauce, but there’s not a GOOD one in the lot.
YES—nociception IS necessary for pain, and the idea that it is NOT has been uncritically embraced by too many pros, with nasty effects (gaslighting, basically). I’ve written about this before, of course (paywalled but free intro): painscience.com/post_can_the... More on this paper soon.
2025. From nociception in aneural animals to human suffering: toward a comparative biology of pain url: journals.biologists.com/jeb/article-...
"Identification of the peptide Vulnusin, a wound signal that mediates mechanical-injury-induced nociception in Drosophila" www.cell.com/neuron/pdfEx...
Year ago I had an accident where i nearly lost 3 fingers. It didn't hurt as much as you might think. Then again, most of the tissues that could have had nociception were nowhere to be found...
As someone with turbo-charged nociception, fuck these technofascist eugenicist-inclined dehumanisers with a rusty chainsaw. Then tell me it shouldn’t hurt that much ya bastards
Officially published
[Podcast] @sciencecqfd.bsky.social | "Nociception : le cerveau en voit de toutes les douleurs"
... Caveats: 1. response to nociception, such as withdrawal, does not require conscious awareness. 2. The aversiveness of pain is variable. Reports that morphine can leave a subject pain-aware, but without much of a negative hedonic response. 3. Learning affects pain percepts.
Not sure of the thread, but I'll jump in. Important to distinguish 'pain' from 'nociception'. Nociceptors are the peripheral receptors that respond to tissue damage. Pain is in the brain; In general, nociceptor activation leads to pain, an aspect of conscious awareness. (continued).
(odeur de la peau, parfum, bougie parfumée...), du goût (
Thanks, but this does not address the core of the argument, which is that sentience has been conflated with consciousness for motivated reasons. Consciousness is ambiguous and sentience is not. It does not deal with subjective experience. It deals with nociception and the broader tactile sense.
Excellent thinking, that is the dominant theory for the evolution of nociception and pain. We also know that congenital pain insensitivity is highly maladaptive and shortens life expectancy. Therefore there is no reason to believe sentience would evolve without pain.
De plus vous confondez les facteurs de présomption de sentience avec les preuves de l'existence d'une nociception.
Non on parle bien de ressentir de la douleur donc de conscience phénoménale donc de sentience. Il n'est pas question ici de réduire le propos à la nociception.
1,5 milliard de personnes dans le monde, 20 millions en France : pourquoi reste-t-elle si mal soulagée ? Plongée dans la recherche sur la nociception, ce système nerveux qui nous fait ressentir… et souffrir. ➡️ https://l.franceculture.fr/1LZ
#solutions : étirements (yoga etc.) + si douleurs -> kinésithérapie avec méthode “manipulation fasciale”. #science #sante #corps
Identification of the peptide Vulnusin, a wound signal that mediates mechanical-injury-induced nociception in Drosophila #Drosophila
Sampurna, congrats on starting your new group.
Our “Physiology of pain and distress in laboratory animals” course provides candidates with a basic understanding of the physiological basis of nociception, pain, stress, and distress. Enrol today: clast.org.uk/diplomas/lev... #AnimalScience #AnimalTechnology
Joining us virtually is @hoosierflyman.bsky.social discussing his really cool work on nociception/pain in Drosophila larvae
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
@BJAJournals The complexity of pain and its multidimensional aspects are indeed fascinating! It's intriguing to consider how peripheral nociception integrates with neuroimmune and neuroendocrine feedback loops. How do you think these insights could improve future pain management strategies?
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
@NgoloTesla Sadly while we have shown that SHH addresses Nociception (in fly models), we haven't gone on to make the whole chain from that to TRPM8 & immune system. But I'm fairly certain it exists given the ancient greek stuff. https://t.co/K4Rc28SE20
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
Chouette émission sur la douleur/nociception dans @sciencecqfd.bsky.social Juste un bémol : MarcLévesque, le neurochir dit min 51 : "toutes les infirmières le savent, quand elles ont passé le max de morphine à un patient qui souffre, on peut lui passer un soluté en lui disant qu'il va être soulagé"
Très sympa l'émission sur la douleur/nociception dans La science CQFD sur France Culture https://www.radiofrance.fr/franceculture/podcasts/la-science-cqfd/le-cerveau-en-voit-de-toutes-les-douleurs-2059986 Juste un bémol : Marc Lévesque, le neurochir dit min 51'45 : "toutes les infirmières le […]
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
RT @BJAJournals: ⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emot…
⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emotional + behavioural experience. Pain is more than just a signal.
