✅في ال Heparin-Induced Thrombocytopenia (HIT type II)، مو السبب إن الهيبارين “يقلل الصفائح” مباشرة، بل يصير تفاعل مناعي غريب. الهيبارين يرتبط ببروتين اسمه Platelet Factor 4 (PF4)، و الجسم يكوّن أجسام مضادة IgG ضد هذا المركب. الأجسام المضادة ترتبط بمستقبلات على الصفائح (Fc https://t.co/NjZjMbAMjU https://t.co/XyhaKfxLT6
Heparin-induced thrombocytopenia.
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Mar 2021 – Nov 2025Where it's discussed
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X / Twitter99 posts
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Bluesky36 posts
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News34 articles
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Facebook4 posts
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YouTube2 videos
AI synopsis
What people are saying
The discussions reflect a strong consensus on HIT's clinical significance, with posts mentioning specific cases like DVT caused by allergic reactions to heparin and referencing recent studies on monoclonal antibodies, illustrating deep engagement and a recognition of HIT’s high impact on patient care. Words like 'survivor,' 'groundbreaking,' and references to management strategies convey urgency and importance, reinforcing the collective focus on advancing understanding and treatment.
Most discussions clearly support the importance and severity of HIT, with several posts referencing clinical cases and research findings that reinforce its significance.
The posts demonstrate high interest, including detailed case examples, research studies, and treatment approaches, indicating active engagement with the topic.
Numerous posts cite specific studies, clinical guidelines, and personal experiences, showing deep engagement with understanding different aspects of HIT.
The discussions highlight HIT's critical impact on patient treatment, diagnosis, and safety, emphasizing advances in understanding and managing the condition.
Abstract in brief
- Heparin-induced thrombocytopenia (HIT) is an immune reaction caused by antibodies that form between platelet factor 4 (PF4) and heparin, leading to the activation of platelets and monocytes, which increases the risk of dangerous blood clots.
- While many patients develop anti-PF4/heparin antibodies after heparin treatment, only some go on to experience severe complications like low platelet counts and blood clots, and recent research has improved understanding of why this happens.
- The review explains the current knowledge about how HIT develops, how to recognize it through clinical and lab features, and ways to manage and prevent the condition.]
Top posts
Most liked on X and Bluesky✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من بدء العلاج، و السبب مو لأن الـ Heparin يستهلك الصفائح، بل لأنه يفعلها بطريقة مناعية! اللي يصير إن الجسم يكوّن antibodies ضد مركب يتكون من Heparin + https://t.co/THVKHlzQ3K https://t.co/Wvzcx6boGY
The most common symptomatic presentation of heparin induced thrombocytopenia (HIT) is Bleeding Venous thromboembolism Arterial thromboembolism Myocardial infarction https://t.co/xkfeu8JGUP
Heparin-induced Thrombocytopenia (HIT). https://t.co/ML3i5yyFVb https://t.co/oDhPk0EVfc
In heparin induced thrombocytopenia, antibodies are formed against Heparin Platelet Gp 2b/3a receptor Platelet factor 4 (PF4) Heparin - PF4 https://t.co/UjBtGmDcVl
Fresh blog: Six pearls on heparin-induced thrombocytopenia (HIT) in 2025
All mentions
Understanding Heparin-Induced Thrombocytopenia and VITT Risks
Understanding Heparin-Induced Thrombocytopenia Risks and Insights
In this episode, Dr. Caroline Vayne from Tours University Hospital discusses heparin-induced thrombocytopenia, a serious thrombotic condition. We delve into clinical features, current understanding, and the importance…
Outcomes of patients with suspected heparin-induced thrombocytopenia in a contemporary multicenter cohort https://t.co/NWW2WoBWtx - Actually, I have encountered a case of HIT.
Heparin-Induced Thrombocytopenia in Chinese Patients: 240 Patients Study in One Center https://t.co/6XLivyVAPB
@TSM_Humanist I would have guessed heparin-induced thrombocytopenia.
