Entre outros, temos o exemplo clássico da dengue: ser infectado sucessivas vezes por diferentes variantes do vírus pode contribuir em manifestações mais graves. https://t.co/KXq5rrJ1mj https://t.co/KATOEdfwR6
Original antigenic sin: A comprehensive review.
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May 2020 – Aug 2025Where it's discussed
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X / Twitter128 posts
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News64 articles
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Blogs4 articles
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YouTube2 videos
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Bluesky1 posts
AI synopsis
What people are saying
Posts show a balance between acknowledging the scientific basis of original antigenic sin and questioning its significance, such as the tweet stating 'Why is
Most discussions acknowledge the concept of original antigenic sin but differ in their opinions about its implications, leading to a neutral overall stance.
The posts show moderate curiosity, with some posts referencing the scientific details and others simply noting the topic's relevance.
Several posts delve into scientific explanations, question the mechanisms, and reference related phenomena, indicating active engagement.
While some discussions consider the potential effects on vaccine responses, the overall impact appears to be limited, mostly raising awareness without declaring transformative implications.
Abstract in brief
- Original antigenic sin is a phenomenon first identified in 1960 by Thomas Francis Jr, which affects how our immune system responds to infections and vaccines.
- It occurs when the immune system relies on its memory of a previous infection to respond to a slightly different strain of a virus, potentially leading to an inadequate immune response.
- This concept has important implications for vaccine design, as it suggests that exposure to one strain might hinder the immune system’s ability to fight new or mutated strains effectively, possibly causing worse disease outcomes.]
Top posts
Most liked on X and BlueskyReferências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https://t.co/BnamqEn0TC https://t.co/IyI69o2oU0 https://t.co/6Pui2hYi8f https://t.co/0Nc3JTvY5f
@jonathanstea the concern is that repeated injections of vaccine can lead to a loss in pathogenic control due to immune system fatigue https://t.co/y3eEm4vFjB https://t.co/vCLxDDa2Ak https://t.co/43k8Zu29Dc
@RadioFreeTom OAS “original antigenic sin” https://t.co/XnkxNxg2Bq https://t.co/A61yohOJCS https://t.co/gpjh5yY3qh
@roxmo @gersonsflores É uma lástima q tenham usado AIDS, pois remete ao HIV. Na vdd é uma imunodeficiência adquirida em virtude de uma característica bem estudada o "pecado antigênico original". https://t.co/NTsBb2vZ5o
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Understanding Cross-Immunity and Original Antigenic Sin in Viral Infections
Could SARS-CoV-2 confer cross-immunity against future coronavirus outbreaks? We explore this possible protection and also discuss the phenomenon of original antigenic sin, which affects how our immune system responds to…
Original Antigenic Sin and Its Impact on COVID-19 and Dengue Responses
This video explores how initial infections modify immune responses, affecting reactions to future virus variants. It discusses the concept of original antigenic sin, its effects on COVID-19 and dengue immunity, and…
@beranes75112 @TAdair41146546 @VigilantFox Source: https://t.co/53wK1EhYCr
@CTVNews https://t.co/8xTip0da26
@AngryCitizenxx If you are ready for "the science" - start here https://t.co/zaj69LAdWD
@rosesheart @liz_churchill10 Regarding Original Antigenic Sin: https://t.co/4az5niq5Qf "original antigenic sin" implies that when the epitope varies slightly, then the immune system relies on memory of the earlier infection, rather than mount another primary or secondary response to the new epitope which
@DawnsMission don't think..... know. See actual science. https://t.co/zaj69LAdWD