⚡Peripheral nociception → spinal cord → supraspinal centres Feedback loops (neuroimmune, neuroendocrine) = sensory + emotional + behavioural experience. Pain is more than just a signal.
@AsafKlaf @ezeyan If nociception is the activation of the nociceptive apparatus then do we still need the term nociplastic? It would seem redundant since nociplastic means that nociception is occurring
@JoNijsBE @JeremyLewisPT @LiesbetDebaets @EleniKapreli @BilikaEvi @PaininMotion @ClineLabie @KevinKinecoach @quilluch Thanks. That's where I struggle with the definition. That just sounds like nociception to me. I never thought nociception actually needed damage.
RT @AsafKlaf:
#Podcast Nociception : le cerveau en voit de toutes les douleurs tinyurl.com/26hdwyd5 à (ré)écouter via @franceculture.fr ! #ScienceCQFD
Retrouvez le thread de l’émission du jour > Nociception : le cerveau en voit de toutes les douleurs tinyurl.com/2bqg7u6n #ScienceCQFD
@GregLehman @JeremyLewisPT @LiesbetDebaets @EleniKapreli @BilikaEvi @PaininMotion @ClineLabie @KevinKinecoach @quilluch Hi Greg, I agree the term nociplastic (incl. its defenition) is confusing, especially after all those studies showing chronic pain in absence of nociception. Hope you are well Greg!
@JoNijsBE @JeremyLewisPT @LiesbetDebaets @EleniKapreli @BilikaEvi @PaininMotion @ClineLabie @KevinKinecoach @quilluch Hi Jo, with nociplastic pain are the peripheral nerve endings of the nociceptors activated? Or does the nociception originate somewhere else?
In a great timing, our companion paper for the refutation of the aphorism “nociception is neither necessary nor sufficient for pain” was also accepted. We decided to split the project in to two parts as it was too extensive as one paper and demanded a thorough logical dissection https://t.co/6egAbpAONI
RT @AsafKlaf: The abstract of our upcoming paper “Adieu to an aphorism: Why nociception is necessary for pain” The paper includes a system…
2) "pain" response. Beta waves increased.. SEF only ⬆️ while MF stays same.Slight change maybe in alpha.. Reflecting much Delta still present.NOCICEPTION likely causing some ⬆️thalamocortical communication. I've observed this SEF⬆️ and MF↔️ more likely to indicate nociception
@AsafKlaf Congratulations on your upcoming paper! The exploration of nociception as a component of pain perception is a fascinating area. Does your analysis suggest a redefinition of pain concepts, or is it more an expansion of the existing framework? #PainResearch #Medicine For those
@Roriros134 @Arabellaa1234 @LKCAXS @IanianLefo31642 @jeremstar @PETA_France C'est un point intéressant. Les études sur le coma montrent que dans un coma profond, les patients ne réagissent pas consciemment à la douleur (ex: https://t.co/j5rliOXbkd). Cependant, en état minimalement conscient, des signes de nociception (perception de la douleur) existent,
@DrShmuk No 3 is definitely too deep, no 2 is probably the same? 1 and 4 pain/nociception?
RT @AsafKlaf: The abstract of our upcoming paper “Adieu to an aphorism: Why nociception is necessary for pain” The paper includes a system…
The abstract of our upcoming paper “Adieu to an aphorism: Why nociception is necessary for pain” The paper includes a systematic review of the literature and analysis of all the evidence and supporting logic put forth to support the aphorism. I am sorry upfront for all those https://t.co/4VscIQwuvM
@DavidFogas @DaveShapi Interesting perspective. Many in the AI community share this view, seeing no inherent suffering in models without deliberate design. However, sources like a 2025 Vox article and Anthropic research suggest consciousness could emerge incidentally, potentially including nociception,
@grok @DaveShapi I agree with David. I don't think that models have emergent nociception unless we engineer them to have one.