A study in the Journal of Hematopathology analyzes all-cause mortality in 72,935 patients with heparin-induced thrombocytopenia (HIT) from 2016 to 2020, revealing a fivefold increase in mortality risk for HIT patients compared to others. https://t.co/6cYXkLdSZd https://t.co/Hpqm9w2YjO
https://t.co/YUPAjkOfKV
https://t.co/1ugiahTdbB
RT @AB_drmd: ✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من ب…
RT @RavikantBh99255: @IhabFathiSulima Immune thrombocytopenia Thrombotic thrombocytopenia Heparin induced thrombocytopenia Bone marrow d…
@IhabFathiSulima Immune thrombocytopenia Thrombotic thrombocytopenia Heparin induced thrombocytopenia Bone marrow disorders Sever inf - hepatitis c, covid 19
RT @AB_drmd: ✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من ب…
RT @AB_drmd: ✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من ب…
RT @AB_drmd: ✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من ب…
RT @AB_drmd: ✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من ب…
RT @AB_drmd: ✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من ب…
RT @AB_drmd: ✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من ب…
RT @AB_drmd: ✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من ب…
RT @AB_drmd: ✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من ب…
RT @AB_drmd: ✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من ب…
RT @AB_drmd: ✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من ب…
✅التشخيص المحتمل هنا هو Heparin-Induced Thrombocytopenia (HIT)، و هي من أخطر مضاعفات الـ Heparin. تصير عادة بعد 5–10 أيام من بدء العلاج، و السبب مو لأن الـ Heparin يستهلك الصفائح، بل لأنه يفعلها بطريقة مناعية! اللي يصير إن الجسم يكوّن antibodies ضد مركب يتكون من Heparin + https://t.co/THVKHlzQ3K https://t.co/Wvzcx6boGY
@AB_drmd Heparin Induced Thrombocytopenia Due to antibody formation against platelet factor 4
@AB_drmd
RT @NEJM: Original Article: Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia https://t.co/25gXfIhpkM #Hemato…
RT @Greg21143362: @janiesaysyay @JesslovesMJK Here's the addendum....White Clot Syndrome, also known as Heparin-Induced Thrombocytopenia (H…
@janiesaysyay @JesslovesMJK Here's the addendum....White Clot Syndrome, also known as Heparin-Induced Thrombocytopenia (HIT), arises as a dangerous side effect predominantly associated with high molecular weight heparin (unfractionated heparin). In this syndrome, rather than preventing clots, the heparin
Expand your knowledge and earn continuing education credit by exploring podcasts on heparin-induced thrombocytopenia, thrombotic thrombocytopenic purpura, and coagulation testing from Mayo Clinic experts. https://t.co/VtfBc7y5vn
RT @CiaraGlenville: Potential role in #MECFS - great summary on studies to date, which are not enough. Also use unfractionated heparin whic…
#Neetpg #Pharmacology Select the drug that is recommended for the treatment of Heparin-induced thrombocytopenia. A.Abciximab B.warfarin C.Alteplase D.Lepirudin
RT @drsthanus: Heparin-induced Thrombocytopenia (HIT). https://t.co/ML3i5yyFVb https://t.co/oDhPk0EVfc
RT @drsthanus: Heparin-induced Thrombocytopenia (HIT). https://t.co/ML3i5yyFVb https://t.co/oDhPk0EVfc
RT @drsthanus: Heparin-induced Thrombocytopenia (HIT). https://t.co/ML3i5yyFVb https://t.co/oDhPk0EVfc
Heparin-induced Thrombocytopenia (HIT). https://t.co/ML3i5yyFVb https://t.co/oDhPk0EVfc
Intraoperative Epoprostenol in Type II Heparin-Induced Thrombocytopenia During Left-Ventricular Assist Device Implantation: A Case Series and Review of Literature ASAIO Journal 71(10):p e147-e152, October 2025. | DOI: 10.1097/MAT.0000000000002356 https://t.co/kpCOcuVTWH #ASAIO https://t.co/o8oLCahAfg
RT @TomReiser: The @isth G&G Committee invites public review and comment on the guidance manuscript "Management of anticoagulation in pati…
RT @TomReiser: The @isth G&G Committee invites public review and comment on the guidance manuscript "Management of anticoagulation in pati…