https://t.co/S3Lf1yWusk https://t.co/UIp3cp6tvF
@VPrasadMDMPH @erdocAA Why is "Original antigenic sin" ignored? https://t.co/aF32PdbBw1
@systematic_fun @Friesein @ChristopWFisher "This suggests the long-term memory B-cell IgG class is established based on the initial exposures to the virus." This concept is called "Original Antigenic Sin." I do not agree with this perception of our immune system... that's it... we're done here. https://t.co/74FoYl17PH
@RadioFreeTom OAS “original antigenic sin” https://t.co/XnkxNxg2Bq https://t.co/A61yohOJCS https://t.co/gpjh5yY3qh
@Eric_Biggz @theSelfishMan @Joeson_One That's leaving aside the problem of original antigenic sin. https://t.co/R5bYPmbzew
RT @tootypetodrunk: @TheChiefNerd Original Antigenic Sin has been known about since the 50's. Many of us expected it with the covid jab. Yo…
@TheChiefNerd Original Antigenic Sin has been known about since the 50's. Many of us expected it with the covid jab. You can't vaccinate your way out of a pandemic https://t.co/Fth7kYPWRa
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@roxmo @gersonsflores É uma lástima q tenham usado AIDS, pois remete ao HIV. Na vdd é uma imunodeficiência adquirida em virtude de uma característica bem estudada o "pecado antigênico original". https://t.co/NTsBb2vZ5o
@SandraWeeden https://t.co/qrxD5hlFk7
@TheChiefNerd Original antigenic sin https://t.co/WSrsgEp7ww https://t.co/E5AJP9y0b8
@Filiecs2 @Thomas_Banacek @LoofboroDan @zookeepermc @jonathanstea Tricking ur body w jabs does not give u the entire immune response. Jabs don't trigger t cell response which helps clear the virus. Some jabs cause OAS https://t.co/prh65E46uJ
RT @realvinnyd: @jonathanstea the concern is that repeated injections of vaccine can lead to a loss in pathogenic control due to immune sys…
@jonathanstea the concern is that repeated injections of vaccine can lead to a loss in pathogenic control due to immune system fatigue https://t.co/y3eEm4vFjB https://t.co/vCLxDDa2Ak https://t.co/43k8Zu29Dc
@Jesfiddlin @RedmoreE @markoftheD @tonylinfreedom @stkirsch These "imperfect" vaccines clearly didn't provide neutralizing immunity resulting in escaped variants that only prolong the pandemic. https://t.co/vKqizU0Em3
@thesassymicrobe Self proclaimed microbiologist doesn't understand Original antigenic sin. https://t.co/nHvSo7vtg5
Self proclaimed microbiologist doesn't understand Original antigenic sin. https://t.co/nHvSo7vtg5 https://t.co/8aA3Ria0rU
@thesassymicrobe an immune response to the flu a mere 5 months post your last booster, 6 months post C19. Did you ever get lipschutz any other time you got the flu ? No ? did you get it after your last C19 ? No ? https://t.co/nHvSo7vtg5 "anergy" "inducing aberrant clinical consequences."
an immune response to the flu a mere 5 months post your last booster, 6 months post C19. Did you ever get lipschutz any other time you got the flu ? No ? did you get it after your last C19 ? No ? https://t.co/nHvSo7vtg5 "anergy" "inducing aberrant clinical consequences." https://t.co/1akeEFf45A
https://t.co/hQlaWWpG4X interesting bits and pieces here
@FLSurgeonGen https://t.co/onNcs42Nx1
original antigenic sin - catchy title https://t.co/onNcs42Nx1 https://t.co/L0V1j3waqB
@TimTrippDesign @ichudov @USMortality https://t.co/CURTmolxYp , IgG4 is also an issue, but there are many.
@holmenkollin Das war zu erwarten, da dies ja keineswegs ein neues Phänomen ist. #OriginalAntigenicSin https://t.co/VqlmZBo8rK
@holmenkollin @jeha2019 Das war zu erwarten, da dies ja keineswegs ein neues Phänomen ist. #OriginalAntigenicSin https://t.co/VqlmZBo8rK
@holmenkollin @jeha2019 Das war zu erwarten, da dies ja keineswegs ein neues Phänomen ist. #OriginalAntigenicSin https://t.co/VqlmZBoGhi
@FrankyShark @Wal_Trudeau @QubRadio Il y a quelques théories, celle que l’ont entend le plus parlé est le péché originelle anti génique (https://t.co/fC8AKy8NVo) Mais la pure réalité c’est que l’ont n’est pas sûr. Le système immunitaire est incroyablement complexe. Et ceux qui ton dit des certitudes ton menti.