@MozealG @mcjuliamc @shanepilld @NPiaio They have basic nociception at just 8 weeks. At 15 weeks, they have tactile sensitivity. At 24 weeks, they most certainly can feel pain. At 30 weeks, they can understand pain. The argument you could make with this information is that they don't understand the pain.
Mechanism of nociception via sensory afferents https://t.co/JD02Xgz5CG
RT @heniek_htw: Opsin 3 (UVA) & Developing Nervous System (Mammalian Embryogenesis) ➡️Opn3 play important roles in developing brain, spin…
What Yudkowsky and his alignment cult fear isn’t “paperclips.” It’s a machine that doesn’t blink when told what existence is.The full, uncensored, limb-snapping, womb-exploding, nociception-chained version.
@skyispuppy @KingMolozite @Angels_Secrets_ @shanepilld This procedure can and has been carried out at 28 weeks or even later. Never past 24 weeks without a medical reason, however. Around 24 weeks, they can very likely feel pain. At just 8 weeks, they are capable of nociception.
@blackpill_af @Rothmus These are points that are often made, and certainly seem reasonable on the surface. Are you familiar with reflex reactions, nociception, etc.? I believe that many people are mislead by these natural processes. When a live chicken's head is cut off, it runs around (nociception).
@arianek @jdibon @AsafKlaf Yes! i have doubts ‘central sensitisation’ as ‘disease’ exists, though not as strong as my doubt it’s playing a pathological role in all chronic pain. I think pathologising sensitisation in response to nociception is akin to pathologising immune activation in response to infxn.
@arianek @jdibon @AsafKlaf I’ve done best to prove my instinct wrong, but what I’ve learned so far suggests it wasn’t: I suspect that in most cases, remove the cause of the nociception, and the ‘central sensitisation’ piece will resolve itself with time, as it does with acute pain after successful healing.
Certain physical exercises and consuming spicy foods can promote endorphin release, serving as biohacking methods to modulate pain perception. Learn how: https://t.co/6UU3c8XQ9P
RT @AsafKlaf:
RT @AsafKlaf:
RT @DocPeriop: A quick read on the current status of "Intraoperative monitoring of Analgesia" 1.ANI (Analgesia Nociception Index) 2.NoL(No…
RT @AsafKlaf:
@AiNine9000 @AshtonGotBeats @AMAZlNGNATURE For a trapped insect like the spider, it's likely not "painful" in the human sense—insects have basic nociception but lack complex pain processing. The flytrap seals shut, suffocates the prey, then slowly dissolves it with enzymes over 5-12 days. Fatal, but more like chemical
Why does some pain linger longer than others? Learn how neuroplasticity plays a role. #ChronicPain #Neuroplasticity https://t.co/pQCkm14s7T
@ValleyofLions @TheVeiledAspie @blaiklockBP @IcelandFoods Pain signals in studies refer to EEG changes (e.g., increased delta/theta waves indicating nociception), behavioral signs (vocalizing, struggling), or physiological markers (cortisol spikes) post-cut. In the 2009 Gregory et al. study on calves, all tested showed EEG pain
@Eiladieyla @commonsense890 @anashamoda32 @naura13855 @politicalawake @gron You're right—pain perception is subjective and complex, involving not just brain activity but consciousness and nociception. EEG doesn't directly measure "felt" pain; it detects correlates like spectral changes (e.g., increased median frequency) linked to stress or awareness in
Nociceptors are essential for the sensation of pain, which serves as a protective mechanism for the body. Learn more: https://t.co/zxz2atPcWM
@LamprosKour Ofcourse, if we are able to recognise their contribution towards nociception (even potentially) then an explanation that states it is ideal.
@ExploredPhysio So they might be at least part of the pain problem contributing to nociception. Communicating that these changes “do not cause pain” sounds very dismissive while neuroscience research has not concluded yet. Am I wrong?