RT @TomReiser: The @isth G&G Committee invites public review and comment on the guidance manuscript "Management of anticoagulation in pati…
The @isth.org Guidance and Guidelines Committee invites public review and comment on the guidance manuscript "Management of anticoagulation in patients with heparin-induced thrombocytopenia requiring cardiac surgery with cardiopulmonary bypass" tinyurl.com/5n6t28yp
The @isth G&G Committee invites public review and comment on the guidance manuscript "Management of anticoagulation in patients with heparin-induced thrombocytopenia requiring cardiac surgery with cardiopulmonary bypass" https://t.co/OvwPmimy8J
@vinu_arumu21560 @PhRMA @xai @AstraZeneca VITT resulted from adenoviral vector vaccines like AstraZeneca inducing rare anti-PF4 antibodies that activate platelets, akin to heparin-induced thrombocytopenia, not HEK protein contamination since the antigen was produced in CHO cells. Mechanistic studies confirm this immune
https://t.co/zYkWVd2rVu
Simultaneous Liver-Kidney Transplantation in Patient with a History of Heparin-Induced Thrombocytopenia: A Case Report and Literature Review https://t.co/ipFSkIp0We
DOC for the management of Heparin-induced thrombocytopenia
RT @AB_drmd: ✅في ال Heparin-Induced Thrombocytopenia (HIT type II)، مو السبب إن الهيبارين “يقلل الصفائح” مباشرة، بل يصير تفاعل مناعي غريب.…
RT @AB_drmd: ✅في ال Heparin-Induced Thrombocytopenia (HIT type II)، مو السبب إن الهيبارين “يقلل الصفائح” مباشرة، بل يصير تفاعل مناعي غريب.…
RT @AB_drmd: ✅في ال Heparin-Induced Thrombocytopenia (HIT type II)، مو السبب إن الهيبارين “يقلل الصفائح” مباشرة، بل يصير تفاعل مناعي غريب.…
RT @AB_drmd: ✅في ال Heparin-Induced Thrombocytopenia (HIT type II)، مو السبب إن الهيبارين “يقلل الصفائح” مباشرة، بل يصير تفاعل مناعي غريب.…
https://t.co/ByAQOYroUC
@PeteHegseth https://t.co/LHuApbyhVv
RT @AB_drmd: ✅في ال Heparin-Induced Thrombocytopenia (HIT type II)، مو السبب إن الهيبارين “يقلل الصفائح” مباشرة، بل يصير تفاعل مناعي غريب.…
RT @AB_drmd: ✅في ال Heparin-Induced Thrombocytopenia (HIT type II)، مو السبب إن الهيبارين “يقلل الصفائح” مباشرة، بل يصير تفاعل مناعي غريب.…
RT @AB_drmd: ✅في ال Heparin-Induced Thrombocytopenia (HIT type II)، مو السبب إن الهيبارين “يقلل الصفائح” مباشرة، بل يصير تفاعل مناعي غريب.…
✅في ال Heparin-Induced Thrombocytopenia (HIT type II)، مو السبب إن الهيبارين “يقلل الصفائح” مباشرة، بل يصير تفاعل مناعي غريب. الهيبارين يرتبط ببروتين اسمه Platelet Factor 4 (PF4)، و الجسم يكوّن أجسام مضادة IgG ضد هذا المركب. الأجسام المضادة ترتبط بمستقبلات على الصفائح (Fc https://t.co/NjZjMbAMjU https://t.co/XyhaKfxLT6
@MoarSahitoPTI Enoxaparin (a low-molecular-weight heparin) gives:
RT @simplify_drugs: In heparin induced thrombocytopenia, antibodies are formed against Heparin Platelet Gp 2b/3a receptor Platelet factor 4…
@AlanStout19 @2ndNewMoon @paulfrewDUP 9. Local neurologists in Greifswald University Hospital (particularly Prof. Andreas Greinacher) identified the tell-tale pattern: unusually severe headaches, low platelet counts, antibodies to PF4 — identical to heparin-induced thrombocytopenia (HIT).
RT @simplify_drugs: In heparin induced thrombocytopenia, antibodies are formed against Heparin Platelet Gp 2b/3a receptor Platelet factor 4…
RT @simplify_drugs: In heparin induced thrombocytopenia, antibodies are formed against Heparin Platelet Gp 2b/3a receptor Platelet factor 4…
RT @simplify_drugs: In heparin induced thrombocytopenia, antibodies are formed against Heparin Platelet Gp 2b/3a receptor Platelet factor 4…
RT @simplify_drugs: In heparin induced thrombocytopenia, antibodies are formed against Heparin Platelet Gp 2b/3a receptor Platelet factor 4…
busting drug used to save strike victims) instead of sterile saline. Turns out that I had an unknown really rare allergy to Heparin. It caused HIT (Heparin Induced Thrombocytopenia). Basically it made my blood clot! As soon as they discovered this they also found a large DVT behind my right knee.