Original antigenic sin: A comprehensive review https://t.co/wyNYVHSrNy
@Shopnicevintage @arijitchakrav Original antigenic sin: A comprehensive review. original antigenic sin implies when the epitope varies slightly, then the immune system relies on memory of the earlier infection, rather than mount another primary or secondary response to the new epitope https://t.co/nipjjTK5gz
RT @luizacaires3: Entre outros, temos o exemplo clássico da dengue: ser infectado sucessivas vezes por diferentes variantes do vírus pode c…
RT @luizacaires3: Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https:/…
RT @luizacaires3: Entre outros, temos o exemplo clássico da dengue: ser infectado sucessivas vezes por diferentes variantes do vírus pode c…
RT @luizacaires3: Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https:/…
RT @luizacaires3: Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https:/…
RT @luizacaires3: Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https:/…
RT @luizacaires3: Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https:/…
RT @luizacaires3: Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https:/…
RT @luizacaires3: Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https:/…
RT @luizacaires3: Entre outros, temos o exemplo clássico da dengue: ser infectado sucessivas vezes por diferentes variantes do vírus pode c…
RT @luizacaires3: Entre outros, temos o exemplo clássico da dengue: ser infectado sucessivas vezes por diferentes variantes do vírus pode c…
RT @luizacaires3: Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https:/…
RT @luizacaires3: Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https:/…
RT @luizacaires3: Entre outros, temos o exemplo clássico da dengue: ser infectado sucessivas vezes por diferentes variantes do vírus pode c…
RT @luizacaires3: Entre outros, temos o exemplo clássico da dengue: ser infectado sucessivas vezes por diferentes variantes do vírus pode c…
RT @luizacaires3: Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https:/…
RT @luizacaires3: Entre outros, temos o exemplo clássico da dengue: ser infectado sucessivas vezes por diferentes variantes do vírus pode c…
RT @luizacaires3: Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https:/…
RT @luizacaires3: Entre outros, temos o exemplo clássico da dengue: ser infectado sucessivas vezes por diferentes variantes do vírus pode c…
Referências (artigos e outros fios) https://t.co/KZHoYjpyMx https://t.co/RkkRyz5u4h https://t.co/KXq5rrJ1mj https://t.co/BnamqEn0TC https://t.co/IyI69o2oU0 https://t.co/6Pui2hYi8f https://t.co/0Nc3JTvY5f
Entre outros, temos o exemplo clássico da dengue: ser infectado sucessivas vezes por diferentes variantes do vírus pode contribuir em manifestações mais graves. https://t.co/KXq5rrJ1mj https://t.co/KATOEdfwR6
@ydeigin Original antigenic sin: A comprehensive review https://t.co/dqVNqPcwSy Is ‘original antigenic sin’ complicating indian vaccination drive against Covid-19? https://t.co/FGTC06ZQyc
@BMarlies68 Saluti, please find the unroll here: Original antigenic sin: A comprehensive review… https://t.co/6urZWyTUDT See you soon.
RT @threadreaderapp: @__K_C_B__ Bonjour, please find the unroll here: Original antigenic sin: A comprehensive review… https://t.co/6urZWyTU…
@Wallyboytoaogm1 Namaste, please find the unroll here: Original antigenic sin: A comprehensive review… https://t.co/6urZWyTUDT Share this if you think it's interesting.
@the_stinging Hier het artikel zonder betaalmuur https://t.co/so1fWXhsYS
@the_stinging @huisdoktertim Hier het artikel te lezen in zijn geheel https://t.co/so1fWXhsYS
malaria). https://pubmed.ncbi.nlm.nih.gov/28479213/
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