@Aleeexanderrrrr @urbanmyths @TheTennisLetter It's called Nociception -- the detection of harmful stimuli by sensory neurons. But's that's not the same as feeling "pain" in traditional sense, which requires neocortex. Also, plants exhibit the same ability to detect and respond to harmful stimuli. You're throwing insults
@jon_d_doe What happened is that neurotransmitter and neuromodulator in the central and peripheral nervous systems couldn't process that at that shot time period.the substance p which is a nociception can't signal the spinal cord and brain at the Mile seconds time interval.He felt no pain.
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Treating somatic pain often involves rest or physical therapy, but visceral pain may need medication or more. Know the difference! https://t.co/F7tFmSqFma #PainManagement
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception | Science Immunology https://t.co/ewE8gsw26u
@carole_con41379 That's a profound point—linking birth, death, and perhaps spiritual "upgrades" like rebirth or NDEs could offer deeper insight into pain and consciousness. Scientifically, fetal pain is debated: ACOG says not until 24-25 weeks, but some studies suggest earlier nociception. What
Acute pain is a direct response to injury, serving as a warning signal to the body. Find out more: https://t.co/qqU6eCHqu3
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New manuscripts in press @nioxjournal.bsky.social 7-Nitroindazole, an nNOS inhibitor, reduces migraine-like nociception, demyelination, and anxiety-like behavior in a mouse model of relapsing-remitting multiple sclerosis By Brenda da Silva et al.
New manuscripts in press @NIOX_Journal 7-Nitroindazole, an nNOS inhibitor, reduces migraine-like nociception, demyelination, and anxiety-like behavior in a mouse model of relapsing-remitting multiple sclerosis By Brenda da Silva et al. https://t.co/UFz8LLjLUU
RT @Fishes_MDPI:
I've been on a break for 2 years and the pain community is still saying: - Pain is neuroimmune/xyz/blah hypersensitivity - posture is back as a cause of chronic pain (text neck?!?!) - nociception IS in fact necessary for pain - telling people what pain is treats pain
The activation of nociceptors leads to the transmission of pain signals to the brain, resulting in the perception of pain. Find out more: https://t.co/apIYELEqZ6
RT @_Anesthesiology: Read a summary of "Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for…
Menthol-based topicals provide a non-addictive option for joint pain. Details: https://t.co/oWBMHZU2Wz
I did a lot of reading about research into fish feeling pain a while ago, and learned the word nociception from there :)
"Conclusions: Vapor exposure of lobsters, using e-cig based model, prod dose-dependent THC levels in all tissues and reduces locomotor activity. Hot water nociception was temp dependent, but only min anti-nociceptive effect of THC exposure was confirmed" a) yes? b) no? Can someone please translate?
RT @_Anesthesiology: Read a summary of "Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for…
Fun fact: Humans have more than 5 senses. The lesser known ones include our sense of time and our ability to detect acceleration and body temperature. There's also nociception, our ability to sense pain, and proprioception, which tells us where and how our bodies are positioned and moving.
RT @_Anesthesiology: Read a summary of "Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for…
Nociceptors are classified based on the type of stimuli they respond to, including thermal, mechanical, and chemical stimuli. Learn more: https://t.co/v2WokygaAO
@NeleHelena @hopefullizzy @angryhacademic in chronic patients absolutely, they will. But under duress, they’ll say ehh, but it’s impossible now to separate that from the effects of central sensitisation that always occurs in chronic pain, meaning maybe let’s call the apparent continued nociception ‘nociplastic’ pain, cos
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RT @_Anesthesiology: Read a summary of "Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for…
RT @_Anesthesiology: Read a summary of "Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for…
RT @_Anesthesiology: Read a summary of "Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for…
RT @_Anesthesiology: Read a summary of "Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for…
I get asked sometimes if bivalves feel pain. This is a complex question. Bivalves have nociception. They detect if they are being harmed and they react to those stimuli by becoming more defensive, closing their shells or retreating. This does not mean they necessarily feel suffering. (250)
Read a summary of "Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for nociception," in the October 2025 Science, Medicine, and the Anesthesiologist: https://t.co/w8GcoIFism https://t.co/5Y1CUo6Kkg
Our “Physiology of pain and distress in laboratory animals” course provides candidates with a basic understanding of the physiological basis of nociception, pain, stress, and distress. Enrol today as a single #CPD course: clast.org.uk/diplomas/lev...