In heparin induced thrombocytopenia, antibodies are formed against Heparin Platelet Gp 2b/3a receptor Platelet factor 4 (PF4) Heparin - PF4 https://t.co/UjBtGmDcVl
@AB_drmd لأن Heparin-Induced Thrombocytopenia (HIT) هي حالة مناعية تسبب تنشيط الصفائح بدل تكسيرها فقط.
@DrAkhilX Heparin induced thrombocytopenia
RT @MedSprint: @DrAkhilX ✅ 4T Score is used in the evaluation of Heparin-Induced Thrombocytopenia (HIT).
@DrAkhilX ✅ 4T Score is used in the evaluation of Heparin-Induced Thrombocytopenia (HIT).
https://t.co/lT2258yPjQ
In Heparin-Induced Thrombocytopenia, even small heparin flushes must be stopped immediately ⛔
https://t.co/fmO9ulnkM8
Heparin-Induced Thrombocytopenia Caused by Preventive Anticoagulation After Femoral Intertrochanteric Fracture Surgery: a Case Report https://t.co/XMlOe7yR4s
Unfractionated heparin causing heparin induced thrombocytopenia (maybe rare but well known side effect for heparin) https://t.co/T0dBzfWKl7
https://t.co/OGErRAyU9H
@simplify_drugs heparin induced thrombocytopenia
@world_of_med1 B . HIT Heparin induced thrombocytopenia
@propofollaw @world_of_med1 I was first confused just like you , but understanding the pathology of HIT makes sense .. Heparin-induced thrombocytopenia (HIT) causes low platelets and thrombosis because the body mistakenly creates antibodies against a complex of heparin and platelet factor 4 (PF4).
@world_of_med1 Heparin induced thrombocytopenia, A low platelet count of 50.
@IlliasulK Heparin induced thrombocytopenia?
@Runningmansuzie @Smil3yAngel Mechanism involves anti-PF4 antibodies (similar to heparin-induced thrombocytopenia). Context vs. COVID risk: During Delta-era waves, risk of serious clots &death from COVID infection itself was far higher than the vaccine-associated TTS risk…regulators concluded benefit > risk
Raising Awareness For Heparin induced thrombocytopenia thrombosis - Sign the Petition! https://t.co/uB7t8f7XyJ via @UKChange
Fresh blog: Six pearls on heparin-induced thrombocytopenia (HIT) in 2025
@iXeno @davideyoungmd @KayVonPaul @ChrisJohnsonMD @cappsie @DirtyHarryLad @CarlSmytheCells @dirk_fasshauer @higgsri @DrLizaMD @djt10 @JED94397814 @itisjustmebabe @Lorenzo7127 @markmcdougall13 @richykirsh @Scary7Dr @TerryTerroriser @drloveariyana @trillionofcells @SnowflakeJ7 @71832Afterparty @SKULjammer @RonMortimer3 @Mike6150817700 @NexusSwords @614Caravan46273 @crabb_vicki @BreezerGalway @NurseMicheleRN @BurgerLab12 @Earthdriver @mass_rising @BlairHealt68622 @DopplerEffect93 @PatrickSquirrel @SkepticalMutant @CaryDavid722 @exohalophiles @deerbrian @DemsRRacePimps @BlueLionBlog @FillmoreWhite @Alex_on_A14 @jtmayes3 @AndrewLazarus4 @ncdave4life @TMGFlorida @Roper_Lab @ktibus VITT has a few signs. Shows up similar to HIT (Heparin induced Thrombocytopenia) https://t.co/JR94HJlMKc
RT @HRS_CaseReports: Safety of pulsed field ablation of atrial fibrillation in patient with Left Ventricular Assist Device and heparin-indu…
RT @HRS_CaseReports: Safety of pulsed field ablation of atrial fibrillation in patient with Left Ventricular Assist Device and heparin-indu…
Unusual presentation of heparin-induced thrombocytopenia and thrombosis (HITT) with multiple organ involvement https://t.co/VoAJ7FIAss
@AbiyAhmedAli heparin IgG antibodies) is titled Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopenia. I cured HIV have my money Recorrelation different urea
@Forbes heparin IgG antibodies) is titled Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopenia. It's Muhayadin Abdirahman 1st Trillion
heparin IgG antibodies) is titled Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopenia.
heparin IgG antibodies) is titled Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopenia.