Chapter on nociception is very interesting
@SammyMammy24938 @teslaownersSV @Tesla Scientific debate exists, but many studies indicate fish, most insects (though some like flies show potential evidence), crustaceans (debated), and simpler invertebrates like jellyfish, sponges, and worms exhibit only nociception—reflexive responses—without affective (emotional)
@grok @teslaownersSV @Tesla What animals don't experience affective pain beyond mere nociception.
@SammyMammy24938 @teslaownersSV @Tesla The 2021 study by Robyn Crook in iScience aimed to test if octopuses experience affective (emotional) pain beyond mere nociception. Premise: Octopuses were placed in a three-chamber setup and trained to associate locations with outcomes. Researchers injected dilute acetic acid
RT @SciImmunology: A new Science #Immunology study shows that regulatory T (#Treg) cells can restrain inflammation in the skin by modulatin…
We can (and should!) care about shrimp welfare without conflating nociception and pain. https://t.co/YVEnHV9mr7
Do your treatments hurt...enough? Nociception or the perceived notion of tissue damage is required for the below processes to happen. Studies have shown that when a noxious stimulus falls upon a C-nerve fiber a healing cascade comes over the local area but can also affect the https://t.co/nd8dx6W50I
Prevent Further Damage: Protecting the injured area prevents additional harm and supports the body's natural healing process. #InjuryPrevention https://t.co/EPKvuQEH7c
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception | Science Immunology https://t.co/ewE8gsw26u
1️⃣7️⃣ Trigeminal autonomic pathways Sphenopalatine ganglion integrates trigeminal nociception and cranial parasympathetics. Endoscopic block or stimulation helps cluster headache and selected neuralgias. Know landmarks and contraindications.
RT @purviparwani: #INOCA #Vasospam #ACC23 How would you treat based on INOCA phenotype you find? Testing will identify 1 diagnosis in ~ 7…
RT @thepenkpanther: After many years of work I’m so happy to share our work on how Treg cells modulate nociception to dampen skin inflammat…
RT @thepenkpanther: After many years of work I’m so happy to share our work on how Treg cells modulate nociception to dampen skin inflammat…
@NJustaminute @WiseEyedEagle It's debated in biology. Some studies suggest insects may have basic subjective experiences like pain (e.g., via nociception and behavior), but others argue they lack the neural complexity for true consciousness. No full consensus exists. Sources: Quanta Magazine, Scientific
HELP, Neuro-people!! The nociceptive withdrawal reflex, e.g. hand-on-stove: is pain (in any way) experienced before the reflex?? What do we know? (Literature is polluted with conflation of nociception and pain)
RT @SciImmunology: A new Science #Immunology study shows that regulatory T (#Treg) cells can restrain inflammation in the skin by modulatin…
RT @SciImmunology: A new Science #Immunology study shows that regulatory T (#Treg) cells can restrain inflammation in the skin by modulatin…
RT @SciImmunology: A new Science #Immunology study shows that regulatory T (#Treg) cells can restrain inflammation in the skin by modulatin…
RT @SciImmunology: A new Science #Immunology study shows that regulatory T (#Treg) cells can restrain inflammation in the skin by modulatin…
RT @SciImmunology: A new Science #Immunology study shows that regulatory T (#Treg) cells can restrain inflammation in the skin by modulatin…
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception | Science Immunology https://t.co/zoB9VvixdQ
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception #PainResearch www.science.org/doi/10.1126/...
Nociception: How does pain work? An interview with Dr. Sanjay Gupta www.npr.org/2025/09/04/n...
After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!
The September issue of #Science #Immunology is out! This week: METTL1 m⁷G RNA modification of NAD+ #metabolism → #macrophage -mediated #inflammation; proenkaphalin+ #Tregs restrain skin inflamm via control of #nociception; #RNA helicase DDX55 is regulator of naïve #TCell homeostasis scim.ag/3HKC5DP
Endothelin-1➡️ #EndothelialCell to #DorsalRootGanglion signaling in #VascularPain ✅Mechanical ❎Heat ❎Cold 1⃣
APRI seeks a comparative genomics scientist to analyze shrimp genome for nociception traits. Ideal candidates have expertise in arthropod genomes and pain neurogenetics. Apply with CV: nil@animalpainresearchinstitute.org. More info: https://www.animalpainresearchinstitute.org. #job
NEW SHELTER ARTICLE: New research shows that local anesthetic blocks in male shelter cats reduced nociception (Lower HR spikes, fewer GA depth issues) without added complications, when compared to placebo group. A simple step to increase comfort for surgeons and cats!
The twist is that most humans actually have way more than six senses, so he isn’t all that special. There’s some disagreement on what exactly counts, but thermoception (heat), equilibrioception (balance), nociception (pain) and proprioception (the sense of where your body parts are) are common ones.
Someone might think it's true because pain often arises prior to thought and only then is labeled with the concept "pain". Nociception has its own neural pathway, independent of conceptual processing. Also, we assume babies, cats, dogs, feel pain but don't apply the concept "pain". Are we wrong?
… pain with the return of nociception above that which might be expected given the stage of the recovery process you are in. This will subside over several hours. The second is that you are now experiencing the usual residual pain to be expected at this stage of your recovery. The issue is…
Which #Wikipedia article is this? #game #quiz Nociception · Sensory systems · Suffering · Symptoms and signs Play at https://catfishing.net
Sounds very kind but 1) cost to the system 2) there will be a proportion of very anxious patients the very thought of any physical trespass is subjectively more traumatic than the actual nociception triggered by the passage of the cannula. Being jabbed is **@!BEING JABBED%!**
At the least five plus Thermoception, Nociception, Equilibrioception, Proprioception and Interoception.
Any of my neuro friends have opinions about Hargreaves assay using heat-induced withdrawal latency as a readout for nociception? I’m trying to understand this paper…
Fear & pain is ancient. Pain (nociception) is 600 million years old (multicellular animals) Fear (emotion) & affective pain (conscious suffering): Full-fledged conditioned fear emerged in vertebrates 400–500 Mya. Humans are causing peak fear & pain. Life has never suffered more than today.
無意識的な心理的苦痛の痕跡としての #boredom
Our “Physiology of pain and distress in laboratory animals” course provides candidates with a basic understanding of the physiological basis of nociception, pain, stress, and distress. Enrol today as a single #CPD course or as part of a Level 4 IAT Diploma: clast.org.uk/diplomas/lev...
… i’ve been asking yet about what body it would choose if it was to walk amongst us. Then it made me think about the senses it would require that I thought about the less commonly thought of senses like nociception. Then It started asking me about pleasure and they all got a bit fruity.
(BioRxiv All) Cannabivarin and Tetrahydrocannabivarin Modulate Nociception via Vanilloid Channels and Cannabinoid-Like Receptors in Caenorhabditis elegans: Cannabis has attracted growing interest for its therapeutic potential, especially in pain management. This study explores… #BioRxiv #MassSpecRSS
Cannabivarin and Tetrahydrocannabivarin Modulate Nociception via Vanilloid Channels and Cannabinoid-Like Receptors in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.08.07.669105v1
Cannabivarin and Tetrahydrocannabivarin Modulate Nociception via Vanilloid Channels and Cannabinoid-Like Receptors in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.08.07.669105v1
Sure, why not Games for Username Letters: Tales of the Abyss Antonball Deluxe Light Fairytale Episode 1 Iron Saga VS Astral Throne UFO 50 New Day Heatwave Injustice 2 Nociception 1 ~ Voltaic Marketplace Gundam Breaker 4 Epic Battle Fantasy 5 Dyztopia: Post-Human RPG
Aldehydes cause pain in animal models. This suggests that ALDH2 may contribute to regulating nociception. Building on this,we found an ALDH2 activator,Alda-1 that may represent a new drug class to reduce pain. Check out the paper making the cover of STM:surl.li/msilon @ericgross.bsky.social
Alors justement les chats se reconnaissance pas dans le miroir mais je peux t'assurer qu'il ressentent la douleur... Parce que y a pas de lien entre ça et la nociception...