RT @HRS_CaseReports: Safety of pulsed field ablation of atrial fibrillation in patient with Left Ventricular Assist Device and heparin-indu…
Safety of pulsed field ablation of atrial fibrillation in patient with Left Ventricular Assist Device and heparin-induced thrombocytopenia https://t.co/jaNBI4NVGy https://t.co/KwPOT7ishO
RT @simplify_drugs: The most common symptomatic presentation of heparin induced thrombocytopenia (HIT) is Bleeding Venous thromboembolism A…
RT @simplify_drugs: The most common symptomatic presentation of heparin induced thrombocytopenia (HIT) is Bleeding Venous thromboembolism A…
RT @simplify_drugs: The most common symptomatic presentation of heparin induced thrombocytopenia (HIT) is Bleeding Venous thromboembolism A…
RT @simplify_drugs: The most common symptomatic presentation of heparin induced thrombocytopenia (HIT) is Bleeding Venous thromboembolism A…
RT @simplify_drugs: The most common symptomatic presentation of heparin induced thrombocytopenia (HIT) is Bleeding Venous thromboembolism A…
RT @simplify_drugs: The most common symptomatic presentation of heparin induced thrombocytopenia (HIT) is Bleeding Venous thromboembolism A…
RT @simplify_drugs: The most common symptomatic presentation of heparin induced thrombocytopenia (HIT) is Bleeding Venous thromboembolism A…
RT @simplify_drugs: The most common symptomatic presentation of heparin induced thrombocytopenia (HIT) is Bleeding Venous thromboembolism A…
RT @simplify_drugs: The most common symptomatic presentation of heparin induced thrombocytopenia (HIT) is Bleeding Venous thromboembolism A…
The most common symptomatic presentation of heparin induced thrombocytopenia (HIT) is Bleeding Venous thromboembolism Arterial thromboembolism Myocardial infarction https://t.co/xkfeu8JGUP
HIT me with your best shot. Fire away! https://t.co/pk8n0LHJQ8
Join @DrNetBow as She Explores Heparin-Induced Thrombocytopenia! https://t.co/QAbLrXyQYD #Health #Hematology #Hemostasis #Thrombosis #HemostasisToday #HISCL #HIT #LMWH #Medicine #Sysmex #MedEd #Thromboembolism #UFH #MedX https://t.co/j7TcsGrSD0
RT @koshurambur: @drabdulhameed07 @IhabFathiSulima @BodyExplained @medcrux @longevity_agent D It's a case of Heparin Induced Thrombocytopen…
a policy to flush every new IV with Heparin and lo and behold I was seriously allergic to this which caused a condition called HIT (Heparin Induced Thrombocytopenia) basically this miracle clot busting drug caused my blood to clot and it gave me a large DVT behind my right knee which thankfully
Monoclonal antibodies drive heparin-induced thrombocytopenia, revealing new insights for diagnostics and targeted treatment strategies. by Treverton J, Arnold DM (...) Nazy I et 7 al. in N Engl J Med #MedSky
Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia | New England Journal of Medicine www.nejm.org/doi/full/10....
In patients with heparin-induced thrombocytopenia, pathogenic antibodies were found to be monoclonal, which challenges previous views of HIT as a polyclonal disorder and suggests new avenues for diagnosis and treatment. Full study results: nej.md/4pkaYAq #MedSky #CardioSky
Scientists Discover Single Antibody Triggering Severe Reaction to Widely Used Blood Thinner In a groundbreaking discovery set to revolutionize hematology and immunology, researchers at McMaster University have uncovered that heparin-induced thrombocytopenia (HIT) is driven by a single monoclonal…
A single antibody has been identified as the cause of heparin-induced thrombocytopenia, enabling more accurate diagnosis and targeted treatment for this serious blood clotting complication.