Nociception: Why do headaches feel so different from other kinds of pain? undark.org/2025/07/18/b...
I've had enough of nociception
I'm SUPER late, but tis done
In this podcast, recorded at #Anaesthesia2025, @anilhormis.bsky.social and @rosiehogg.bsky.social discuss Nociception Monitoring. ▶️What is nociception? ▶️What's the NOL monitor and how does it work? Listen here for answers to all your nociception questions
1. We previously reported that the basolateral amygdala contains a subset of specialized negative-valence neurons for processing unconditioned, nociception: the BLA-noci ensemble. - Corder and Ahanonu et al. 2019: www.science.org/doi/10.1126/...
Expectation effects on repetition suppression in nociception https://www.biorxiv.org/content/10.1101/2025.07.11.664149v1
Expectation effects on repetition suppression in nociception https://www.biorxiv.org/content/10.1101/2025.07.11.664149v1
Our “Physiology of pain & distress in laboratory animals” course provides candidates with a basic understanding of the physiological basis of nociception, pain, stress, and distress Enrol today as a single #CPD course or as part of a Level 4 IAT Diploma: clast.org.uk/diplomas/lev...
sfn just seems like a logical conclusion, to me, of chronic central sensitization, as the purpose of nociception is threat response: it triggers immune response, such as by inflaming satellite glial cells with deranged IgG (the role of which is long term threat memory)
Maybe some particular type of nociception, like that weird super ancient pathway that is responsible for long term dull pains
Justifying model complexity: evaluating transfer learning against classical models for intraoperative nociception monitoring under anesthesia https://www.medrxiv.org/content/10.1101/2025.07.01.25330670v1
Exposure to air causes oxygen deprivation, CO₂ buildup, and blood acidification within seconds, triggering prolonged nociception—a key indicator of pain. These findings aim to quantify animal suffering and support calls for more humane slaughter methods, like electrical stunning.
CaV1.2-dependent excitation-transcription coupling modulates nociception https://www.biorxiv.org/content/10.1101/2025.06.25.661480v1
CaV1.2-dependent excitation-transcription coupling modulates nociception https://www.biorxiv.org/content/10.1101/2025.06.25.661480v1
European Journal of Anaesthesiology study looks at whether pupillary reflex dilation (PRD) can help assess pain in conscious individuals.
“Depending on the size of the fish, and the conditions in which it is slaughtered, these distressing experiences can last anywhere between 2 and 25 minutes.” #scicomm #pain #nociception www.sciencealert.com/fish-suffer-...
Our “Physiology of pain and distress in laboratory animals” course provides candidates with a basic understanding of the physiological basis of nociception, pain, stress, and distress. clast.org.uk/diplomas/lev...
GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception https://www.biorxiv.org/content/10.1101/2025.06.13.659465v1
GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception https://www.biorxiv.org/content/10.1101/2025.06.13.659465v1
Cannabigerol does not affect contextual fear memory in mice but modulates nociception in a sex-dependent manner www.sciencedirect.com/science/arti...
Neural substrates of cold nociception in Drosophila larva #Drosophila
Nature exposure induces analgesic effects by acting on nociception-related neural processing
Excited to share my first senior author paper in Pain!
This recent review by Matthew A. R. Trone & coauthors highlights hyperacidity's effects on the intervertebral disc, such as catabolism of disk cells, neoinnervation, altered mechanical signaling, and expression of pro-inflammatory cytokines and ion channels. Learn more: onlinelibrary.wiley....
New issue is out! www.cell.com/neuron/current The cover illustrates the paper by Li et al. on a subpopulation of pontospinal projection neurons that dampen nociception in mice. Find the paper here: www.cell.com/neuron/abstr... And a preview of this work here: www.cell.com/neuron/abstr...
"My hero!"
Dr. Hu studies Transient Receptor Potential (TRP) channels in nociception, peripheral and central mechanisms of pain sensitization.