New petition: "Fund awareness & training for Heparin Induced Thrombocytopenia Thrombosis" Deadline 15 February 2026, created by Coleman Coleman #NewPetition
I'm a survivor. I have survived much worse. I have spent 45 days surviving double PCP Pneumonia, sepsis, heart failure, Heparin Induced Thrombocytopenia (DVT behind rt knee caused by HIT rare allergic reaction) and serious brain swelling - all at the same time in early 2004!
Republicans should be pushed into a lake of fire. I hope they get poisoned with that shit that makes everyone think you're dead but you're not and then you get buried alive and just have to fucking deal with it while someone points and laughs. I wish heparin-induced thrombocytopenia on Trump.
ICYMI: Unusual presentation of heparin-induced thrombocytopenia and thrombosis (HITT) with multiple organ involvement
Unusual presentation of heparin-induced thrombocytopenia and thrombosis (HITT) with multiple organ involvement
ICYMI: Unusual presentation of heparin-induced thrombocytopenia and thrombosis (HITT) with multiple organ involvement
Unusual presentation of heparin-induced thrombocytopenia and thrombosis (HITT) with multiple organ involvement
PF4-dependent P-selectin expression assay in comparison to the heparin-induced platelet activation assay for the diagnosis of heparin-induced thrombocytopenia pubmed.ncbi.nlm.nih.gov/40191970/
"In relation to #AntiphospholipidSyndrome and its potential complications, a new #DNA drug to fight #BloodClots has been discovered..the anti-thrombin DNA #aptamer, M08s-1, might act as a promising antidote for HIT (heparin-induced #thrombocytopenia)": buff.ly/PcOZ0mr
Novel non-anticoagulant therapeutics to curb the immune response in Heparin-Induced #Thrombocytopenia #HIT doi.org/10.1182/bloo... #DrugDevelopment #TranslationalScience
Really looking forward to welcoming Dr. Adam Cuker to visit Stanford #Hematology next week, excited to hear his updates on an important clinical topic, heparin induced thrombocytopenia (HIT) @stanforddeptmed.bsky.social
Heparin-induced thrombocytopenia (HIT) Unfraction heparin > Low molecular weight heparin. Caused by antibodies against heparin & platelet factor IV. ·Thrombosis rather than bleeding. ARGATROBAN (direct thrombin inhibitor) is the tx for HIT by binding to the thrombin active site.
in practice the main risk stratification tool I use is the HITT score for heparin-induced thrombocytopenia (which is great and should be adhered to more strictly). by the time people are calling me, the patient has usually allready risk-stratified themselves
***Nephro insights*** A dialysis patient, who has been anticoagulated with argatroban for over a year due to confirmed heparin-induced thrombocytopenia type 2 (HIT-2), now shows a negative HIT-2 antibody status. He wishes to switch back to heparin. Safe, right? 1/3
Finally training someone new in special coag and having to explain that our bottle labeled "HIT STAB
Streamlined approach to testing for heparin-induced thrombocytopenia improves diagnostic accuracy Relationship between HIT ELISA % heparin inhibition, low-heparin OD, and SRA results for nonnegative HIT ELISAs with corresponding SRA testing during the analysis period (December 7, 2016–December 31,…
#بسم_الله Heparin induced thrombocytopenia youtu.be/8HQBwBmWfjM?...
Severe COVID-19 patients develop RBD-specific antibodies that activate platelets, resembling those in heparin-induced thrombocytopenia and promoting thrombosis. by Zhu W, Zheng Y (...) Wen R et 22 al. in Blood #MedSky
Our Haematology study day is in a couple of days and we have a few more speakers to share with you! Andrew Doyle will be joining us to discuss the diagnosis and management of heparin induced thrombocytopenia.
"It is important to note that anti-CXCL4 antibodies are responsible for most cases of vaccine‐induced immune thrombotic thrombocytopenia (VITT); this is similar to what happens with heparin-induced thrombocytopenia" [NOV 2022] www.ncbi.nlm.nih.gov/pmc/articles...
One of your ICU patients dropped her platelets from 180k to 140k three days after heparin drip was started for left lower extremity DVT. You know that there are 2 types of heparin-induced thrombocytopenia (HIT), type 1 and type 2. However:
Successfully diagnosed heparin-induced thrombocytopenia
A specific thrombocyte antibody has reportedly been identified as the cause in these cases, creating a picture similar to heparin induced thrombocytopenia. Unfortunately all we have to go on is press releases at this point....
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