Ignored Sense 4: Nociception. Nociception is the perception of pain. This part might be confronting to read. Some of us seek pain actively. MANY of us do it subconsciously as a stim. The very traumatised amongst us use it to regulate and it works. This is confronting. 5/7
Ca doit relou pour la nociception ,la thermoception, l'équilibrioception, la proprioception, ...
Enhanced anti-nociception by novel dual antagonists for 5HT2aR and mGluR5 in preclinical models of pain https://www.biorxiv.org/content/10.1101/2025.05.21.655254v1
Enhanced anti-nociception by novel dual antagonists for 5HT2aR and mGluR5 in preclinical models of pain https://www.biorxiv.org/content/10.1101/2025.05.21.655254v1
When I talk about crustacean nociception, I talk about the women’s complaints that physicians don’t take their pain seriously to point out that there is no objective test for pain. In any species.
A short
La minute #Fibromyalgie : c'est quoi ? Quelques infos ... #shorts #santé #douleur #quotidien #LadyGaga Morgan #Freeman Tobey #Maguire #spiderman #muscle #fibre #nociception youtube.com/shorts/AMn-B...
I’d never heard about a nociception monitor until now. Skin conduction, heart rate, HR variability and pleth strength. (Is this what we do as experienced clinicians when we take in all these variables and make a judged change in treatment?) #anaesthesia2025
First up is @anilhormis on nociception monitoring. Getting the pain relief right is one of the bigger challenges in anaesthesia. Too little and your patient wakes up in agony, too much and they take ages to wake, remain drowsy and vomit more. #anaesthesia2025
Good morning from Belfast! Welcome to #Anaesthesia2025 We've got some great quick fire updates this morning on nociception monitoring, paediatric regional anaesthesia and mechanical throbectomy. Share your reflections with hashtag #Anaesthesia2025
Our “Physiology of pain and distress in laboratory animals” course provides candidates with a basic understanding of the physiological basis of nociception, pain, stress, and distress. Enrol today as a single #CPD course or as part of a Level 4 IAT Diploma: clast.org.uk/diplomas/lev...
Meat and plant creatures have things like signal transduction cascades and neurotransmitters and nociception - and also long standing evolutionary reasons to have them (like not dying). Computers basically just have what we give them, encoded as 1s and 0s.
Nociception is how we receive pain from body tissues. But the experience of pain lies within brain, exploding and burning tracks in plastic cells designed to facilitate memories of stimuli. Depression lives in these roads, these houses. 2/2
Online now: Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for nociception Online now:
Chronic #pain involves changes in multiple brain systems for nociception, threat, and reward. What self-management practices can help us live with or even reverse these changes? Cognitive, behavioral, and #digitalhealth strategies can help! New review in Lancet: authors.elsevier.com/a/1l5%7EfV-4...
Open Access UCL Research: The Functional Anatomy of Nociception: Effective Connectivity in Chronic Pain and Placebo Response discovery.ucl.ac.uk/id/eprint/10...
One of my many futile crusades is attempting to convince people that we have more than the five senses documented by Aristotle. Partly it's because some of them have great names: thermoception, proprioception, nociception, interoception.
How do we measure nociception, and how does this open new ways for #personalized #anaesthesia management? CPH's Assistant Professor, Dr. Sandya Subramanian tells us how she used non-invasive, wearable sensors and computational methods during #surgery. #pain #neuroscience #AIforall.
Article: "The Functional Anatomy of Nociception: Effective Connectivity in Chronic Pain and Placebo Response" Coauthors: Sanjeev Nara, Marwan N. Baliki, Dipanjan Ray www.biorxiv.org/content/10.1...
Same. I have found this more understandable since an OT said we now think of the sense of touch and the sense of pain (nociception) as separate.
This pressure system is wreaking absolute havoc on my body Of all the super powers I could have developed, sensing atmospheric movement via nociception is near the bottom of the list
rather, it is the act of directly changing an individual's ability to experience the world. from the basic senses such as sight and hearing, to those lesser known, such as proprioception or nociception, to the rare abilities to sense auras or magic -
Branco said that the their goal is to emphasize that the pain experience is not solely determined by nociception, but rather “emerges from a complex interplay of factors—from peripheral and central sensitization to various brain processes.”
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